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FYN (FYN proto-oncogene, Src family tyrosine kinase)

Identity

Alias (NCBI)SLK
SYN
p59-FYN
HGNC (Hugo) FYN
HGNC Alias symbSYN
SLK
MGC45350
HGNC Previous nameFYN oncogene related to SRC, FGR, YES
LocusID (NCBI) 2534
Atlas_Id 40653
Location 6q21  [Link to chromosome band 6q21]
Location_base_pair Starts at 111660332 and ends at 111759131 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ECHDC1 (6q22.33)::FYN (6q21)FYN (6q21)::CEACAM5 (19q13.2)FYN (6q21)::COL6A3 (2q37.3)
FYN (6q21)::FYN (6q21)FYN (6q21)::LAMA4 (6q21)KMT2A (11q23.3)::FYN (6q21)
MBOAT1 (6p22.3)::FYN (6q21)NPRL3 (16p13.3)::FYN (6q21)PTPRZ1 (7q31.32)::FYN (6q21)
REV3L (6q21)::FYN (6q21)ECHDC1 6q22.33::FYN 6q21FYN 6q21::LAMA4 6q21
MBOAT1 6p22.3::FYN 6q21MLL FYN 6q21PTPRZ1 7q31.32::FYN 6q21
REV3L 6q21::FYN 6q21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  del(11)(q23q23) KMT2A::ARHGEF12

External links

 

Nomenclature
HGNC (Hugo)FYN   4037
Cards
Entrez_Gene (NCBI)FYN    FYN proto-oncogene, Src family tyrosine kinase
AliasesSLK; SYN; p59-FYN
GeneCards (Weizmann)FYN
Ensembl hg19 (Hinxton)ENSG00000010810 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000010810 [Gene_View]  ENSG00000010810 [Sequence]  chr6:111660332-111759131 [Contig_View]  FYN [Vega]
ICGC DataPortalENSG00000010810
TCGA cBioPortalFYN
AceView (NCBI)FYN
Genatlas (Paris)FYN
SOURCE (Princeton)FYN
Genetics Home Reference (NIH)FYN
Genomic and cartography
GoldenPath hg38 (UCSC)FYN  -     chr6:111660332-111759131 -  6q21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FYN  -     6q21   [Description]    (hg19-Feb_2009)
GoldenPathFYN - 6q21 [CytoView hg19]  FYN - 6q21 [CytoView hg38]
ImmunoBaseENSG00000010810
Genome Data Viewer NCBIFYN [Mapview hg19]  
OMIM137025   
Gene and transcription
Genbank (Entrez)AB451293 AB451426 AI187118 AK056699 AY429536
RefSeq transcript (Entrez)NM_001242779 NM_001370529 NM_002037 NM_153047 NM_153048
Consensus coding sequences : CCDS (NCBI)FYN
Gene ExpressionFYN [ NCBI-GEO ]   FYN [ EBI - ARRAY_EXPRESS ]   FYN [ SEEK ]   FYN [ MEM ]
Gene Expression Viewer (FireBrowse)FYN [ Firebrowse - Broad ]
GenevisibleExpression of FYN in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2534
GTEX Portal (Tissue expression)FYN
Human Protein AtlasENSG00000010810-FYN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP06241   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP06241  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP06241
Catalytic activity : Enzyme2.7.10.2 [ Enzyme-Expasy ]   2.7.10.22.7.10.2 [ IntEnz-EBI ]   2.7.10.2 [ BRENDA ]   2.7.10.2 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP06241
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)Fyn/Yrk_SH3    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    SH2    SH2_dom_sf    SH3-like_dom_sf    SH3_domain    Tyr_kinase_AS    Tyr_kinase_cat_dom   
Domain families : Pfam (Sanger)PK_Tyr_Ser-Thr (PF07714)    SH2 (PF00017)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam07714    pfam00017    pfam00018   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  TyrKc (SM00219)  
Conserved Domain (NCBI)FYN
PDB (RSDB)1A0N    1AOT    1AOU    1AVZ    1AZG    1EFN    1FYN    1G83    1M27    1NYF    1NYG    1SHF    1ZBJ    2DQ7    2MQI    2MRJ    2MRK    3H0F    3H0H    3H0I    3UA6    3UA7    4D8D    4EIK    4U17    4U1P    4ZNX    5ZAU    6EDF    6IPY    6IPZ   
PDB Europe1A0N    1AOT    1AOU    1AVZ    1AZG    1EFN    1FYN    1G83    1M27    1NYF    1NYG    1SHF    1ZBJ    2DQ7    2MQI    2MRJ    2MRK    3H0F    3H0H    3H0I    3UA6    3UA7    4D8D    4EIK    4U17    4U1P    4ZNX    5ZAU    6EDF    6IPY    6IPZ   
PDB (PDBSum)1A0N    1AOT    1AOU    1AVZ    1AZG    1EFN    1FYN    1G83    1M27    1NYF    1NYG    1SHF    1ZBJ    2DQ7    2MQI    2MRJ    2MRK    3H0F    3H0H    3H0I    3UA6    3UA7    4D8D    4EIK    4U17    4U1P    4ZNX    5ZAU    6EDF    6IPY    6IPZ   
PDB (IMB)1A0N    1AOT    1AOU    1AVZ    1AZG    1EFN    1FYN    1G83    1M27    1NYF    1NYG    1SHF    1ZBJ    2DQ7    2MQI    2MRJ    2MRK    3H0F    3H0H    3H0I    3UA6    3UA7    4D8D    4EIK    4U17    4U1P    4ZNX    5ZAU    6EDF    6IPY    6IPZ   
Structural Biology KnowledgeBase1A0N    1AOT    1AOU    1AVZ    1AZG    1EFN    1FYN    1G83    1M27    1NYF    1NYG    1SHF    1ZBJ    2DQ7    2MQI    2MRJ    2MRK    3H0F    3H0H    3H0I    3UA6    3UA7    4D8D    4EIK    4U17    4U1P    4ZNX    5ZAU    6EDF    6IPY    6IPZ   
SCOP (Structural Classification of Proteins)1A0N    1AOT    1AOU    1AVZ    1AZG    1EFN    1FYN    1G83    1M27    1NYF    1NYG    1SHF    1ZBJ    2DQ7    2MQI    2MRJ    2MRK    3H0F    3H0H    3H0I    3UA6    3UA7    4D8D    4EIK    4U17    4U1P    4ZNX    5ZAU    6EDF    6IPY    6IPZ   
CATH (Classification of proteins structures)1A0N    1AOT    1AOU    1AVZ    1AZG    1EFN    1FYN    1G83    1M27    1NYF    1NYG    1SHF    1ZBJ    2DQ7    2MQI    2MRJ    2MRK    3H0F    3H0H    3H0I    3UA6    3UA7    4D8D    4EIK    4U17    4U1P    4ZNX    5ZAU    6EDF    6IPY    6IPZ   
SuperfamilyP06241
AlphaFold pdb e-kbP06241   
Human Protein Atlas [tissue]ENSG00000010810-FYN [tissue]
HPRD00655
Protein Interaction databases
DIP (DOE-UCLA)P06241
IntAct (EBI)P06241
BioGRIDFYN
STRING (EMBL)FYN
ZODIACFYN
Ontologies - Pathways
QuickGOP06241
Ontology : AmiGOresponse to singlet oxygen  neuron migration  stimulatory C-type lectin receptor signaling pathway  adaptive immune response  negative regulation of inflammatory response to antigenic stimulus  heart process  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  signaling receptor binding  protein binding  ATP binding  nucleus  mitochondrion  endosome  cytosol  cytosol  actin filament  plasma membrane  plasma membrane  protein phosphorylation  protein phosphorylation  calcium ion transport  transmembrane receptor protein tyrosine kinase signaling pathway  axon guidance  learning  feeding behavior  regulation of cell shape  negative regulation of gene expression  negative regulation of hydrogen peroxide biosynthetic process  positive regulation of neuron projection development  postsynaptic density  phospholipase activator activity  peptidyl-tyrosine phosphorylation  peptidyl-tyrosine phosphorylation  peptidyl-tyrosine phosphorylation  enzyme binding  cell differentiation  dendrite  forebrain development  extrinsic component of cytoplasmic side of plasma membrane  T cell costimulation  negative regulation of protein ubiquitination  type 5 metabotropic glutamate receptor binding  intracellular signal transduction  cellular response to platelet-derived growth factor stimulus  Fc-gamma receptor signaling pathway involved in phagocytosis  negative regulation of protein catabolic process  positive regulation of tyrosine phosphorylation of STAT protein  response to hydrogen peroxide  identical protein binding  alpha-tubulin binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  phospholipase binding  cell body  transmembrane transporter binding  innate immune response  membrane raft  membrane raft  membrane raft  membrane raft  response to ethanol  protein autophosphorylation  metal ion binding  ephrin receptor binding  vascular endothelial growth factor receptor signaling pathway  ephrin receptor signaling pathway  tau protein binding  tau protein binding  tau protein binding  perinuclear region of cytoplasm  dendrite morphogenesis  tau-protein kinase activity  regulation of peptidyl-tyrosine phosphorylation  activated T cell proliferation  modulation of chemical synaptic transmission  T cell receptor signaling pathway  T cell receptor signaling pathway  leukocyte migration  detection of mechanical stimulus involved in sensory perception of pain  growth factor receptor binding  cellular response to transforming growth factor beta stimulus  positive regulation of protein targeting to membrane  perinuclear endoplasmic reticulum  dendritic spine maintenance  scaffold protein binding  glial cell projection  disordered domain specific binding  Schaffer collateral - CA1 synapse  positive regulation of protein localization to nucleus  regulation of glutamate receptor signaling pathway  positive regulation of neuron death  negative regulation of dendritic spine maintenance  negative regulation of oxidative stress-induced cell death  response to amyloid-beta  cellular response to amyloid-beta  cellular response to L-glutamate  cellular response to glycine  positive regulation of protein localization to membrane  regulation of calcium ion import across plasma membrane  positive regulation of cysteine-type endopeptidase activity  
Ontology : EGO-EBIresponse to singlet oxygen  neuron migration  stimulatory C-type lectin receptor signaling pathway  adaptive immune response  negative regulation of inflammatory response to antigenic stimulus  heart process  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  signaling receptor binding  protein binding  ATP binding  nucleus  mitochondrion  endosome  cytosol  cytosol  actin filament  plasma membrane  plasma membrane  protein phosphorylation  protein phosphorylation  calcium ion transport  transmembrane receptor protein tyrosine kinase signaling pathway  axon guidance  learning  feeding behavior  regulation of cell shape  negative regulation of gene expression  negative regulation of hydrogen peroxide biosynthetic process  positive regulation of neuron projection development  postsynaptic density  phospholipase activator activity  peptidyl-tyrosine phosphorylation  peptidyl-tyrosine phosphorylation  peptidyl-tyrosine phosphorylation  enzyme binding  cell differentiation  dendrite  forebrain development  extrinsic component of cytoplasmic side of plasma membrane  T cell costimulation  negative regulation of protein ubiquitination  type 5 metabotropic glutamate receptor binding  intracellular signal transduction  cellular response to platelet-derived growth factor stimulus  Fc-gamma receptor signaling pathway involved in phagocytosis  negative regulation of protein catabolic process  positive regulation of tyrosine phosphorylation of STAT protein  response to hydrogen peroxide  identical protein binding  alpha-tubulin binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  phospholipase binding  cell body  transmembrane transporter binding  innate immune response  membrane raft  membrane raft  membrane raft  membrane raft  response to ethanol  protein autophosphorylation  metal ion binding  ephrin receptor binding  vascular endothelial growth factor receptor signaling pathway  ephrin receptor signaling pathway  tau protein binding  tau protein binding  tau protein binding  perinuclear region of cytoplasm  dendrite morphogenesis  tau-protein kinase activity  regulation of peptidyl-tyrosine phosphorylation  activated T cell proliferation  modulation of chemical synaptic transmission  T cell receptor signaling pathway  T cell receptor signaling pathway  leukocyte migration  detection of mechanical stimulus involved in sensory perception of pain  growth factor receptor binding  cellular response to transforming growth factor beta stimulus  positive regulation of protein targeting to membrane  perinuclear endoplasmic reticulum  dendritic spine maintenance  scaffold protein binding  glial cell projection  disordered domain specific binding  Schaffer collateral - CA1 synapse  positive regulation of protein localization to nucleus  regulation of glutamate receptor signaling pathway  positive regulation of neuron death  negative regulation of dendritic spine maintenance  negative regulation of oxidative stress-induced cell death  response to amyloid-beta  cellular response to amyloid-beta  cellular response to L-glutamate  cellular response to glycine  positive regulation of protein localization to membrane  regulation of calcium ion import across plasma membrane  positive regulation of cysteine-type endopeptidase activity  
Pathways : BIOCARTABIOCARTA_TSP1PATHWAY    BIOCARTA_REELINPATHWAY    BIOCARTA_BIOPEPTIDESPATHWAY    BIOCARTA_EPHA4PATHWAY    BIOCARTA_ECMPATHWAY    BIOCARTA_IL7PATHWAY    BIOCARTA_INTEGRINPATHWAY    BIOCARTA_TCRAPATHWAY    BIOCARTA_TCRPATHWAY   
Pathways : KEGGKEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION    KEGG_AXON_GUIDANCE    KEGG_FOCAL_ADHESION    KEGG_ADHERENS_JUNCTION    KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY    KEGG_T_CELL_RECEPTOR_SIGNALING    KEGG_FC_EPSILON_RI_SIGNALING    KEGG_PRION_DISEASES    KEGG_VIRAL_MYOCARDITIS   
NDEx NetworkFYN
Atlas of Cancer Signalling NetworkFYN
Wikipedia pathwaysFYN
Orthology - Evolution
OrthoDB2534
GeneTree (enSembl)ENSG00000010810
Phylogenetic Trees/Animal Genes : TreeFamFYN
Homologs : HomoloGeneFYN
Homology/Alignments : Family Browser (UCSC)FYN
Gene fusions - Rearrangements
Fusion : MitelmanECHDC1::FYN [6q22.33/6q21]  
Fusion : MitelmanMBOAT1::FYN [6p22.3/6q21]  
Fusion : MitelmanPTPRZ1::FYN [7q31.32/6q21]  
Fusion : QuiverFYN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFYN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FYN
dbVarFYN
ClinVarFYN
MonarchFYN
1000_GenomesFYN 
Exome Variant ServerFYN
GNOMAD BrowserENSG00000010810
Varsome BrowserFYN
ACMGFYN variants
VarityP06241
Genomic Variants (DGV)FYN [DGVbeta]
DECIPHERFYN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFYN 
Mutations
ICGC Data PortalFYN 
TCGA Data PortalFYN 
Broad Tumor PortalFYN
OASIS PortalFYN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFYN  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFYN
Mutations and Diseases : HGMDFYN
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFYN
DgiDB (Drug Gene Interaction Database)FYN
DoCM (Curated mutations)FYN
CIViC (Clinical Interpretations of Variants in Cancer)FYN
Cancer3DFYN
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM137025   
Orphanet
DisGeNETFYN
MedgenFYN
Genetic Testing Registry FYN
NextProtP06241 [Medical]
GENETestsFYN
Target ValidationFYN
Huge Navigator FYN [HugePedia]
ClinGenFYN
Clinical trials, drugs, therapy
MyCancerGenomeFYN
Protein Interactions : CTDFYN
Pharm GKB GenePA28454
PharosP06241
Clinical trialFYN
Miscellaneous
canSAR (ICR)FYN
HarmonizomeFYN
ARCHS4FYN
DataMed IndexFYN
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFYN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:34:21 CET 2022
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