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FZD8 (frizzled class receptor 8)

Identity

Alias_namesfrizzled (Drosophila) homolog 8
frizzled homolog 8 (Drosophila)
frizzled 8, seven transmembrane spanning receptor
frizzled family receptor 8
Other aliasFZ-8
hFZ8
HGNC (Hugo) FZD8
LocusID (NCBI) 8325
Atlas_Id 40658
Location 10p11.21  [Link to chromosome band 10p11]
Location_base_pair Starts at 35638249 and ends at 35641434 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FZD8   4046
Cards
Entrez_Gene (NCBI)FZD8  8325  frizzled class receptor 8
AliasesFZ-8; hFZ8
GeneCards (Weizmann)FZD8
Ensembl hg19 (Hinxton)ENSG00000177283 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000177283 [Gene_View]  chr10:35638249-35641434 [Contig_View]  FZD8 [Vega]
ICGC DataPortalENSG00000177283
TCGA cBioPortalFZD8
AceView (NCBI)FZD8
Genatlas (Paris)FZD8
WikiGenes8325
SOURCE (Princeton)FZD8
Genetics Home Reference (NIH)FZD8
Genomic and cartography
GoldenPath hg38 (UCSC)FZD8  -     chr10:35638249-35641434 -  10p11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FZD8  -     10p11.21   [Description]    (hg19-Feb_2009)
EnsemblFZD8 - 10p11.21 [CytoView hg19]  FZD8 - 10p11.21 [CytoView hg38]
Mapping of homologs : NCBIFZD8 [Mapview hg19]  FZD8 [Mapview hg38]
OMIM606146   
Gene and transcription
Genbank (Entrez)AB043703 AF086500 BC111845
RefSeq transcript (Entrez)NM_031866
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FZD8
Cluster EST : UnigeneHs.302634 [ NCBI ]
CGAP (NCI)Hs.302634
Alternative Splicing GalleryENSG00000177283
Gene ExpressionFZD8 [ NCBI-GEO ]   FZD8 [ EBI - ARRAY_EXPRESS ]   FZD8 [ SEEK ]   FZD8 [ MEM ]
Gene Expression Viewer (FireBrowse)FZD8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8325
GTEX Portal (Tissue expression)FZD8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H461   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H461  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H461
Splice isoforms : SwissVarQ9H461
PhosPhoSitePlusQ9H461
Domaine pattern : Prosite (Expaxy)FZ (PS50038)    G_PROTEIN_RECEP_F2_4 (PS50261)   
Domains : Interpro (EBI)Frizzled    Frizzled/SFRP    Frizzled_dom    GPCR_2-like   
Domain families : Pfam (Sanger)Frizzled (PF01534)    Fz (PF01392)   
Domain families : Pfam (NCBI)pfam01534    pfam01392   
Domain families : Smart (EMBL)FRI (SM00063)  Frizzled (SM01330)  
Conserved Domain (NCBI)FZD8
DMDM Disease mutations8325
Blocks (Seattle)FZD8
SuperfamilyQ9H461
Human Protein AtlasENSG00000177283
Peptide AtlasQ9H461
HPRD05852
IPIIPI00010807   
Protein Interaction databases
DIP (DOE-UCLA)Q9H461
IntAct (EBI)Q9H461
FunCoupENSG00000177283
BioGRIDFZD8
STRING (EMBL)FZD8
ZODIACFZD8
Ontologies - Pathways
QuickGOQ9H461
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  angiogenesis  G-protein coupled receptor activity  receptor binding  protein binding  Golgi apparatus  G-protein coupled receptor signaling pathway  integral component of membrane  Wnt-protein binding  PDZ domain binding  neuron differentiation  ubiquitin protein ligase binding  T cell differentiation in thymus  Wnt-activated receptor activity  positive regulation of JUN kinase activity  positive regulation of transcription from RNA polymerase II promoter  canonical Wnt signaling pathway  Wnt-Frizzled-LRP5/6 complex  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  angiogenesis  G-protein coupled receptor activity  receptor binding  protein binding  Golgi apparatus  G-protein coupled receptor signaling pathway  integral component of membrane  Wnt-protein binding  PDZ domain binding  neuron differentiation  ubiquitin protein ligase binding  T cell differentiation in thymus  Wnt-activated receptor activity  positive regulation of JUN kinase activity  positive regulation of transcription from RNA polymerase II promoter  canonical Wnt signaling pathway  Wnt-Frizzled-LRP5/6 complex  
Pathways : KEGGWnt signaling pathway    Hippo signaling pathway    Melanogenesis    HTLV-I infection    Pathways in cancer    Proteoglycans in cancer    Basal cell carcinoma   
NDEx NetworkFZD8
Atlas of Cancer Signalling NetworkFZD8
Wikipedia pathwaysFZD8
Orthology - Evolution
OrthoDB8325
GeneTree (enSembl)ENSG00000177283
Phylogenetic Trees/Animal Genes : TreeFamFZD8
HOVERGENQ9H461
HOGENOMQ9H461
Homologs : HomoloGeneFZD8
Homology/Alignments : Family Browser (UCSC)FZD8
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFZD8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FZD8
dbVarFZD8
ClinVarFZD8
1000_GenomesFZD8 
Exome Variant ServerFZD8
ExAC (Exome Aggregation Consortium)FZD8 (select the gene name)
Genetic variants : HAPMAP8325
Genomic Variants (DGV)FZD8 [DGVbeta]
DECIPHERFZD8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFZD8 
Mutations
ICGC Data PortalFZD8 
TCGA Data PortalFZD8 
Broad Tumor PortalFZD8
OASIS PortalFZD8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFZD8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFZD8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FZD8
DgiDB (Drug Gene Interaction Database)FZD8
DoCM (Curated mutations)FZD8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FZD8 (select a term)
intoGenFZD8
Cancer3DFZD8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606146   
Orphanet
MedgenFZD8
Genetic Testing Registry FZD8
NextProtQ9H461 [Medical]
TSGene8325
GENETestsFZD8
Target ValidationFZD8
Huge Navigator FZD8 [HugePedia]
snp3D : Map Gene to Disease8325
BioCentury BCIQFZD8
ClinGenFZD8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8325
Chemical/Pharm GKB GenePA28463
Clinical trialFZD8
Miscellaneous
canSAR (ICR)FZD8 (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFZD8
EVEXFZD8
GoPubMedFZD8
iHOPFZD8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:09:11 CEST 2017

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