| Nomenclature |
|---|
| HGNC (Hugo) | FZD2 4040 |
| Cards |
|---|
| Entrez_Gene (NCBI) | FZD2 2535 frizzled class receptor 2 |
| Aliases | Fz2; fz-2; fzE2; hFz2 |
| GeneCards (Weizmann) | FZD2 |
| Ensembl hg19 (Hinxton) | ENSG00000180340 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000180340 [Gene_View] chr17:44557444-44561262 [Contig_View] FZD2 [Vega] |
| ICGC DataPortal | ENSG00000180340 |
| TCGA cBioPortal | FZD2 |
| AceView (NCBI) | FZD2 |
| Genatlas (Paris) | FZD2 |
| WikiGenes | 2535 |
| SOURCE (Princeton) | FZD2 |
| Genetics Home Reference (NIH) | FZD2 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | FZD2 - chr17:44557444-44561262 + 17q21.31 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | FZD2 - 17q21.31 [Description] (hg19-Feb_2009) |
| Ensembl | FZD2 - 17q21.31 [CytoView hg19] FZD2 - 17q21.31 [CytoView hg38] |
| Mapping of homologs : NCBI | FZD2 [Mapview hg19] FZD2 [Mapview hg38] |
| OMIM | 600667 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB017364 AI376463 AW023425 BC052266 BC113402 |
| RefSeq transcript (Entrez) | NM_001466 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | FZD2 |
| Cluster EST : Unigene | Hs.732654 [ NCBI ] |
| CGAP (NCI) | Hs.732654 |
| Alternative Splicing Gallery | ENSG00000180340 |
| Gene Expression | FZD2 [ NCBI-GEO ] FZD2 [ EBI - ARRAY_EXPRESS ]
FZD2 [ SEEK ] FZD2 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | FZD2 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevisible | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 2535 |
| GTEX Portal (Tissue expression) | FZD2 |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q14332 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q14332 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q14332 |
| Splice isoforms : SwissVar | Q14332 |
| PhosPhoSitePlus | Q14332 |
| Domaine pattern : Prosite (Expaxy) | FZ (PS50038) G_PROTEIN_RECEP_F2_4 (PS50261) |
| Domains : Interpro (EBI) | Frizzled Frizzled/SFRP Frizzled_dom FZD2 GPCR_2-like |
| Domain families : Pfam (Sanger) | Frizzled (PF01534) Fz (PF01392) |
| Domain families : Pfam (NCBI) | pfam01534 pfam01392 |
| Domain families : Smart (EMBL) | FRI (SM00063) Frizzled (SM01330) |
| Conserved Domain (NCBI) | FZD2 |
| DMDM Disease mutations | 2535 |
| Blocks (Seattle) | FZD2 |
| Superfamily | Q14332 |
| Human Protein Atlas | ENSG00000180340 |
| Peptide Atlas | Q14332 |
| HPRD | 02813 |
| IPI | IPI00016027 IPI01015116 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q14332 |
| IntAct (EBI) | Q14332 |
| FunCoup | ENSG00000180340 |
| BioGRID | FZD2 |
| STRING (EMBL) | FZD2 |
| ZODIAC | FZD2 |
| Ontologies - Pathways |
|---|
| QuickGO | Q14332 |
| Ontology : AmiGO | membranous septum morphogenesis muscular septum morphogenesis outflow tract morphogenesis G-protein coupled receptor activity protein binding cytoplasm plasma membrane plasma membrane focal adhesion G-protein coupled receptor signaling pathway Wnt signaling pathway, calcium modulating pathway sensory perception of smell integral component of membrane Wnt-protein binding PDZ domain binding neuron differentiation clathrin-coated endocytic vesicle membrane positive regulation of cGMP metabolic process epithelial cell differentiation Wnt-activated receptor activity positive regulation of transcription, DNA-templated positive regulation of sequence-specific DNA binding transcription factor activity hard palate development canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway Wnt signaling pathway, planar cell polarity pathway inner ear receptor cell development cochlea morphogenesis planar cell polarity pathway involved in neural tube closure beta-catenin destruction complex disassembly |
| Ontology : EGO-EBI | membranous septum morphogenesis muscular septum morphogenesis outflow tract morphogenesis G-protein coupled receptor activity protein binding cytoplasm plasma membrane plasma membrane focal adhesion G-protein coupled receptor signaling pathway Wnt signaling pathway, calcium modulating pathway sensory perception of smell integral component of membrane Wnt-protein binding PDZ domain binding neuron differentiation clathrin-coated endocytic vesicle membrane positive regulation of cGMP metabolic process epithelial cell differentiation Wnt-activated receptor activity positive regulation of transcription, DNA-templated positive regulation of sequence-specific DNA binding transcription factor activity hard palate development canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway Wnt signaling pathway, planar cell polarity pathway inner ear receptor cell development cochlea morphogenesis planar cell polarity pathway involved in neural tube closure beta-catenin destruction complex disassembly |
| Pathways : KEGG | Wnt signaling pathway Hippo signaling pathway Melanogenesis HTLV-I infection Pathways in cancer Proteoglycans in cancer Basal cell carcinoma |
| NDEx Network | FZD2 |
| Atlas of Cancer Signalling Network | FZD2 |
| Wikipedia pathways | FZD2 |
| Orthology - Evolution |
|---|
| OrthoDB | 2535 |
| GeneTree (enSembl) | ENSG00000180340 |
| Phylogenetic Trees/Animal Genes : TreeFam | FZD2 |
| HOVERGEN | Q14332 |
| HOGENOM | Q14332 |
| Homologs : HomoloGene | FZD2 |
| Homology/Alignments : Family Browser (UCSC) | FZD2 |
| Gene fusions - Rearrangements |
|---|
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | FZD2 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | FZD2 |
| dbVar | FZD2 |
| ClinVar | FZD2 |
| 1000_Genomes | FZD2 |
| Exome Variant Server | FZD2 |
| ExAC (Exome Aggregation Consortium) | FZD2 (select the gene name) |
| Genetic variants : HAPMAP | 2535 |
| Genomic Variants (DGV) | FZD2 [DGVbeta] |
| DECIPHER | FZD2 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | FZD2 |
| Mutations |
|---|
| ICGC Data Portal | FZD2 |
| TCGA Data Portal | FZD2 |
| Broad Tumor Portal | FZD2 |
| OASIS Portal | FZD2 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | FZD2 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | FZD2 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search FZD2 |
| DgiDB (Drug Gene Interaction Database) | FZD2 |
| DoCM (Curated mutations) | FZD2 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | FZD2 (select a term) |
| intoGen | FZD2 |
| Cancer3D | FZD2(select the gene name) |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 600667 |
| Orphanet | 12264 |
| Medgen | FZD2 |
| Genetic Testing Registry | FZD2
|
| NextProt | Q14332 [Medical] |
| TSGene | 2535 |
| GENETests | FZD2 |
| Target Validation | FZD2 |
| Huge Navigator |
FZD2 [HugePedia] |
| snp3D : Map Gene to Disease | 2535 |
| BioCentury BCIQ | FZD2 |
| ClinGen | FZD2 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 2535 |
| Chemical/Pharm GKB Gene | PA28457 |
| Clinical trial | FZD2 |
| Miscellaneous |
|---|
| canSAR (ICR) | FZD2 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 33 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | FZD2 |
| EVEX | FZD2 |
| GoPubMed | FZD2 |
| iHOP | FZD2 |
