G0S2 (G0/G1 switch 2)

2003-11-01  

Identity

HGNC
LOCATION
1q32.2
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 50486
MIM: 614447
HGNC: 30229
Ensembl: ENSG00000123689

Variants:

dbSNP: 50486
ClinVar: 50486
TCGA: ENSG00000123689
COSMIC: G0S2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123689ENST00000367029P27469

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
1000

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781

References

Pubmed IDYearTitleCitations
160866692005The G0/G1 switch gene 2 is a novel PPAR target gene.94
197067692009Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2.54
228912932012G0/G1 switch gene-2 regulates human adipocyte lipolysis by affecting activity and localization of adipose triglyceride lipase.42
216133582011Fasting, but not exercise, increases adipose triglyceride lipase (ATGL) protein and reduces G(0)/G(1) switch gene 2 (G0S2) protein and mRNA content in human adipose tissue.26
239513082013The g0/g1 switch gene 2 is an important regulator of hepatic triglyceride metabolism.23
186361622008G0S2 is an all-trans-retinoic acid target gene.20
198169382010Identification of G0S2 as a gene frequently methylated in squamous lung cancer by combination of in silico and experimental approaches.20
263180462015Inhibition of adipose triglyceride lipase (ATGL) by the putative tumor suppressor G0S2 or a small molecule inhibitor attenuates the growth of cancer cells.20
198786462009Impact of DNA demethylation of the G0S2 gene on the transcription of G0S2 in squamous lung cancer cell lines with or without nuclear receptor agonists.17
241832362014G0S2 inhibits the proliferation of K562 cells by interacting with nucleolin in the cytosol.14

Citation

Dessen P

G0S2 (G0/G1 switch 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40660/g0s2