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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
Donations are also welcome
If each casual visitor gives 3 Euros or Dollars, the Atlas is saved in a week !
If each professional gives 100 Euros or Dollars once a year (now), the Atlas is saved in 2 weeks !
Don't let the Atlas imminent demise
Note: we send fiscal receipts for donations equal or above 50 Euros or Dollars

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FZD4 (frizzled class receptor 4)

Identity

Other namesCD344
EVR1
FEVR
FZD4S
Fz-4
Fz4
FzE4
GPCR
hFz4
HGNC (Hugo) FZD4
LocusID (NCBI) 8322
Location 11q14.2
Location_base_pair Starts at 86656717 and ends at 86666440 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FZD4   4042
Cards
Entrez_Gene (NCBI)FZD4  8322  frizzled class receptor 4
GeneCards (Weizmann)FZD4
Ensembl hg19 (Hinxton)ENSG00000174804 [Gene_View]  chr11:86656717-86666440 [Contig_View]  FZD4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000174804 [Gene_View]  chr11:86656717-86666440 [Contig_View]  FZD4 [Vega]
ICGC DataPortalENSG00000174804
cBioPortalFZD4
AceView (NCBI)FZD4
Genatlas (Paris)FZD4
WikiGenes8322
SOURCE (Princeton)FZD4
Genomic and cartography
GoldenPath hg19 (UCSC)FZD4  -     chr11:86656717-86666440 -  11q14.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FZD4  -     11q14.2   [Description]    (hg38-Dec_2013)
EnsemblFZD4 - 11q14.2 [CytoView hg19]  FZD4 - 11q14.2 [CytoView hg38]
Mapping of homologs : NCBIFZD4 [Mapview hg19]  FZD4 [Mapview hg38]
OMIM133780   604579   
Gene and transcription
Genbank (Entrez)AB032417 AB054881 AK025516 AK025791 AK292768
RefSeq transcript (Entrez)NM_012193
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_011752 NT_167190 NW_004929380
Consensus coding sequences : CCDS (NCBI)FZD4
Cluster EST : UnigeneHs.591968 [ NCBI ]
CGAP (NCI)Hs.591968
Alternative Splicing : Fast-db (Paris)GSHG0006079
Alternative Splicing GalleryENSG00000174804
Gene ExpressionFZD4 [ NCBI-GEO ]     FZD4 [ SEEK ]   FZD4 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9ULV1 (Uniprot)
NextProtQ9ULV1  [Medical]
With graphics : InterProQ9ULV1
Splice isoforms : SwissVarQ9ULV1 (Swissvar)
Domaine pattern : Prosite (Expaxy)FZ (PS50038)    G_PROTEIN_RECEP_F2_4 (PS50261)   
Domains : Interpro (EBI)Frizzled    Frizzled/SFRP    Frizzled_dom    FZD4    GPCR_2-like   
Related proteins : CluSTrQ9ULV1
Domain families : Pfam (Sanger)Frizzled (PF01534)    Fz (PF01392)   
Domain families : Pfam (NCBI)pfam01534    pfam01392   
Domain families : Smart (EMBL)FRI (SM00063)  
DMDM Disease mutations8322
Blocks (Seattle)Q9ULV1
Human Protein AtlasENSG00000174804
Peptide AtlasQ9ULV1
HPRD05203
IPIIPI00387029   IPI00977659   
Protein Interaction databases
DIP (DOE-UCLA)Q9ULV1
IntAct (EBI)Q9ULV1
FunCoupENSG00000174804
BioGRIDFZD4
IntegromeDBFZD4
STRING (EMBL)FZD4
Ontologies - Pathways
QuickGOQ9ULV1
Ontology : AmiGOvasculogenesis  G-protein coupled receptor activity  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  cell-cell junction  G-protein coupled receptor signaling pathway  Wnt signaling pathway, calcium modulating pathway  sensory perception of sound  cell surface  negative regulation of cell-substrate adhesion  integral component of membrane  Wnt signaling pathway  Wnt-protein binding  cytokine binding  PDZ domain binding  PDZ domain binding  neuron differentiation  clathrin-coated endocytic vesicle membrane  regulation of vascular endothelial growth factor receptor signaling pathway  ubiquitin protein ligase binding  locomotion involved in locomotory behavior  substrate adhesion-dependent cell spreading  extracellular matrix-cell signaling  progesterone secretion  protein homodimerization activity  Wnt-activated receptor activity  positive regulation of JUN kinase activity  positive regulation of transcription, DNA-templated  protein heterodimerization activity  positive regulation of sequence-specific DNA binding transcription factor activity  canonical Wnt signaling pathway  retina vasculature morphogenesis in camera-type eye  cerebellum vasculature morphogenesis  retinal blood vessel morphogenesis  extracellular exosome  cellular response to retinoic acid  
Ontology : EGO-EBIvasculogenesis  G-protein coupled receptor activity  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  cell-cell junction  G-protein coupled receptor signaling pathway  Wnt signaling pathway, calcium modulating pathway  sensory perception of sound  cell surface  negative regulation of cell-substrate adhesion  integral component of membrane  Wnt signaling pathway  Wnt-protein binding  cytokine binding  PDZ domain binding  PDZ domain binding  neuron differentiation  clathrin-coated endocytic vesicle membrane  regulation of vascular endothelial growth factor receptor signaling pathway  ubiquitin protein ligase binding  locomotion involved in locomotory behavior  substrate adhesion-dependent cell spreading  extracellular matrix-cell signaling  progesterone secretion  protein homodimerization activity  Wnt-activated receptor activity  positive regulation of JUN kinase activity  positive regulation of transcription, DNA-templated  protein heterodimerization activity  positive regulation of sequence-specific DNA binding transcription factor activity  canonical Wnt signaling pathway  retina vasculature morphogenesis in camera-type eye  cerebellum vasculature morphogenesis  retinal blood vessel morphogenesis  extracellular exosome  cellular response to retinoic acid  
Pathways : KEGGWnt signaling pathway    Hippo signaling pathway    Melanogenesis    HTLV-I infection    Pathways in cancer    Proteoglycans in cancer    Basal cell carcinoma   
Protein Interaction DatabaseFZD4
DoCM (Curated mutations)FZD4
Wikipedia pathwaysFZD4
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerFZD4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FZD4
dbVarFZD4
ClinVarFZD4
1000_GenomesFZD4 
Exome Variant ServerFZD4
SNP (GeneSNP Utah)FZD4
SNP : HGBaseFZD4
Genetic variants : HAPMAPFZD4
Genomic Variants (DGV)FZD4 [DGVbeta]
Mutations
ICGC Data PortalENSG00000174804 
Somatic Mutations in Cancer : COSMICFZD4 
CONAN: Copy Number AnalysisFZD4 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)Eye diseases - LOVD
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)11:86656717-86666440
Mutations and Diseases : HGMDFZD4
OMIM133780    604579   
MedgenFZD4
NextProtQ9ULV1 [Medical]
GENETestsFZD4
Disease Genetic AssociationFZD4
Huge Navigator FZD4 [HugePedia]  FZD4 [HugeCancerGEM]
snp3D : Map Gene to Disease8322
DGIdb (Drug Gene Interaction db)FZD4
General knowledge
Homologs : HomoloGeneFZD4
Homology/Alignments : Family Browser (UCSC)FZD4
Phylogenetic Trees/Animal Genes : TreeFamFZD4
Chemical/Protein Interactions : CTD8322
Chemical/Pharm GKB GenePA28459
Clinical trialFZD4
Cancer Resource (Charite)ENSG00000174804
Other databases
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
CoreMineFZD4
GoPubMedFZD4
iHOPFZD4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Mar 28 15:27:14 CET 2015

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.