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GAPDH (glyceraldehyde-3-phosphate dehydrogenase)

Identity

Alias (NCBI)G3PD
GAPD
HEL-S-162eP
HGNC (Hugo) GAPDH
HGNC Previous nameGAPD
LocusID (NCBI) 2597
Atlas_Id 42889
Location 12p13.31  [Link to chromosome band 12p13]
Location_base_pair Starts at 6534517 and ends at 6538371 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AMD1 (6q21) / GAPDH (12p13.31)CALML4 (15q23) / GAPDH (12p13.31)CDKN1A (6p21.2) / GAPDH (12p13.31)
CPT1A (11q13.3) / GAPDH (12p13.31)GAPDH (12p13.31) / AHNAK (11q12.3)GAPDH (12p13.31) / BCL6 (3q27.3)
GAPDH (12p13.31) / BUB1 (2q13)GAPDH (12p13.31) / FAM3C (7q31.31)GAPDH (12p13.31) / FBXL7 (5p15.1)
GAPDH (12p13.31) / GAPDH (12p13.31)GAPDH (12p13.31) / JUP (17q21.2)GAPDH (12p13.31) / KRT13 (17q21.2)
GAPDH (12p13.31) / MRPS17 (7p11.2)GAPDH (12p13.31) / MRPS18B (6p21.33)GAPDH (12p13.31) / PEA15 (1q23.2)
GAPDH (12p13.31) / PLCD1 (3p22.2)GAPDH (12p13.31) / RPL23 (17q12)GAPDH (12p13.31) / RPN2 (20q11.23)
GAPDH (12p13.31) / SERPINA1 (14q32.13)GAPDH (12p13.31) / SON (21q22.11)GAPDH (12p13.31) / UBQLN4 (1q22)
MALAT1 (11q13.1) / GAPDH (12p13.31)PDCD4 (10q25.2) / GAPDH (12p13.31)PRICKLE4 (6p21.1) / GAPDH (12p13.31)
PRMT2 (21q22.3) / GAPDH (12p13.31)RPL28 (19q13.42) / GAPDH (12p13.31)SKP1 (5q31.1) / GAPDH (12p13.31)
SRRT (7q22.1) / GAPDH (12p13.31)VWA5A (11q24.2) / GAPDH (12p13.31)ZNF638 (2p13.2) / GAPDH (12p13.31)
ZNF836 (19q13.41) / GAPDH (12p13.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(3;12)(q27;p13) GAPDH/BCL6


External links

 

Nomenclature
HGNC (Hugo)GAPDH   4141
Cards
Entrez_Gene (NCBI)GAPDH    glyceraldehyde-3-phosphate dehydrogenase
AliasesG3PD; GAPD; HEL-S-162eP
GeneCards (Weizmann)GAPDH
Ensembl hg19 (Hinxton)ENSG00000111640 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111640 [Gene_View]  ENSG00000111640 [Sequence]  chr12:6534517-6538371 [Contig_View]  GAPDH [Vega]
ICGC DataPortalENSG00000111640
TCGA cBioPortalGAPDH
AceView (NCBI)GAPDH
Genatlas (Paris)GAPDH
SOURCE (Princeton)GAPDH
Genetics Home Reference (NIH)GAPDH
Genomic and cartography
GoldenPath hg38 (UCSC)GAPDH  -     chr12:6534517-6538371 +  12p13.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GAPDH  -     12p13.31   [Description]    (hg19-Feb_2009)
GoldenPathGAPDH - 12p13.31 [CytoView hg19]  GAPDH - 12p13.31 [CytoView hg38]
ImmunoBaseENSG00000111640
Genome Data Viewer NCBIGAPDH [Mapview hg19]  
OMIM138400   
Gene and transcription
Genbank (Entrez)AB062273 AF261085 AJ844644 AJ844645 AK026525
RefSeq transcript (Entrez)NM_001256799 NM_001289745 NM_001289746 NM_001357938 NM_001357943 NM_001357944 NM_002046
Consensus coding sequences : CCDS (NCBI)GAPDH
Gene ExpressionGAPDH [ NCBI-GEO ]   GAPDH [ EBI - ARRAY_EXPRESS ]   GAPDH [ SEEK ]   GAPDH [ MEM ]
Gene Expression Viewer (FireBrowse)GAPDH [ Firebrowse - Broad ]
GenevisibleExpression of GAPDH in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2597
GTEX Portal (Tissue expression)GAPDH
Human Protein AtlasENSG00000111640-GAPDH [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04406   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP04406  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP04406
Catalytic activity : Enzyme1.2.1.12 [ Enzyme-Expasy ]   1.2.1.121.2.1.12 [ IntEnz-EBI ]   1.2.1.12 [ BRENDA ]   1.2.1.12 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP04406
Domaine pattern : Prosite (Expaxy)GAPDH (PS00071)   
Domains : Interpro (EBI)GlycerAld/Erythrose_P_DH    GlycerAld_3-P_DH_AS    GlycerAld_3-P_DH_cat    GlycerAld_3-P_DH_NAD(P)-bd    Glyceraldehyde-3-P_DH_1    NAD(P)-bd_dom_sf   
Domain families : Pfam (Sanger)Gp_dh_C (PF02800)    Gp_dh_N (PF00044)   
Domain families : Pfam (NCBI)pfam02800    pfam00044   
Domain families : Smart (EMBL)Gp_dh_N (SM00846)  
Conserved Domain (NCBI)GAPDH
PDB (RSDB)1U8F    1ZNQ    2FEH    3GPD    4WNC    4WNI    6ADE    6IQ6    6YND    6YNE    6YNF    6YNH   
PDB Europe1U8F    1ZNQ    2FEH    3GPD    4WNC    4WNI    6ADE    6IQ6    6YND    6YNE    6YNF    6YNH   
PDB (PDBSum)1U8F    1ZNQ    2FEH    3GPD    4WNC    4WNI    6ADE    6IQ6    6YND    6YNE    6YNF    6YNH   
PDB (IMB)1U8F    1ZNQ    2FEH    3GPD    4WNC    4WNI    6ADE    6IQ6    6YND    6YNE    6YNF    6YNH   
Structural Biology KnowledgeBase1U8F    1ZNQ    2FEH    3GPD    4WNC    4WNI    6ADE    6IQ6    6YND    6YNE    6YNF    6YNH   
SCOP (Structural Classification of Proteins)1U8F    1ZNQ    2FEH    3GPD    4WNC    4WNI    6ADE    6IQ6    6YND    6YNE    6YNF    6YNH   
CATH (Classification of proteins structures)1U8F    1ZNQ    2FEH    3GPD    4WNC    4WNI    6ADE    6IQ6    6YND    6YNE    6YNF    6YNH   
SuperfamilyP04406
AlphaFold pdb e-kbP04406   
Human Protein Atlas [tissue]ENSG00000111640-GAPDH [tissue]
HPRD00713
Protein Interaction databases
DIP (DOE-UCLA)P04406
IntAct (EBI)P04406
BioGRIDGAPDH
STRING (EMBL)GAPDH
ZODIACGAPDH
Ontologies - Pathways
QuickGOP04406
Ontology : AmiGOmicrotubule cytoskeleton organization  positive regulation of cytokine production  glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity  glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity  glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity  protein binding  nucleus  nucleus  nucleus  cytoplasm  cytoplasm  lipid droplet  cytosol  cytosol  cytosol  cytosol  plasma membrane  gluconeogenesis  glycolytic process  microtubule binding  negative regulation of endopeptidase activity  microtubule cytoskeleton  membrane  regulation of macroautophagy  negative regulation of translation  negative regulation of translation  aspartic-type endopeptidase inhibitor activity  killing of cells of other organism  nuclear membrane  vesicle  positive regulation of type I interferon production  peptidyl-cysteine S-nitrosylase activity  peptidyl-cysteine S-trans-nitrosylation  identical protein binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  intracellular membrane-bounded organelle  perinuclear region of cytoplasm  NADP binding  protein stabilization  defense response to fungus  NAD binding  neuron apoptotic process  killing by host of symbiont cells  canonical glycolysis  antimicrobial humoral immune response mediated by antimicrobial peptide  extracellular exosome  cellular response to interferon-gamma  GAIT complex  disordered domain specific binding  ribonucleoprotein complex  
Ontology : EGO-EBImicrotubule cytoskeleton organization  positive regulation of cytokine production  glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity  glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity  glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity  protein binding  nucleus  nucleus  nucleus  cytoplasm  cytoplasm  lipid droplet  cytosol  cytosol  cytosol  cytosol  plasma membrane  gluconeogenesis  glycolytic process  microtubule binding  negative regulation of endopeptidase activity  microtubule cytoskeleton  membrane  regulation of macroautophagy  negative regulation of translation  negative regulation of translation  aspartic-type endopeptidase inhibitor activity  killing of cells of other organism  nuclear membrane  vesicle  positive regulation of type I interferon production  peptidyl-cysteine S-nitrosylase activity  peptidyl-cysteine S-trans-nitrosylation  identical protein binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  intracellular membrane-bounded organelle  perinuclear region of cytoplasm  NADP binding  protein stabilization  defense response to fungus  NAD binding  neuron apoptotic process  killing by host of symbiont cells  canonical glycolysis  antimicrobial humoral immune response mediated by antimicrobial peptide  extracellular exosome  cellular response to interferon-gamma  GAIT complex  disordered domain specific binding  ribonucleoprotein complex  
Pathways : BIOCARTADownregulated of MTA-3 in ER-negative Breast Tumors [Genes]    Glycolysis Pathway [Genes]   
Pathways : KEGGGlycolysis / Gluconeogenesis    HIF-1 signaling pathway    Alzheimer's disease   
NDEx NetworkGAPDH
Atlas of Cancer Signalling NetworkGAPDH
Wikipedia pathwaysGAPDH
Orthology - Evolution
OrthoDB2597
GeneTree (enSembl)ENSG00000111640
Phylogenetic Trees/Animal Genes : TreeFamGAPDH
Homologs : HomoloGeneGAPDH
Homology/Alignments : Family Browser (UCSC)GAPDH
Gene fusions - Rearrangements
Fusion : MitelmanGAPDH/BCL6 [12p13.31/3q27.3]  
Fusion : MitelmanGAPDH/KRT13 [12p13.31/17q21.2]  
Fusion : MitelmanGAPDH/MRPS18B [12p13.31/6p21.33]  
Fusion Cancer (Beijing)GAPDH [12p13.31]  -  PLCD1 [3p22.2]  [FUSC001361]
Fusion Cancer (Beijing)VWA5A [11q24.2]  -  GAPDH [12p13.31]  [FUSC001399]
Fusion : QuiverGAPDH
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGAPDH [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GAPDH
dbVarGAPDH
ClinVarGAPDH
MonarchGAPDH
1000_GenomesGAPDH 
Exome Variant ServerGAPDH
GNOMAD BrowserENSG00000111640
Varsome BrowserGAPDH
ACMGGAPDH variants
VarityP04406
Genomic Variants (DGV)GAPDH [DGVbeta]
DECIPHERGAPDH [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGAPDH 
Mutations
ICGC Data PortalGAPDH 
TCGA Data PortalGAPDH 
Broad Tumor PortalGAPDH
OASIS PortalGAPDH [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGAPDH  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGAPDH
Mutations and Diseases : HGMDGAPDH
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaGAPDH
DgiDB (Drug Gene Interaction Database)GAPDH
DoCM (Curated mutations)GAPDH
CIViC (Clinical Interpretations of Variants in Cancer)GAPDH
Cancer3DGAPDH
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138400   
Orphanet
DisGeNETGAPDH
MedgenGAPDH
Genetic Testing Registry GAPDH
NextProtP04406 [Medical]
GENETestsGAPDH
Target ValidationGAPDH
Huge Navigator GAPDH [HugePedia]
ClinGenGAPDH
Clinical trials, drugs, therapy
MyCancerGenomeGAPDH
Protein Interactions : CTDGAPDH
Pharm GKB GenePA28554
PharosP04406
Clinical trialGAPDH
Miscellaneous
canSAR (ICR)GAPDH
HarmonizomeGAPDH
DataMed IndexGAPDH
Probes
Litterature
PubMed449 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGAPDH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:10:22 CEST 2021

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