Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

FYB1 (FYN binding protein 1)

Identity

Alias_namesFYN-binding protein (FYB-120/130)
Alias_symbol (synonym)SLAP-130
FYB-120/130
Other aliasADAP
FYB
PRO0823
SLAP130
THC3
HGNC (Hugo) FYB1
LocusID (NCBI) 2533
Atlas_Id 51500
Location 5p13.1  [Link to chromosome band 5p13]
Location_base_pair Starts at 39105252 and ends at 39219606 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CSMD2 1p35.1 / FYB 5p13.1RICTOR 5p13.1 / FYB 5p13.1
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)FYB1   4036
Cards
Entrez_Gene (NCBI)FYB1  2533  FYN binding protein 1
AliasesADAP; FYB; PRO0823; SLAP-130; 
SLAP130; THC3
GeneCards (Weizmann)FYB1
Ensembl hg19 (Hinxton)ENSG00000082074 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000082074 [Gene_View]  ENSG00000082074 [Sequence]  chr5:39105252-39219606 [Contig_View]  FYB1 [Vega]
ICGC DataPortalENSG00000082074
TCGA cBioPortalFYB1
AceView (NCBI)FYB1
Genatlas (Paris)FYB1
WikiGenes2533
SOURCE (Princeton)FYB1
Genetics Home Reference (NIH)FYB1
Genomic and cartography
GoldenPath hg38 (UCSC)FYB1  -     chr5:39105252-39219606 -  5p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FYB1  -     5p13.1   [Description]    (hg19-Feb_2009)
EnsemblFYB1 - 5p13.1 [CytoView hg19]  FYB1 - 5p13.1 [CytoView hg38]
Mapping of homologs : NCBIFYB1 [Mapview hg19]  FYB1 [Mapview hg38]
OMIM273900   602731   
Gene and transcription
Genbank (Entrez)AF001862 AF116653 AF198052 AI961953 AK123918
RefSeq transcript (Entrez)NM_001243093 NM_001349333 NM_001465 NM_018594 NM_199335
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FYB1
Cluster EST : UnigeneHs.691768 [ NCBI ]
CGAP (NCI)Hs.691768
Alternative Splicing GalleryENSG00000082074
Gene ExpressionFYB1 [ NCBI-GEO ]   FYB1 [ EBI - ARRAY_EXPRESS ]   FYB1 [ SEEK ]   FYB1 [ MEM ]
Gene Expression Viewer (FireBrowse)FYB1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2533
GTEX Portal (Tissue expression)FYB1
Human Protein AtlasENSG00000082074-FYB1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15117   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15117  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15117
Splice isoforms : SwissVarO15117
PhosPhoSitePlusO15117
Domaine pattern : Prosite (Expaxy)SH3 (PS50002)   
Domains : Interpro (EBI)FYB    FYB_hSH3    hSH3    SH3-like_dom_sf    SH3_domain   
Domain families : Pfam (Sanger)hSH3 (PF14603)    SH3_2 (PF07653)   
Domain families : Pfam (NCBI)pfam14603    pfam07653   
Domain families : Smart (EMBL)SH3 (SM00326)  
Conserved Domain (NCBI)FYB1
DMDM Disease mutations2533
Blocks (Seattle)FYB1
PDB (RSDB)1RI9    2GTJ    2GTO   
PDB Europe1RI9    2GTJ    2GTO   
PDB (PDBSum)1RI9    2GTJ    2GTO   
PDB (IMB)1RI9    2GTJ    2GTO   
Structural Biology KnowledgeBase1RI9    2GTJ    2GTO   
SCOP (Structural Classification of Proteins)1RI9    2GTJ    2GTO   
CATH (Classification of proteins structures)1RI9    2GTJ    2GTO   
SuperfamilyO15117
Human Protein Atlas [tissue]ENSG00000082074-FYB1 [tissue]
Peptide AtlasO15117
HPRD04107
IPIIPI00446986   IPI00073110   IPI00967826   IPI00001189   IPI01012476   IPI00966351   IPI00967174   IPI00966901   
Protein Interaction databases
DIP (DOE-UCLA)O15117
IntAct (EBI)O15117
FunCoupENSG00000082074
BioGRIDFYB1
STRING (EMBL)FYB1
ZODIACFYB1
Ontologies - Pathways
QuickGOO15117
Ontology : AmiGOsignaling receptor binding  protein binding  nucleus  cytosol  plasma membrane  protein phosphorylation  NLS-bearing protein import into nucleus  immune response  signal transduction  integrin-mediated signaling pathway  biological_process  lipid binding  actin cytoskeleton  cell junction  intracellular signal transduction  protein-containing complex binding  T cell receptor signaling pathway  T cell receptor signaling pathway  protein localization to plasma membrane  
Ontology : EGO-EBIsignaling receptor binding  protein binding  nucleus  cytosol  plasma membrane  protein phosphorylation  NLS-bearing protein import into nucleus  immune response  signal transduction  integrin-mediated signaling pathway  biological_process  lipid binding  actin cytoskeleton  cell junction  intracellular signal transduction  protein-containing complex binding  T cell receptor signaling pathway  T cell receptor signaling pathway  protein localization to plasma membrane  
NDEx NetworkFYB1
Atlas of Cancer Signalling NetworkFYB1
Wikipedia pathwaysFYB1
Orthology - Evolution
OrthoDB2533
GeneTree (enSembl)ENSG00000082074
Phylogenetic Trees/Animal Genes : TreeFamFYB1
HOGENOMO15117
Homologs : HomoloGeneFYB1
Homology/Alignments : Family Browser (UCSC)FYB1
Gene fusions - Rearrangements
Fusion : MitelmanCSMD2/FYB [1p35.1/5p13.1]  [t(1;5)(p34;p13)]  
Fusion : MitelmanRICTOR/FYB [5p13.1/5p13.1]  [t(5;5)(p13;p13)]  
Fusion PortalCSMD2 1p35.1 FYB 5p13.1 OV
Fusion PortalRICTOR 5p13.1 FYB 5p13.1 LUAD LUSC
Fusion : QuiverFYB1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFYB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FYB1
dbVarFYB1
ClinVarFYB1
1000_GenomesFYB1 
Exome Variant ServerFYB1
ExAC (Exome Aggregation Consortium)ENSG00000082074
GNOMAD BrowserENSG00000082074
Varsome BrowserFYB1
Genetic variants : HAPMAP2533
Genomic Variants (DGV)FYB1 [DGVbeta]
DECIPHERFYB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFYB1 
Mutations
ICGC Data PortalFYB1 
TCGA Data PortalFYB1 
Broad Tumor PortalFYB1
OASIS PortalFYB1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDFYB1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FYB1
DgiDB (Drug Gene Interaction Database)FYB1
DoCM (Curated mutations)FYB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FYB1 (select a term)
intoGenFYB1
Cancer3DFYB1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM273900    602731   
Orphanet
DisGeNETFYB1
MedgenFYB1
Genetic Testing Registry FYB1
NextProtO15117 [Medical]
TSGene2533
GENETestsFYB1
Target ValidationFYB1
Huge Navigator FYB1 [HugePedia]
snp3D : Map Gene to Disease2533
BioCentury BCIQFYB1
ClinGenFYB1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2533
Chemical/Pharm GKB GenePA28452
Clinical trialFYB1
Miscellaneous
canSAR (ICR)FYB1 (select the gene name)
DataMed IndexFYB1
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFYB1
EVEXFYB1
GoPubMedFYB1
iHOPFYB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 17 18:13:30 CET 2019

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.