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GAREM1 (GRB2 associated regulator of MAPK1 subtype 1)

Identity

Alias_namesC18orf11
FAM59A
GAREM
chromosome 18 open reading frame 11
family with sequence similarity 59, member A
GRB2 associated, regulator of MAPK1
Alias_symbol (synonym)FLJ21610
Other aliasGm944
HGNC (Hugo) GAREM1
LocusID (NCBI) 64762
Atlas_Id 56129
Location 18q12.1  [Link to chromosome band 18q12]
Location_base_pair Starts at 32263521 and ends at 32470484 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GAREM1 (18q12.1) / GTF2H1 (11p15.1)GAREM1 (18q12.1) / SDHAF3 (7q21.3)LAMA3 (18q11.2) / GAREM1 (18q12.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)GAREM1   26136
Cards
Entrez_Gene (NCBI)GAREM1  64762  GRB2 associated regulator of MAPK1 subtype 1
AliasesC18orf11; FAM59A; GAREM; Gm944
GeneCards (Weizmann)GAREM1
Ensembl hg19 (Hinxton)ENSG00000141441 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000141441 [Gene_View]  ENSG00000141441 [Sequence]  chr18:32263521-32470484 [Contig_View]  GAREM1 [Vega]
ICGC DataPortalENSG00000141441
TCGA cBioPortalGAREM1
AceView (NCBI)GAREM1
Genatlas (Paris)GAREM1
WikiGenes64762
SOURCE (Princeton)GAREM1
Genetics Home Reference (NIH)GAREM1
Genomic and cartography
GoldenPath hg38 (UCSC)GAREM1  -     chr18:32263521-32470484 -  18q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GAREM1  -     18q12.1   [Description]    (hg19-Feb_2009)
EnsemblGAREM1 - 18q12.1 [CytoView hg19]  GAREM1 - 18q12.1 [CytoView hg38]
Mapping of homologs : NCBIGAREM1 [Mapview hg19]  GAREM1 [Mapview hg38]
OMIM617998   
Gene and transcription
Genbank (Entrez)AF086529 AI479499 AK025263 AK025660 AK297430
RefSeq transcript (Entrez)NM_001242409 NM_022751
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GAREM1
Cluster EST : UnigeneHs.444314 [ NCBI ]
CGAP (NCI)Hs.444314
Alternative Splicing GalleryENSG00000141441
Gene ExpressionGAREM1 [ NCBI-GEO ]   GAREM1 [ EBI - ARRAY_EXPRESS ]   GAREM1 [ SEEK ]   GAREM1 [ MEM ]
Gene Expression Viewer (FireBrowse)GAREM1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64762
GTEX Portal (Tissue expression)GAREM1
Human Protein AtlasENSG00000141441-GAREM1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H706   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H706  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H706
Splice isoforms : SwissVarQ9H706
PhosPhoSitePlusQ9H706
Domains : Interpro (EBI)CABIT_dom    SAM/pointed_sf   
Domain families : Pfam (Sanger)CABIT (PF12736)   
Domain families : Pfam (NCBI)pfam12736   
Conserved Domain (NCBI)GAREM1
DMDM Disease mutations64762
Blocks (Seattle)GAREM1
PDB (RSDB)2DKZ   
PDB Europe2DKZ   
PDB (PDBSum)2DKZ   
PDB (IMB)2DKZ   
Structural Biology KnowledgeBase2DKZ   
SCOP (Structural Classification of Proteins)2DKZ   
CATH (Classification of proteins structures)2DKZ   
SuperfamilyQ9H706
Human Protein Atlas [tissue]ENSG00000141441-GAREM1 [tissue]
Peptide AtlasQ9H706
HPRD12685
IPIIPI00794930   IPI00827957   IPI00171499   
Protein Interaction databases
DIP (DOE-UCLA)Q9H706
IntAct (EBI)Q9H706
FunCoupENSG00000141441
BioGRIDGAREM1
STRING (EMBL)GAREM1
ZODIACGAREM1
Ontologies - Pathways
QuickGOQ9H706
Ontology : AmiGOprotein binding  plasma membrane  epidermal growth factor receptor signaling pathway  positive regulation of cell proliferation  positive regulation of cell division  proline-rich region binding  positive regulation of ERK1 and ERK2 cascade  cellular response to epidermal growth factor stimulus  
Ontology : EGO-EBIprotein binding  plasma membrane  epidermal growth factor receptor signaling pathway  positive regulation of cell proliferation  positive regulation of cell division  proline-rich region binding  positive regulation of ERK1 and ERK2 cascade  cellular response to epidermal growth factor stimulus  
NDEx NetworkGAREM1
Atlas of Cancer Signalling NetworkGAREM1
Wikipedia pathwaysGAREM1
Orthology - Evolution
OrthoDB64762
GeneTree (enSembl)ENSG00000141441
Phylogenetic Trees/Animal Genes : TreeFamGAREM1
HOGENOMQ9H706
Homologs : HomoloGeneGAREM1
Homology/Alignments : Family Browser (UCSC)GAREM1
Gene fusions - Rearrangements
Fusion : QuiverGAREM1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGAREM1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GAREM1
dbVarGAREM1
ClinVarGAREM1
1000_GenomesGAREM1 
Exome Variant ServerGAREM1
ExAC (Exome Aggregation Consortium)ENSG00000141441
GNOMAD BrowserENSG00000141441
Varsome BrowserGAREM1
Genetic variants : HAPMAP64762
Genomic Variants (DGV)GAREM1 [DGVbeta]
DECIPHERGAREM1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGAREM1 
Mutations
ICGC Data PortalGAREM1 
TCGA Data PortalGAREM1 
Broad Tumor PortalGAREM1
OASIS PortalGAREM1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDGAREM1
BioMutasearch GAREM1
DgiDB (Drug Gene Interaction Database)GAREM1
DoCM (Curated mutations)GAREM1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GAREM1 (select a term)
intoGenGAREM1
Cancer3DGAREM1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617998   
Orphanet
DisGeNETGAREM1
MedgenGAREM1
Genetic Testing Registry GAREM1
NextProtQ9H706 [Medical]
TSGene64762
GENETestsGAREM1
Target ValidationGAREM1
Huge Navigator GAREM1 [HugePedia]
snp3D : Map Gene to Disease64762
BioCentury BCIQGAREM1
ClinGenGAREM1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64762
Chemical/Pharm GKB GenePA134888032
Clinical trialGAREM1
Miscellaneous
canSAR (ICR)GAREM1 (select the gene name)
DataMed IndexGAREM1
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGAREM1
EVEXGAREM1
GoPubMedGAREM1
iHOPGAREM1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Feb 14 16:31:50 CET 2019
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