| Alias (NCBI) | Fz2 |
| OMOD2 |
| fz-2 |
| fzE2 |
| hFz2 |
| HGNC (Hugo) |
FZD2 |
| HGNC Previous name | frizzled (Drosophila) homolog 2 |
| frizzled homolog 2 (Drosophila) |
| frizzled 2, seven transmembrane spanning receptor |
| frizzled family receptor 2 |
| LocusID (NCBI) |
2535 |
| Atlas_Id |
50090 |
| Location |
17q21.31 [Link to chromosome band 17q21] |
| Location_base_pair |
Starts at 44557484 and ends at 44561262 bp from pter ( according to hg38-Dec_2013) |
| Nomenclature |
|---|
| HGNC (Hugo) | FZD2 4040 |
| Cards |
|---|
| Entrez_Gene (NCBI) | FZD2 frizzled class receptor 2 |
| Aliases | Fz2; OMOD2; fz-2; fzE2; |
| hFz2 |
| GeneCards (Weizmann) | FZD2 |
| Ensembl hg19 (Hinxton) | ENSG00000180340 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000180340 [Gene_View] ENSG00000180340 [Sequence] chr17:44557484-44561262 [Contig_View] FZD2 [Vega] |
| ICGC DataPortal | ENSG00000180340 |
| TCGA cBioPortal | FZD2 |
| AceView (NCBI) | FZD2 |
| Genatlas (Paris) | FZD2 |
| SOURCE (Princeton) | FZD2 |
| Genetics Home Reference (NIH) | FZD2 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | FZD2 - chr17:44557484-44561262 + 17q21.31 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | FZD2 - 17q21.31 [Description] (hg19-Feb_2009) |
| GoldenPath | FZD2 - 17q21.31 [CytoView hg19] FZD2 - 17q21.31 [CytoView hg38] |
| ImmunoBase | ENSG00000180340 |
| genome Data Viewer NCBI | FZD2 [Mapview hg19] |
| OMIM | 164745 600667 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB017364 AI376463 AW023425 BC052266 BC113402 |
| RefSeq transcript (Entrez) | NM_001466 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | FZD2 |
| Alternative Splicing Gallery | ENSG00000180340 |
| Gene Expression | FZD2 [ NCBI-GEO ] FZD2 [ EBI - ARRAY_EXPRESS ]
FZD2 [ SEEK ] FZD2 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | FZD2 [ Firebrowse - Broad ] |
| Genevisible | Expression of FZD2 in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 2535 |
| GTEX Portal (Tissue expression) | FZD2 |
| Human Protein Atlas | ENSG00000180340-FZD2 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q14332 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q14332 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q14332 |
| Splice isoforms : SwissVar | Q14332 |
| PhosPhoSitePlus | Q14332 |
| Domaine pattern : Prosite (Expaxy) | FZ (PS50038) G_PROTEIN_RECEP_F2_4 (PS50261) |
| Domains : Interpro (EBI) | Frizzled/SFRP Frizzled/Smoothened_TM Frizzled_dom Frizzled_dom_sf FZ2_CRD FZD1/2 GPCR_2-like |
| Domain families : Pfam (Sanger) | Frizzled (PF01534) Fz (PF01392) |
| Domain families : Pfam (NCBI) | pfam01534 pfam01392 |
| Domain families : Smart (EMBL) | FRI (SM00063) Frizzled (SM01330) |
| Conserved Domain (NCBI) | FZD2 |
| Blocks (Seattle) | FZD2 |
| PDB (RSDB) | 6C0B |
| PDB Europe | 6C0B |
| PDB (PDBSum) | 6C0B |
| PDB (IMB) | 6C0B |
| Structural Biology KnowledgeBase | 6C0B |
| SCOP (Structural Classification of Proteins) | 6C0B |
| CATH (Classification of proteins structures) | 6C0B |
| Superfamily | Q14332 |
| Human Protein Atlas [tissue] | ENSG00000180340-FZD2 [tissue] |
| Peptide Atlas | Q14332 |
| HPRD | 02813 |
| IPI | IPI00016027 IPI01015116 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q14332 |
| IntAct (EBI) | Q14332 |
| BioGRID | FZD2 |
| STRING (EMBL) | FZD2 |
| ZODIAC | FZD2 |
| Ontologies - Pathways |
|---|
| QuickGO | Q14332 |
| Ontology : AmiGO | membranous septum morphogenesis muscular septum morphogenesis outflow tract morphogenesis G protein-coupled receptor activity protein binding cytoplasm plasma membrane plasma membrane plasma membrane focal adhesion G protein-coupled receptor signaling pathway Wnt signaling pathway, calcium modulating pathway sensory perception of smell integral component of membrane Wnt signaling pathway Wnt-protein binding Wnt-protein binding PDZ domain binding neuron differentiation clathrin-coated endocytic vesicle membrane epithelial cell differentiation non-canonical Wnt signaling pathway Wnt-activated receptor activity Wnt-activated receptor activity Wnt-activated receptor activity positive regulation of transcription, DNA-templated positive regulation of DNA-binding transcription factor activity hard palate development canonical Wnt signaling pathway canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway Wnt signaling pathway, planar cell polarity pathway inner ear receptor cell development cochlea morphogenesis planar cell polarity pathway involved in neural tube closure beta-catenin destruction complex disassembly |
| Ontology : EGO-EBI | membranous septum morphogenesis muscular septum morphogenesis outflow tract morphogenesis G protein-coupled receptor activity protein binding cytoplasm plasma membrane plasma membrane plasma membrane focal adhesion G protein-coupled receptor signaling pathway Wnt signaling pathway, calcium modulating pathway sensory perception of smell integral component of membrane Wnt signaling pathway Wnt-protein binding Wnt-protein binding PDZ domain binding neuron differentiation clathrin-coated endocytic vesicle membrane epithelial cell differentiation non-canonical Wnt signaling pathway Wnt-activated receptor activity Wnt-activated receptor activity Wnt-activated receptor activity positive regulation of transcription, DNA-templated positive regulation of DNA-binding transcription factor activity hard palate development canonical Wnt signaling pathway canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway Wnt signaling pathway, planar cell polarity pathway inner ear receptor cell development cochlea morphogenesis planar cell polarity pathway involved in neural tube closure beta-catenin destruction complex disassembly |
| Pathways : KEGG | Wnt signaling pathway Hippo signaling pathway Melanogenesis HTLV-I infection Pathways in cancer Proteoglycans in cancer Basal cell carcinoma |
| NDEx Network | FZD2 |
| Atlas of Cancer Signalling Network | FZD2 |
| Wikipedia pathways | FZD2 |
| Orthology - Evolution |
|---|
| OrthoDB | 2535 |
| GeneTree (enSembl) | ENSG00000180340 |
| Phylogenetic Trees/Animal Genes : TreeFam | FZD2 |
| HOGENOM | Q14332 |
| Homologs : HomoloGene | FZD2 |
| Homology/Alignments : Family Browser (UCSC) | FZD2 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | FZD2 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | FZD2 [hg38] |
| dbVar | FZD2 |
| ClinVar | FZD2 |
| Monarch | FZD2 |
| 1000_Genomes | FZD2 |
| Exome Variant Server | FZD2 |
| GNOMAD Browser | ENSG00000180340 |
| Varsome Browser | FZD2 |
| Genomic Variants (DGV) | FZD2 [DGVbeta] |
| DECIPHER | FZD2 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | FZD2 |
| Mutations |
|---|
| ICGC Data Portal | FZD2 |
| TCGA Data Portal | FZD2 |
| Broad Tumor Portal | FZD2 |
| OASIS Portal | FZD2 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | FZD2 [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | FZD2 |
| Mutations and Diseases : HGMD | FZD2 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search FZD2 |
| DgiDB (Drug Gene Interaction Database) | FZD2 |
| DoCM (Curated mutations) | FZD2 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | FZD2 (select a term) |
| intoGen | FZD2 |
| Cancer3D | FZD2(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 164745 600667 |
| Orphanet | 12264 |
| DisGeNET | FZD2 |
| Medgen | FZD2 |
| Genetic Testing Registry | FZD2
|
| NextProt | Q14332 [Medical] |
| GENETests | FZD2 |
| Target Validation | FZD2 |
| Huge Navigator |
FZD2 [HugePedia] |
| ClinGen | FZD2 |
| Clinical trials, drugs, therapy |
|---|
| MyCancerGenome | FZD2 |
| Protein Interactions : CTD | |
| Pharm GKB Gene | PA28457 |
| Pharos | Q14332 |
| Clinical trial | FZD2 |
| Miscellaneous |
|---|
| canSAR (ICR) | FZD2 (select the gene name) |
| Harmonizome | FZD2 |
| DataMed Index | FZD2 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 47 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| EVEX | FZD2 |
