GAPDH (glyceraldehyde-3-phosphate dehydrogenase)

2004-12-01  

Identity

HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
G3PD,GAPD,HEL-S-162eP
FUSION GENES

Other Information

Locus ID:

NCBI: 2597
MIM: 138400
HGNC: 4141
Ensembl: ENSG00000111640

Variants:

dbSNP: 2597
ClinVar: 2597
TCGA: ENSG00000111640
COSMIC: GAPDH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111640ENST00000229239P04406
ENSG00000111640ENST00000229239V9HVZ4
ENSG00000111640ENST00000396856E7EUT5
ENSG00000111640ENST00000396858P04406
ENSG00000111640ENST00000396859P04406
ENSG00000111640ENST00000396859V9HVZ4
ENSG00000111640ENST00000396861P04406
ENSG00000111640ENST00000396861V9HVZ4
ENSG00000111640ENST00000619601P04406

Expression (GTEx)

0
1000
2000
3000
4000
5000
6000
7000

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Alzheimer's diseaseKEGGko05010
Glycolysis / GluconeogenesisKEGGhsa00010
Alzheimer's diseaseKEGGhsa05010
Metabolic pathwaysKEGGhsa01100
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvateKEGGhsa_M00001
Glycolysis, core module involving three-carbon compoundsKEGGhsa_M00002
Gluconeogenesis, oxaloacetate => fructose-6PKEGGhsa_M00003
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvateKEGGM00001
Glycolysis, core module involving three-carbon compoundsKEGGM00002
Gluconeogenesis, oxaloacetate => fructose-6PKEGGM00003
HIF-1 signaling pathwayKEGGhsa04066
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glucose metabolismREACTOMER-HSA-70326
GlycolysisREACTOMER-HSA-70171
GluconeogenesisREACTOMER-HSA-70263

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
213363102011p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase.216
157699082005GAPDH as a housekeeping gene: analysis of GAPDH mRNA expression in a panel of 72 human tissues.184
207279682011The diverse functions of GAPDH: views from different subcellular compartments.149
185528332008Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis.121
157461842005Proteomic analysis of neurofibrillary tangles in Alzheimer disease identifies GAPDH as a detergent-insoluble paired helical filament tau binding protein.60
250092272014Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step.59
218957362012GAPDH: a common enzyme with uncommon functions.57
191655272009Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.56
196056962009Intracellular receptor for human host defense peptide LL-37 in monocytes.51
196507662009Oxidative modifications of glyceraldehyde-3-phosphate dehydrogenase play a key role in its multiple cellular functions.49

Citation

Dessen P

GAPDH (glyceraldehyde-3-phosphate dehydrogenase)

Atlas Genet Cytogenet Oncol Haematol. 2004-12-01

Online version: http://atlasgeneticsoncology.org/gene/42889/gapdh