Atlas of Genetics and Cytogenetics in Oncology and Haematology


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FZD3 (frizzled class receptor 3)

Identity

Alias_namesfrizzled (Drosophila) homolog 3
frizzled homolog 3 (Drosophila)
frizzled 3, seven transmembrane spanning receptor
frizzled family receptor 3
Other aliasFz-3
HGNC (Hugo) FZD3
LocusID (NCBI) 7976
Atlas_Id 50138
Location 8p21.1  [Link to chromosome band 8p21]
Location_base_pair Starts at 28494205 and ends at 28574268 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FZD3 (8p21.1) / CTBP1 (4p16.3)FZD3 (8p21.1) / ZNF141 (4p16.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FZD3   4041
Cards
Entrez_Gene (NCBI)FZD3  7976  frizzled class receptor 3
AliasesFz-3
GeneCards (Weizmann)FZD3
Ensembl hg19 (Hinxton)ENSG00000104290 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104290 [Gene_View]  chr8:28494205-28574268 [Contig_View]  FZD3 [Vega]
ICGC DataPortalENSG00000104290
TCGA cBioPortalFZD3
AceView (NCBI)FZD3
Genatlas (Paris)FZD3
WikiGenes7976
SOURCE (Princeton)FZD3
Genetics Home Reference (NIH)FZD3
Genomic and cartography
GoldenPath hg38 (UCSC)FZD3  -     chr8:28494205-28574268 +  8p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FZD3  -     8p21.1   [Description]    (hg19-Feb_2009)
EnsemblFZD3 - 8p21.1 [CytoView hg19]  FZD3 - 8p21.1 [CytoView hg38]
Mapping of homologs : NCBIFZD3 [Mapview hg19]  FZD3 [Mapview hg38]
OMIM606143   
Gene and transcription
Genbank (Entrez)AB039723 AJ272427 AK291480 AY005130 BC034278
RefSeq transcript (Entrez)NM_017412 NM_145866
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FZD3
Cluster EST : UnigeneHs.734277 [ NCBI ]
CGAP (NCI)Hs.734277
Alternative Splicing GalleryENSG00000104290
Gene ExpressionFZD3 [ NCBI-GEO ]   FZD3 [ EBI - ARRAY_EXPRESS ]   FZD3 [ SEEK ]   FZD3 [ MEM ]
Gene Expression Viewer (FireBrowse)FZD3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7976
GTEX Portal (Tissue expression)FZD3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NPG1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NPG1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NPG1
Splice isoforms : SwissVarQ9NPG1
PhosPhoSitePlusQ9NPG1
Domaine pattern : Prosite (Expaxy)FZ (PS50038)    G_PROTEIN_RECEP_F2_4 (PS50261)   
Domains : Interpro (EBI)Frizzled    Frizzled/SFRP    Frizzled_dom    FZD3_vertebrates    GPCR_2-like   
Domain families : Pfam (Sanger)Frizzled (PF01534)    Fz (PF01392)   
Domain families : Pfam (NCBI)pfam01534    pfam01392   
Domain families : Smart (EMBL)FRI (SM00063)  Frizzled (SM01330)  
Conserved Domain (NCBI)FZD3
DMDM Disease mutations7976
Blocks (Seattle)FZD3
SuperfamilyQ9NPG1
Human Protein AtlasENSG00000104290
Peptide AtlasQ9NPG1
HPRD05849
IPIIPI00424119   IPI00985167   
Protein Interaction databases
DIP (DOE-UCLA)Q9NPG1
IntAct (EBI)Q9NPG1
FunCoupENSG00000104290
BioGRIDFZD3
STRING (EMBL)FZD3
ZODIACFZD3
Ontologies - Pathways
QuickGOQ9NPG1
Ontology : AmiGOestablishment of planar polarity  neuron migration  neural tube closure  hair follicle development  positive regulation of neuroblast proliferation  G-protein coupled receptor activity  protein binding  cytoplasm  plasma membrane  plasma membrane  G-protein coupled receptor signaling pathway  Wnt signaling pathway, calcium modulating pathway  cell surface  integral component of membrane  apical plasma membrane  lateral plasma membrane  Wnt-protein binding  Wnt-protein binding  PDZ domain binding  neuron differentiation  axon  dendrite  filopodium tip  cell proliferation in midbrain  post-anal tail morphogenesis  dopaminergic neuron axon guidance  serotonergic neuron axon guidance  inner ear morphogenesis  response to drug  Wnt-activated receptor activity  Wnt-activated receptor activity  neuronal cell body  negative regulation of mitotic cell cycle, embryonic  presynaptic active zone  response to electrical stimulus  canonical Wnt signaling pathway  Wnt signaling pathway, planar cell polarity pathway  sympathetic ganglion development  commissural neuron axon guidance  negative regulation of execution phase of apoptosis  midbrain morphogenesis  planar cell polarity pathway involved in axon guidance  
Ontology : EGO-EBIestablishment of planar polarity  neuron migration  neural tube closure  hair follicle development  positive regulation of neuroblast proliferation  G-protein coupled receptor activity  protein binding  cytoplasm  plasma membrane  plasma membrane  G-protein coupled receptor signaling pathway  Wnt signaling pathway, calcium modulating pathway  cell surface  integral component of membrane  apical plasma membrane  lateral plasma membrane  Wnt-protein binding  Wnt-protein binding  PDZ domain binding  neuron differentiation  axon  dendrite  filopodium tip  cell proliferation in midbrain  post-anal tail morphogenesis  dopaminergic neuron axon guidance  serotonergic neuron axon guidance  inner ear morphogenesis  response to drug  Wnt-activated receptor activity  Wnt-activated receptor activity  neuronal cell body  negative regulation of mitotic cell cycle, embryonic  presynaptic active zone  response to electrical stimulus  canonical Wnt signaling pathway  Wnt signaling pathway, planar cell polarity pathway  sympathetic ganglion development  commissural neuron axon guidance  negative regulation of execution phase of apoptosis  midbrain morphogenesis  planar cell polarity pathway involved in axon guidance  
Pathways : KEGGWnt signaling pathway    Hippo signaling pathway    Melanogenesis    HTLV-I infection    Pathways in cancer    Proteoglycans in cancer    MicroRNAs in cancer    Basal cell carcinoma   
NDEx NetworkFZD3
Atlas of Cancer Signalling NetworkFZD3
Wikipedia pathwaysFZD3
Orthology - Evolution
OrthoDB7976
GeneTree (enSembl)ENSG00000104290
Phylogenetic Trees/Animal Genes : TreeFamFZD3
HOVERGENQ9NPG1
HOGENOMQ9NPG1
Homologs : HomoloGeneFZD3
Homology/Alignments : Family Browser (UCSC)FZD3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFZD3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FZD3
dbVarFZD3
ClinVarFZD3
1000_GenomesFZD3 
Exome Variant ServerFZD3
ExAC (Exome Aggregation Consortium)FZD3 (select the gene name)
Genetic variants : HAPMAP7976
Genomic Variants (DGV)FZD3 [DGVbeta]
DECIPHERFZD3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFZD3 
Mutations
ICGC Data PortalFZD3 
TCGA Data PortalFZD3 
Broad Tumor PortalFZD3
OASIS PortalFZD3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFZD3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFZD3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch FZD3
DgiDB (Drug Gene Interaction Database)FZD3
DoCM (Curated mutations)FZD3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FZD3 (select a term)
intoGenFZD3
Cancer3DFZD3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606143   
Orphanet
MedgenFZD3
Genetic Testing Registry FZD3
NextProtQ9NPG1 [Medical]
TSGene7976
GENETestsFZD3
Huge Navigator FZD3 [HugePedia]
snp3D : Map Gene to Disease7976
BioCentury BCIQFZD3
ClinGenFZD3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7976
Chemical/Pharm GKB GenePA28458
Clinical trialFZD3
Miscellaneous
canSAR (ICR)FZD3 (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFZD3
EVEXFZD3
GoPubMedFZD3
iHOPFZD3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:16:38 CEST 2017

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