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GART (phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase)

Identity

Alias_namesPRGS
PGFT
Other aliasAIRS
GARS
GARTF
PAIS
HGNC (Hugo) GART
LocusID (NCBI) 2618
Atlas_Id 54324
Location 21q22.11  [Link to chromosome band 21q22]
Location_base_pair Starts at 33503931 and ends at 33542158 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GART (21q22.11) / FCHO2 (5q13.2)GART (21q22.11) / PCP4 (21q22.2)GART (21q22.11) / VCP (9p13.3)
IFNGR2 (21q22.11) / GART (21q22.11)RCAN1 (21q22.12) / GART (21q22.11)UBE2G2 (21q22.3) / GART (21q22.11)
GART 21q22.11 / PCP4 21q22.2RCAN1 21q22.12 / GART 21q22.11UBE2G2 21q22.3 / GART 21q22.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GART   4163
Cards
Entrez_Gene (NCBI)GART  2618  phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
AliasesAIRS; GARS; GARTF; PAIS; 
PGFT; PRGS
GeneCards (Weizmann)GART
Ensembl hg19 (Hinxton)ENSG00000159131 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000159131 [Gene_View]  chr21:33503931-33542158 [Contig_View]  GART [Vega]
ICGC DataPortalENSG00000159131
TCGA cBioPortalGART
AceView (NCBI)GART
Genatlas (Paris)GART
WikiGenes2618
SOURCE (Princeton)GART
Genetics Home Reference (NIH)GART
Genomic and cartography
GoldenPath hg38 (UCSC)GART  -     chr21:33503931-33542158 -  21q22.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GART  -     21q22.11   [Description]    (hg19-Feb_2009)
EnsemblGART - 21q22.11 [CytoView hg19]  GART - 21q22.11 [CytoView hg38]
Mapping of homologs : NCBIGART [Mapview hg19]  GART [Mapview hg38]
OMIM138440   
Gene and transcription
Genbank (Entrez)AB208785 AF008655 AK292560 AK292897 AK295980
RefSeq transcript (Entrez)NM_000819 NM_001136005 NM_001136006 NM_175085
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GART
Cluster EST : UnigeneHs.473648 [ NCBI ]
CGAP (NCI)Hs.473648
Alternative Splicing GalleryENSG00000159131
Gene ExpressionGART [ NCBI-GEO ]   GART [ EBI - ARRAY_EXPRESS ]   GART [ SEEK ]   GART [ MEM ]
Gene Expression Viewer (FireBrowse)GART [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2618
GTEX Portal (Tissue expression)GART
Protein : pattern, domain, 3D structure
UniProt/SwissProtP22102   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP22102  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP22102
Splice isoforms : SwissVarP22102
Catalytic activity : Enzyme6.3.4.13 [ Enzyme-Expasy ]   6.3.4.136.3.4.13 [ IntEnz-EBI ]   6.3.4.13 [ BRENDA ]   6.3.4.13 [ KEGG ]   
PhosPhoSitePlusP22102
Domaine pattern : Prosite (Expaxy)ATP_GRASP (PS50975)    GARS (PS00184)    GART (PS00373)   
Domains : Interpro (EBI)###############################################################################################################################################################################################################################################################                                                               
Domain families : Pfam (Sanger)AIRS (PF00586)    AIRS_C (PF02769)    Formyl_trans_N (PF00551)    GARS_A (PF01071)    GARS_C (PF02843)    GARS_N (PF02844)   
Domain families : Pfam (NCBI)pfam00586    pfam02769    pfam00551    pfam01071    pfam02843    pfam02844   
Domain families : Smart (EMBL)GARS_C (SM01210)  
Conserved Domain (NCBI)GART
DMDM Disease mutations2618
Blocks (Seattle)GART
PDB (SRS)1MEJ    1MEN    1MEO    1NJS    1RBM    1RBQ    1RBY    1RBZ    1RC0    1RC1    1ZLX    1ZLY    2QK4    2V9Y    4EW1    4EW2    4EW3    4ZYT    4ZYU    4ZYV    4ZYW    4ZYX    4ZYY    4ZYZ    4ZZ0    4ZZ1    4ZZ2    4ZZ3    5J9F   
PDB (PDBSum)1MEJ    1MEN    1MEO    1NJS    1RBM    1RBQ    1RBY    1RBZ    1RC0    1RC1    1ZLX    1ZLY    2QK4    2V9Y    4EW1    4EW2    4EW3    4ZYT    4ZYU    4ZYV    4ZYW    4ZYX    4ZYY    4ZYZ    4ZZ0    4ZZ1    4ZZ2    4ZZ3    5J9F   
PDB (IMB)1MEJ    1MEN    1MEO    1NJS    1RBM    1RBQ    1RBY    1RBZ    1RC0    1RC1    1ZLX    1ZLY    2QK4    2V9Y    4EW1    4EW2    4EW3    4ZYT    4ZYU    4ZYV    4ZYW    4ZYX    4ZYY    4ZYZ    4ZZ0    4ZZ1    4ZZ2    4ZZ3    5J9F   
PDB (RSDB)1MEJ    1MEN    1MEO    1NJS    1RBM    1RBQ    1RBY    1RBZ    1RC0    1RC1    1ZLX    1ZLY    2QK4    2V9Y    4EW1    4EW2    4EW3    4ZYT    4ZYU    4ZYV    4ZYW    4ZYX    4ZYY    4ZYZ    4ZZ0    4ZZ1    4ZZ2    4ZZ3    5J9F   
Structural Biology KnowledgeBase1MEJ    1MEN    1MEO    1NJS    1RBM    1RBQ    1RBY    1RBZ    1RC0    1RC1    1ZLX    1ZLY    2QK4    2V9Y    4EW1    4EW2    4EW3    4ZYT    4ZYU    4ZYV    4ZYW    4ZYX    4ZYY    4ZYZ    4ZZ0    4ZZ1    4ZZ2    4ZZ3    5J9F   
SCOP (Structural Classification of Proteins)1MEJ    1MEN    1MEO    1NJS    1RBM    1RBQ    1RBY    1RBZ    1RC0    1RC1    1ZLX    1ZLY    2QK4    2V9Y    4EW1    4EW2    4EW3    4ZYT    4ZYU    4ZYV    4ZYW    4ZYX    4ZYY    4ZYZ    4ZZ0    4ZZ1    4ZZ2    4ZZ3    5J9F   
CATH (Classification of proteins structures)1MEJ    1MEN    1MEO    1NJS    1RBM    1RBQ    1RBY    1RBZ    1RC0    1RC1    1ZLX    1ZLY    2QK4    2V9Y    4EW1    4EW2    4EW3    4ZYT    4ZYU    4ZYV    4ZYW    4ZYX    4ZYY    4ZYZ    4ZZ0    4ZZ1    4ZZ2    4ZZ3    5J9F   
SuperfamilyP22102
Human Protein AtlasENSG00000159131
Peptide AtlasP22102
HPRD00716
IPIIPI00025273   IPI00218408   IPI01012741   IPI00384624   IPI00657864   IPI00657700   IPI00657647   IPI00657768   IPI00879865   IPI00893596   IPI00916747   IPI00917833   
Protein Interaction databases
DIP (DOE-UCLA)P22102
IntAct (EBI)P22102
FunCoupENSG00000159131
BioGRIDGART
STRING (EMBL)GART
ZODIACGART
Ontologies - Pathways
QuickGOP22102
Ontology : AmiGObrainstem development  phosphoribosylamine-glycine ligase activity  phosphoribosylformylglycinamidine cyclo-ligase activity  phosphoribosylglycinamide formyltransferase activity  ATP binding  cytosol  'de novo' IMP biosynthetic process  glycine metabolic process  purine nucleobase biosynthetic process  purine ribonucleoside monophosphate biosynthetic process  response to organic substance  response to inorganic substance  cerebellum development  cerebral cortex development  tetrahydrofolate biosynthetic process  metal ion binding  extracellular exosome  
Ontology : EGO-EBIbrainstem development  phosphoribosylamine-glycine ligase activity  phosphoribosylformylglycinamidine cyclo-ligase activity  phosphoribosylglycinamide formyltransferase activity  ATP binding  cytosol  'de novo' IMP biosynthetic process  glycine metabolic process  purine nucleobase biosynthetic process  purine ribonucleoside monophosphate biosynthetic process  response to organic substance  response to inorganic substance  cerebellum development  cerebral cortex development  tetrahydrofolate biosynthetic process  metal ion binding  extracellular exosome  
Pathways : KEGGPurine metabolism    One carbon pool by folate   
NDEx NetworkGART
Atlas of Cancer Signalling NetworkGART
Wikipedia pathwaysGART
Orthology - Evolution
OrthoDB2618
GeneTree (enSembl)ENSG00000159131
Phylogenetic Trees/Animal Genes : TreeFamGART
HOVERGENP22102
HOGENOMP22102
Homologs : HomoloGeneGART
Homology/Alignments : Family Browser (UCSC)GART
Gene fusions - Rearrangements
Fusion : MitelmanGART/PCP4 [21q22.11/21q22.2]  
Fusion : MitelmanIFNGR2/GART [21q22.11/21q22.11]  [t(21;21)(q22;q22)]  
Fusion : MitelmanRCAN1/GART [21q22.12/21q22.11]  [t(21;21)(q22;q22)]  
Fusion : MitelmanUBE2G2/GART [21q22.3/21q22.11]  [t(21;21)(q22;q22)]  
Fusion: TCGAGART 21q22.11 PCP4 21q22.2 LUSC
Fusion: TCGARCAN1 21q22.12 GART 21q22.11 BRCA
Fusion: TCGAUBE2G2 21q22.3 GART 21q22.11 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGART [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GART
dbVarGART
ClinVarGART
1000_GenomesGART 
Exome Variant ServerGART
ExAC (Exome Aggregation Consortium)GART (select the gene name)
Genetic variants : HAPMAP2618
Genomic Variants (DGV)GART [DGVbeta]
DECIPHERGART [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGART 
Mutations
ICGC Data PortalGART 
TCGA Data PortalGART 
Broad Tumor PortalGART
OASIS PortalGART [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGART  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGART
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GART
DgiDB (Drug Gene Interaction Database)GART
DoCM (Curated mutations)GART (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GART (select a term)
intoGenGART
Cancer3DGART(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138440   
Orphanet
MedgenGART
Genetic Testing Registry GART
NextProtP22102 [Medical]
TSGene2618
GENETestsGART
Target ValidationGART
Huge Navigator GART [HugePedia]
snp3D : Map Gene to Disease2618
BioCentury BCIQGART
ClinGenGART
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2618
Chemical/Pharm GKB GenePA28576
Clinical trialGART
Miscellaneous
canSAR (ICR)GART (select the gene name)
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGART
EVEXGART
GoPubMedGART
iHOPGART
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:09:28 CEST 2017

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