FZD1 (frizzled class receptor 1)

2009-04-01  

Identity

HGNC
LOCATION
7q21.13
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 8321
MIM: 603408
HGNC: 4038
Ensembl: ENSG00000157240

Variants:

dbSNP: 8321
ClinVar: 8321
TCGA: ENSG00000157240
COSMIC: FZD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000157240ENST00000287934Q9UP38

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
Wnt signaling pathwayKEGGko04310
MelanogenesisKEGGko04916
Basal cell carcinomaKEGGko05217
mTOR signaling pathwayKEGGhsa04150
Wnt signaling pathwayKEGGhsa04310
MelanogenesisKEGGhsa04916
Pathways in cancerKEGGhsa05200
Basal cell carcinomaKEGGhsa05217
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Wnt signalingKEGGhsa_M00677
Wnt signalingKEGGM00677
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Disassembly of the destruction complex and recruitment of AXIN to the membraneREACTOMER-HSA-4641262
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
PCP/CE pathwayREACTOMER-HSA-4086400
Asymmetric localization of PCP proteinsREACTOMER-HSA-4608870
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
194211422009The Wnt receptor FZD1 mediates chemoresistance in neuroblastoma through activation of the Wnt/beta-catenin pathway.70
152524412004Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity.43
147393012004The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway.40
174961522007Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis.32
224844972012Interference of Frizzled 1 (FZD1) reverses multidrug resistance in breast cancer cells through the Wnt/β-catenin pathway.29
191485012009Canonical and noncanonical Wnt pathway: a comparison among normal ovary, benign ovarian tumor and ovarian cancer.28
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20
206348912010Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.18
183826622008A cryptic frizzled module in cell surface collagen 18 inhibits Wnt/beta-catenin signaling.17
276435542016miR-135b reverses chemoresistance of non-small cell lung cancer cells by downregulation of FZD1.12

Citation

Dessen P

FZD1 (frizzled class receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-04-01

Online version: http://atlasgeneticsoncology.org/gene/50856/fzd1