Atlas of Genetics and Cytogenetics in Oncology and Haematology


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G3BP2 (G3BP stress granule assembly factor 2)

Identity

Alias_namesGTPase activating protein (SH3 domain) binding protein 2
Alias_symbol (synonym)KIAA0660
Other alias-
HGNC (Hugo) G3BP2
LocusID (NCBI) 9908
Atlas_Id 47700
Location 4q21.1  [Link to chromosome band 4q21]
Location_base_pair Starts at 75642769 and ends at 75673159 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDKL2 (4q21.1) / G3BP2 (4q21.1)G3BP2 (4q21.1) / NAAA (4q21.1)PDGFC (4q32.1) / G3BP2 (4q21.1)
CDKL2 4q21.1 / G3BP2 4q21.1G3BP2 4q21.1 / NAAA 4q21.1PDGFC 4q32.1 / G3BP2 4q21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)G3BP2   30291
Cards
Entrez_Gene (NCBI)G3BP2  9908  G3BP stress granule assembly factor 2
Aliases
GeneCards (Weizmann)G3BP2
Ensembl hg19 (Hinxton)ENSG00000138757 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138757 [Gene_View]  chr4:75642769-75673159 [Contig_View]  G3BP2 [Vega]
ICGC DataPortalENSG00000138757
TCGA cBioPortalG3BP2
AceView (NCBI)G3BP2
Genatlas (Paris)G3BP2
WikiGenes9908
SOURCE (Princeton)G3BP2
Genetics Home Reference (NIH)G3BP2
Genomic and cartography
GoldenPath hg38 (UCSC)G3BP2  -     chr4:75642769-75673159 -  4q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)G3BP2  -     4q21.1   [Description]    (hg19-Feb_2009)
EnsemblG3BP2 - 4q21.1 [CytoView hg19]  G3BP2 - 4q21.1 [CytoView hg38]
Mapping of homologs : NCBIG3BP2 [Mapview hg19]  G3BP2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AA781267 AB014560 AF051311 AF053535 AF070615
RefSeq transcript (Entrez)NM_012297 NM_203504 NM_203505
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)G3BP2
Cluster EST : UnigeneHs.613996 [ NCBI ]
CGAP (NCI)Hs.613996
Alternative Splicing GalleryENSG00000138757
Gene ExpressionG3BP2 [ NCBI-GEO ]   G3BP2 [ EBI - ARRAY_EXPRESS ]   G3BP2 [ SEEK ]   G3BP2 [ MEM ]
Gene Expression Viewer (FireBrowse)G3BP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9908
GTEX Portal (Tissue expression)G3BP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UN86   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UN86  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UN86
Splice isoforms : SwissVarQ9UN86
PhosPhoSitePlusQ9UN86
Domaine pattern : Prosite (Expaxy)NTF2_DOMAIN (PS50177)    RRM (PS50102)   
Domains : Interpro (EBI)NTF2    NTF2-like_dom    Nuclear_transport_factor_2_euk    Nucleotide-bd_a/b_plait    RRM_dom   
Domain families : Pfam (Sanger)NTF2 (PF02136)    RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam02136    pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  
Conserved Domain (NCBI)G3BP2
DMDM Disease mutations9908
Blocks (Seattle)G3BP2
PDB (SRS)5DRV   
PDB (PDBSum)5DRV   
PDB (IMB)5DRV   
PDB (RSDB)5DRV   
Structural Biology KnowledgeBase5DRV   
SCOP (Structural Classification of Proteins)5DRV   
CATH (Classification of proteins structures)5DRV   
SuperfamilyQ9UN86
Human Protein AtlasENSG00000138757
Peptide AtlasQ9UN86
HPRD06570
IPIIPI00009057   IPI00179890   IPI00965308   IPI00966712   IPI00966366   IPI00965049   IPI00966981   IPI00966108   IPI00967913   IPI01019015   IPI00967594   IPI00964602   IPI00966769   
Protein Interaction databases
DIP (DOE-UCLA)Q9UN86
IntAct (EBI)Q9UN86
FunCoupENSG00000138757
BioGRIDG3BP2
STRING (EMBL)G3BP2
ZODIACG3BP2
Ontologies - Pathways
QuickGOQ9UN86
Ontology : AmiGORNA binding  mRNA binding  protein binding  cytoplasm  cytosol  cytosol  cytoplasmic sequestering of NF-kappaB  Ras protein signal transduction  receptor signaling complex scaffold activity  intracellular ribonucleoprotein complex  stress granule assembly  mRNA transport  
Ontology : EGO-EBIRNA binding  mRNA binding  protein binding  cytoplasm  cytosol  cytosol  cytoplasmic sequestering of NF-kappaB  Ras protein signal transduction  receptor signaling complex scaffold activity  intracellular ribonucleoprotein complex  stress granule assembly  mRNA transport  
NDEx NetworkG3BP2
Atlas of Cancer Signalling NetworkG3BP2
Wikipedia pathwaysG3BP2
Orthology - Evolution
OrthoDB9908
GeneTree (enSembl)ENSG00000138757
Phylogenetic Trees/Animal Genes : TreeFamG3BP2
HOVERGENQ9UN86
HOGENOMQ9UN86
Homologs : HomoloGeneG3BP2
Homology/Alignments : Family Browser (UCSC)G3BP2
Gene fusions - Rearrangements
Fusion : MitelmanCDKL2/G3BP2 [4q21.1/4q21.1]  [t(4;4)(q21;q21)]  
Fusion : MitelmanG3BP2/NAAA [4q21.1/4q21.1]  [t(4;4)(q21;q21)]  
Fusion : MitelmanPDGFC/G3BP2 [4q32.1/4q21.1]  [t(4;4)(q21;q32)]  
Fusion: TCGACDKL2 4q21.1 G3BP2 4q21.1 LUAD
Fusion: TCGAG3BP2 4q21.1 NAAA 4q21.1 LUAD
Fusion: TCGAPDGFC 4q32.1 G3BP2 4q21.1 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerG3BP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)G3BP2
dbVarG3BP2
ClinVarG3BP2
1000_GenomesG3BP2 
Exome Variant ServerG3BP2
ExAC (Exome Aggregation Consortium)G3BP2 (select the gene name)
Genetic variants : HAPMAP9908
Genomic Variants (DGV)G3BP2 [DGVbeta]
DECIPHERG3BP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisG3BP2 
Mutations
ICGC Data PortalG3BP2 
TCGA Data PortalG3BP2 
Broad Tumor PortalG3BP2
OASIS PortalG3BP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICG3BP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDG3BP2
intOGen PortalG3BP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch G3BP2
DgiDB (Drug Gene Interaction Database)G3BP2
DoCM (Curated mutations)G3BP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)G3BP2 (select a term)
intoGenG3BP2
Cancer3DG3BP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenG3BP2
Genetic Testing Registry G3BP2
NextProtQ9UN86 [Medical]
TSGene9908
GENETestsG3BP2
Target ValidationG3BP2
Huge Navigator G3BP2 [HugePedia]
snp3D : Map Gene to Disease9908
BioCentury BCIQG3BP2
ClinGenG3BP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9908
Chemical/Pharm GKB GenePA162389134
Clinical trialG3BP2
Miscellaneous
canSAR (ICR)G3BP2 (select the gene name)
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineG3BP2
EVEXG3BP2
GoPubMedG3BP2
iHOPG3BP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:01:39 CEST 2017

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