Atlas of Genetics and Cytogenetics in Oncology and Haematology


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FZD3 (frizzled class receptor 3)

Identity

Alias (NCBI)Fz-3
HGNC (Hugo) FZD3
HGNC Previous namefrizzled (Drosophila) homolog 3
 frizzled homolog 3 (Drosophila)
 frizzled 3, seven transmembrane spanning receptor
 frizzled family receptor 3
LocusID (NCBI) 7976
Atlas_Id 50138
Location 8p21.1  [Link to chromosome band 8p21]
Location_base_pair Starts at 28494205 and ends at 28574268 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FZD3 (8p21.1)::CTBP1 (4p16.3)FZD3 (8p21.1)::ZNF141 (4p16.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)FZD3   4041
LRG (Locus Reference Genomic)LRG_859
Cards
Entrez_Gene (NCBI)FZD3    frizzled class receptor 3
AliasesFz-3
GeneCards (Weizmann)FZD3
Ensembl hg19 (Hinxton)ENSG00000104290 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104290 [Gene_View]  ENSG00000104290 [Sequence]  chr8:28494205-28574268 [Contig_View]  FZD3 [Vega]
ICGC DataPortalENSG00000104290
TCGA cBioPortalFZD3
AceView (NCBI)FZD3
Genatlas (Paris)FZD3
SOURCE (Princeton)FZD3
Genetics Home Reference (NIH)FZD3
Genomic and cartography
GoldenPath hg38 (UCSC)FZD3  -     chr8:28494205-28574268 +  8p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FZD3  -     8p21.1   [Description]    (hg19-Feb_2009)
GoldenPathFZD3 - 8p21.1 [CytoView hg19]  FZD3 - 8p21.1 [CytoView hg38]
ImmunoBaseENSG00000104290
Genome Data Viewer NCBIFZD3 [Mapview hg19]  
OMIM606143   
Gene and transcription
Genbank (Entrez)AB039723 AJ272427 AK291480 AY005130 BC034278
RefSeq transcript (Entrez)NM_017412 NM_145866
Consensus coding sequences : CCDS (NCBI)FZD3
Gene ExpressionFZD3 [ NCBI-GEO ]   FZD3 [ EBI - ARRAY_EXPRESS ]   FZD3 [ SEEK ]   FZD3 [ MEM ]
Gene Expression Viewer (FireBrowse)FZD3 [ Firebrowse - Broad ]
GenevisibleExpression of FZD3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7976
GTEX Portal (Tissue expression)FZD3
Human Protein AtlasENSG00000104290-FZD3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NPG1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NPG1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NPG1
PhosPhoSitePlusQ9NPG1
Domaine pattern : Prosite (Expaxy)FZ (PS50038)    G_PROTEIN_RECEP_F2_4 (PS50261)   
Domains : Interpro (EBI)Frizzled/SFRP    Frizzled/Smoothened_TM    Frizzled_dom    Frizzled_dom_sf    FZ3_CRD    FZD3_vertebrates    GPCR_2-like   
Domain families : Pfam (Sanger)Frizzled (PF01534)    Fz (PF01392)   
Domain families : Pfam (NCBI)pfam01534    pfam01392   
Domain families : Smart (EMBL)FRI (SM00063)  Frizzled (SM01330)  
Conserved Domain (NCBI)FZD3
SuperfamilyQ9NPG1
AlphaFold pdb e-kbQ9NPG1   
Human Protein Atlas [tissue]ENSG00000104290-FZD3 [tissue]
HPRD05849
Protein Interaction databases
DIP (DOE-UCLA)Q9NPG1
IntAct (EBI)Q9NPG1
BioGRIDFZD3
STRING (EMBL)FZD3
ZODIACFZD3
Ontologies - Pathways
QuickGOQ9NPG1
Ontology : AmiGOestablishment of planar polarity  neuron migration  neural tube closure  hair follicle development  positive regulation of neuroblast proliferation  G protein-coupled receptor activity  protein binding  cytoplasm  plasma membrane  plasma membrane  plasma membrane  G protein-coupled receptor signaling pathway  response to xenobiotic stimulus  cell surface  integral component of membrane  apical plasma membrane  lateral plasma membrane  Wnt-protein binding  Wnt-protein binding  Wnt-protein binding  PDZ domain binding  neuron differentiation  axon  dendrite  filopodium tip  cell proliferation in midbrain  non-canonical Wnt signaling pathway  post-anal tail morphogenesis  dopaminergic neuron axon guidance  serotonergic neuron axon guidance  inner ear morphogenesis  Wnt-activated receptor activity  Wnt-activated receptor activity  Wnt-activated receptor activity  neuronal cell body  negative regulation of mitotic cell cycle, embryonic  presynaptic active zone  response to electrical stimulus  canonical Wnt signaling pathway  canonical Wnt signaling pathway  Wnt signaling pathway, planar cell polarity pathway  sympathetic ganglion development  commissural neuron axon guidance  negative regulation of execution phase of apoptosis  midbrain morphogenesis  planar cell polarity pathway involved in axon guidance  
Ontology : EGO-EBIestablishment of planar polarity  neuron migration  neural tube closure  hair follicle development  positive regulation of neuroblast proliferation  G protein-coupled receptor activity  protein binding  cytoplasm  plasma membrane  plasma membrane  plasma membrane  G protein-coupled receptor signaling pathway  response to xenobiotic stimulus  cell surface  integral component of membrane  apical plasma membrane  lateral plasma membrane  Wnt-protein binding  Wnt-protein binding  Wnt-protein binding  PDZ domain binding  neuron differentiation  axon  dendrite  filopodium tip  cell proliferation in midbrain  non-canonical Wnt signaling pathway  post-anal tail morphogenesis  dopaminergic neuron axon guidance  serotonergic neuron axon guidance  inner ear morphogenesis  Wnt-activated receptor activity  Wnt-activated receptor activity  Wnt-activated receptor activity  neuronal cell body  negative regulation of mitotic cell cycle, embryonic  presynaptic active zone  response to electrical stimulus  canonical Wnt signaling pathway  canonical Wnt signaling pathway  Wnt signaling pathway, planar cell polarity pathway  sympathetic ganglion development  commissural neuron axon guidance  negative regulation of execution phase of apoptosis  midbrain morphogenesis  planar cell polarity pathway involved in axon guidance  
Pathways : KEGGKEGG_WNT_SIGNALING    KEGG_MELANOGENESIS    KEGG_PATHWAYS_IN_CANCER    KEGG_BASAL_CELL_CARCINOMA   
NDEx NetworkFZD3
Atlas of Cancer Signalling NetworkFZD3
Wikipedia pathwaysFZD3
Orthology - Evolution
OrthoDB7976
GeneTree (enSembl)ENSG00000104290
Phylogenetic Trees/Animal Genes : TreeFamFZD3
Homologs : HomoloGeneFZD3
Homology/Alignments : Family Browser (UCSC)FZD3
Gene fusions - Rearrangements
Fusion : QuiverFZD3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFZD3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FZD3
dbVarFZD3
ClinVarFZD3
MonarchFZD3
1000_GenomesFZD3 
Exome Variant ServerFZD3
GNOMAD BrowserENSG00000104290
Varsome BrowserFZD3
ACMGFZD3 variants
VarityQ9NPG1
Genomic Variants (DGV)FZD3 [DGVbeta]
DECIPHERFZD3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFZD3 
Mutations
ICGC Data PortalFZD3 
TCGA Data PortalFZD3 
Broad Tumor PortalFZD3
OASIS PortalFZD3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFZD3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFZD3
Mutations and Diseases : HGMDFZD3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFZD3
DgiDB (Drug Gene Interaction Database)FZD3
DoCM (Curated mutations)FZD3
CIViC (Clinical Interpretations of Variants in Cancer)FZD3
Cancer3DFZD3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606143   
Orphanet
DisGeNETFZD3
MedgenFZD3
Genetic Testing Registry FZD3
NextProtQ9NPG1 [Medical]
GENETestsFZD3
Target ValidationFZD3
Huge Navigator FZD3 [HugePedia]
ClinGenFZD3
Clinical trials, drugs, therapy
MyCancerGenomeFZD3
Protein Interactions : CTDFZD3
Pharm GKB GenePA28458
PharosQ9NPG1
Clinical trialFZD3
Miscellaneous
canSAR (ICR)FZD3
HarmonizomeFZD3
ARCHS4FZD3
DataMed IndexFZD3
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFZD3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 20 12:34:22 CET 2022

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