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GABARAPL2 (GABA type A receptor associated protein like 2)

Identity

Alias_namesGABA(A) receptor-associated protein like 2
Alias_symbol (synonym)GEF2
ATG8
GATE16
GATE-16
ATG8C
Other aliasGEF-2
HGNC (Hugo) GABARAPL2
LocusID (NCBI) 11345
Atlas_Id 53460
Location 16q23.1  [Link to chromosome band 16q23]
Location_base_pair Starts at 75566351 and ends at 75577881 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GABARAPL2 (16q23.1) / TP63 (3q28)PLCH2 (1p36.32) / GABARAPL2 (16q23.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GABARAPL2   13291
Cards
Entrez_Gene (NCBI)GABARAPL2  11345  GABA type A receptor associated protein like 2
AliasesATG8; ATG8C; GATE-16; GATE16; 
GEF-2; GEF2
GeneCards (Weizmann)GABARAPL2
Ensembl hg19 (Hinxton)ENSG00000034713 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000034713 [Gene_View]  chr16:75566351-75577881 [Contig_View]  GABARAPL2 [Vega]
ICGC DataPortalENSG00000034713
TCGA cBioPortalGABARAPL2
AceView (NCBI)GABARAPL2
Genatlas (Paris)GABARAPL2
WikiGenes11345
SOURCE (Princeton)GABARAPL2
Genetics Home Reference (NIH)GABARAPL2
Genomic and cartography
GoldenPath hg38 (UCSC)GABARAPL2  -     chr16:75566351-75577881 +  16q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GABARAPL2  -     16q23.1   [Description]    (hg19-Feb_2009)
EnsemblGABARAPL2 - 16q23.1 [CytoView hg19]  GABARAPL2 - 16q23.1 [CytoView hg38]
Mapping of homologs : NCBIGABARAPL2 [Mapview hg19]  GABARAPL2 [Mapview hg38]
OMIM607452   
Gene and transcription
Genbank (Entrez)AB030710 AF077046 AF087848 AJ010569 AK289788
RefSeq transcript (Entrez)NM_007285
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GABARAPL2
Cluster EST : UnigeneHs.461379 [ NCBI ]
CGAP (NCI)Hs.461379
Alternative Splicing GalleryENSG00000034713
Gene ExpressionGABARAPL2 [ NCBI-GEO ]   GABARAPL2 [ EBI - ARRAY_EXPRESS ]   GABARAPL2 [ SEEK ]   GABARAPL2 [ MEM ]
Gene Expression Viewer (FireBrowse)GABARAPL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11345
GTEX Portal (Tissue expression)GABARAPL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP60520   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP60520  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP60520
Splice isoforms : SwissVarP60520
PhosPhoSitePlusP60520
Domains : Interpro (EBI)Atg8-like    Ubiquitin-rel_dom   
Domain families : Pfam (Sanger)Atg8 (PF02991)   
Domain families : Pfam (NCBI)pfam02991   
Conserved Domain (NCBI)GABARAPL2
DMDM Disease mutations11345
Blocks (Seattle)GABARAPL2
PDB (SRS)4CO7   
PDB (PDBSum)4CO7   
PDB (IMB)4CO7   
PDB (RSDB)4CO7   
Structural Biology KnowledgeBase4CO7   
SCOP (Structural Classification of Proteins)4CO7   
CATH (Classification of proteins structures)4CO7   
SuperfamilyP60520
Human Protein AtlasENSG00000034713
Peptide AtlasP60520
HPRD16246
IPIIPI00026358   
Protein Interaction databases
DIP (DOE-UCLA)P60520
IntAct (EBI)P60520
FunCoupENSG00000034713
BioGRIDGABARAPL2
STRING (EMBL)GABARAPL2
ZODIACGABARAPL2
Ontologies - Pathways
QuickGOP60520
Ontology : AmiGOGolgi membrane  Golgi membrane  SNARE binding  autophagosome membrane  autophagosome membrane  protein binding  intracellular  cytoplasm  autophagosome  Golgi apparatus  cytosol  cytosol  intra-Golgi vesicle-mediated transport  autophagy  microtubule binding  protein transport  macroautophagy  cytoplasmic vesicle  ubiquitin protein ligase binding  positive regulation of ATPase activity  beta-tubulin binding  GABA receptor binding  GABA receptor binding  ATPase binding  membrane organization  autophagosome maturation  negative regulation of proteasomal protein catabolic process  
Ontology : EGO-EBIGolgi membrane  Golgi membrane  SNARE binding  autophagosome membrane  autophagosome membrane  protein binding  intracellular  cytoplasm  autophagosome  Golgi apparatus  cytosol  cytosol  intra-Golgi vesicle-mediated transport  autophagy  microtubule binding  protein transport  macroautophagy  cytoplasmic vesicle  ubiquitin protein ligase binding  positive regulation of ATPase activity  beta-tubulin binding  GABA receptor binding  GABA receptor binding  ATPase binding  membrane organization  autophagosome maturation  negative regulation of proteasomal protein catabolic process  
Pathways : KEGGFoxO signaling pathway    Regulation of autophagy    GABAergic synapse   
NDEx NetworkGABARAPL2
Atlas of Cancer Signalling NetworkGABARAPL2
Wikipedia pathwaysGABARAPL2
Orthology - Evolution
OrthoDB11345
GeneTree (enSembl)ENSG00000034713
Phylogenetic Trees/Animal Genes : TreeFamGABARAPL2
HOVERGENP60520
HOGENOMP60520
Homologs : HomoloGeneGABARAPL2
Homology/Alignments : Family Browser (UCSC)GABARAPL2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGABARAPL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GABARAPL2
dbVarGABARAPL2
ClinVarGABARAPL2
1000_GenomesGABARAPL2 
Exome Variant ServerGABARAPL2
ExAC (Exome Aggregation Consortium)GABARAPL2 (select the gene name)
Genetic variants : HAPMAP11345
Genomic Variants (DGV)GABARAPL2 [DGVbeta]
DECIPHERGABARAPL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGABARAPL2 
Mutations
ICGC Data PortalGABARAPL2 
TCGA Data PortalGABARAPL2 
Broad Tumor PortalGABARAPL2
OASIS PortalGABARAPL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGABARAPL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGABARAPL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GABARAPL2
DgiDB (Drug Gene Interaction Database)GABARAPL2
DoCM (Curated mutations)GABARAPL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GABARAPL2 (select a term)
intoGenGABARAPL2
Cancer3DGABARAPL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607452   
Orphanet
MedgenGABARAPL2
Genetic Testing Registry GABARAPL2
NextProtP60520 [Medical]
TSGene11345
GENETestsGABARAPL2
Target ValidationGABARAPL2
Huge Navigator GABARAPL2 [HugePedia]
snp3D : Map Gene to Disease11345
BioCentury BCIQGABARAPL2
ClinGenGABARAPL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11345
Chemical/Pharm GKB GenePA28482
Clinical trialGABARAPL2
Miscellaneous
canSAR (ICR)GABARAPL2 (select the gene name)
Probes
Litterature
PubMed75 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGABARAPL2
EVEXGABARAPL2
GoPubMedGABARAPL2
iHOPGABARAPL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:09:14 CEST 2017

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