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FZD8 (frizzled class receptor 8)

Identity

Alias (NCBI)FZ-8
hFZ8
HGNC (Hugo) FZD8
HGNC Previous namefrizzled (Drosophila) homolog 8
 frizzled homolog 8 (Drosophila)
 frizzled 8, seven transmembrane spanning receptor
 frizzled family receptor 8
LocusID (NCBI) 8325
Atlas_Id 40658
Location 10p11.21  [Link to chromosome band 10p11]
Location_base_pair Starts at 35638249 and ends at 35641434 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)FZD8   4046
Cards
Entrez_Gene (NCBI)FZD8    frizzled class receptor 8
AliasesFZ-8; hFZ8
GeneCards (Weizmann)FZD8
Ensembl hg19 (Hinxton)ENSG00000177283 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000177283 [Gene_View]  ENSG00000177283 [Sequence]  chr10:35638249-35641434 [Contig_View]  FZD8 [Vega]
ICGC DataPortalENSG00000177283
TCGA cBioPortalFZD8
AceView (NCBI)FZD8
Genatlas (Paris)FZD8
SOURCE (Princeton)FZD8
Genetics Home Reference (NIH)FZD8
Genomic and cartography
GoldenPath hg38 (UCSC)FZD8  -     chr10:35638249-35641434 -  10p11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FZD8  -     10p11.21   [Description]    (hg19-Feb_2009)
GoldenPathFZD8 - 10p11.21 [CytoView hg19]  FZD8 - 10p11.21 [CytoView hg38]
ImmunoBaseENSG00000177283
Genome Data Viewer NCBIFZD8 [Mapview hg19]  
OMIM606146   
Gene and transcription
Genbank (Entrez)AB043703 AF086500
RefSeq transcript (Entrez)NM_031866
Consensus coding sequences : CCDS (NCBI)FZD8
Gene ExpressionFZD8 [ NCBI-GEO ]   FZD8 [ EBI - ARRAY_EXPRESS ]   FZD8 [ SEEK ]   FZD8 [ MEM ]
Gene Expression Viewer (FireBrowse)FZD8 [ Firebrowse - Broad ]
GenevisibleExpression of FZD8 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8325
GTEX Portal (Tissue expression)FZD8
Human Protein AtlasENSG00000177283-FZD8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H461   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H461  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H461
PhosPhoSitePlusQ9H461
Domaine pattern : Prosite (Expaxy)FZ (PS50038)    G_PROTEIN_RECEP_F2_4 (PS50261)   
Domains : Interpro (EBI)Frizzled/SFRP    Frizzled/Smoothened_TM    Frizzled_dom    Frizzled_dom_sf    FZ8_CRD    GPCR_2-like   
Domain families : Pfam (Sanger)Frizzled (PF01534)    Fz (PF01392)   
Domain families : Pfam (NCBI)pfam01534    pfam01392   
Domain families : Smart (EMBL)FRI (SM00063)  Frizzled (SM01330)  
Conserved Domain (NCBI)FZD8
PDB (RSDB)5UN5    5UN6    6NDZ   
PDB Europe5UN5    5UN6    6NDZ   
PDB (PDBSum)5UN5    5UN6    6NDZ   
PDB (IMB)5UN5    5UN6    6NDZ   
Structural Biology KnowledgeBase5UN5    5UN6    6NDZ   
SCOP (Structural Classification of Proteins)5UN5    5UN6    6NDZ   
CATH (Classification of proteins structures)5UN5    5UN6    6NDZ   
SuperfamilyQ9H461
AlphaFold pdb e-kbQ9H461   
Human Protein Atlas [tissue]ENSG00000177283-FZD8 [tissue]
HPRD05852
Protein Interaction databases
DIP (DOE-UCLA)Q9H461
IntAct (EBI)Q9H461
BioGRIDFZD8
STRING (EMBL)FZD8
ZODIACFZD8
Ontologies - Pathways
QuickGOQ9H461
Ontology : AmiGOG protein-coupled receptor activity  protein binding  Golgi apparatus  plasma membrane  G protein-coupled receptor signaling pathway  integral component of membrane  integral component of membrane  Wnt-protein binding  PDZ domain binding  neuron differentiation  ubiquitin protein ligase binding  non-canonical Wnt signaling pathway  Wnt-activated receptor activity  Wnt-activated receptor activity  Wnt-activated receptor activity  canonical Wnt signaling pathway  canonical Wnt signaling pathway  canonical Wnt signaling pathway  
Ontology : EGO-EBIG protein-coupled receptor activity  protein binding  Golgi apparatus  plasma membrane  G protein-coupled receptor signaling pathway  integral component of membrane  integral component of membrane  Wnt-protein binding  PDZ domain binding  neuron differentiation  ubiquitin protein ligase binding  non-canonical Wnt signaling pathway  Wnt-activated receptor activity  Wnt-activated receptor activity  Wnt-activated receptor activity  canonical Wnt signaling pathway  canonical Wnt signaling pathway  canonical Wnt signaling pathway  
Pathways : KEGGWnt signaling pathway    Hippo signaling pathway    Melanogenesis    HTLV-I infection    Pathways in cancer    Proteoglycans in cancer    Basal cell carcinoma   
NDEx NetworkFZD8
Atlas of Cancer Signalling NetworkFZD8
Wikipedia pathwaysFZD8
Orthology - Evolution
OrthoDB8325
GeneTree (enSembl)ENSG00000177283
Phylogenetic Trees/Animal Genes : TreeFamFZD8
Homologs : HomoloGeneFZD8
Homology/Alignments : Family Browser (UCSC)FZD8
Gene fusions - Rearrangements
Fusion : QuiverFZD8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFZD8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FZD8
dbVarFZD8
ClinVarFZD8
MonarchFZD8
1000_GenomesFZD8 
Exome Variant ServerFZD8
GNOMAD BrowserENSG00000177283
Varsome BrowserFZD8
ACMGFZD8 variants
VarityQ9H461
Genomic Variants (DGV)FZD8 [DGVbeta]
DECIPHERFZD8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFZD8 
Mutations
ICGC Data PortalFZD8 
TCGA Data PortalFZD8 
Broad Tumor PortalFZD8
OASIS PortalFZD8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFZD8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFZD8
Mutations and Diseases : HGMDFZD8
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFZD8
DgiDB (Drug Gene Interaction Database)FZD8
DoCM (Curated mutations)FZD8
CIViC (Clinical Interpretations of Variants in Cancer)FZD8
Cancer3DFZD8
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606146   
Orphanet
DisGeNETFZD8
MedgenFZD8
Genetic Testing Registry FZD8
NextProtQ9H461 [Medical]
GENETestsFZD8
Target ValidationFZD8
Huge Navigator FZD8 [HugePedia]
ClinGenFZD8
Clinical trials, drugs, therapy
MyCancerGenomeFZD8
Protein Interactions : CTDFZD8
Pharm GKB GenePA28463
PharosQ9H461
Clinical trialFZD8
Miscellaneous
canSAR (ICR)FZD8
HarmonizomeFZD8
DataMed IndexFZD8
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFZD8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:10:08 CEST 2021

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