Atlas of Genetics and Cytogenetics in Oncology and Haematology


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FZD2 (frizzled class receptor 2)

Identity

Alias_namesfrizzled (Drosophila) homolog 2
frizzled homolog 2 (Drosophila)
frizzled 2, seven transmembrane spanning receptor
frizzled family receptor 2
Other aliasFz2
fz-2
fzE2
hFz2
HGNC (Hugo) FZD2
LocusID (NCBI) 2535
Atlas_Id 50090
Location 17q21.31  [Link to chromosome band 17q21]
Location_base_pair Starts at 44557444 and ends at 44561262 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ZNF3 (7q22.1) / FZD2 (17q21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FZD2   4040
Cards
Entrez_Gene (NCBI)FZD2  2535  frizzled class receptor 2
AliasesFz2; fz-2; fzE2; hFz2
GeneCards (Weizmann)FZD2
Ensembl hg19 (Hinxton)ENSG00000180340 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000180340 [Gene_View]  chr17:44557444-44561262 [Contig_View]  FZD2 [Vega]
ICGC DataPortalENSG00000180340
TCGA cBioPortalFZD2
AceView (NCBI)FZD2
Genatlas (Paris)FZD2
WikiGenes2535
SOURCE (Princeton)FZD2
Genetics Home Reference (NIH)FZD2
Genomic and cartography
GoldenPath hg38 (UCSC)FZD2  -     chr17:44557444-44561262 +  17q21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FZD2  -     17q21.31   [Description]    (hg19-Feb_2009)
EnsemblFZD2 - 17q21.31 [CytoView hg19]  FZD2 - 17q21.31 [CytoView hg38]
Mapping of homologs : NCBIFZD2 [Mapview hg19]  FZD2 [Mapview hg38]
OMIM600667   
Gene and transcription
Genbank (Entrez)AB017364 AI376463 AW023425 BC052266 BC113402
RefSeq transcript (Entrez)NM_001466
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FZD2
Cluster EST : UnigeneHs.732654 [ NCBI ]
CGAP (NCI)Hs.732654
Alternative Splicing GalleryENSG00000180340
Gene ExpressionFZD2 [ NCBI-GEO ]   FZD2 [ EBI - ARRAY_EXPRESS ]   FZD2 [ SEEK ]   FZD2 [ MEM ]
Gene Expression Viewer (FireBrowse)FZD2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2535
GTEX Portal (Tissue expression)FZD2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14332   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14332  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14332
Splice isoforms : SwissVarQ14332
PhosPhoSitePlusQ14332
Domaine pattern : Prosite (Expaxy)FZ (PS50038)    G_PROTEIN_RECEP_F2_4 (PS50261)   
Domains : Interpro (EBI)Frizzled    Frizzled/SFRP    Frizzled_dom    FZD2    GPCR_2-like   
Domain families : Pfam (Sanger)Frizzled (PF01534)    Fz (PF01392)   
Domain families : Pfam (NCBI)pfam01534    pfam01392   
Domain families : Smart (EMBL)FRI (SM00063)  Frizzled (SM01330)  
Conserved Domain (NCBI)FZD2
DMDM Disease mutations2535
Blocks (Seattle)FZD2
SuperfamilyQ14332
Human Protein AtlasENSG00000180340
Peptide AtlasQ14332
HPRD02813
IPIIPI00016027   IPI01015116   
Protein Interaction databases
DIP (DOE-UCLA)Q14332
IntAct (EBI)Q14332
FunCoupENSG00000180340
BioGRIDFZD2
STRING (EMBL)FZD2
ZODIACFZD2
Ontologies - Pathways
QuickGOQ14332
Ontology : AmiGOmembranous septum morphogenesis  muscular septum morphogenesis  outflow tract morphogenesis  G-protein coupled receptor activity  protein binding  cytoplasm  plasma membrane  plasma membrane  focal adhesion  G-protein coupled receptor signaling pathway  Wnt signaling pathway, calcium modulating pathway  sensory perception of smell  integral component of membrane  Wnt-protein binding  PDZ domain binding  neuron differentiation  clathrin-coated endocytic vesicle membrane  positive regulation of cGMP metabolic process  epithelial cell differentiation  Wnt-activated receptor activity  positive regulation of transcription, DNA-templated  positive regulation of sequence-specific DNA binding transcription factor activity  hard palate development  canonical Wnt signaling pathway  Wnt signaling pathway, planar cell polarity pathway  Wnt signaling pathway, planar cell polarity pathway  inner ear receptor cell development  cochlea morphogenesis  planar cell polarity pathway involved in neural tube closure  beta-catenin destruction complex disassembly  
Ontology : EGO-EBImembranous septum morphogenesis  muscular septum morphogenesis  outflow tract morphogenesis  G-protein coupled receptor activity  protein binding  cytoplasm  plasma membrane  plasma membrane  focal adhesion  G-protein coupled receptor signaling pathway  Wnt signaling pathway, calcium modulating pathway  sensory perception of smell  integral component of membrane  Wnt-protein binding  PDZ domain binding  neuron differentiation  clathrin-coated endocytic vesicle membrane  positive regulation of cGMP metabolic process  epithelial cell differentiation  Wnt-activated receptor activity  positive regulation of transcription, DNA-templated  positive regulation of sequence-specific DNA binding transcription factor activity  hard palate development  canonical Wnt signaling pathway  Wnt signaling pathway, planar cell polarity pathway  Wnt signaling pathway, planar cell polarity pathway  inner ear receptor cell development  cochlea morphogenesis  planar cell polarity pathway involved in neural tube closure  beta-catenin destruction complex disassembly  
Pathways : KEGGWnt signaling pathway    Hippo signaling pathway    Melanogenesis    HTLV-I infection    Pathways in cancer    Proteoglycans in cancer    Basal cell carcinoma   
NDEx NetworkFZD2
Atlas of Cancer Signalling NetworkFZD2
Wikipedia pathwaysFZD2
Orthology - Evolution
OrthoDB2535
GeneTree (enSembl)ENSG00000180340
Phylogenetic Trees/Animal Genes : TreeFamFZD2
HOVERGENQ14332
HOGENOMQ14332
Homologs : HomoloGeneFZD2
Homology/Alignments : Family Browser (UCSC)FZD2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFZD2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FZD2
dbVarFZD2
ClinVarFZD2
1000_GenomesFZD2 
Exome Variant ServerFZD2
ExAC (Exome Aggregation Consortium)FZD2 (select the gene name)
Genetic variants : HAPMAP2535
Genomic Variants (DGV)FZD2 [DGVbeta]
DECIPHERFZD2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFZD2 
Mutations
ICGC Data PortalFZD2 
TCGA Data PortalFZD2 
Broad Tumor PortalFZD2
OASIS PortalFZD2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFZD2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFZD2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FZD2
DgiDB (Drug Gene Interaction Database)FZD2
DoCM (Curated mutations)FZD2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FZD2 (select a term)
intoGenFZD2
Cancer3DFZD2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600667   
Orphanet12264   
MedgenFZD2
Genetic Testing Registry FZD2
NextProtQ14332 [Medical]
TSGene2535
GENETestsFZD2
Target ValidationFZD2
Huge Navigator FZD2 [HugePedia]
snp3D : Map Gene to Disease2535
BioCentury BCIQFZD2
ClinGenFZD2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2535
Chemical/Pharm GKB GenePA28457
Clinical trialFZD2
Miscellaneous
canSAR (ICR)FZD2 (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFZD2
EVEXFZD2
GoPubMedFZD2
iHOPFZD2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:01:38 CEST 2017

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