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GARS (glycyl-tRNA synthetase)

Identity

Other namesCMT2D
DSMAV
GlyRS
HMN5
SMAD1
HGNC (Hugo) GARS
LocusID (NCBI) 2617
Atlas_Id 52713
Location 7p14.3
Location_base_pair Starts at 30634351 and ends at 30673648 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATP5E (20q13.32) / GARS (7p14.3)CBX3 (7p15.2) / GARS (7p14.3)GARS (7p14.3) / DDX17 (22q13.1)
GARS (7p14.3) / FKBP15 (9q32)GARS (7p14.3) / WAPL (10q23.2)MCL1 (1q21.3) / GARS (7p14.3)
PIM3 (22q13.33) / GARS (7p14.3)USH2A (1q41) / GARS (7p14.3)CBX3 7p15.2 / GARS 7p14.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GARS   4162
Cards
Entrez_Gene (NCBI)GARS  2617  glycyl-tRNA synthetase
AliasesCMT2D; DSMAV; GlyRS; HMN5; 
SMAD1
GeneCards (Weizmann)GARS
Ensembl hg19 (Hinxton)ENSG00000106105 [Gene_View]  chr7:30634351-30673648 [Contig_View]  GARS [Vega]
Ensembl hg38 (Hinxton)ENSG00000106105 [Gene_View]  chr7:30634351-30673648 [Contig_View]  GARS [Vega]
ICGC DataPortalENSG00000106105
TCGA cBioPortalGARS
AceView (NCBI)GARS
Genatlas (Paris)GARS
WikiGenes2617
SOURCE (Princeton)GARS
Genomic and cartography
GoldenPath hg19 (UCSC)GARS  -     chr7:30634351-30673648 +  7p14.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GARS  -     7p14.3   [Description]    (hg38-Dec_2013)
EnsemblGARS - 7p14.3 [CytoView hg19]  GARS - 7p14.3 [CytoView hg38]
Mapping of homologs : NCBIGARS [Mapview hg19]  GARS [Mapview hg38]
OMIM600287   600794   601472   
Gene and transcription
Genbank (Entrez)AA464978 AA772440 AK074524 AK295490 AK310351
RefSeq transcript (Entrez)NM_001316772 NM_002047
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_007942 NT_007819 NW_004929329
Consensus coding sequences : CCDS (NCBI)GARS
Cluster EST : UnigeneHs.404321 [ NCBI ]
CGAP (NCI)Hs.404321
Alternative Splicing GalleryENSG00000106105
Gene ExpressionGARS [ NCBI-GEO ]   GARS [ EBI - ARRAY_EXPRESS ]   GARS [ SEEK ]   GARS [ MEM ]
Gene Expression Viewer (FireBrowse)GARS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2617
GTEX Portal (Tissue expression)GARS
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41250 (Uniprot)
NextProtP41250  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP41250
Splice isoforms : SwissVarP41250 (Swissvar)
PhosPhoSitePlusP41250
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_II (PS50862)    WHEP_TRS_1 (PS00762)    WHEP_TRS_2 (PS51185)   
Domains : Interpro (EBI)aa-tRNA-synt_IIb    aa-tRNA-synth_II    Anticodon-bd    Gly-tRNA_synthase/POLG2    S15_NS1_RNA-bd    tRNA-synt_gly    WHEP-TRS_dom   
Domain families : Pfam (Sanger)HGTP_anticodon (PF03129)    tRNA-synt_2b (PF00587)    WHEP-TRS (PF00458)   
Domain families : Pfam (NCBI)pfam03129    pfam00587    pfam00458   
Domain families : Smart (EMBL)WHEP-TRS (SM00991)  
DMDM Disease mutations2617
Blocks (Seattle)GARS
PDB (SRS)2PME    2PMF    2Q5H    2Q5I    2ZT5    2ZT6    2ZT7    2ZT8    2ZXF    4KQE    4KR2    4KR3    4QEI   
PDB (PDBSum)2PME    2PMF    2Q5H    2Q5I    2ZT5    2ZT6    2ZT7    2ZT8    2ZXF    4KQE    4KR2    4KR3    4QEI   
PDB (IMB)2PME    2PMF    2Q5H    2Q5I    2ZT5    2ZT6    2ZT7    2ZT8    2ZXF    4KQE    4KR2    4KR3    4QEI   
PDB (RSDB)2PME    2PMF    2Q5H    2Q5I    2ZT5    2ZT6    2ZT7    2ZT8    2ZXF    4KQE    4KR2    4KR3    4QEI   
Structural Biology KnowledgeBase2PME    2PMF    2Q5H    2Q5I    2ZT5    2ZT6    2ZT7    2ZT8    2ZXF    4KQE    4KR2    4KR3    4QEI   
SCOP (Structural Classification of Proteins)2PME    2PMF    2Q5H    2Q5I    2ZT5    2ZT6    2ZT7    2ZT8    2ZXF    4KQE    4KR2    4KR3    4QEI   
CATH (Classification of proteins structures)2PME    2PMF    2Q5H    2Q5I    2ZT5    2ZT6    2ZT7    2ZT8    2ZXF    4KQE    4KR2    4KR3    4QEI   
SuperfamilyP41250
Human Protein AtlasENSG00000106105
Peptide AtlasP41250
HPRD02617
IPIIPI00783097   IPI00917627   IPI00917798   
Protein Interaction databases
DIP (DOE-UCLA)P41250
IntAct (EBI)P41250
FunCoupENSG00000106105
BioGRIDGARS
STRING (EMBL)GARS
ZODIACGARS
Ontologies - Pathways
QuickGOP41250
Ontology : AmiGOglycine-tRNA ligase activity  glycine-tRNA ligase activity  ATP binding  nucleoplasm  cytoplasm  mitochondrial matrix  cytosol  tRNA aminoacylation for protein translation  glycyl-tRNA aminoacylation  diadenosine tetraphosphate biosynthetic process  secretory granule  axon  protein dimerization activity  extracellular exosome  
Ontology : EGO-EBIglycine-tRNA ligase activity  glycine-tRNA ligase activity  ATP binding  nucleoplasm  cytoplasm  mitochondrial matrix  cytosol  tRNA aminoacylation for protein translation  glycyl-tRNA aminoacylation  diadenosine tetraphosphate biosynthetic process  secretory granule  axon  protein dimerization activity  extracellular exosome  
Pathways : KEGGAminoacyl-tRNA biosynthesis   
NDEx Network
Atlas of Cancer Signalling NetworkGARS
Wikipedia pathwaysGARS
Orthology - Evolution
OrthoDB2617
GeneTree (enSembl)ENSG00000106105
Phylogenetic Trees/Animal Genes : TreeFamGARS
Homologs : HomoloGeneGARS
Homology/Alignments : Family Browser (UCSC)GARS
Gene fusions - Rearrangements
Fusion: TCGACBX3 7p15.2 GARS 7p14.3 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerGARS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GARS
dbVarGARS
ClinVarGARS
1000_GenomesGARS 
Exome Variant ServerGARS
ExAC (Exome Aggregation Consortium)GARS (select the gene name)
Genetic variants : HAPMAP2617
Genomic Variants (DGV)GARS [DGVbeta]
Mutations
ICGC Data PortalGARS 
TCGA Data PortalGARS 
Broad Tumor PortalGARS
OASIS PortalGARS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGARS 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch GARS
DgiDB (Drug Gene Interaction Database)GARS
DoCM (Curated mutations)GARS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GARS (select a term)
intoGenGARS
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)7:30634351-30673648  ENSG00000106105
CONAN: Copy Number AnalysisGARS 
Mutations and Diseases : HGMDGARS
OMIM600287    600794    601472   
MedgenGARS
Genetic Testing Registry GARS
NextProtP41250 [Medical]
TSGene2617
GENETestsGARS
Huge Navigator GARS [HugePedia]
snp3D : Map Gene to Disease2617
BioCentury BCIQGARS
ClinGenGARS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2617
Chemical/Pharm GKB GenePA28575
Clinical trialGARS
Miscellaneous
canSAR (ICR)GARS (select the gene name)
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGARS
EVEXGARS
GoPubMedGARS
iHOPGARS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat May 28 11:03:39 CEST 2016

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