Atlas of Genetics and Cytogenetics in Oncology and Haematology


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FZD7 (frizzled class receptor 7)

Identity

Alias_namesfrizzled (Drosophila) homolog 7
frizzled homolog 7 (Drosophila)
frizzled 7, seven transmembrane spanning receptor
frizzled family receptor 7
Alias_symbol (synonym)FzE3
Other alias
HGNC (Hugo) FZD7
LocusID (NCBI) 8324
Atlas_Id 40657
Location 2q33.1  [Link to chromosome band 2q33]
Location_base_pair Starts at 202899310 and ends at 202903160 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
C20orf27 (20p13) / FZD7 (2q33.1)RPL13A (19q13.33) / FZD7 (2q33.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FZD7   4045
Cards
Entrez_Gene (NCBI)FZD7  8324  frizzled class receptor 7
AliasesFzE3
GeneCards (Weizmann)FZD7
Ensembl hg19 (Hinxton)ENSG00000155760 [Gene_View]  chr2:202899310-202903160 [Contig_View]  FZD7 [Vega]
Ensembl hg38 (Hinxton)ENSG00000155760 [Gene_View]  chr2:202899310-202903160 [Contig_View]  FZD7 [Vega]
ICGC DataPortalENSG00000155760
TCGA cBioPortalFZD7
AceView (NCBI)FZD7
Genatlas (Paris)FZD7
WikiGenes8324
SOURCE (Princeton)FZD7
Genetics Home Reference (NIH)FZD7
Genomic and cartography
GoldenPath hg19 (UCSC)FZD7  -     chr2:202899310-202903160 +  2q33.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FZD7  -     2q33.1   [Description]    (hg38-Dec_2013)
EnsemblFZD7 - 2q33.1 [CytoView hg19]  FZD7 - 2q33.1 [CytoView hg38]
Mapping of homologs : NCBIFZD7 [Mapview hg19]  FZD7 [Mapview hg38]
OMIM603410   
Gene and transcription
Genbank (Entrez)AB010881 AB017365 BC015915 JF432234
RefSeq transcript (Entrez)NM_003507
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)FZD7
Cluster EST : UnigeneHs.173859 [ NCBI ]
CGAP (NCI)Hs.173859
Alternative Splicing GalleryENSG00000155760
Gene ExpressionFZD7 [ NCBI-GEO ]   FZD7 [ EBI - ARRAY_EXPRESS ]   FZD7 [ SEEK ]   FZD7 [ MEM ]
Gene Expression Viewer (FireBrowse)FZD7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8324
GTEX Portal (Tissue expression)FZD7
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75084   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75084  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75084
Splice isoforms : SwissVarO75084
PhosPhoSitePlusO75084
Domaine pattern : Prosite (Expaxy)FZ (PS50038)    G_PROTEIN_RECEP_F2_4 (PS50261)   
Domains : Interpro (EBI)Frizzled    Frizzled/SFRP    Frizzled_dom    FZD7    GPCR_2-like   
Domain families : Pfam (Sanger)Frizzled (PF01534)    Fz (PF01392)   
Domain families : Pfam (NCBI)pfam01534    pfam01392   
Domain families : Smart (EMBL)FRI (SM00063)  
Conserved Domain (NCBI)FZD7
DMDM Disease mutations8324
Blocks (Seattle)FZD7
SuperfamilyO75084
Human Protein AtlasENSG00000155760
Peptide AtlasO75084
HPRD04560
IPIIPI00024012   
Protein Interaction databases
DIP (DOE-UCLA)O75084
IntAct (EBI)O75084
FunCoupENSG00000155760
BioGRIDFZD7
STRING (EMBL)FZD7
ZODIACFZD7
Ontologies - Pathways
QuickGOO75084
Ontology : AmiGOG-protein coupled receptor activity  frizzled binding  protein binding  plasma membrane  plasma membrane  regulation of transcription, DNA-templated  G-protein coupled receptor signaling pathway  negative regulation of cell-substrate adhesion  skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration  integral component of membrane  Wnt-protein binding  Wnt-protein binding  stem cell population maintenance  PDZ domain binding  neuron differentiation  T cell differentiation in thymus  substrate adhesion-dependent cell spreading  regulation of catenin import into nucleus  non-canonical Wnt signaling pathway via JNK cascade  positive regulation of phosphorylation  negative regulation of ectodermal cell fate specification  Wnt-activated receptor activity  Wnt-activated receptor activity  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of JNK cascade  somatic stem cell division  positive regulation of epithelial cell proliferation involved in wound healing  canonical Wnt signaling pathway  canonical Wnt signaling pathway  Wnt signaling pathway, planar cell polarity pathway  Wnt signaling pathway, planar cell polarity pathway  mesenchymal to epithelial transition  cellular response to retinoic acid  
Ontology : EGO-EBIG-protein coupled receptor activity  frizzled binding  protein binding  plasma membrane  plasma membrane  regulation of transcription, DNA-templated  G-protein coupled receptor signaling pathway  negative regulation of cell-substrate adhesion  skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration  integral component of membrane  Wnt-protein binding  Wnt-protein binding  stem cell population maintenance  PDZ domain binding  neuron differentiation  T cell differentiation in thymus  substrate adhesion-dependent cell spreading  regulation of catenin import into nucleus  non-canonical Wnt signaling pathway via JNK cascade  positive regulation of phosphorylation  negative regulation of ectodermal cell fate specification  Wnt-activated receptor activity  Wnt-activated receptor activity  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of JNK cascade  somatic stem cell division  positive regulation of epithelial cell proliferation involved in wound healing  canonical Wnt signaling pathway  canonical Wnt signaling pathway  Wnt signaling pathway, planar cell polarity pathway  Wnt signaling pathway, planar cell polarity pathway  mesenchymal to epithelial transition  cellular response to retinoic acid  
Pathways : KEGGWnt signaling pathway    Hippo signaling pathway    Melanogenesis    HTLV-I infection    Pathways in cancer    Proteoglycans in cancer    Basal cell carcinoma   
NDEx NetworkFZD7
Atlas of Cancer Signalling NetworkFZD7
Wikipedia pathwaysFZD7
Orthology - Evolution
OrthoDB8324
GeneTree (enSembl)ENSG00000155760
Phylogenetic Trees/Animal Genes : TreeFamFZD7
HOVERGENO75084
HOGENOMO75084
Homologs : HomoloGeneFZD7
Homology/Alignments : Family Browser (UCSC)FZD7
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFZD7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FZD7
dbVarFZD7
ClinVarFZD7
1000_GenomesFZD7 
Exome Variant ServerFZD7
ExAC (Exome Aggregation Consortium)FZD7 (select the gene name)
Genetic variants : HAPMAP8324
Genomic Variants (DGV)FZD7 [DGVbeta]
DECIPHER (Syndromes)2:202899310-202903160  ENSG00000155760
CONAN: Copy Number AnalysisFZD7 
Mutations
ICGC Data PortalFZD7 
TCGA Data PortalFZD7 
Broad Tumor PortalFZD7
OASIS PortalFZD7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFZD7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFZD7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FZD7
DgiDB (Drug Gene Interaction Database)FZD7
DoCM (Curated mutations)FZD7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FZD7 (select a term)
intoGenFZD7
Cancer3DFZD7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603410   
Orphanet
MedgenFZD7
Genetic Testing Registry FZD7
NextProtO75084 [Medical]
TSGene8324
GENETestsFZD7
Huge Navigator FZD7 [HugePedia]
snp3D : Map Gene to Disease8324
BioCentury BCIQFZD7
ClinGenFZD7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8324
Chemical/Pharm GKB GenePA28462
Clinical trialFZD7
Miscellaneous
canSAR (ICR)FZD7 (select the gene name)
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFZD7
EVEXFZD7
GoPubMedFZD7
iHOPFZD7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:01:51 CEST 2017

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