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GAL (galanin and GMAP prepropeptide)

Identity

Alias (NCBI)ETL8
GAL-GMAP
GALN
GLNN
GMAP
HGNC (Hugo) GAL
HGNC Alias symbGMAP
GAL-GMAP
GLNN
HGNC Alias namegalanin-message-associated peptide
HGNC Previous nameGALN
HGNC Previous namegalanin
LocusID (NCBI) 51083
Atlas_Id 45909
Location 11q13.2  [Link to chromosome band 11q13]
Location_base_pair Starts at 68684544 and ends at 68691175 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GAB2 (11q14.1) / GAL (11q13.3)GAL (11q13.3) / TEK (9p21.2)LRP5 (11q13.2) / GAL (11q13.3)
OSBP (11q12.1) / GAL (11q13.3)OSBP 11q12.1 / GAL 11q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(11;11)(q12;q13) OSBP/GAL
LRP5/GAL (11q13)


External links

Nomenclature
HGNC (Hugo)GAL   4114
Cards
Entrez_Gene (NCBI)GAL    galanin and GMAP prepropeptide
AliasesETL8; GAL-GMAP; GALN; GLNN; 
GMAP
GeneCards (Weizmann)GAL
Ensembl hg19 (Hinxton)ENSG00000069482 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000069482 [Gene_View]  ENSG00000069482 [Sequence]  chr11:68684544-68691175 [Contig_View]  GAL [Vega]
ICGC DataPortalENSG00000069482
TCGA cBioPortalGAL
AceView (NCBI)GAL
Genatlas (Paris)GAL
SOURCE (Princeton)GAL
Genetics Home Reference (NIH)GAL
Genomic and cartography
GoldenPath hg38 (UCSC)GAL  -     chr11:68684544-68691175 +  11q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GAL  -     11q13.2   [Description]    (hg19-Feb_2009)
GoldenPathGAL - 11q13.2 [CytoView hg19]  GAL - 11q13.2 [CytoView hg38]
ImmunoBaseENSG00000069482
genome Data Viewer NCBIGAL [Mapview hg19]  
OMIM137035   616461   
Gene and transcription
Genbank (Entrez)AF077047 BC030241 BM846531 M77140
RefSeq transcript (Entrez)NM_015973
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GAL
Alternative Splicing GalleryENSG00000069482
Gene ExpressionGAL [ NCBI-GEO ]   GAL [ EBI - ARRAY_EXPRESS ]   GAL [ SEEK ]   GAL [ MEM ]
Gene Expression Viewer (FireBrowse)GAL [ Firebrowse - Broad ]
GenevisibleExpression of GAL in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51083
GTEX Portal (Tissue expression)GAL
Human Protein AtlasENSG00000069482-GAL [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP22466   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP22466  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP22466
Splice isoforms : SwissVarP22466
PhosPhoSitePlusP22466
Domaine pattern : Prosite (Expaxy)GALANIN (PS00861)   
Domains : Interpro (EBI)Galanin    Galanin_pre    GMAP   
Domain families : Pfam (Sanger)Galanin (PF01296)    GMAP (PF06540)   
Domain families : Pfam (NCBI)pfam01296    pfam06540   
Domain families : Smart (EMBL)Galanin (SM00071)  
Conserved Domain (NCBI)GAL
Blocks (Seattle)GAL
SuperfamilyP22466
Human Protein Atlas [tissue]ENSG00000069482-GAL [tissue]
Peptide AtlasP22466
HPRD00658
IPIIPI00026637   IPI00082837   
Protein Interaction databases
DIP (DOE-UCLA)P22466
IntAct (EBI)P22466
BioGRIDGAL
STRING (EMBL)GAL
ZODIACGAL
Ontologies - Pathways
QuickGOP22466
Ontology : AmiGOgalanin receptor activity  neuropeptide hormone activity  neuropeptide hormone activity  neuropeptide hormone activity  protein binding  extracellular region  extracellular space  extracellular space  Golgi apparatus  inflammatory response  G protein-coupled receptor signaling pathway  neuropeptide signaling pathway  nervous system development  feeding behavior  protein kinase A signaling  cAMP-mediated signaling  insulin secretion  secretory granule  galanin receptor binding  type 1 galanin receptor binding  type 2 galanin receptor binding  type 3 galanin receptor binding  regulation of glucocorticoid metabolic process  response to insulin  response to immobilization stress  response to drug  neuronal cell body  positive regulation of apoptotic process  response to estrogen  positive regulation of transcription by RNA polymerase II  negative regulation of lymphocyte proliferation  positive regulation of cortisol secretion  positive regulation of timing of catagen  positive regulation of large conductance calcium-activated potassium channel activity  
Ontology : EGO-EBIgalanin receptor activity  neuropeptide hormone activity  neuropeptide hormone activity  neuropeptide hormone activity  protein binding  extracellular region  extracellular space  extracellular space  Golgi apparatus  inflammatory response  G protein-coupled receptor signaling pathway  neuropeptide signaling pathway  nervous system development  feeding behavior  protein kinase A signaling  cAMP-mediated signaling  insulin secretion  secretory granule  galanin receptor binding  type 1 galanin receptor binding  type 2 galanin receptor binding  type 3 galanin receptor binding  regulation of glucocorticoid metabolic process  response to insulin  response to immobilization stress  response to drug  neuronal cell body  positive regulation of apoptotic process  response to estrogen  positive regulation of transcription by RNA polymerase II  negative regulation of lymphocyte proliferation  positive regulation of cortisol secretion  positive regulation of timing of catagen  positive regulation of large conductance calcium-activated potassium channel activity  
NDEx NetworkGAL
Atlas of Cancer Signalling NetworkGAL
Wikipedia pathwaysGAL
Orthology - Evolution
OrthoDB51083
GeneTree (enSembl)ENSG00000069482
Phylogenetic Trees/Animal Genes : TreeFamGAL
HOGENOMP22466
Homologs : HomoloGeneGAL
Homology/Alignments : Family Browser (UCSC)GAL
Gene fusions - Rearrangements
Fusion : MitelmanOSBP/GAL [11q12.1/11q13.3]  
Fusion PortalOSBP 11q12.1 GAL 11q13.3 BRCA
Fusion : QuiverGAL
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGAL [hg38]
dbVarGAL
ClinVarGAL
MonarchGAL
1000_GenomesGAL 
Exome Variant ServerGAL
GNOMAD BrowserENSG00000069482
Varsome BrowserGAL
Genomic Variants (DGV)GAL [DGVbeta]
DECIPHERGAL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGAL 
Mutations
ICGC Data PortalGAL 
TCGA Data PortalGAL 
Broad Tumor PortalGAL
OASIS PortalGAL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGAL  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGAL
Mutations and Diseases : HGMDGAL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GAL
DgiDB (Drug Gene Interaction Database)GAL
DoCM (Curated mutations)GAL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GAL (select a term)
intoGenGAL
Cancer3DGAL(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM137035    616461   
Orphanet
DisGeNETGAL
MedgenGAL
Genetic Testing Registry GAL
NextProtP22466 [Medical]
GENETestsGAL
Target ValidationGAL
Huge Navigator GAL [HugePedia]
ClinGenGAL
Clinical trials, drugs, therapy
MyCancerGenomeGAL
Protein Interactions : CTD
Pharm GKB GenePA28529
PharosP22466
Clinical trialGAL
Miscellaneous
canSAR (ICR)GAL (select the gene name)
HarmonizomeGAL
DataMed IndexGAL
Probes
Litterature
PubMed123 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGAL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jan 1 18:16:34 CET 2021

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