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GAPDH (glyceraldehyde-3-phosphate dehydrogenase)

Identity

Other namesG3PD
GAPD
HEL-S-162eP
HGNC (Hugo) GAPDH
LocusID (NCBI) 2597
Atlas_Id 42889
Location 12p13.31
Location_base_pair Starts at 6644385 and ends at 6647541 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AMD1 (6q21) / GAPDH (12p13.31)CALML4 (15q23) / GAPDH (12p13.31)CDKN1A (6p21.2) / GAPDH (12p13.31)
CPT1A (11q13.3) / GAPDH (12p13.31)GAPDH (12p13.31) / AHNAK (11q12.3)GAPDH (12p13.31) / BCL6 (3q27.3)
GAPDH (12p13.31) / BUB1 (2q13)GAPDH (12p13.31) / FAM3C (7q31.31)GAPDH (12p13.31) / FBXL7 (5p15.1)
GAPDH (12p13.31) / GAPDH (12p13.31)GAPDH (12p13.31) / JUP (17q21.2)GAPDH (12p13.31) / KRT13 (17q21.2)
GAPDH (12p13.31) / MRPS17 (7p11.2)GAPDH (12p13.31) / MRPS18B (6p21.33)GAPDH (12p13.31) / PEA15 (1q23.2)
GAPDH (12p13.31) / PLCD1 (3p22.2)GAPDH (12p13.31) / RPL23 (17q12)GAPDH (12p13.31) / RPN2 (20q11.23)
GAPDH (12p13.31) / SERPINA1 (14q32.13)GAPDH (12p13.31) / SON (21q22.11)GAPDH (12p13.31) / UBQLN4 (1q22)
MALAT1 (11q13.1) / GAPDH (12p13.31)PDCD4 (10q25.2) / GAPDH (12p13.31)PRICKLE4 (6p21.1) / GAPDH (12p13.31)
PRMT2 (21q22.3) / GAPDH (12p13.31)RPL28 (19q13.42) / GAPDH (12p13.31)SKP1 (5q31.1) / GAPDH (12p13.31)
SRRT (7q22.1) / GAPDH (12p13.31)VWA5A (11q24.2) / GAPDH (12p13.31)ZNF638 (2p13.2) / GAPDH (12p13.31)
ZNF836 (19q13.41) / GAPDH (12p13.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(3;12)(q27;p13) GAPDH/BCL6

External links

Nomenclature
HGNC (Hugo)GAPDH   4141
Cards
Entrez_Gene (NCBI)GAPDH  2597  glyceraldehyde-3-phosphate dehydrogenase
AliasesG3PD; GAPD; HEL-S-162eP
GeneCards (Weizmann)GAPDH
Ensembl hg19 (Hinxton)ENSG00000111640 [Gene_View]  chr12:6644385-6647541 [Contig_View]  GAPDH [Vega]
Ensembl hg38 (Hinxton)ENSG00000111640 [Gene_View]  chr12:6644385-6647541 [Contig_View]  GAPDH [Vega]
ICGC DataPortalENSG00000111640
TCGA cBioPortalGAPDH
AceView (NCBI)GAPDH
Genatlas (Paris)GAPDH
WikiGenes2597
SOURCE (Princeton)GAPDH
Genomic and cartography
GoldenPath hg19 (UCSC)GAPDH  -     chr12:6644385-6647541 +  12p13.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GAPDH  -     12p13.31   [Description]    (hg38-Dec_2013)
EnsemblGAPDH - 12p13.31 [CytoView hg19]  GAPDH - 12p13.31 [CytoView hg38]
Mapping of homologs : NCBIGAPDH [Mapview hg19]  GAPDH [Mapview hg38]
OMIM138400   
Gene and transcription
Genbank (Entrez)AB062273 AF261085 AJ844644 AJ844645 AK026525
RefSeq transcript (Entrez)NM_001256799 NM_001289745 NM_001289746 NM_002046
RefSeq genomic (Entrez)NC_000012 NC_018923 NG_007073 NT_009759 NW_004929382
Consensus coding sequences : CCDS (NCBI)GAPDH
Cluster EST : UnigeneHs.598320 [ NCBI ]
CGAP (NCI)Hs.598320
Alternative Splicing GalleryENSG00000111640
Gene ExpressionGAPDH [ NCBI-GEO ]   GAPDH [ EBI - ARRAY_EXPRESS ]   GAPDH [ SEEK ]   GAPDH [ MEM ]
Gene Expression Viewer (FireBrowse)GAPDH [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2597
GTEX Portal (Tissue expression)GAPDH
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04406 (Uniprot)
NextProtP04406  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP04406
Splice isoforms : SwissVarP04406 (Swissvar)
Catalytic activity : Enzyme1.2.1.12 [ Enzyme-Expasy ]   1.2.1.121.2.1.12 [ IntEnz-EBI ]   1.2.1.12 [ BRENDA ]   1.2.1.12 [ KEGG ]   
PhosPhoSitePlusP04406
Domaine pattern : Prosite (Expaxy)GAPDH (PS00071)   
Domains : Interpro (EBI)GlycerAld/Erythrose_P_DH    GlycerAld_3-P_DH_AS    GlycerAld_3-P_DH_cat    GlycerAld_3-P_DH_NAD(P)-bd    Glyceraldehyde-3-P_DH_1    NAD(P)-bd_dom   
Domain families : Pfam (Sanger)Gp_dh_C (PF02800)    Gp_dh_N (PF00044)   
Domain families : Pfam (NCBI)pfam02800    pfam00044   
Domain families : Smart (EMBL)Gp_dh_N (SM00846)  
DMDM Disease mutations2597
Blocks (Seattle)GAPDH
PDB (SRS)1U8F    1ZNQ    2FEH    3GPD    4WNC    4WNI   
PDB (PDBSum)1U8F    1ZNQ    2FEH    3GPD    4WNC    4WNI   
PDB (IMB)1U8F    1ZNQ    2FEH    3GPD    4WNC    4WNI   
PDB (RSDB)1U8F    1ZNQ    2FEH    3GPD    4WNC    4WNI   
Structural Biology KnowledgeBase1U8F    1ZNQ    2FEH    3GPD    4WNC    4WNI   
SCOP (Structural Classification of Proteins)1U8F    1ZNQ    2FEH    3GPD    4WNC    4WNI   
CATH (Classification of proteins structures)1U8F    1ZNQ    2FEH    3GPD    4WNC    4WNI   
SuperfamilyP04406
Human Protein AtlasENSG00000111640
Peptide AtlasP04406
HPRD00713
IPIIPI00219018   IPI00795622   IPI00794508   IPI00789134   IPI00795257   
Protein Interaction databases
DIP (DOE-UCLA)P04406
IntAct (EBI)P04406
FunCoupENSG00000111640
BioGRIDGAPDH
STRING (EMBL)GAPDH
ZODIACGAPDH
Ontologies - Pathways
QuickGOP04406
Ontology : AmiGOmicrotubule cytoskeleton organization  glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity  glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity  glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity  protein binding  nucleus  nucleus  cytoplasm  cytoplasm  lipid particle  cytosol  cytosol  cytosol  plasma membrane  gluconeogenesis  microtubule binding  microtubule cytoskeleton  membrane  regulation of macroautophagy  negative regulation of translation  negative regulation of translation  intracellular ribonucleoprotein complex  nuclear membrane  vesicle  peptidyl-cysteine S-nitrosylase activity  peptidyl-cysteine S-trans-nitrosylation  identical protein binding  intracellular membrane-bounded organelle  perinuclear region of cytoplasm  NADP binding  protein stabilization  NAD binding  neuron apoptotic process  canonical glycolysis  extracellular exosome  cellular response to interferon-gamma  GAIT complex  
Ontology : EGO-EBImicrotubule cytoskeleton organization  glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity  glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity  glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity  protein binding  nucleus  nucleus  cytoplasm  cytoplasm  lipid particle  cytosol  cytosol  cytosol  plasma membrane  gluconeogenesis  microtubule binding  microtubule cytoskeleton  membrane  regulation of macroautophagy  negative regulation of translation  negative regulation of translation  intracellular ribonucleoprotein complex  nuclear membrane  vesicle  peptidyl-cysteine S-nitrosylase activity  peptidyl-cysteine S-trans-nitrosylation  identical protein binding  intracellular membrane-bounded organelle  perinuclear region of cytoplasm  NADP binding  protein stabilization  NAD binding  neuron apoptotic process  canonical glycolysis  extracellular exosome  cellular response to interferon-gamma  GAIT complex  
Pathways : BIOCARTADownregulated of MTA-3 in ER-negative Breast Tumors [Genes]    Glycolysis Pathway [Genes]   
Pathways : KEGGGlycolysis / Gluconeogenesis    HIF-1 signaling pathway    Alzheimer's disease   
NDEx Network
Atlas of Cancer Signalling NetworkGAPDH
Wikipedia pathwaysGAPDH
Orthology - Evolution
OrthoDB2597
GeneTree (enSembl)ENSG00000111640
Phylogenetic Trees/Animal Genes : TreeFamGAPDH
Homologs : HomoloGeneGAPDH
Homology/Alignments : Family Browser (UCSC)GAPDH
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerGAPDH [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GAPDH
dbVarGAPDH
ClinVarGAPDH
1000_GenomesGAPDH 
Exome Variant ServerGAPDH
ExAC (Exome Aggregation Consortium)GAPDH (select the gene name)
Genetic variants : HAPMAP2597
Genomic Variants (DGV)GAPDH [DGVbeta]
Mutations
ICGC Data PortalGAPDH 
TCGA Data PortalGAPDH 
Broad Tumor PortalGAPDH
OASIS PortalGAPDH [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGAPDH 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GAPDH
DgiDB (Drug Gene Interaction Database)GAPDH
DoCM (Curated mutations)GAPDH (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GAPDH (select a term)
intoGenGAPDH
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)12:6644385-6647541  ENSG00000111640
CONAN: Copy Number AnalysisGAPDH 
Mutations and Diseases : HGMDGAPDH
OMIM138400   
MedgenGAPDH
Genetic Testing Registry GAPDH
NextProtP04406 [Medical]
TSGene2597
GENETestsGAPDH
Huge Navigator GAPDH [HugePedia]
snp3D : Map Gene to Disease2597
BioCentury BCIQGAPDH
ClinGenGAPDH
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2597
Chemical/Pharm GKB GenePA28554
Clinical trialGAPDH
Miscellaneous
canSAR (ICR)GAPDH (select the gene name)
Probes
Litterature
PubMed306 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGAPDH
EVEXGAPDH
GoPubMedGAPDH
iHOPGAPDH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat May 28 11:03:38 CEST 2016

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