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FYB1 (FYN binding protein 1)

Identity

Alias (NCBI)ADAP
FYB
PRO0823
SLAP-130
SLAP130
THC3
HGNC (Hugo) FYB1
HGNC Alias symbSLAP-130
FYB-120/130
ADAP
HGNC Alias nameadhesion and degranulation promoting adaptor protein
HGNC Previous nameFYB
HGNC Previous nameFYN-binding protein (FYB-120/130)
 FYN binding protein
LocusID (NCBI) 2533
Atlas_Id 51500
Location 5p13.1  [Link to chromosome band 5p13]
Location_base_pair Starts at 39105252 and ends at 39219563 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CSMD2 1p35.1 / FYB 5p13.1RICTOR 5p13.1 / FYB 5p13.1
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



External links

 

Nomenclature
HGNC (Hugo)FYB1   4036
Cards
Entrez_Gene (NCBI)FYB1    FYN binding protein 1
AliasesADAP; FYB; PRO0823; SLAP-130; 
SLAP130; THC3
GeneCards (Weizmann)FYB1
Ensembl hg19 (Hinxton)ENSG00000082074 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000082074 [Gene_View]  ENSG00000082074 [Sequence]  chr5:39105252-39219563 [Contig_View]  FYB1 [Vega]
ICGC DataPortalENSG00000082074
TCGA cBioPortalFYB1
AceView (NCBI)FYB1
Genatlas (Paris)FYB1
SOURCE (Princeton)FYB1
Genetics Home Reference (NIH)FYB1
Genomic and cartography
GoldenPath hg38 (UCSC)FYB1  -     chr5:39105252-39219563 -  5p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FYB1  -     5p13.1   [Description]    (hg19-Feb_2009)
GoldenPathFYB1 - 5p13.1 [CytoView hg19]  FYB1 - 5p13.1 [CytoView hg38]
ImmunoBaseENSG00000082074
Genome Data Viewer NCBIFYB1 [Mapview hg19]  
OMIM273900   602731   
Gene and transcription
Genbank (Entrez)AF001862 AF116653 AF198052 AI961953 AK123918
RefSeq transcript (Entrez)NM_001243093 NM_001349333 NM_001465 NM_018594 NM_199335
Consensus coding sequences : CCDS (NCBI)FYB1
Gene ExpressionFYB1 [ NCBI-GEO ]   FYB1 [ EBI - ARRAY_EXPRESS ]   FYB1 [ SEEK ]   FYB1 [ MEM ]
Gene Expression Viewer (FireBrowse)FYB1 [ Firebrowse - Broad ]
GenevisibleExpression of FYB1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2533
GTEX Portal (Tissue expression)FYB1
Human Protein AtlasENSG00000082074-FYB1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15117   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15117  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15117
PhosPhoSitePlusO15117
Domaine pattern : Prosite (Expaxy)SH3 (PS50002)   
Domains : Interpro (EBI)FYB1    FYB1/2-like    FYB_hSH3    hSH3    SH3-like_dom_sf    SH3_domain   
Domain families : Pfam (Sanger)hSH3 (PF14603)    SH3_2 (PF07653)   
Domain families : Pfam (NCBI)pfam14603    pfam07653   
Domain families : Smart (EMBL)SH3 (SM00326)  
Conserved Domain (NCBI)FYB1
PDB (RSDB)1RI9    2GTJ    2GTO   
PDB Europe1RI9    2GTJ    2GTO   
PDB (PDBSum)1RI9    2GTJ    2GTO   
PDB (IMB)1RI9    2GTJ    2GTO   
Structural Biology KnowledgeBase1RI9    2GTJ    2GTO   
SCOP (Structural Classification of Proteins)1RI9    2GTJ    2GTO   
CATH (Classification of proteins structures)1RI9    2GTJ    2GTO   
SuperfamilyO15117
AlphaFold pdb e-kbO15117   
Human Protein Atlas [tissue]ENSG00000082074-FYB1 [tissue]
HPRD04107
Protein Interaction databases
DIP (DOE-UCLA)O15117
IntAct (EBI)O15117
BioGRIDFYB1
STRING (EMBL)FYB1
ZODIACFYB1
Ontologies - Pathways
QuickGOO15117
Ontology : AmiGOsignaling receptor binding  protein binding  nucleus  cytosol  plasma membrane  immune response  integrin-mediated signaling pathway  biological_process  lipid binding  actin cytoskeleton  cell junction  protein-containing complex  protein-containing complex binding  T cell receptor signaling pathway  T cell receptor signaling pathway  protein localization to plasma membrane  
Ontology : EGO-EBIsignaling receptor binding  protein binding  nucleus  cytosol  plasma membrane  immune response  integrin-mediated signaling pathway  biological_process  lipid binding  actin cytoskeleton  cell junction  protein-containing complex  protein-containing complex binding  T cell receptor signaling pathway  T cell receptor signaling pathway  protein localization to plasma membrane  
NDEx NetworkFYB1
Atlas of Cancer Signalling NetworkFYB1
Wikipedia pathwaysFYB1
Orthology - Evolution
OrthoDB2533
GeneTree (enSembl)ENSG00000082074
Phylogenetic Trees/Animal Genes : TreeFamFYB1
Homologs : HomoloGeneFYB1
Homology/Alignments : Family Browser (UCSC)FYB1
Gene fusions - Rearrangements
Fusion : MitelmanCSMD2/FYB [1p35.1/5p13.1]  
Fusion : MitelmanRICTOR/FYB [5p13.1/5p13.1]  
Fusion : QuiverFYB1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFYB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FYB1
dbVarFYB1
ClinVarFYB1
MonarchFYB1
1000_GenomesFYB1 
Exome Variant ServerFYB1
GNOMAD BrowserENSG00000082074
Varsome BrowserFYB1
ACMGFYB1 variants
VarityO15117
Genomic Variants (DGV)FYB1 [DGVbeta]
DECIPHERFYB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFYB1 
Mutations
ICGC Data PortalFYB1 
TCGA Data PortalFYB1 
Broad Tumor PortalFYB1
OASIS PortalFYB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFYB1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFYB1
Mutations and Diseases : HGMDFYB1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFYB1
DgiDB (Drug Gene Interaction Database)FYB1
DoCM (Curated mutations)FYB1
CIViC (Clinical Interpretations of Variants in Cancer)FYB1
Cancer3DFYB1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM273900    602731   
Orphanet
DisGeNETFYB1
MedgenFYB1
Genetic Testing Registry FYB1
NextProtO15117 [Medical]
GENETestsFYB1
Target ValidationFYB1
Huge Navigator FYB1 [HugePedia]
ClinGenFYB1
Clinical trials, drugs, therapy
MyCancerGenomeFYB1
Protein Interactions : CTDFYB1
Pharm GKB GenePA28452
PharosO15117
Clinical trialFYB1
Miscellaneous
canSAR (ICR)FYB1
HarmonizomeFYB1
DataMed IndexFYB1
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFYB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:10:06 CEST 2021

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