Atlas of Genetics and Cytogenetics in Oncology and Haematology

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GAK (cyclin G associated kinase)

Identity

Alias (NCBI)DNAJ26
DNAJC26
HGNC (Hugo) GAK
HGNC Alias symbDNAJC26
HGNC Alias nameauxilin-2
LocusID (NCBI) 2580
Atlas_Id 40681
Location 4p16.3  [Link to chromosome band 4p16]
Location_base_pair Starts at 849277 and ends at 932316 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GAK (4p16.3) / ARHGEF1 (19q13.2)GAK (4p16.3) / ATP6V0A2 (12q24.31)GAK (4p16.3) / BPTF (17q24.2)
GAK (4p16.3) / MAGI1 (3p14.1)GAK (4p16.3) / MYL5 (4p16.3)TMEM119 (12q23.3) / GAK (4p16.3)
GAK 4p16.3 / MAGI1 3p14.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(3;4)(p14;p16) GAK/MAGI1

External links

Nomenclature
HGNC (Hugo)GAK   4113
Cards
Entrez_Gene (NCBI)GAK  2580  cyclin G associated kinase
AliasesDNAJ26; DNAJC26
GeneCards (Weizmann)GAK
Ensembl hg19 (Hinxton)ENSG00000178950 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000178950 [Gene_View]  ENSG00000178950 [Sequence]  chr4:849277-932316 [Contig_View]  GAK [Vega]
ICGC DataPortalENSG00000178950
TCGA cBioPortalGAK
AceView (NCBI)GAK
Genatlas (Paris)GAK
WikiGenes2580
SOURCE (Princeton)GAK
Genetics Home Reference (NIH)GAK
Genomic and cartography
GoldenPath hg38 (UCSC)GAK  -     chr4:849277-932316 -  4p16.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GAK  -     4p16.3   [Description]    (hg19-Feb_2009)
GoldenPathGAK - 4p16.3 [CytoView hg19]  GAK - 4p16.3 [CytoView hg38]
ImmunoBaseENSG00000178950
genome Data Viewer NCBIGAK [Mapview hg19]  
OMIM602052   
Gene and transcription
Genbank (Entrez)AA287110 AB208854 AI138676 AK092587 AK097714
RefSeq transcript (Entrez)NM_001286833 NM_001318134 NM_005255
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GAK
Alternative Splicing GalleryENSG00000178950
Gene ExpressionGAK [ NCBI-GEO ]   GAK [ EBI - ARRAY_EXPRESS ]   GAK [ SEEK ]   GAK [ MEM ]
Gene Expression Viewer (FireBrowse)GAK [ Firebrowse - Broad ]
GenevisibleExpression of GAK in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2580
GTEX Portal (Tissue expression)GAK
Human Protein AtlasENSG00000178950-GAK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14976   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14976  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14976
Splice isoforms : SwissVarO14976
PhosPhoSitePlusO14976
Domaine pattern : Prosite (Expaxy)C2_TENSIN (PS51182)    DNAJ_2 (PS50076)    PPASE_TENSIN (PS51181)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)DnaJ_domain    J_dom_sf    Kinase-like_dom_sf    Prot-tyrosine_phosphatase-like    Prot_kinase_dom    Ser/Thr_kinase_AS    Tensin_C2-dom    Tensin_phosphatase   
Domain families : Pfam (Sanger)Pkinase (PF00069)    PTEN_C2 (PF10409)   
Domain families : Pfam (NCBI)pfam00069    pfam10409   
Domain families : Smart (EMBL)DnaJ (SM00271)  PTEN_C2 (SM01326)  S_TKc (SM00220)  
Conserved Domain (NCBI)GAK
DMDM Disease mutations2580
Blocks (Seattle)GAK
PDB (RSDB)4C57    4C58    4C59    4O38    4Y8D    5Y7Z    5Y80   
PDB Europe4C57    4C58    4C59    4O38    4Y8D    5Y7Z    5Y80   
PDB (PDBSum)4C57    4C58    4C59    4O38    4Y8D    5Y7Z    5Y80   
PDB (IMB)4C57    4C58    4C59    4O38    4Y8D    5Y7Z    5Y80   
Structural Biology KnowledgeBase4C57    4C58    4C59    4O38    4Y8D    5Y7Z    5Y80   
SCOP (Structural Classification of Proteins)4C57    4C58    4C59    4O38    4Y8D    5Y7Z    5Y80   
CATH (Classification of proteins structures)4C57    4C58    4C59    4O38    4Y8D    5Y7Z    5Y80   
SuperfamilyO14976
Human Protein Atlas [tissue]ENSG00000178950-GAK [tissue]
Peptide AtlasO14976
HPRD03631
IPIIPI00298949   IPI00784139   IPI00442170   IPI00444993   IPI00384168   IPI00965736   IPI00968171   IPI00966048   IPI00964028   IPI00966579   IPI00964549   IPI00967338   IPI00964882   
Protein Interaction databases
DIP (DOE-UCLA)O14976
IntAct (EBI)O14976
FunCoupENSG00000178950
BioGRIDGAK
STRING (EMBL)GAK
ZODIACGAK
Ontologies - Pathways
QuickGOO14976
Ontology : AmiGOprotein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  Golgi apparatus  cytosol  focal adhesion  protein phosphorylation  receptor-mediated endocytosis  receptor-mediated endocytosis  endoplasmic reticulum organization  Golgi organization  cell cycle  negative regulation of neuron projection development  membrane  synaptic vesicle uncoating  clathrin binding  cyclin binding  vesicle  vesicle  protein localization to Golgi apparatus  intracellular membrane-bounded organelle  intracellular membrane-bounded organelle  perinuclear region of cytoplasm  chaperone cofactor-dependent protein refolding  chaperone binding  membrane organization  clathrin coat disassembly  clathrin coat disassembly  clathrin-dependent endocytosis  clathrin-dependent endocytosis  protein localization to plasma membrane  Golgi to lysosome transport  presynapse  clathrin-coated pit assembly  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  Golgi apparatus  cytosol  focal adhesion  protein phosphorylation  receptor-mediated endocytosis  receptor-mediated endocytosis  endoplasmic reticulum organization  Golgi organization  cell cycle  negative regulation of neuron projection development  membrane  synaptic vesicle uncoating  clathrin binding  cyclin binding  vesicle  vesicle  protein localization to Golgi apparatus  intracellular membrane-bounded organelle  intracellular membrane-bounded organelle  perinuclear region of cytoplasm  chaperone cofactor-dependent protein refolding  chaperone binding  membrane organization  clathrin coat disassembly  clathrin coat disassembly  clathrin-dependent endocytosis  clathrin-dependent endocytosis  protein localization to plasma membrane  Golgi to lysosome transport  presynapse  clathrin-coated pit assembly  
NDEx NetworkGAK
Atlas of Cancer Signalling NetworkGAK
Wikipedia pathwaysGAK
Orthology - Evolution
OrthoDB2580
GeneTree (enSembl)ENSG00000178950
Phylogenetic Trees/Animal Genes : TreeFamGAK
HOGENOMO14976
Homologs : HomoloGeneGAK
Homology/Alignments : Family Browser (UCSC)GAK
Gene fusions - Rearrangements
Fusion : MitelmanGAK/MAGI1 [4p16.3/3p14.1]  
Fusion PortalGAK 4p16.3 MAGI1 3p14.1 BRCA
Fusion : QuiverGAK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGAK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GAK
dbVarGAK
ClinVarGAK
MonarchGAK
1000_GenomesGAK 
Exome Variant ServerGAK
GNOMAD BrowserENSG00000178950
Varsome BrowserGAK
Genetic variants : HAPMAP2580
Genomic Variants (DGV)GAK [DGVbeta]
DECIPHERGAK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGAK 
Mutations
ICGC Data PortalGAK 
TCGA Data PortalGAK 
Broad Tumor PortalGAK
OASIS PortalGAK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGAK  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGAK
Mutations and Diseases : HGMDGAK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GAK
DgiDB (Drug Gene Interaction Database)GAK
DoCM (Curated mutations)GAK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GAK (select a term)
intoGenGAK
Cancer3DGAK(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602052   
Orphanet
DisGeNETGAK
MedgenGAK
Genetic Testing Registry GAK
NextProtO14976 [Medical]
TSGene2580
GENETestsGAK
Target ValidationGAK
Huge Navigator GAK [HugePedia]
snp3D : Map Gene to Disease2580
BioCentury BCIQGAK
ClinGenGAK
Clinical trials, drugs, therapy
Protein Interactions : CTD2580
Pharm GKB GenePA28528
Clinical trialGAK
Miscellaneous
canSAR (ICR)GAK (select the gene name)
HarmonizomeGAK
DataMed IndexGAK
Probes
Litterature
PubMed77 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGAK
EVEXGAK
GoPubMedGAK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 14 14:12:14 CEST 2020
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