| Nomenclature | | HGNC (Hugo) | GAB2 14458 |
| Entrez_Gene (NCBI) | GAB2 9846 GRB2-associated binding protein 2 |
| Cards |
|---|
| GeneCards (Weizmann) | GAB2 |
| Ensembl (Hinxton) | ENSG00000033327 [Gene_View] GAB2 [Vega] |
| AceView (NCBI) | GAB2 |
| Genatlas (Paris) | GAB2 |
| euGene (Indiana) | 9846 |
| SOURCE (Stanford) | NM_012296 NM_080491
|
| Gene Expression (Array Express) |
ENSG00000033327
|
| Genomic and cartography |
|---|
| GoldenPath (UCSC) | GAB2 - 11q14.1 chr11:77603990-77730574 - 11q14.1 [Description] (hg18-March_2006) |
| Ensembl | GAB2 - 11q14.1 [CytoView] |
| Mapping of homologs : NCBI | GAB2 [Mapview] |
| OMIM | 606203 |
| Gene and transcription |
| Gene : Genbank (Entrez) | AA865573 AB011143 AB018413 AI858080 BC131711 |
| Reference sequence (RefSeq transcript) :SRS | NM_012296 NM_080491 |
| Reference transcript : Entrez | NM_012296 NM_080491 |
| RefSeq genomic : SRS | AC_000054 AC_000143 NC_000011 NG_016171 NT_167190 NW_001838028 NW_925106 |
| RefSeq genomic : Entrez | AC_000054 AC_000143 NC_000011 NG_016171 NT_167190 NW_001838028 NW_925106 |
| Consensus coding sequences : CCDS NCBI | GAB2 |
| Cluster EST : Unigene | Hs.429434 [ SRS ] Hs.429434 [ NCBI ] |
| Alternative Splicing : Fast-db (Paris) | 12313 |
| Protein : pattern, domain, 3D structure |
|---|
| Protein : UniProt/SwissProt | Q9UQC2 (SRS) Q9UQC2 (Expasy) Q9UQC2 (Uniprot) |
| With graphics : InterPro | Q9UQC2 |
| Splice isoforms : VarSplice FASTA | Q9UQC2(VarSplice FASTA) |
| Domaine pattern : Prosite (SRS) | PH_DOMAIN (PS50003) |
| Domain pattern : Prosite (Expaxy) | PH_DOMAIN (PS50003) |
| Domains : Interpro (SRS) | PH_type Pleckstrin_homology |
| Domains : Interpro (EBI) | PH_type Pleckstrin_homology |
| Related proteins : CluSTr | Q9UQC2 |
| Domain families : Pfam SRS | PH (PF00169) |
| Domain families : Pfam Sanger | PH (PF00169) |
| Domain families : Pfam NCBI | pfam00169 |
| Domain families : Smart EMBL | PH (SM00233) |
| Blocks (Seattle) | Q9UQC2 |
| Crystal structure of protein : PDB SRS | 2VWF 2W0Z |
| Crystal structure of protein : PDBSum | 2VWF 2W0Z |
| Crystal structure of protein : IMB | 2VWF 2W0Z |
| Crystal structure of protein : PDB RSDB | 2VWF 2W0Z |
| HPRD | 05866 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q9UQC2 |
| IntAct (EBI) | Q9UQC2 |
| Polymorphism : SNP, mutations, diseases |
|---|
| Single Nucleotide Polymorphism (SNP) : dbSNP NCBI | GAB2 |
| SNP : GeneSNP Utah | GAB2 |
| SNP : HGBase | GAB2 |
| Genetic variants : HAPMAP | GAB2 |
| Somatic Mutations in Cancer : COSMIC | GAB2 |
| Mutations and Diseases : HGMD | GAB2 |
| Hereditary diseases : OMIM | 606203 |
| Hereditary diseases : GENETests | 606203 |
| Diseases : Genetic Association | GAB2 |
| General knowledge |
|---|
| Homologs : HomoloGene | GAB2 |
| Homology/Alignments : Family Browser UCSC | GAB2 |
| Phylogenetic Trees/Animal Genes : TreeFam | GAB2 |
| Chemical/Protein Interactions : CTD | 9846 |
| Keywords Ontology : AmiGO | transmembrane receptor protein tyrosine kinase adaptor protein activity SH3/SH2 adaptor activity protein binding phosphatidylinositol-3,4,5-trisphosphate binding cytoplasm plasma membrane positive regulation of cell proliferation osteoclast differentiation positive regulation of mast cell degranulation phosphatidylinositol-3,4-bisphosphate binding phosphoinositide-mediated signaling |
| Keywords Ontology : EGO-EBI | transmembrane receptor protein tyrosine kinase adaptor protein activity SH3/SH2 adaptor activity protein binding phosphatidylinositol-3,4,5-trisphosphate binding cytoplasm plasma membrane positive regulation of cell proliferation osteoclast differentiation positive regulation of mast cell degranulation phosphatidylinositol-3,4-bisphosphate binding phosphoinositide-mediated signaling |
| Pathways : BIOCARTA | |
| Pathways : KEGG | Fc epsilon RI signaling pathway |
| Other databases |
|---|
| Probes |
|---|
| Probes : Imagenes | GAB2 Related clones (RZPD - Berlin) |
| Literature |
|---|
| PubMed | 62 Pubmed reference(s) in Entrez |
| PubGene | GAB2 |
