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FYN (FYN proto-oncogene, Src family tyrosine kinase)

Identity

Alias_namesFYN oncogene related to SRC, FGR, YES
Alias_symbol (synonym)SYN
SLK
MGC45350
Other aliasp59-FYN
HGNC (Hugo) FYN
LocusID (NCBI) 2534
Atlas_Id 40653
Location 6q21  [Link to chromosome band 6q21]
Location_base_pair Starts at 111660332 and ends at 111759131 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ECHDC1 (6q22.33) / FYN (6q21)FYN (6q21) / CEACAM5 (19q13.2)FYN (6q21) / COL6A3 (2q37.3)
FYN (6q21) / FYN (6q21)FYN (6q21) / LAMA4 (6q21)KMT2A (11q23.3) / FYN (6q21)
MBOAT1 (6p22.3) / FYN (6q21)NPRL3 (16p13.3) / FYN (6q21)PTPRZ1 (7q31.32) / FYN (6q21)
REV3L (6q21) / FYN (6q21)ECHDC1 6q22.33 / FYN 6q21FYN 6q21 / LAMA4 6q21
MBOAT1 6p22.3 / FYN 6q21MLL FYN 6q21PTPRZ1 7q31.32 / FYN 6q21
REV3L 6q21 / FYN 6q21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  del(11)(q23q23) KMT2A/ARHGEF12

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(6;6)(p22;q21) MBOAT1/FYN
t(6;6)(q21;q22) ECHDC1/FYN
t(6;7)(q21;q31) PTPRZ1/FYN
t(6;11)(q21;q23) KMT2A/FYN

External links

Nomenclature
HGNC (Hugo)FYN   4037
Cards
Entrez_Gene (NCBI)FYN  2534  FYN proto-oncogene, Src family tyrosine kinase
AliasesSLK; SYN; p59-FYN
GeneCards (Weizmann)FYN
Ensembl hg19 (Hinxton)ENSG00000010810 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000010810 [Gene_View]  ENSG00000010810 [Sequence]  chr6:111660332-111759131 [Contig_View]  FYN [Vega]
ICGC DataPortalENSG00000010810
TCGA cBioPortalFYN
AceView (NCBI)FYN
Genatlas (Paris)FYN
WikiGenes2534
SOURCE (Princeton)FYN
Genetics Home Reference (NIH)FYN
Genomic and cartography
GoldenPath hg38 (UCSC)FYN  -     chr6:111660332-111759131 -  6q21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FYN  -     6q21   [Description]    (hg19-Feb_2009)
GoldenPathFYN - 6q21 [CytoView hg19]  FYN - 6q21 [CytoView hg38]
Genome Data Viewer NCBIFYN [Mapview hg19]  
OMIM137025   
Gene and transcription
Genbank (Entrez)AB451293 AB451426 AI187118 AK056699 AY429536
RefSeq transcript (Entrez)NM_001242779 NM_001370529 NM_002037 NM_153047 NM_153048
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FYN
Alternative Splicing GalleryENSG00000010810
Gene ExpressionFYN [ NCBI-GEO ]   FYN [ EBI - ARRAY_EXPRESS ]   FYN [ SEEK ]   FYN [ MEM ]
Gene Expression Viewer (FireBrowse)FYN [ Firebrowse - Broad ]
GenevisibleExpression of FYN in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2534
GTEX Portal (Tissue expression)FYN
Human Protein AtlasENSG00000010810-FYN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP06241   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP06241  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP06241
Splice isoforms : SwissVarP06241
Catalytic activity : Enzyme2.7.10.2 [ Enzyme-Expasy ]   2.7.10.22.7.10.2 [ IntEnz-EBI ]   2.7.10.2 [ BRENDA ]   2.7.10.2 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP06241
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)Fyn/Yrk_SH3    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    SH2    SH2_dom_sf    SH3-like_dom_sf    SH3_domain    Tyr_kinase_AS    Tyr_kinase_cat_dom   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)    SH2 (PF00017)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam07714    pfam00017    pfam00018   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  TyrKc (SM00219)  
Conserved Domain (NCBI)FYN
DMDM Disease mutations2534
PDB (RSDB)1A0N    1AOT    1AOU    1AVZ    1AZG    1EFN    1FYN    1G83    1M27    1NYF    1NYG    1SHF    1ZBJ    2DQ7    2MQI    2MRJ    2MRK    3H0F    3H0H    3H0I    3UA6    3UA7    4D8D    4EIK    4U17    4U1P    4ZNX    5ZAU    6EDF    6IPY    6IPZ   
PDB Europe1A0N    1AOT    1AOU    1AVZ    1AZG    1EFN    1FYN    1G83    1M27    1NYF    1NYG    1SHF    1ZBJ    2DQ7    2MQI    2MRJ    2MRK    3H0F    3H0H    3H0I    3UA6    3UA7    4D8D    4EIK    4U17    4U1P    4ZNX    5ZAU    6EDF    6IPY    6IPZ   
PDB (PDBSum)1A0N    1AOT    1AOU    1AVZ    1AZG    1EFN    1FYN    1G83    1M27    1NYF    1NYG    1SHF    1ZBJ    2DQ7    2MQI    2MRJ    2MRK    3H0F    3H0H    3H0I    3UA6    3UA7    4D8D    4EIK    4U17    4U1P    4ZNX    5ZAU    6EDF    6IPY    6IPZ   
PDB (IMB)1A0N    1AOT    1AOU    1AVZ    1AZG    1EFN    1FYN    1G83    1M27    1NYF    1NYG    1SHF    1ZBJ    2DQ7    2MQI    2MRJ    2MRK    3H0F    3H0H    3H0I    3UA6    3UA7    4D8D    4EIK    4U17    4U1P    4ZNX    5ZAU    6EDF    6IPY    6IPZ   
Structural Biology KnowledgeBase1A0N    1AOT    1AOU    1AVZ    1AZG    1EFN    1FYN    1G83    1M27    1NYF    1NYG    1SHF    1ZBJ    2DQ7    2MQI    2MRJ    2MRK    3H0F    3H0H    3H0I    3UA6    3UA7    4D8D    4EIK    4U17    4U1P    4ZNX    5ZAU    6EDF    6IPY    6IPZ   
SCOP (Structural Classification of Proteins)1A0N    1AOT    1AOU    1AVZ    1AZG    1EFN    1FYN    1G83    1M27    1NYF    1NYG    1SHF    1ZBJ    2DQ7    2MQI    2MRJ    2MRK    3H0F    3H0H    3H0I    3UA6    3UA7    4D8D    4EIK    4U17    4U1P    4ZNX    5ZAU    6EDF    6IPY    6IPZ   
CATH (Classification of proteins structures)1A0N    1AOT    1AOU    1AVZ    1AZG    1EFN    1FYN    1G83    1M27    1NYF    1NYG    1SHF    1ZBJ    2DQ7    2MQI    2MRJ    2MRK    3H0F    3H0H    3H0I    3UA6    3UA7    4D8D    4EIK    4U17    4U1P    4ZNX    5ZAU    6EDF    6IPY    6IPZ   
SuperfamilyP06241
Human Protein Atlas [tissue]ENSG00000010810-FYN [tissue]
Peptide AtlasP06241
HPRD00655
IPIIPI00219012   IPI00640091   IPI00166845   IPI00639876   IPI01013062   IPI00972994   IPI00980724   IPI00977969   IPI00984877   IPI00982697   IPI00980116   IPI00979454   IPI00978962   IPI00977646   IPI00976632   IPI00982063   IPI00979979   IPI00977053   IPI00975816   
Protein Interaction databases
DIP (DOE-UCLA)P06241
IntAct (EBI)P06241
FunCoupENSG00000010810
BioGRIDFYN
STRING (EMBL)FYN
ZODIACFYN
Ontologies - Pathways
QuickGOP06241
Ontology : AmiGOMAPK cascade  response to singlet oxygen  neuron migration  stimulatory C-type lectin receptor signaling pathway  adaptive immune response  heart process  protein tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  signaling receptor binding  protein binding  ATP binding  nucleus  mitochondrion  endosome  cytosol  cytosol  actin filament  plasma membrane  plasma membrane  protein phosphorylation  protein phosphorylation  calcium ion transport  transmembrane receptor protein tyrosine kinase signaling pathway  axon guidance  blood coagulation  learning  feeding behavior  regulation of cell shape  negative regulation of gene expression  negative regulation of hydrogen peroxide biosynthetic process  positive regulation of neuron projection development  positive regulation of phosphatidylinositol 3-kinase signaling  postsynaptic density  peptidyl-tyrosine phosphorylation  peptidyl-tyrosine phosphorylation  peptidyl-tyrosine phosphorylation  cytokine-mediated signaling pathway  enzyme binding  cell differentiation  platelet activation  dendrite  forebrain development  extrinsic component of cytoplasmic side of plasma membrane  T cell costimulation  negative regulation of protein ubiquitination  type 5 metabotropic glutamate receptor binding  intracellular signal transduction  cellular response to platelet-derived growth factor stimulus  peptidyl-tyrosine autophosphorylation  Fc-gamma receptor signaling pathway involved in phagocytosis  regulation of cell proliferation  negative regulation of protein catabolic process  positive regulation of tyrosine phosphorylation of STAT protein  response to hydrogen peroxide  T cell receptor binding  CD4 receptor binding  CD8 receptor binding  identical protein binding  alpha-tubulin binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of neuron apoptotic process  phosphatidylinositol 3-kinase binding  cell body  ion channel binding  innate immune response  membrane raft  membrane raft  membrane raft  membrane raft  response to ethanol  metal ion binding  ephrin receptor binding  vascular endothelial growth factor receptor signaling pathway  ephrin receptor signaling pathway  tau protein binding  tau protein binding  tau protein binding  perinuclear region of cytoplasm  dendrite morphogenesis  tau-protein kinase activity  regulation of defense response to virus by virus  regulation of peptidyl-tyrosine phosphorylation  activated T cell proliferation  modulation of chemical synaptic transmission  T cell receptor signaling pathway  T cell receptor signaling pathway  leukocyte migration  detection of mechanical stimulus involved in sensory perception of pain  peptide hormone receptor binding  positive regulation of protein kinase B signaling  growth factor receptor binding  cellular response to peptide hormone stimulus  cellular response to transforming growth factor beta stimulus  positive regulation of protein targeting to membrane  perinuclear endoplasmic reticulum  dendritic spine maintenance  glial cell projection  disordered domain specific binding  Schaffer collateral - CA1 synapse  glutamatergic synapse  postsynaptic density, intracellular component  positive regulation of protein localization to nucleus  regulation of glutamate receptor signaling pathway  positive regulation of neuron death  negative regulation of dendritic spine maintenance  negative regulation of oxidative stress-induced cell death  positive regulation of non-membrane spanning protein tyrosine kinase activity  response to amyloid-beta  cellular response to amyloid-beta  cellular response to L-glutamate  cellular response to glycine  positive regulation of protein localization to membrane  regulation of calcium ion import across plasma membrane  positive regulation of cysteine-type endopeptidase activity  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBIMAPK cascade  response to singlet oxygen  neuron migration  stimulatory C-type lectin receptor signaling pathway  adaptive immune response  heart process  protein tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  signaling receptor binding  protein binding  ATP binding  nucleus  mitochondrion  endosome  cytosol  cytosol  actin filament  plasma membrane  plasma membrane  protein phosphorylation  protein phosphorylation  calcium ion transport  transmembrane receptor protein tyrosine kinase signaling pathway  axon guidance  blood coagulation  learning  feeding behavior  regulation of cell shape  negative regulation of gene expression  negative regulation of hydrogen peroxide biosynthetic process  positive regulation of neuron projection development  positive regulation of phosphatidylinositol 3-kinase signaling  postsynaptic density  peptidyl-tyrosine phosphorylation  peptidyl-tyrosine phosphorylation  peptidyl-tyrosine phosphorylation  cytokine-mediated signaling pathway  enzyme binding  cell differentiation  platelet activation  dendrite  forebrain development  extrinsic component of cytoplasmic side of plasma membrane  T cell costimulation  negative regulation of protein ubiquitination  type 5 metabotropic glutamate receptor binding  intracellular signal transduction  cellular response to platelet-derived growth factor stimulus  peptidyl-tyrosine autophosphorylation  Fc-gamma receptor signaling pathway involved in phagocytosis  regulation of cell proliferation  negative regulation of protein catabolic process  positive regulation of tyrosine phosphorylation of STAT protein  response to hydrogen peroxide  T cell receptor binding  CD4 receptor binding  CD8 receptor binding  identical protein binding  alpha-tubulin binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of neuron apoptotic process  phosphatidylinositol 3-kinase binding  cell body  ion channel binding  innate immune response  membrane raft  membrane raft  membrane raft  membrane raft  response to ethanol  metal ion binding  ephrin receptor binding  vascular endothelial growth factor receptor signaling pathway  ephrin receptor signaling pathway  tau protein binding  tau protein binding  tau protein binding  perinuclear region of cytoplasm  dendrite morphogenesis  tau-protein kinase activity  regulation of defense response to virus by virus  regulation of peptidyl-tyrosine phosphorylation  activated T cell proliferation  modulation of chemical synaptic transmission  T cell receptor signaling pathway  T cell receptor signaling pathway  leukocyte migration  detection of mechanical stimulus involved in sensory perception of pain  peptide hormone receptor binding  positive regulation of protein kinase B signaling  growth factor receptor binding  cellular response to peptide hormone stimulus  cellular response to transforming growth factor beta stimulus  positive regulation of protein targeting to membrane  perinuclear endoplasmic reticulum  dendritic spine maintenance  glial cell projection  disordered domain specific binding  Schaffer collateral - CA1 synapse  glutamatergic synapse  postsynaptic density, intracellular component  positive regulation of protein localization to nucleus  regulation of glutamate receptor signaling pathway  positive regulation of neuron death  negative regulation of dendritic spine maintenance  negative regulation of oxidative stress-induced cell death  positive regulation of non-membrane spanning protein tyrosine kinase activity  response to amyloid-beta  cellular response to amyloid-beta  cellular response to L-glutamate  cellular response to glycine  positive regulation of protein localization to membrane  regulation of calcium ion import across plasma membrane  positive regulation of cysteine-type endopeptidase activity  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Pathways : KEGGAxon guidance    Osteoclast differentiation    Focal adhesion    Adherens junction    Natural killer cell mediated cytotoxicity    T cell receptor signaling pathway    Fc epsilon RI signaling pathway    Cholinergic synapse    Prion diseases    Pathogenic Escherichia coli infection    Measles    Viral myocarditis   
NDEx NetworkFYN
Atlas of Cancer Signalling NetworkFYN
Wikipedia pathwaysFYN
Orthology - Evolution
OrthoDB2534
GeneTree (enSembl)ENSG00000010810
Phylogenetic Trees/Animal Genes : TreeFamFYN
HOGENOMP06241
Homologs : HomoloGeneFYN
Homology/Alignments : Family Browser (UCSC)FYN
Gene fusions - Rearrangements
Fusion : MitelmanECHDC1/FYN [6q22.33/6q21]  
Fusion : MitelmanMBOAT1/FYN [6p22.3/6q21]  
Fusion : MitelmanPTPRZ1/FYN [7q31.32/6q21]  
Fusion PortalECHDC1 6q22.33 FYN 6q21 LUAD
Fusion PortalFYN 6q21 LAMA4 6q21 LUAD
Fusion PortalMBOAT1 6p22.3 FYN 6q21 BRCA
Fusion PortalMLL FYN 6q21 LUAD
Fusion PortalPTPRZ1 7q31.32 FYN 6q21 LGG
Fusion PortalREV3L 6q21 FYN 6q21 BRCA SKCM
Fusion : QuiverFYN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFYN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FYN
dbVarFYN
ClinVarFYN
1000_GenomesFYN 
Exome Variant ServerFYN
GNOMAD BrowserENSG00000010810
Varsome BrowserFYN
Genetic variants : HAPMAP2534
Genomic Variants (DGV)FYN [DGVbeta]
DECIPHERFYN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFYN 
Mutations
ICGC Data PortalFYN 
TCGA Data PortalFYN 
Broad Tumor PortalFYN
OASIS PortalFYN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFYN  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFYN
Mutations and Diseases : HGMDFYN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutaselect FYN
DgiDB (Drug Gene Interaction Database)FYN
DoCM (Curated mutations)FYN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FYN (select a term)
intoGenFYN
Cancer3DFYN (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM137025   
Orphanet
DisGeNETFYN
MedgenFYN
Genetic Testing Registry FYN
NextProtP06241 [Medical]
TSGene2534
GENETestsFYN
Open Targets GeneticsENSG00000010810  [validation]
snp3D : Map Gene to Disease2534
BioCentury BCIQFYN
ClinGenFYN
Clinical trials, drugs, therapy
Protein Interactions : CTD2534
Pharm GKB GenePA28454
Clinical trialFYN
Miscellaneous
canSAR (ICR)FYN (select the gene name)
HarmonizomeFYN
DataMed IndexFYN
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFYN
EVEXFYN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jul 11 19:49:40 CEST 2020
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