FZD8 (frizzled class receptor 8)

2003-06-01  

Identity

HGNC
LOCATION
10p11.21
LOCUSID
ALIAS
FZ-8,hFZ8

Other Information

Locus ID:

NCBI: 8325
MIM: 606146
HGNC: 4046
Ensembl: ENSG00000177283

Variants:

dbSNP: 8325
ClinVar: 8325
TCGA: ENSG00000177283
COSMIC: FZD8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177283ENST00000374694Q9H461

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
Wnt signaling pathwayKEGGko04310
MelanogenesisKEGGko04916
Basal cell carcinomaKEGGko05217
mTOR signaling pathwayKEGGhsa04150
Wnt signaling pathwayKEGGhsa04310
MelanogenesisKEGGhsa04916
Pathways in cancerKEGGhsa05200
Basal cell carcinomaKEGGhsa05217
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Wnt signalingKEGGhsa_M00677
Wnt signalingKEGGM00677
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by WNT in cancerREACTOMER-HSA-4791275
RNF mutants show enhanced WNT signaling and proliferationREACTOMER-HSA-5340588
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Regulation of FZD by ubiquitinationREACTOMER-HSA-4641263
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
PCP/CE pathwayREACTOMER-HSA-4086400
Asymmetric localization of PCP proteinsREACTOMER-HSA-4608870
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
384945822024CircMCTP2 enhances the progression of bladder cancer by regulating the miR-99a-5p/FZD8 axis.0
384945822024CircMCTP2 enhances the progression of bladder cancer by regulating the miR-99a-5p/FZD8 axis.0
367206642023Overexpressions of RHOA, CSNK1A1, DVL2, FZD8, and LRP5 genes enhance gastric cancer development in the presence of Helicobacter pylori.0
367206642023Overexpressions of RHOA, CSNK1A1, DVL2, FZD8, and LRP5 genes enhance gastric cancer development in the presence of Helicobacter pylori.0
361276852022MiR-99a alleviates apoptosis and extracellular matrix degradation in experimentally induced spine osteoarthritis by targeting FZD8.2
361276852022MiR-99a alleviates apoptosis and extracellular matrix degradation in experimentally induced spine osteoarthritis by targeting FZD8.2
319850402020Frizzled-4 is required for normal bone acquisition despite compensation by Frizzled-8.5
321610082020FZD8 Indicates a Poor Prognosis and Promotes Gastric Cancer Invasion and Metastasis via B-Catenin Signaling Pathway.10
319850402020Frizzled-4 is required for normal bone acquisition despite compensation by Frizzled-8.5
321610082020FZD8 Indicates a Poor Prognosis and Promotes Gastric Cancer Invasion and Metastasis via B-Catenin Signaling Pathway.10
297171142018Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer.55
300514932018Wnt receptor Frizzled 8 is a target of ERG in prostate cancer.15
297171142018Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer.55
300514932018Wnt receptor Frizzled 8 is a target of ERG in prostate cancer.15
282478402017MicroRNA-520b Suppresses Proliferation, Migration, and Invasion of Spinal Osteosarcoma Cells via Downregulation of Frizzled-8.19

Citation

Dessen P

FZD8 (frizzled class receptor 8)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40658/fzd8