GABARAPL1 (GABA type A receptor associated protein like 1)

2010-05-01  

Identity

HGNC
LOCATION
12p13.2
LOCUSID
ALIAS
APG8-LIKE,APG8L,ATG8,ATG8B,ATG8L,GEC1
FUSION GENES

Other Information

Locus ID:

NCBI: 23710
MIM: 607420
HGNC: 4068
Ensembl: ENSG00000139112

Variants:

dbSNP: 23710
ClinVar: 23710
TCGA: ENSG00000139112
COSMIC: GABARAPL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139112ENST00000266458Q9H0R8
ENSG00000139112ENST00000266458A0A024RAP5
ENSG00000139112ENST00000421801Q9H0R8
ENSG00000139112ENST00000535576F5GYD9
ENSG00000139112ENST00000537201F5H007
ENSG00000139112ENST00000539170F5GYD9
ENSG00000139112ENST00000539408F5H007
ENSG00000139112ENST00000540424F5H007
ENSG00000139112ENST00000541453F5GX12
ENSG00000139112ENST00000541960G3V1T7
ENSG00000139112ENST00000542722F5H007
ENSG00000139112ENST00000543602Q9H0R8
ENSG00000139112ENST00000544284F5GYD9
ENSG00000139112ENST00000545047F5GX12
ENSG00000139112ENST00000545290A0A0G2JKT8
ENSG00000139112ENST00000545859F5GZY7
ENSG00000139112ENST00000545887Q9H0R8
ENSG00000139112ENST00000545887A0A024RAP5
ENSG00000139112ENST00000546017F5GYD9
ENSG00000139112ENST00000629504F5H007

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
GABAergic synapseKEGGko04727
GABAergic synapseKEGGhsa04727
FoxO signaling pathwayKEGGhsa04068
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Apelin signaling pathwayKEGGhsa04371
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
195496852009Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis.94
247474382014Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3.72
218930482011Starch-binding domain-containing protein 1 (Stbd1) and glycogen metabolism: Identification of the Atg8 family interacting motif (AIM) in Stbd1 required for interaction with GABARAPL1.47
164319222006GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor.42
216208602011Characterization of the interaction of GABARAPL-1 with the LIR motif of NBR1.39
215973192011GABARAPL1 (GEC1): original or copycat?31
206286242010Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".29
248791492014The role of GABARAPL1/GEC1 in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells.29
146250902003Expression of gec1/GABARAPL1 versus GABARAP mRNAs in human: predominance of gec1/GABARAPL1 in the central nervous system.21
276239372016MicroRNA-195 regulates proliferation, migration, angiogenesis and autophagy of endothelial progenitor cells by targeting GABARAPL1.20

Citation

Dessen P

GABARAPL1 (GABA type A receptor associated protein like 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-05-01

Online version: http://atlasgeneticsoncology.org/gene/51482/gabarapl1