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FZD6 (frizzled class receptor 6)

Identity

Alias_namesfrizzled (Drosophila) homolog 6
frizzled homolog 6 (Drosophila)
frizzled 6, seven transmembrane spanning receptor
frizzled family receptor 6
Alias_symbol (synonym)Hfz6
Other aliasFZ-6
FZ6
HFZ6
NDNC10
HGNC (Hugo) FZD6
LocusID (NCBI) 8323
Atlas_Id 40656
Location 8q22.3  [Link to chromosome band 8q22]
Location_base_pair Starts at 104310661 and ends at 104345094 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FZD6 (8q22.3) / SDC2 (8q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FZD6   4044
Cards
Entrez_Gene (NCBI)FZD6  8323  frizzled class receptor 6
AliasesFZ-6; FZ6; HFZ6; NDNC10
GeneCards (Weizmann)FZD6
Ensembl hg19 (Hinxton)ENSG00000164930 [Gene_View]  chr8:104310661-104345094 [Contig_View]  FZD6 [Vega]
Ensembl hg38 (Hinxton)ENSG00000164930 [Gene_View]  chr8:104310661-104345094 [Contig_View]  FZD6 [Vega]
ICGC DataPortalENSG00000164930
TCGA cBioPortalFZD6
AceView (NCBI)FZD6
Genatlas (Paris)FZD6
WikiGenes8323
SOURCE (Princeton)FZD6
Genetics Home Reference (NIH)FZD6
Genomic and cartography
GoldenPath hg19 (UCSC)FZD6  -     chr8:104310661-104345094 +  8q22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FZD6  -     8q22.3   [Description]    (hg38-Dec_2013)
EnsemblFZD6 - 8q22.3 [CytoView hg19]  FZD6 - 8q22.3 [CytoView hg38]
Mapping of homologs : NCBIFZD6 [Mapview hg19]  FZD6 [Mapview hg38]
OMIM603409   614157   
Gene and transcription
Genbank (Entrez)AB012911 AB209734 AF072873 AK296824 AK299341
RefSeq transcript (Entrez)NM_001164615 NM_001164616 NM_001317796 NM_003506
RefSeq genomic (Entrez)NC_000008 NC_018919 NG_028909 NT_008046 NW_004929340
Consensus coding sequences : CCDS (NCBI)FZD6
Cluster EST : UnigeneHs.676099 [ NCBI ]
CGAP (NCI)Hs.676099
Alternative Splicing GalleryENSG00000164930
Gene ExpressionFZD6 [ NCBI-GEO ]   FZD6 [ EBI - ARRAY_EXPRESS ]   FZD6 [ SEEK ]   FZD6 [ MEM ]
Gene Expression Viewer (FireBrowse)FZD6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8323
GTEX Portal (Tissue expression)FZD6
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60353   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60353  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60353
Splice isoforms : SwissVarO60353
PhosPhoSitePlusO60353
Domaine pattern : Prosite (Expaxy)FZ (PS50038)    G_PROTEIN_RECEP_F2_4 (PS50261)   
Domains : Interpro (EBI)Frizzled    Frizzled/SFRP    Frizzled_dom    FZD6    GPCR_2-like   
Domain families : Pfam (Sanger)Frizzled (PF01534)    Fz (PF01392)   
Domain families : Pfam (NCBI)pfam01534    pfam01392   
Domain families : Smart (EMBL)FRI (SM00063)  
Conserved Domain (NCBI)FZD6
DMDM Disease mutations8323
Blocks (Seattle)FZD6
SuperfamilyO60353
Human Protein AtlasENSG00000164930
Peptide AtlasO60353
HPRD04559
IPIIPI00020228   IPI00944671   IPI01011511   IPI00383006   IPI00789179   IPI00789797   IPI01012835   IPI01013313   IPI00974412   
Protein Interaction databases
DIP (DOE-UCLA)O60353
IntAct (EBI)O60353
FunCoupENSG00000164930
BioGRIDFZD6
STRING (EMBL)FZD6
ZODIACFZD6
Ontologies - Pathways
QuickGOO60353
Ontology : AmiGOestablishment of planar polarity  neural tube closure  hair follicle development  G-protein coupled receptor activity  protein binding  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway  Wnt signaling pathway, calcium modulating pathway  cell surface  integral component of membrane  apical plasma membrane  apicolateral plasma membrane  Wnt-protein binding  Wnt-protein binding  Wnt-protein binding  platelet activation  cytoplasmic vesicle membrane  ubiquitin protein ligase binding  cell proliferation in midbrain  non-canonical Wnt signaling pathway  embryonic nail plate morphogenesis  inner ear morphogenesis  Wnt-activated receptor activity  Wnt-activated receptor activity  negative regulation of sequence-specific DNA binding transcription factor activity  Wnt signaling pathway, planar cell polarity pathway  negative regulation of canonical Wnt signaling pathway  midbrain morphogenesis  
Ontology : EGO-EBIestablishment of planar polarity  neural tube closure  hair follicle development  G-protein coupled receptor activity  protein binding  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway  Wnt signaling pathway, calcium modulating pathway  cell surface  integral component of membrane  apical plasma membrane  apicolateral plasma membrane  Wnt-protein binding  Wnt-protein binding  Wnt-protein binding  platelet activation  cytoplasmic vesicle membrane  ubiquitin protein ligase binding  cell proliferation in midbrain  non-canonical Wnt signaling pathway  embryonic nail plate morphogenesis  inner ear morphogenesis  Wnt-activated receptor activity  Wnt-activated receptor activity  negative regulation of sequence-specific DNA binding transcription factor activity  Wnt signaling pathway, planar cell polarity pathway  negative regulation of canonical Wnt signaling pathway  midbrain morphogenesis  
Pathways : KEGGWnt signaling pathway    Hippo signaling pathway    Melanogenesis    HTLV-I infection    Pathways in cancer    Proteoglycans in cancer    Basal cell carcinoma   
NDEx NetworkFZD6
Atlas of Cancer Signalling NetworkFZD6
Wikipedia pathwaysFZD6
Orthology - Evolution
OrthoDB8323
GeneTree (enSembl)ENSG00000164930
Phylogenetic Trees/Animal Genes : TreeFamFZD6
HOVERGENO60353
HOGENOMO60353
Homologs : HomoloGeneFZD6
Homology/Alignments : Family Browser (UCSC)FZD6
Gene fusions - Rearrangements
Fusion : MitelmanFZD6/SDC2 [8q22.3/8q22.1]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFZD6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FZD6
dbVarFZD6
ClinVarFZD6
1000_GenomesFZD6 
Exome Variant ServerFZD6
ExAC (Exome Aggregation Consortium)FZD6 (select the gene name)
Genetic variants : HAPMAP8323
Genomic Variants (DGV)FZD6 [DGVbeta]
DECIPHER (Syndromes)8:104310661-104345094  ENSG00000164930
CONAN: Copy Number AnalysisFZD6 
Mutations
ICGC Data PortalFZD6 
TCGA Data PortalFZD6 
Broad Tumor PortalFZD6
OASIS PortalFZD6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFZD6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFZD6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch FZD6
DgiDB (Drug Gene Interaction Database)FZD6
DoCM (Curated mutations)FZD6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FZD6 (select a term)
intoGenFZD6
Cancer3DFZD6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603409    614157   
Orphanet20491   
MedgenFZD6
Genetic Testing Registry FZD6
NextProtO60353 [Medical]
TSGene8323
GENETestsFZD6
Huge Navigator FZD6 [HugePedia]
snp3D : Map Gene to Disease8323
BioCentury BCIQFZD6
ClinGenFZD6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8323
Chemical/Pharm GKB GenePA28461
Clinical trialFZD6
Miscellaneous
canSAR (ICR)FZD6 (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFZD6
EVEXFZD6
GoPubMedFZD6
iHOPFZD6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:06:49 CET 2017

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