Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

GARS (glycyl-tRNA synthetase)

Identity

Other namesCMT2D
DSMAV
GlyRS
HMN5
SMAD1
HGNC (Hugo) GARS
LocusID (NCBI) 2617
Atlas_Id 52713
Location 7p14.3
Location_base_pair Starts at 30634181 and ends at 30673648 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)GARS   4162
Cards
Entrez_Gene (NCBI)GARS  2617  glycyl-tRNA synthetase
GeneCards (Weizmann)GARS
Ensembl hg19 (Hinxton)ENSG00000106105 [Gene_View]  chr7:30634181-30673648 [Contig_View]  GARS [Vega]
Ensembl hg38 (Hinxton)ENSG00000106105 [Gene_View]  chr7:30634181-30673648 [Contig_View]  GARS [Vega]
ICGC DataPortalENSG00000106105
TCGA cBioPortalGARS
AceView (NCBI)GARS
Genatlas (Paris)GARS
WikiGenes2617
SOURCE (Princeton)GARS
Genomic and cartography
GoldenPath hg19 (UCSC)GARS  -     chr7:30634181-30673648 +  7p14.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GARS  -     7p14.3   [Description]    (hg38-Dec_2013)
EnsemblGARS - 7p14.3 [CytoView hg19]  GARS - 7p14.3 [CytoView hg38]
Mapping of homologs : NCBIGARS [Mapview hg19]  GARS [Mapview hg38]
OMIM600287   600794   601472   
Gene and transcription
Genbank (Entrez)AA772440 AK074524 AK295490 AK310351 BC000065
RefSeq transcript (Entrez)NM_002047
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_007942 NT_007819 NW_004929329
Consensus coding sequences : CCDS (NCBI)GARS
Cluster EST : UnigeneHs.404321 [ NCBI ]
CGAP (NCI)Hs.404321
Alternative Splicing : Fast-db (Paris)GSHG0027254
Alternative Splicing GalleryENSG00000106105
Gene ExpressionGARS [ NCBI-GEO ]     GARS [ SEEK ]   GARS [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41250 (Uniprot)
NextProtP41250  [Medical]  [Publications]
With graphics : InterProP41250
Splice isoforms : SwissVarP41250 (Swissvar)
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_II (PS50862)    WHEP_TRS_1 (PS00762)    WHEP_TRS_2 (PS51185)   
Domains : Interpro (EBI)aa-tRNA-synt_IIb_cons-dom    aa-tRNA-synth_II    Anticodon-bd    Gly-tRNA_synthase/POLG2    S15_NS1_RNA-bd    tRNA-synt_gly    WHEP-TRS   
Related proteins : CluSTrP41250
Domain families : Pfam (Sanger)HGTP_anticodon (PF03129)    tRNA-synt_2b (PF00587)    WHEP-TRS (PF00458)   
Domain families : Pfam (NCBI)pfam03129    pfam00587    pfam00458   
Domain families : Smart (EMBL)WHEP-TRS (SM00991)  
DMDM Disease mutations2617
Blocks (Seattle)P41250
PDB (SRS)2PME    2PMF    2Q5H    2Q5I    2ZT5    2ZT6    2ZT7    2ZT8    2ZXF    4KQE    4KR2    4KR3   
PDB (PDBSum)2PME    2PMF    2Q5H    2Q5I    2ZT5    2ZT6    2ZT7    2ZT8    2ZXF    4KQE    4KR2    4KR3   
PDB (IMB)2PME    2PMF    2Q5H    2Q5I    2ZT5    2ZT6    2ZT7    2ZT8    2ZXF    4KQE    4KR2    4KR3   
PDB (RSDB)2PME    2PMF    2Q5H    2Q5I    2ZT5    2ZT6    2ZT7    2ZT8    2ZXF    4KQE    4KR2    4KR3   
Human Protein AtlasENSG00000106105
Peptide AtlasP41250
HPRD02617
IPIIPI00783097   IPI00917627   IPI00917798   
Protein Interaction databases
DIP (DOE-UCLA)P41250
IntAct (EBI)P41250
FunCoupENSG00000106105
BioGRIDGARS
IntegromeDBGARS
STRING (EMBL)GARS
Ontologies - Pathways
QuickGOP41250
Ontology : AmiGOglycine-tRNA ligase activity  glycine-tRNA ligase activity  ATP binding  nucleoplasm  cytoplasm  mitochondrial matrix  cytosol  tRNA aminoacylation for protein translation  glycyl-tRNA aminoacylation  gene expression  diadenosine tetraphosphate biosynthetic process  secretory granule  axon  protein dimerization activity  extracellular exosome  
Ontology : EGO-EBIglycine-tRNA ligase activity  glycine-tRNA ligase activity  ATP binding  nucleoplasm  cytoplasm  mitochondrial matrix  cytosol  tRNA aminoacylation for protein translation  glycyl-tRNA aminoacylation  gene expression  diadenosine tetraphosphate biosynthetic process  secretory granule  axon  protein dimerization activity  extracellular exosome  
Pathways : KEGGAminoacyl-tRNA biosynthesis   
Protein Interaction DatabaseGARS
DoCM (Curated mutations)GARS
Wikipedia pathwaysGARS
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerGARS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GARS
dbVarGARS
ClinVarGARS
1000_GenomesGARS 
Exome Variant ServerGARS
SNP (GeneSNP Utah)GARS
SNP : HGBaseGARS
Genetic variants : HAPMAPGARS
Genomic Variants (DGV)GARS [DGVbeta]
Mutations
ICGC Data PortalGARS 
TCGA Data PortalGARS 
Tumor PortalGARS
Somatic Mutations in Cancer : COSMICGARS 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)7:30634181-30673648
CONAN: Copy Number AnalysisGARS 
Mutations and Diseases : HGMDGARS
OMIM600287    600794    601472   
MedgenGARS
NextProtP41250 [Medical]
GENETestsGARS
Disease Genetic AssociationGARS
Huge Navigator GARS [HugePedia]  GARS [HugeCancerGEM]
snp3D : Map Gene to Disease2617
DGIdb (Drug Gene Interaction db)GARS
BioCentury BCIQGARS
General knowledge
Homologs : HomoloGeneGARS
Homology/Alignments : Family Browser (UCSC)GARS
Phylogenetic Trees/Animal Genes : TreeFamGARS
Chemical/Protein Interactions : CTD2617
Chemical/Pharm GKB GenePA28575
Clinical trialGARS
Cancer Resource (Charite)ENSG00000106105
Other databases
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
CoreMineGARS
GoPubMedGARS
iHOPGARS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jun 27 11:36:07 CEST 2015

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.