GADD45G (growth arrest and DNA damage inducible gamma)

2003-08-01  

Identity

HGNC
LOCATION
9q22.2
LOCUSID
ALIAS
CR6,DDIT2,GADD45gamma,GRP17
FUSION GENES

Other Information

Locus ID:

NCBI: 10912
MIM: 604949
HGNC: 4097
Ensembl: ENSG00000130222

Variants:

dbSNP: 10912
ClinVar: 10912
TCGA: ENSG00000130222
COSMIC: GADD45G

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130222ENST00000252506O95257
ENSG00000130222ENST00000375769Q5VZ88

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Cell cycleKEGGko04110
p53 signaling pathwayKEGGko04115
ApoptosisKEGGko04210
MAPK signaling pathwayKEGGhsa04010
Cell cycleKEGGhsa04110
p53 signaling pathwayKEGGhsa04115
ApoptosisKEGGhsa04210
FoxO signaling pathwayKEGGhsa04068

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
161664182005The stress-responsive gene GADD45G is a functional tumor suppressor, with its response to environmental stresses frequently disrupted epigenetically in multiple tumors.76
153535982004NF-kappa B-mediated repression of growth arrest- and DNA-damage-inducible proteins 45alpha and gamma is essential for cancer cell survival.55
235121052013Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study.39
127169092003CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle.37
118891972002Loss of expression of GADD45 gamma, a growth inhibitory gene, in human pituitary adenomas: implications for tumorigenesis.33
190483892009Gadd45-alpha and Gadd45-gamma utilize p38 and JNK signaling pathways to induce cell cycle G2/M arrest in Hep-G2 hepatoma cells.27
171788902006A novel pathway involving melanoma differentiation associated gene-7/interleukin-24 mediates nonsteroidal anti-inflammatory drug-induced apoptosis and growth arrest of cancer cells.19
236161232013Methylation-mediated repression of GADD45A and GADD45G expression in gastric cardia adenocarcinoma.17
238978412014Growth arrest and DNA damage 45G down-regulation contributes to Janus kinase/signal transducer and activator of transcription 3 activation and cellular senescence evasion in hepatocellular carcinoma.16
146724122003GADD45gamma, down-regulated in 65% hepatocellular carcinoma (HCC) from 23 chinese patients, inhibits cell growth and induces cell cycle G2/M arrest for hepatoma Hep-G2 cell lines.14

Citation

Dessen P

GADD45G (growth arrest and DNA damage inducible gamma)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40667/gadd45g