FZD10 (frizzled class receptor 10)

2003-06-01  

Identity

HGNC
LOCATION
12q24.33
LOCUSID
ALIAS
CD350,FZ-10,Fz10,FzE7,hFz10

Other Information

Locus ID:

NCBI: 11211
MIM: 606147
HGNC: 4039
Ensembl: ENSG00000111432

Variants:

dbSNP: 11211
ClinVar: 11211
TCGA: ENSG00000111432
COSMIC: FZD10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111432ENST00000229030Q9ULW2
ENSG00000111432ENST00000539839F5H450

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
Wnt signaling pathwayKEGGko04310
MelanogenesisKEGGko04916
Basal cell carcinomaKEGGko05217
mTOR signaling pathwayKEGGhsa04150
Wnt signaling pathwayKEGGhsa04310
MelanogenesisKEGGhsa04916
Pathways in cancerKEGGhsa05200
Basal cell carcinomaKEGGhsa05217
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Wnt signalingKEGGhsa_M00677
Wnt signalingKEGGM00677
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
367644932023N6-Methyladenosine-Mediated Up-Regulation of FZD10 Regulates Liver Cancer Stem Cells' Properties and Lenvatinib Resistance Through WNT/β-Catenin and Hippo Signaling Pathways.50
367644932023N6-Methyladenosine-Mediated Up-Regulation of FZD10 Regulates Liver Cancer Stem Cells' Properties and Lenvatinib Resistance Through WNT/β-Catenin and Hippo Signaling Pathways.50
362107082022[Exosomal FZD10 derived from non-small cell lung cancer cells promotes angiogenesis of human umbilical venous endothelial cells in vitro].0
362107082022[Exosomal FZD10 derived from non-small cell lung cancer cells promotes angiogenesis of human umbilical venous endothelial cells in vitro].0
321387712020SEPT9_v2, frequently silenced by promoter hypermethylation, exerts anti-tumor functions through inactivation of Wnt/β-catenin signaling pathway via miR92b-3p/FZD10 in nasopharyngeal carcinoma cells.3
329331732020A Possible Role of FZD10 Delivering Exosomes Derived from Colon Cancers Cell Lines in Inducing Activation of Epithelial-Mesenchymal Transition in Normal Colon Epithelial Cell Line.14
329444032020Targeting fatty acid synthase sensitizes human nasopharyngeal carcinoma cells to radiation via downregulating frizzled class receptor 10.17
321387712020SEPT9_v2, frequently silenced by promoter hypermethylation, exerts anti-tumor functions through inactivation of Wnt/β-catenin signaling pathway via miR92b-3p/FZD10 in nasopharyngeal carcinoma cells.3
329331732020A Possible Role of FZD10 Delivering Exosomes Derived from Colon Cancers Cell Lines in Inducing Activation of Epithelial-Mesenchymal Transition in Normal Colon Epithelial Cell Line.14
329444032020Targeting fatty acid synthase sensitizes human nasopharyngeal carcinoma cells to radiation via downregulating frizzled class receptor 10.17
309673982019N(6)-Methylation of Adenosine of FZD10 mRNA Contributes to PARP Inhibitor Resistance.85
309673982019N(6)-Methylation of Adenosine of FZD10 mRNA Contributes to PARP Inhibitor Resistance.85
295009152018A fusion-protein approach enabling mammalian cell production of tumor targeting protein domains for therapeutic development.2
295009152018A fusion-protein approach enabling mammalian cell production of tumor targeting protein domains for therapeutic development.2
281265912017FZD(10)-Gα(13) signalling axis points to a role of FZD(10) in CNS angiogenesis.13

Citation

Dessen P

FZD10 (frizzled class receptor 10)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40654/fzd10