GABRG1 (gamma-aminobutyric acid type A receptor subunit gamma1)

2014-11-01  

Identity

HGNC
LOCATION
4p12
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 2565
MIM: 137166
HGNC: 4086
Ensembl: ENSG00000163285

Variants:

dbSNP: 2565
ClinVar: 2565
TCGA: ENSG00000163285
COSMIC: GABRG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163285ENST00000295452Q8N1C3

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
GABAergic synapseKEGGko04727
GABAergic synapseKEGGhsa04727
Retrograde endocannabinoid signalingKEGGhsa04723
Retrograde endocannabinoid signalingKEGGko04723
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
Nicotine addictionKEGGhsa05033
Nicotine addictionKEGGko05033

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
197363512009Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation.151
160801142005Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism.107
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
188186592009GABRG1 and GABRA2 as independent predictors for alcoholism in two populations.51
175079112008Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene.50
175079112008Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene.50
190789612010Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.47
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
204680642010Association study of 182 candidate genes in anorexia nervosa.30
244258692014GABAA receptor α and γ subunits shape synaptic currents via different mechanisms.26

Citation

Dessen P

GABRG1 (gamma-aminobutyric acid type A receptor subunit gamma1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63654/gabrg1