Atlas of Genetics and Cytogenetics in Oncology and Haematology


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FZD7 (frizzled class receptor 7)

Identity

Alias (NCBI)FzE3
HGNC (Hugo) FZD7
HGNC Alias symbFzE3
HGNC Previous namefrizzled (Drosophila) homolog 7
 frizzled homolog 7 (Drosophila)
 frizzled 7, seven transmembrane spanning receptor
 frizzled family receptor 7
LocusID (NCBI) 8324
Atlas_Id 40657
Location 2q33.1  [Link to chromosome band 2q33]
Location_base_pair Starts at 202034587 and ends at 202038437 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C20orf27 (20p13)::FZD7 (2q33.1)RPL13A (19q13.33)::FZD7 (2q33.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)FZD7   4045
Cards
Entrez_Gene (NCBI)FZD7    frizzled class receptor 7
AliasesFzE3
GeneCards (Weizmann)FZD7
Ensembl hg19 (Hinxton)ENSG00000155760 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000155760 [Gene_View]  ENSG00000155760 [Sequence]  chr2:202034587-202038437 [Contig_View]  FZD7 [Vega]
ICGC DataPortalENSG00000155760
TCGA cBioPortalFZD7
AceView (NCBI)FZD7
Genatlas (Paris)FZD7
SOURCE (Princeton)FZD7
Genetics Home Reference (NIH)FZD7
Genomic and cartography
GoldenPath hg38 (UCSC)FZD7  -     chr2:202034587-202038437 +  2q33.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FZD7  -     2q33.1   [Description]    (hg19-Feb_2009)
GoldenPathFZD7 - 2q33.1 [CytoView hg19]  FZD7 - 2q33.1 [CytoView hg38]
ImmunoBaseENSG00000155760
Genome Data Viewer NCBIFZD7 [Mapview hg19]  
OMIM603410   
Gene and transcription
Genbank (Entrez)AB010881 AB017365 BC015915
RefSeq transcript (Entrez)NM_003507
Consensus coding sequences : CCDS (NCBI)FZD7
Gene ExpressionFZD7 [ NCBI-GEO ]   FZD7 [ EBI - ARRAY_EXPRESS ]   FZD7 [ SEEK ]   FZD7 [ MEM ]
Gene Expression Viewer (FireBrowse)FZD7 [ Firebrowse - Broad ]
GenevisibleExpression of FZD7 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8324
GTEX Portal (Tissue expression)FZD7
Human Protein AtlasENSG00000155760-FZD7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75084   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75084  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75084
PhosPhoSitePlusO75084
Domaine pattern : Prosite (Expaxy)FZ (PS50038)    G_PROTEIN_RECEP_F2_4 (PS50261)   
Domains : Interpro (EBI)Frizzled-7_CRD    Frizzled/SFRP    Frizzled/Smoothened_TM    Frizzled_dom    Frizzled_dom_sf    FZD7    GPCR_2-like   
Domain families : Pfam (Sanger)Frizzled (PF01534)    Fz (PF01392)   
Domain families : Pfam (NCBI)pfam01534    pfam01392   
Domain families : Smart (EMBL)FRI (SM00063)  Frizzled (SM01330)  
Conserved Domain (NCBI)FZD7
PDB (RSDB)4Z33    5T44    5URV    5WBS    6NE2    6NE4    6O3A    6O3B   
PDB Europe4Z33    5T44    5URV    5WBS    6NE2    6NE4    6O3A    6O3B   
PDB (PDBSum)4Z33    5T44    5URV    5WBS    6NE2    6NE4    6O3A    6O3B   
PDB (IMB)4Z33    5T44    5URV    5WBS    6NE2    6NE4    6O3A    6O3B   
Structural Biology KnowledgeBase4Z33    5T44    5URV    5WBS    6NE2    6NE4    6O3A    6O3B   
SCOP (Structural Classification of Proteins)4Z33    5T44    5URV    5WBS    6NE2    6NE4    6O3A    6O3B   
CATH (Classification of proteins structures)4Z33    5T44    5URV    5WBS    6NE2    6NE4    6O3A    6O3B   
SuperfamilyO75084
AlphaFold pdb e-kbO75084   
Human Protein Atlas [tissue]ENSG00000155760-FZD7 [tissue]
HPRD04560
Protein Interaction databases
DIP (DOE-UCLA)O75084
IntAct (EBI)O75084
BioGRIDFZD7
STRING (EMBL)FZD7
ZODIACFZD7
Ontologies - Pathways
QuickGOO75084
Ontology : AmiGOG protein-coupled receptor activity  frizzled binding  protein binding  phosphatidylinositol-4,5-bisphosphate binding  plasma membrane  plasma membrane  plasma membrane  regulation of transcription, DNA-templated  G protein-coupled receptor signaling pathway  negative regulation of cell-substrate adhesion  skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration  integral component of membrane  integral component of membrane  Wnt-protein binding  Wnt-protein binding  Wnt-protein binding  stem cell population maintenance  PDZ domain binding  neuron differentiation  T cell differentiation in thymus  substrate adhesion-dependent cell spreading  non-canonical Wnt signaling pathway  non-canonical Wnt signaling pathway via JNK cascade  positive regulation of phosphorylation  negative regulation of ectodermal cell fate specification  Wnt-activated receptor activity  Wnt-activated receptor activity  Wnt-activated receptor activity  intracellular membrane-bounded organelle  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of JNK cascade  somatic stem cell division  recycling endosome membrane  positive regulation of epithelial cell proliferation involved in wound healing  canonical Wnt signaling pathway  canonical Wnt signaling pathway  canonical Wnt signaling pathway  Wnt signaling pathway, planar cell polarity pathway  mesenchymal to epithelial transition  regulation of canonical Wnt signaling pathway  cellular response to retinoic acid  negative regulation of cardiac muscle cell differentiation  
Ontology : EGO-EBIG protein-coupled receptor activity  frizzled binding  protein binding  phosphatidylinositol-4,5-bisphosphate binding  plasma membrane  plasma membrane  plasma membrane  regulation of transcription, DNA-templated  G protein-coupled receptor signaling pathway  negative regulation of cell-substrate adhesion  skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration  integral component of membrane  integral component of membrane  Wnt-protein binding  Wnt-protein binding  Wnt-protein binding  stem cell population maintenance  PDZ domain binding  neuron differentiation  T cell differentiation in thymus  substrate adhesion-dependent cell spreading  non-canonical Wnt signaling pathway  non-canonical Wnt signaling pathway via JNK cascade  positive regulation of phosphorylation  negative regulation of ectodermal cell fate specification  Wnt-activated receptor activity  Wnt-activated receptor activity  Wnt-activated receptor activity  intracellular membrane-bounded organelle  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of JNK cascade  somatic stem cell division  recycling endosome membrane  positive regulation of epithelial cell proliferation involved in wound healing  canonical Wnt signaling pathway  canonical Wnt signaling pathway  canonical Wnt signaling pathway  Wnt signaling pathway, planar cell polarity pathway  mesenchymal to epithelial transition  regulation of canonical Wnt signaling pathway  cellular response to retinoic acid  negative regulation of cardiac muscle cell differentiation  
Pathways : KEGGKEGG_WNT_SIGNALING    KEGG_MELANOGENESIS    KEGG_PATHWAYS_IN_CANCER    KEGG_BASAL_CELL_CARCINOMA   
NDEx NetworkFZD7
Atlas of Cancer Signalling NetworkFZD7
Wikipedia pathwaysFZD7
Orthology - Evolution
OrthoDB8324
GeneTree (enSembl)ENSG00000155760
Phylogenetic Trees/Animal Genes : TreeFamFZD7
Homologs : HomoloGeneFZD7
Homology/Alignments : Family Browser (UCSC)FZD7
Gene fusions - Rearrangements
Fusion : QuiverFZD7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFZD7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FZD7
dbVarFZD7
ClinVarFZD7
MonarchFZD7
1000_GenomesFZD7 
Exome Variant ServerFZD7
GNOMAD BrowserENSG00000155760
Varsome BrowserFZD7
ACMGFZD7 variants
VarityO75084
Genomic Variants (DGV)FZD7 [DGVbeta]
DECIPHERFZD7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFZD7 
Mutations
ICGC Data PortalFZD7 
TCGA Data PortalFZD7 
Broad Tumor PortalFZD7
OASIS PortalFZD7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFZD7  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFZD7
Mutations and Diseases : HGMDFZD7
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFZD7
DgiDB (Drug Gene Interaction Database)FZD7
DoCM (Curated mutations)FZD7
CIViC (Clinical Interpretations of Variants in Cancer)FZD7
Cancer3DFZD7
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603410   
Orphanet
DisGeNETFZD7
MedgenFZD7
Genetic Testing Registry FZD7
NextProtO75084 [Medical]
GENETestsFZD7
Target ValidationFZD7
Huge Navigator FZD7 [HugePedia]
ClinGenFZD7
Clinical trials, drugs, therapy
MyCancerGenomeFZD7
Protein Interactions : CTDFZD7
Pharm GKB GenePA28462
PharosO75084
Clinical trialFZD7
Miscellaneous
canSAR (ICR)FZD7
HarmonizomeFZD7
ARCHS4FZD7
DataMed IndexFZD7
Probes
Litterature
PubMed93 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFZD7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:34:22 CET 2022

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