GAD2 (glutamate decarboxylase 2)

2006-12-01  

Identity

HGNC
LOCATION
10p12.1
LOCUSID
ALIAS
GAD65

Other Information

Locus ID:

NCBI: 2572
MIM: 138275
HGNC: 4093
Ensembl: ENSG00000136750

Variants:

dbSNP: 2572
ClinVar: 2572
TCGA: ENSG00000136750
COSMIC: GAD2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136750ENST00000259271Q05329
ENSG00000136750ENST00000259271Q5VZ30
ENSG00000136750ENST00000376261Q05329
ENSG00000136750ENST00000376261Q5VZ30
ENSG00000136750ENST00000428517Q5VZ31
ENSG00000136750ENST00000648567A0A3B3IU09

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
beta-Alanine metabolismKEGGko00410
Taurine and hypotaurine metabolismKEGGko00430
Butanoate metabolismKEGGko00650
Type I diabetes mellitusKEGGko04940
beta-Alanine metabolismKEGGhsa00410
Taurine and hypotaurine metabolismKEGGhsa00430
Butanoate metabolismKEGGhsa00650
Type I diabetes mellitusKEGGhsa04940
Alanine, aspartate and glutamate metabolismKEGGko00250
Alanine, aspartate and glutamate metabolismKEGGhsa00250
Metabolic pathwaysKEGGhsa01100
GABAergic synapseKEGGko04727
GABAergic synapseKEGGhsa04727
GABA (gamma-Aminobutyrate) shuntKEGGhsa_M00027
GABA (gamma-Aminobutyrate) shuntKEGGM00027
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Release CycleREACTOMER-HSA-112310
GABA synthesis, release, reuptake and degradationREACTOMER-HSA-888590
GABA synthesisREACTOMER-HSA-888568

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
206597892010Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data.85
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
167182802006Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism.62
167182802006Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism.62
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
123767042002Subthalamic GAD gene therapy in a Parkinson's disease rat model.56
173846442007GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop.54
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46

Citation

Dessen P

GAD2 (glutamate decarboxylase 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-12-01

Online version: http://atlasgeneticsoncology.org/gene/42996/gad2