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GAPDH (glyceraldehyde-3-phosphate dehydrogenase)

Identity

Other namesG3PD
GAPD
HGNC (Hugo) GAPDH
LocusID (NCBI) 2597
Location 12p13.31
Location_base_pair Starts at 6644409 and ends at 6647537 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias t0817q24q22ID1494

External links

Nomenclature
HGNC (Hugo)GAPDH   4141
Cards
Entrez_Gene (NCBI)GAPDH  2597  glyceraldehyde-3-phosphate dehydrogenase
GeneCards (Weizmann)GAPDH
Ensembl (Hinxton)ENSG00000111640 [Gene_View]  chr12:6644409-6647537 [Contig_View]  GAPDH [Vega]
ICGC DataPortalENSG00000111640
cBioPortalGAPDH
AceView (NCBI)GAPDH
Genatlas (Paris)GAPDH
WikiGenes2597
SOURCE (Princeton)NM_001256799 NM_002046
Genomic and cartography
GoldenPath (UCSC)GAPDH  -  12p13.31   chr12:6644409-6647537 +  12p13.31   [Description]    (hg19-Feb_2009)
EnsemblGAPDH - 12p13.31 [CytoView]
Mapping of homologs : NCBIGAPDH [Mapview]
OMIM138400   
Gene and transcription
Genbank (Entrez)AB062273 AF261085 AJ844644 AJ844645 AK026525
RefSeq transcript (Entrez)NM_001256799 NM_002046
RefSeq genomic (Entrez)AC_000144 NC_000012 NC_018923 NG_007073 NT_009759 NW_001838050 NW_004929382
Consensus coding sequences : CCDS (NCBI)GAPDH
Cluster EST : UnigeneHs.598320 [ NCBI ]
CGAP (NCI)Hs.598320
Alternative Splicing : Fast-db (Paris)GSHG0006418
Alternative Splicing GalleryENSG00000111640
Gene ExpressionGAPDH [ NCBI-GEO ]     GAPDH [ SEEK ]   GAPDH [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04406 (Uniprot)
NextProtP04406  [Medical]
With graphics : InterProP04406
Splice isoforms : SwissVarP04406 (Swissvar)
Catalytic activity : Enzyme1.2.1.12 [ Enzyme-Expasy ]   1.2.1.121.2.1.12 [ IntEnz-EBI ]   1.2.1.12 [ BRENDA ]   1.2.1.12 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)GAPDH (PS00071)   
Domains : Interpro (EBI)GlycerAld/Erythrose_P_DH [organisation]   GlycerAld_3-P_DH_AS [organisation]   GlycerAld_3-P_DH_cat [organisation]   GlycerAld_3-P_DH_NAD(P)-bd [organisation]   Glyceraldehyde-3-P_DH_1 [organisation]   NAD(P)-bd_dom [organisation]  
Related proteins : CluSTrP04406
Domain families : Pfam (Sanger)Gp_dh_C (PF02800)    Gp_dh_N (PF00044)   
Domain families : Pfam (NCBI)pfam02800    pfam00044   
Domain families : Smart (EMBL)Gp_dh_N (SM00846)  
DMDM Disease mutations2597
Blocks (Seattle)P04406
PDB (SRS)1U8F    1ZNQ    2FEH    3GPD   
PDB (PDBSum)1U8F    1ZNQ    2FEH    3GPD   
PDB (IMB)1U8F    1ZNQ    2FEH    3GPD   
PDB (RSDB)1U8F    1ZNQ    2FEH    3GPD   
Human Protein AtlasENSG00000111640 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP04406
HPRD00713
IPIIPI00219018   IPI00795622   IPI00794508   IPI00789134   IPI00795257   
Protein Interaction databases
DIP (DOE-UCLA)P04406
IntAct (EBI)P04406
FunCoupENSG00000111640
BioGRIDGAPDH
InParanoidP04406
Interologous Interaction database P04406
IntegromeDBGAPDH
STRING (EMBL)GAPDH
Ontologies - Pathways
Ontology : AmiGOmicrotubule cytoskeleton organization  glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity  glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity  protein binding  nucleus  cytoplasm  cytoplasm  cytoplasm  lipid particle  cytosol  cytosol  plasma membrane  carbohydrate metabolic process  glucose metabolic process  gluconeogenesis  glycolysis  glycolysis  glycolysis  microtubule binding  microtubule cytoskeleton  negative regulation of translation  negative regulation of translation  ribonucleoprotein complex  peptidyl-cysteine S-nitrosylase activity  peptidyl-cysteine S-trans-nitrosylation  identical protein binding  small molecule metabolic process  perinuclear region of cytoplasm  NADP binding  protein stabilization  NAD binding  neuron apoptotic process  extracellular vesicular exosome  cellular response to interferon-gamma  GAIT complex  
Ontology : EGO-EBImicrotubule cytoskeleton organization  glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity  glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity  protein binding  nucleus  cytoplasm  cytoplasm  cytoplasm  lipid particle  cytosol  cytosol  plasma membrane  carbohydrate metabolic process  glucose metabolic process  gluconeogenesis  glycolysis  glycolysis  glycolysis  microtubule binding  microtubule cytoskeleton  negative regulation of translation  negative regulation of translation  ribonucleoprotein complex  peptidyl-cysteine S-nitrosylase activity  peptidyl-cysteine S-trans-nitrosylation  identical protein binding  small molecule metabolic process  perinuclear region of cytoplasm  NADP binding  protein stabilization  NAD binding  neuron apoptotic process  extracellular vesicular exosome  cellular response to interferon-gamma  GAIT complex  
Pathways : BIOCARTADownregulated of MTA-3 in ER-negative Breast Tumors [Genes]    Glycolysis Pathway [Genes]   
Pathways : KEGGGlycolysis / Gluconeogenesis    HIF-1 signaling pathway    Alzheimer's disease   
Protein Interaction DatabaseGAPDH
Wikipedia pathwaysGAPDH
Gene fusion - rearrangments
Rearrangement : TICdbGAPDH [12p13.31]  -  BCL6 [3q27.3]
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)GAPDH
snp3D : Map Gene to Disease2597
SNP (GeneSNP Utah)GAPDH
SNP : HGBaseGAPDH
Genetic variants : HAPMAPGAPDH
Exome VariantGAPDH
1000_GenomesGAPDH 
ICGC programENSG00000111640 
Somatic Mutations in Cancer : COSMICGAPDH 
CONAN: Copy Number AnalysisGAPDH 
Mutations and Diseases : HGMDGAPDH
Genomic VariantsGAPDH  GAPDH [DGVbeta]
dbVarGAPDH
ClinVarGAPDH
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM138400   
MedgenGAPDH
GENETestsGAPDH
Disease Genetic AssociationGAPDH
Huge Navigator GAPDH [HugePedia]  GAPDH [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneGAPDH
Homology/Alignments : Family Browser (UCSC)GAPDH
Phylogenetic Trees/Animal Genes : TreeFamGAPDH
Chemical/Protein Interactions : CTD2597
Chemical/Pharm GKB GenePA28554
Clinical trialGAPDH
Cancer Resource (Charite)ENSG00000111640
Other databases
Probes
Litterature
PubMed246 Pubmed reference(s) in Entrez
CoreMineGAPDH
iHOPGAPDH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jul 11 16:56:48 CEST 2014

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