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FZR1 (fizzy and cell division cycle 20 related 1)

Identity

Alias_namesfizzy/cell division cycle 20 related 1 (Drosophila)
Alias_symbol (synonym)HCDH1
CDH1
HCDH
FZR
FZR2
KIAA1242
CDC20C
Other alias
HGNC (Hugo) FZR1
LocusID (NCBI) 51343
Atlas_Id 47270
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 3522956 and ends at 3536757 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDK11B (1p36.33) / FZR1 (19p13.3)FZR1 (19p13.3) / CNN1 (19p13.2)FZR1 (19p13.3) / NCLN (19p13.3)
FZR1 (19p13.3) / NFIC (19p13.3)NMUR1 (2q37.1) / FZR1 (19p13.3)FZR1 19p13.3 / CNN1 19p13.2
FZR1 19p13.3 / NCLN 19p13.3FZR1 19p13.3 / NFIC 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FZR1   24824
Cards
Entrez_Gene (NCBI)FZR1  51343  fizzy and cell division cycle 20 related 1
AliasesCDC20C; CDH1; FZR; FZR2; 
HCDH; HCDH1
GeneCards (Weizmann)FZR1
Ensembl hg19 (Hinxton)ENSG00000105325 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105325 [Gene_View]  chr19:3522956-3536757 [Contig_View]  FZR1 [Vega]
ICGC DataPortalENSG00000105325
TCGA cBioPortalFZR1
AceView (NCBI)FZR1
Genatlas (Paris)FZR1
WikiGenes51343
SOURCE (Princeton)FZR1
Genetics Home Reference (NIH)FZR1
Genomic and cartography
GoldenPath hg38 (UCSC)FZR1  -     chr19:3522956-3536757 +  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FZR1  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblFZR1 - 19p13.3 [CytoView hg19]  FZR1 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBIFZR1 [Mapview hg19]  FZR1 [Mapview hg38]
OMIM603619   
Gene and transcription
Genbank (Entrez)AB013462 AB013463 AB033068 AF080397 AF083810
RefSeq transcript (Entrez)NM_001136197 NM_001136198 NM_016263
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FZR1
Cluster EST : UnigeneHs.413133 [ NCBI ]
CGAP (NCI)Hs.413133
Alternative Splicing GalleryENSG00000105325
Gene ExpressionFZR1 [ NCBI-GEO ]   FZR1 [ EBI - ARRAY_EXPRESS ]   FZR1 [ SEEK ]   FZR1 [ MEM ]
Gene Expression Viewer (FireBrowse)FZR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51343
GTEX Portal (Tissue expression)FZR1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UM11   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UM11  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UM11
Splice isoforms : SwissVarQ9UM11
PhosPhoSitePlusQ9UM11
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)Apc4_WD40_dom    Cdc20/Fizzy    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)ANAPC4_WD40 (PF12894)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam12894    pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)FZR1
DMDM Disease mutations51343
Blocks (Seattle)FZR1
PDB (SRS)4UI9    5L9T    5L9U   
PDB (PDBSum)4UI9    5L9T    5L9U   
PDB (IMB)4UI9    5L9T    5L9U   
PDB (RSDB)4UI9    5L9T    5L9U   
Structural Biology KnowledgeBase4UI9    5L9T    5L9U   
SCOP (Structural Classification of Proteins)4UI9    5L9T    5L9U   
CATH (Classification of proteins structures)4UI9    5L9T    5L9U   
SuperfamilyQ9UM11
Human Protein AtlasENSG00000105325
Peptide AtlasQ9UM11
HPRD04687
IPIIPI00383919   IPI00099464   IPI00043958   
Protein Interaction databases
DIP (DOE-UCLA)Q9UM11
IntAct (EBI)Q9UM11
FunCoupENSG00000105325
BioGRIDFZR1
STRING (EMBL)FZR1
ZODIACFZR1
Ontologies - Pathways
QuickGOQ9UM11
Ontology : AmiGOprotein binding  nucleoplasm  nucleoplasm  anaphase-promoting complex  cytosol  DNA repair  positive regulation of cell proliferation  anaphase-promoting complex binding  anaphase-promoting complex-dependent catabolic process  anaphase-promoting complex-dependent catabolic process  G2 DNA damage checkpoint  nuclear membrane  regulation of meiotic nuclear division  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  positive regulation of protein catabolic process  cell division  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  lens fiber cell differentiation  protein K11-linked ubiquitination  negative regulation of cell aging  ubiquitin-protein transferase activator activity  positive regulation of ubiquitin protein ligase activity  
Ontology : EGO-EBIprotein binding  nucleoplasm  nucleoplasm  anaphase-promoting complex  cytosol  DNA repair  positive regulation of cell proliferation  anaphase-promoting complex binding  anaphase-promoting complex-dependent catabolic process  anaphase-promoting complex-dependent catabolic process  G2 DNA damage checkpoint  nuclear membrane  regulation of meiotic nuclear division  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  positive regulation of protein catabolic process  cell division  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  lens fiber cell differentiation  protein K11-linked ubiquitination  negative regulation of cell aging  ubiquitin-protein transferase activator activity  positive regulation of ubiquitin protein ligase activity  
Pathways : KEGGCell cycle    Ubiquitin mediated proteolysis    Progesterone-mediated oocyte maturation   
NDEx NetworkFZR1
Atlas of Cancer Signalling NetworkFZR1
Wikipedia pathwaysFZR1
Orthology - Evolution
OrthoDB51343
GeneTree (enSembl)ENSG00000105325
Phylogenetic Trees/Animal Genes : TreeFamFZR1
HOVERGENQ9UM11
HOGENOMQ9UM11
Homologs : HomoloGeneFZR1
Homology/Alignments : Family Browser (UCSC)FZR1
Gene fusions - Rearrangements
Fusion : MitelmanFZR1/CNN1 [19p13.3/19p13.2]  
Fusion : MitelmanFZR1/NCLN [19p13.3/19p13.3]  [t(19;19)(p13;p13)]  
Fusion : MitelmanFZR1/NFIC [19p13.3/19p13.3]  [t(19;19)(p13;p13)]  
Fusion: TCGAFZR1 19p13.3 CNN1 19p13.2 LUSC
Fusion: TCGAFZR1 19p13.3 NCLN 19p13.3 LUAD
Fusion: TCGAFZR1 19p13.3 NFIC 19p13.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFZR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FZR1
dbVarFZR1
ClinVarFZR1
1000_GenomesFZR1 
Exome Variant ServerFZR1
ExAC (Exome Aggregation Consortium)FZR1 (select the gene name)
Genetic variants : HAPMAP51343
Genomic Variants (DGV)FZR1 [DGVbeta]
DECIPHERFZR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFZR1 
Mutations
ICGC Data PortalFZR1 
TCGA Data PortalFZR1 
Broad Tumor PortalFZR1
OASIS PortalFZR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFZR1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFZR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FZR1
DgiDB (Drug Gene Interaction Database)FZR1
DoCM (Curated mutations)FZR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FZR1 (select a term)
intoGenFZR1
Cancer3DFZR1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603619   
Orphanet
MedgenFZR1
Genetic Testing Registry FZR1
NextProtQ9UM11 [Medical]
TSGene51343
GENETestsFZR1
Target ValidationFZR1
Huge Navigator FZR1 [HugePedia]
snp3D : Map Gene to Disease51343
BioCentury BCIQFZR1
ClinGenFZR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51343
Chemical/Pharm GKB GenePA134896003
Clinical trialFZR1
Miscellaneous
canSAR (ICR)FZR1 (select the gene name)
Probes
Litterature
PubMed167 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFZR1
EVEXFZR1
GoPubMedFZR1
iHOPFZR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:09:12 CEST 2017

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