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GAK (cyclin G associated kinase)

Identity

Other namesDNAJ26
DNAJC26
HGNC (Hugo) GAK
LocusID (NCBI) 2580
Atlas_Id 40681
Location 4p16.3
Location_base_pair Starts at 843063 and ends at 926178 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
GAK (4p16.3) / ARHGEF1 (19q13.2)GAK (4p16.3) / ATP6V0A2 (12q24.31)GAK (4p16.3) / BPTF (17q24.2)
GAK (4p16.3) / MAGI1 (3p14.1)GAK (4p16.3) / MYL5 (4p16.3)TMEM119 (12q23.3) / GAK (4p16.3)
GAK 4p16.3 / MAGI1 3p14.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GAK   4113
Cards
Entrez_Gene (NCBI)GAK  2580  cyclin G associated kinase
GeneCards (Weizmann)GAK
Ensembl hg19 (Hinxton)ENSG00000178950 [Gene_View]  chr4:843063-926178 [Contig_View]  GAK [Vega]
Ensembl hg38 (Hinxton)ENSG00000178950 [Gene_View]  chr4:843063-926178 [Contig_View]  GAK [Vega]
ICGC DataPortalENSG00000178950
TCGA cBioPortalGAK
AceView (NCBI)GAK
Genatlas (Paris)GAK
WikiGenes2580
SOURCE (Princeton)GAK
Genomic and cartography
GoldenPath hg19 (UCSC)GAK  -     chr4:843063-926178 -  4p16.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GAK  -     4p16.3   [Description]    (hg38-Dec_2013)
EnsemblGAK - 4p16.3 [CytoView hg19]  GAK - 4p16.3 [CytoView hg38]
Mapping of homologs : NCBIGAK [Mapview hg19]  GAK [Mapview hg38]
OMIM602052   
Gene and transcription
Genbank (Entrez)AA287110 AB208854 AI138676 AK092587 AK097714
RefSeq transcript (Entrez)NM_001286833 NM_001318134 NM_005255
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_006051 NW_004929313
Consensus coding sequences : CCDS (NCBI)GAK
Cluster EST : UnigeneHs.369607 [ NCBI ]
CGAP (NCI)Hs.369607
Alternative Splicing GalleryENSG00000178950
Gene ExpressionGAK [ NCBI-GEO ]   GAK [ EBI - ARRAY_EXPRESS ]   GAK [ SEEK ]   GAK [ MEM ]
Gene Expression Viewer (FireBrowse)GAK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2580
GTEX Portal (Tissue expression)GAK
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14976 (Uniprot)
NextProtO14976  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14976
Splice isoforms : SwissVarO14976 (Swissvar)
PhosPhoSitePlusO14976
Domaine pattern : Prosite (Expaxy)C2_TENSIN (PS51182)    DNAJ_2 (PS50076)    PPASE_TENSIN (PS51181)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)C2_dom    DnaJ_domain    Kinase-like_dom    Prot-tyrosine_phosphatase-like    Prot_kinase_dom    Ser/Thr_kinase_AS    Tensin_C2-dom    Tensin_lipid_phosphatase_dom   
Domain families : Pfam (Sanger)DnaJ (PF00226)    Pkinase (PF00069)    PTEN_C2 (PF10409)   
Domain families : Pfam (NCBI)pfam00226    pfam00069    pfam10409   
Domain families : Smart (EMBL)DnaJ (SM00271)  
DMDM Disease mutations2580
Blocks (Seattle)GAK
PDB (SRS)4C57    4C58    4C59    4O38    4Y8D   
PDB (PDBSum)4C57    4C58    4C59    4O38    4Y8D   
PDB (IMB)4C57    4C58    4C59    4O38    4Y8D   
PDB (RSDB)4C57    4C58    4C59    4O38    4Y8D   
Structural Biology KnowledgeBase4C57    4C58    4C59    4O38    4Y8D   
SCOP (Structural Classification of Proteins)4C57    4C58    4C59    4O38    4Y8D   
CATH (Classification of proteins structures)4C57    4C58    4C59    4O38    4Y8D   
SuperfamilyO14976
Human Protein AtlasENSG00000178950
Peptide AtlasO14976
HPRD03631
IPIIPI00298949   IPI00784139   IPI00442170   IPI00444993   IPI00384168   IPI00965736   IPI00968171   IPI00966048   IPI00964028   IPI00966579   IPI00964549   IPI00967338   IPI00964882   
Protein Interaction databases
DIP (DOE-UCLA)O14976
IntAct (EBI)O14976
FunCoupENSG00000178950
BioGRIDGAK
STRING (EMBL)GAK
ZODIACGAK
Ontologies - Pathways
QuickGOO14976
Ontology : AmiGOprotein serine/threonine kinase activity  protein binding  ATP binding  Golgi apparatus  focal adhesion  protein phosphorylation  Golgi organization  cell cycle  negative regulation of neuron projection development  membrane  vesicle  intracellular membrane-bounded organelle  perinuclear region of cytoplasm  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein binding  ATP binding  Golgi apparatus  focal adhesion  protein phosphorylation  Golgi organization  cell cycle  negative regulation of neuron projection development  membrane  vesicle  intracellular membrane-bounded organelle  perinuclear region of cytoplasm  
NDEx Network
Atlas of Cancer Signalling NetworkGAK
Wikipedia pathwaysGAK
Orthology - Evolution
OrthoDB2580
GeneTree (enSembl)ENSG00000178950
Phylogenetic Trees/Animal Genes : TreeFamGAK
Homologs : HomoloGeneGAK
Homology/Alignments : Family Browser (UCSC)GAK
Gene fusions - Rearrangements
Fusion: TCGAGAK 4p16.3 MAGI1 3p14.1 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerGAK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GAK
dbVarGAK
ClinVarGAK
1000_GenomesGAK 
Exome Variant ServerGAK
ExAC (Exome Aggregation Consortium)GAK (select the gene name)
Genetic variants : HAPMAP2580
Genomic Variants (DGV)GAK [DGVbeta]
Mutations
ICGC Data PortalGAK 
TCGA Data PortalGAK 
Broad Tumor PortalGAK
OASIS PortalGAK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGAK 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GAK
DgiDB (Drug Gene Interaction Database)GAK
DoCM (Curated mutations)GAK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GAK (select a term)
intoGenGAK
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)4:843063-926178  ENSG00000178950
CONAN: Copy Number AnalysisGAK 
Mutations and Diseases : HGMDGAK
OMIM602052   
MedgenGAK
Genetic Testing Registry GAK
NextProtO14976 [Medical]
TSGene2580
GENETestsGAK
Huge Navigator GAK [HugePedia]
snp3D : Map Gene to Disease2580
BioCentury BCIQGAK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2580
Chemical/Pharm GKB GenePA28528
Clinical trialGAK
Miscellaneous
canSAR (ICR)GAK (select the gene name)
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGAK
EVEXGAK
GoPubMedGAK
iHOPGAK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun May 8 18:47:10 CEST 2016

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