GAK (cyclin G associated kinase)

2003-02-01 Affiliation

Identity

HGNC

GAK

LOCATION

4p16.3

LOCUSID

2580

ALIAS

DNAJ26,DNAJC26

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2580
MIM: 602052
HGNC: 4113
Ensembl: ENSG00000178950

Variants:

dbSNP: 2580
ClinVar: 2580
TCGA: ENSG00000178950
COSMIC: GAK

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000178950	ENST00000314167	O14976
ENSG00000178950	ENST00000502656	D6RAW3
ENSG00000178950	ENST00000504668	H0Y9M4
ENSG00000178950	ENST00000505819	D6RE78
ENSG00000178950	ENST00000507580	D6RF16
ENSG00000178950	ENST00000510799	H0YA39
ENSG00000178950	ENST00000511163	O14976
ENSG00000178950	ENST00000511229	D6RC24
ENSG00000178950	ENST00000511980	H0Y8H5
ENSG00000178950	ENST00000512325	D6RAQ7
ENSG00000178950	ENST00000618573	A0A087X1U9
ENSG00000178950	ENST00000628912	D6RE78

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
trans-Golgi Network Vesicle Budding	REACTOME	R-HSA-199992
Clathrin derived vesicle budding	REACTOME	R-HSA-421837
Golgi Associated Vesicle Biogenesis	REACTOME	R-HSA-432722
Clathrin-mediated endocytosis	REACTOME	R-HSA-8856828

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20711177	2010	Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease.	266
24510904	2014	Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.	136
21044948	2011	Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21.	95
16895969	2006	Recruitment dynamics of GAK and auxilin to clathrin-coated pits during endocytosis.	55
19654208	2009	GAK, a regulator of clathrin-mediated membrane traffic, also controls centrosome integrity and chromosome congression.	33
17538018	2007	Canonical interaction of cyclin G associated kinase with adaptor protein 1 regulates lysosomal enzyme sorting.	27
25653444	2015	AP-2-associated protein kinase 1 and cyclin G-associated kinase regulate hepatitis C virus entry and are potential drug targets.	27
15240878	2004	The serine/threonine kinase cyclin G-associated kinase regulates epidermal growth factor receptor signaling.	23
21058943	2011	Replication of GWAS associations for GAK and MAPT in Parkinson's disease.	23
21058943	2011	Replication of GWAS associations for GAK and MAPT in Parkinson's disease.	23

Citation

Dessen P

GAK (cyclin G associated kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40681/gak