Atlas of Genetics and Cytogenetics in Oncology and Haematology


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FZD1 (frizzled class receptor 1)

Identity

Alias_namesfrizzled (Drosophila) homolog 1
frizzled homolog 1 (Drosophila)
frizzled 1, seven transmembrane spanning receptor
frizzled family receptor 1
Alias_symbol (synonym)DKFZp564G072
Other alias-
HGNC (Hugo) FZD1
LocusID (NCBI) 8321
Atlas_Id 50856
Location 7q21.13  [Link to chromosome band 7q21]
Location_base_pair Starts at 91264468 and ends at 91268817 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FZD1 (7q21.13) / FZD1 (7q21.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FZD1   4038
Cards
Entrez_Gene (NCBI)FZD1  8321  frizzled class receptor 1
Aliases
GeneCards (Weizmann)FZD1
Ensembl hg19 (Hinxton)ENSG00000157240 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000157240 [Gene_View]  chr7:91264468-91268817 [Contig_View]  FZD1 [Vega]
ICGC DataPortalENSG00000157240
TCGA cBioPortalFZD1
AceView (NCBI)FZD1
Genatlas (Paris)FZD1
WikiGenes8321
SOURCE (Princeton)FZD1
Genetics Home Reference (NIH)FZD1
Genomic and cartography
GoldenPath hg38 (UCSC)FZD1  -     chr7:91264468-91268817 +  7q21.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FZD1  -     7q21.13   [Description]    (hg19-Feb_2009)
EnsemblFZD1 - 7q21.13 [CytoView hg19]  FZD1 - 7q21.13 [CytoView hg38]
Mapping of homologs : NCBIFZD1 [Mapview hg19]  FZD1 [Mapview hg38]
OMIM603408   
Gene and transcription
Genbank (Entrez)AB017363 AF072872 AK314996 AL049994 BC017719
RefSeq transcript (Entrez)NM_003505
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FZD1
Cluster EST : UnigeneHs.94234 [ NCBI ]
CGAP (NCI)Hs.94234
Alternative Splicing GalleryENSG00000157240
Gene ExpressionFZD1 [ NCBI-GEO ]   FZD1 [ EBI - ARRAY_EXPRESS ]   FZD1 [ SEEK ]   FZD1 [ MEM ]
Gene Expression Viewer (FireBrowse)FZD1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8321
GTEX Portal (Tissue expression)FZD1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UP38   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UP38  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UP38
Splice isoforms : SwissVarQ9UP38
PhosPhoSitePlusQ9UP38
Domaine pattern : Prosite (Expaxy)FZ (PS50038)    G_PROTEIN_RECEP_F2_4 (PS50261)   
Domains : Interpro (EBI)Frizzled    Frizzled/SFRP    Frizzled_dom    FZD1    GPCR_2-like   
Domain families : Pfam (Sanger)Frizzled (PF01534)    Fz (PF01392)   
Domain families : Pfam (NCBI)pfam01534    pfam01392   
Domain families : Smart (EMBL)FRI (SM00063)  Frizzled (SM01330)  
Conserved Domain (NCBI)FZD1
DMDM Disease mutations8321
Blocks (Seattle)FZD1
SuperfamilyQ9UP38
Human Protein AtlasENSG00000157240
Peptide AtlasQ9UP38
HPRD04558
IPIIPI00054521   
Protein Interaction databases
DIP (DOE-UCLA)Q9UP38
IntAct (EBI)Q9UP38
FunCoupENSG00000157240
BioGRIDFZD1
STRING (EMBL)FZD1
ZODIACFZD1
Ontologies - Pathways
QuickGOQ9UP38
Ontology : AmiGOpositive regulation of protein phosphorylation  membranous septum morphogenesis  muscular septum morphogenesis  outflow tract morphogenesis  G-protein coupled receptor activity  receptor binding  frizzled binding  protein binding  plasma membrane  focal adhesion  G-protein coupled receptor signaling pathway  cell-cell signaling  cell surface  integral component of membrane  Wnt-protein binding  Wnt-protein binding  PDZ domain binding  neuron differentiation  negative regulation of BMP signaling pathway  epithelial cell differentiation  negative regulation of catenin import into nucleus  autocrine signaling  response to drug  Wnt-activated receptor activity  Wnt-activated receptor activity  Wnt-activated receptor activity  canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation  canonical Wnt signaling pathway involved in osteoblast differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of sequence-specific DNA binding transcription factor activity  hard palate development  canonical Wnt signaling pathway  canonical Wnt signaling pathway  canonical Wnt signaling pathway  Wnt signaling pathway, planar cell polarity pathway  planar cell polarity pathway involved in neural tube closure  presynapse assembly  negative regulation of oxidative stress-induced neuron death  beta-catenin destruction complex disassembly  Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  Wnt signalosome  
Ontology : EGO-EBIpositive regulation of protein phosphorylation  membranous septum morphogenesis  muscular septum morphogenesis  outflow tract morphogenesis  G-protein coupled receptor activity  receptor binding  frizzled binding  protein binding  plasma membrane  focal adhesion  G-protein coupled receptor signaling pathway  cell-cell signaling  cell surface  integral component of membrane  Wnt-protein binding  Wnt-protein binding  PDZ domain binding  neuron differentiation  negative regulation of BMP signaling pathway  epithelial cell differentiation  negative regulation of catenin import into nucleus  autocrine signaling  response to drug  Wnt-activated receptor activity  Wnt-activated receptor activity  Wnt-activated receptor activity  canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation  canonical Wnt signaling pathway involved in osteoblast differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of sequence-specific DNA binding transcription factor activity  hard palate development  canonical Wnt signaling pathway  canonical Wnt signaling pathway  canonical Wnt signaling pathway  Wnt signaling pathway, planar cell polarity pathway  planar cell polarity pathway involved in neural tube closure  presynapse assembly  negative regulation of oxidative stress-induced neuron death  beta-catenin destruction complex disassembly  Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  Wnt signalosome  
Pathways : BIOCARTA [Genes]   
Pathways : KEGGWnt signaling pathway    Hippo signaling pathway    Melanogenesis    HTLV-I infection    Pathways in cancer    Proteoglycans in cancer    Basal cell carcinoma   
NDEx NetworkFZD1
Atlas of Cancer Signalling NetworkFZD1
Wikipedia pathwaysFZD1
Orthology - Evolution
OrthoDB8321
GeneTree (enSembl)ENSG00000157240
Phylogenetic Trees/Animal Genes : TreeFamFZD1
HOVERGENQ9UP38
HOGENOMQ9UP38
Homologs : HomoloGeneFZD1
Homology/Alignments : Family Browser (UCSC)FZD1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFZD1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FZD1
dbVarFZD1
ClinVarFZD1
1000_GenomesFZD1 
Exome Variant ServerFZD1
ExAC (Exome Aggregation Consortium)FZD1 (select the gene name)
Genetic variants : HAPMAP8321
Genomic Variants (DGV)FZD1 [DGVbeta]
DECIPHERFZD1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFZD1 
Mutations
ICGC Data PortalFZD1 
TCGA Data PortalFZD1 
Broad Tumor PortalFZD1
OASIS PortalFZD1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFZD1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFZD1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FZD1
DgiDB (Drug Gene Interaction Database)FZD1
DoCM (Curated mutations)FZD1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FZD1 (select a term)
intoGenFZD1
Cancer3DFZD1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603408   
Orphanet
MedgenFZD1
Genetic Testing Registry FZD1
NextProtQ9UP38 [Medical]
TSGene8321
GENETestsFZD1
Huge Navigator FZD1 [HugePedia]
snp3D : Map Gene to Disease8321
BioCentury BCIQFZD1
ClinGenFZD1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8321
Chemical/Pharm GKB GenePA28455
Clinical trialFZD1
Miscellaneous
canSAR (ICR)FZD1 (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFZD1
EVEXFZD1
GoPubMedFZD1
iHOPFZD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:16:37 CEST 2017

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