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GARS (glycyl-tRNA synthetase)

Identity

Other namesCMT2D
DSMAV
GlyRS
HMN5
SMAD1
HGNC (Hugo) GARS
LocusID (NCBI) 2617
Location 7p14.3
Location_base_pair Starts at 30634181 and ends at 30673648 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)GARS   4162
Cards
Entrez_Gene (NCBI)GARS  2617  glycyl-tRNA synthetase
GeneCards (Weizmann)GARS
Ensembl (Hinxton)ENSG00000106105 [Gene_View]  chr7:30634181-30673648 [Contig_View]  GARS [Vega]
AceView (NCBI)GARS
Genatlas (Paris)GARS
WikiGenes2617
SOURCE (Princeton)NM_002047
Genomic and cartography
GoldenPath (UCSC)GARS  -  7p14.3   chr7:30634181-30673648 +  7p14.3   [Description]    (hg19-Feb_2009)
EnsemblGARS - 7p14.3 [CytoView]
Mapping of homologs : NCBIGARS [Mapview]
OMIM600287   600794   601472   
Gene and transcription
Genbank (Entrez)AA772440 AK074524 AK295490 AK310351 BC000065
RefSeq transcript (Entrez)NM_002047
RefSeq genomic (Entrez)AC_000068 AC_000139 NC_000007 NC_018918 NG_007942 NT_007819 NT_079592 NW_001839003 NW_004929329
Consensus coding sequences : CCDS (NCBI)GARS
Cluster EST : UnigeneHs.404321 [ NCBI ]
CGAP (NCI)Hs.404321
Alternative Splicing : Fast-db (Paris)GSHG0027254
Alternative Splicing GalleryENSG00000106105
Gene ExpressionGARS [ NCBI-GEO ]     GARS [ SEEK ]   GARS [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41250 (Uniprot)
NextProtP41250  [Medical]
With graphics : InterProP41250
Splice isoforms : SwissVarP41250 (Swissvar)
Catalytic activity : Enzyme6.1.1.14 [ Enzyme-Expasy ]   6.1.1.146.1.1.14 [ IntEnz-EBI ]   6.1.1.14 [ BRENDA ]   6.1.1.14 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_II (PS50862)    WHEP_TRS_1 (PS00762)    WHEP_TRS_2 (PS51185)   
Domains : Interpro (EBI)aa-tRNA-synt_IIb_cons-dom    aa-tRNA-synth_II    Anticodon-bd    Gly-tRNA_synthase/POLG2    S15_NS1_RNA-bd    tRNA-synt_gly    WHEP-TRS   
Related proteins : CluSTrP41250
Domain families : Pfam (Sanger)HGTP_anticodon (PF03129)    tRNA-synt_2b (PF00587)    WHEP-TRS (PF00458)   
Domain families : Pfam (NCBI)pfam03129    pfam00587    pfam00458   
Domain families : Smart (EMBL)WHEP-TRS (SM00991)  
DMDM Disease mutations2617
Blocks (Seattle)P41250
PDB (SRS)2PME    2PMF    2Q5H    2Q5I    2ZT5    2ZT6    2ZT7    2ZT8    2ZXF   
PDB (PDBSum)2PME    2PMF    2Q5H    2Q5I    2ZT5    2ZT6    2ZT7    2ZT8    2ZXF   
PDB (IMB)2PME    2PMF    2Q5H    2Q5I    2ZT5    2ZT6    2ZT7    2ZT8    2ZXF   
PDB (RSDB)2PME    2PMF    2Q5H    2Q5I    2ZT5    2ZT6    2ZT7    2ZT8    2ZXF   
Human Protein AtlasENSG00000106105
Peptide AtlasP41250
HPRD02617
IPIIPI00783097   IPI00917627   IPI00917798   
Protein Interaction databases
DIP (DOE-UCLA)P41250
IntAct (EBI)P41250
FunCoupENSG00000106105
BioGRIDGARS
InParanoidP41250
Interologous Interaction database P41250
IntegromeDBGARS
STRING (EMBL)GARS
Ontologies - Pathways
Ontology : AmiGOglycine-tRNA ligase activity  glycine-tRNA ligase activity  ATP binding  cytoplasm  mitochondrial matrix  cytosol  tRNA aminoacylation for protein translation  glycyl-tRNA aminoacylation  cell death  gene expression  diadenosine tetraphosphate biosynthetic process  secretory granule  protein dimerization activity  
Ontology : EGO-EBIglycine-tRNA ligase activity  glycine-tRNA ligase activity  ATP binding  cytoplasm  mitochondrial matrix  cytosol  tRNA aminoacylation for protein translation  glycyl-tRNA aminoacylation  cell death  gene expression  diadenosine tetraphosphate biosynthetic process  secretory granule  protein dimerization activity  
Pathways : KEGGAminoacyl-tRNA biosynthesis   
REACTOMEGARS
Protein Interaction DatabaseGARS
Wikipedia pathwaysGARS
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)GARS
SNP (GeneSNP Utah)GARS
SNP : HGBaseGARS
Genetic variants : HAPMAPGARS
1000_GenomesGARS 
ICGC programENSG00000106105 
Somatic Mutations in Cancer : COSMICGARS 
CONAN: Copy Number AnalysisGARS 
Mutations and Diseases : HGMDGARS
OMIM600287    600794    601472   
GENETestsGARS
Disease Genetic AssociationGARS
Huge Navigator GARS [HugePedia]  GARS [HugeCancerGEM]
Genomic VariantsGARS  GARS [DGVbeta]
Exome VariantGARS
dbVarGARS
ClinVarGARS
snp3D : Map Gene to Disease2617
General knowledge
Homologs : HomoloGeneGARS
Homology/Alignments : Family Browser (UCSC)GARS
Phylogenetic Trees/Animal Genes : TreeFamGARS
Chemical/Protein Interactions : CTD2617
Chemical/Pharm GKB GenePA28575
Clinical trialGARS
Cancer Resource (Charite)ENSG00000106105
Other databases
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
CoreMineGARS
iHOPGARS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 17:07:03 CEST 2014

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