Atlas of Genetics and Cytogenetics in Oncology and Haematology


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FZD4 (frizzled family receptor 4)

Identity

Other namesCD344
EVR1
FEVR
FZD4S
Fz-4
Fz4
FzE4
GPCR
hFz4
HGNC (Hugo) FZD4
LocusID (NCBI) 8322
Location 11q14.2
Location_base_pair Starts at 86656717 and ends at 86666440 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FZD4   4042
Cards
Entrez_Gene (NCBI)FZD4  8322  frizzled family receptor 4
GeneCards (Weizmann)FZD4
Ensembl (Hinxton)ENSG00000174804 [Gene_View]  chr11:86656717-86666440 [Contig_View]  FZD4 [Vega]
AceView (NCBI)FZD4
Genatlas (Paris)FZD4
WikiGenes8322
SOURCE (Princeton)NM_012193
Genomic and cartography
GoldenPath (UCSC)FZD4  -  11q14.2   chr11:86656717-86666440 -  11q14.2   [Description]    (hg19-Feb_2009)
EnsemblFZD4 - 11q14.2 [CytoView]
Mapping of homologs : NCBIFZD4 [Mapview]
OMIM133780   604579   
Gene and transcription
Genbank (Entrez)AB032417 AB054881 AK025516 AK025791 AK292768
RefSeq transcript (Entrez)NM_012193
RefSeq genomic (Entrez)AC_000143 NC_000011 NC_018922 NG_011752 NT_167190 NW_001838028 NW_004929380
Consensus coding sequences : CCDS (NCBI)FZD4
Cluster EST : UnigeneHs.591968 [ NCBI ]
CGAP (NCI)Hs.591968
Alternative Splicing : Fast-db (Paris)GSHG0006079
Alternative Splicing GalleryENSG00000174804
Gene ExpressionFZD4 [ NCBI-GEO ]     FZD4 [ SEEK ]   FZD4 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9ULV1 (Uniprot)
NextProtQ9ULV1  [Medical]
With graphics : InterProQ9ULV1
Splice isoforms : SwissVarQ9ULV1 (Swissvar)
Domaine pattern : Prosite (Expaxy)FZ (PS50038)    G_PROTEIN_RECEP_F2_4 (PS50261)   
Domains : Interpro (EBI)Frizzled    Frizzled/SFRP    Frizzled_dom    FZD4    GPCR_2-like   
Related proteins : CluSTrQ9ULV1
Domain families : Pfam (Sanger)Frizzled (PF01534)    Fz (PF01392)   
Domain families : Pfam (NCBI)pfam01534    pfam01392   
Domain families : Smart (EMBL)FRI (SM00063)  
DMDM Disease mutations8322
Blocks (Seattle)Q9ULV1
Human Protein AtlasENSG00000174804
Peptide AtlasQ9ULV1
HPRD05203
IPIIPI00387029   IPI00977659   
Protein Interaction databases
DIP (DOE-UCLA)Q9ULV1
IntAct (EBI)Q9ULV1
FunCoupENSG00000174804
BioGRIDFZD4
InParanoidQ9ULV1
Interologous Interaction database Q9ULV1
IntegromeDBFZD4
STRING (EMBL)FZD4
Ontologies - Pathways
Ontology : AmiGOvasculogenesis  G-protein coupled receptor activity  protein binding  cytoplasm  plasma membrane  integral to plasma membrane  cell-cell junction  Wnt receptor signaling pathway, calcium modulating pathway  brain development  sensory perception of sound  embryo development  cell surface  negative regulation of cell-substrate adhesion  Wnt receptor signaling pathway  Wnt-protein binding  cytokine binding  PDZ domain binding  PDZ domain binding  neuron differentiation  regulation of vascular endothelial growth factor receptor signaling pathway  ubiquitin protein ligase binding  locomotion involved in locomotory behavior  substrate adhesion-dependent cell spreading  extracellular matrix-cell signaling  progesterone secretion  protein homodimerization activity  Wnt-activated receptor activity  cell projection  positive regulation of JUN kinase activity  positive regulation of transcription, DNA-dependent  protein heterodimerization activity  positive regulation of sequence-specific DNA binding transcription factor activity  canonical Wnt receptor signaling pathway  retina vasculature morphogenesis in camera-type eye  cerebellum vasculature morphogenesis  retinal blood vessel morphogenesis  cellular response to retinoic acid  
Ontology : EGO-EBIvasculogenesis  G-protein coupled receptor activity  protein binding  cytoplasm  plasma membrane  integral to plasma membrane  cell-cell junction  Wnt receptor signaling pathway, calcium modulating pathway  brain development  sensory perception of sound  embryo development  cell surface  negative regulation of cell-substrate adhesion  Wnt receptor signaling pathway  Wnt-protein binding  cytokine binding  PDZ domain binding  PDZ domain binding  neuron differentiation  regulation of vascular endothelial growth factor receptor signaling pathway  ubiquitin protein ligase binding  locomotion involved in locomotory behavior  substrate adhesion-dependent cell spreading  extracellular matrix-cell signaling  progesterone secretion  protein homodimerization activity  Wnt-activated receptor activity  cell projection  positive regulation of JUN kinase activity  positive regulation of transcription, DNA-dependent  protein heterodimerization activity  positive regulation of sequence-specific DNA binding transcription factor activity  canonical Wnt receptor signaling pathway  retina vasculature morphogenesis in camera-type eye  cerebellum vasculature morphogenesis  retinal blood vessel morphogenesis  cellular response to retinoic acid  
Pathways : KEGGWnt signaling pathway    Hippo signaling pathway    Melanogenesis    HTLV-I infection    Pathways in cancer    Proteoglycans in cancer    Basal cell carcinoma   
REACTOMEFZD4
Protein Interaction DatabaseFZD4
Wikipedia pathwaysFZD4
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)FZD4
SNP (GeneSNP Utah)FZD4
SNP : HGBaseFZD4
Genetic variants : HAPMAPFZD4
1000_GenomesFZD4 
ICGC programENSG00000174804 
Somatic Mutations in Cancer : COSMICFZD4 
CONAN: Copy Number AnalysisFZD4 
Mutations and Diseases : HGMDFZD4
OMIM133780    604579   
GENETestsFZD4
Disease Genetic AssociationFZD4
Huge Navigator FZD4 [HugePedia]  FZD4 [HugeCancerGEM]
Genomic VariantsFZD4  FZD4 [DGVbeta]
Exome VariantFZD4
dbVarFZD4
ClinVarFZD4
snp3D : Map Gene to Disease8322
General knowledge
Homologs : HomoloGeneFZD4
Homology/Alignments : Family Browser (UCSC)FZD4
Phylogenetic Trees/Animal Genes : TreeFamFZD4
Chemical/Protein Interactions : CTD8322
Chemical/Pharm GKB GenePA28459
Clinical trialFZD4
Cancer Resource (Charite)ENSG00000174804
Other databases
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
CoreMineFZD4
iHOPFZD4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Mar 31 09:24:42 CEST 2014

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