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GAS6 (growth arrest specific 6)

Identity

Alias_namesAXLLG
AXL receptor tyrosine kinase ligand
Alias_symbol (synonym)AXSF
FLJ34709
DKFZp666G247
Other alias
HGNC (Hugo) GAS6
LocusID (NCBI) 2621
Atlas_Id 40687
Location 13q34  [Link to chromosome band 13q34]
Location_base_pair Starts at 113820549 and ends at 113864103 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GAS6 (13q34) / DYSF (2p13.2)GAS6 (13q34) / GAS6 (13q34)GAS6 (13q34) / GPC5 (13q31.3)
HTATSF1 (Xq26.3) / GAS6 (13q34)GAS6 13q34 / GPC5 13q31.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GAS6   4168
Cards
Entrez_Gene (NCBI)GAS6  2621  growth arrest specific 6
AliasesAXLLG; AXSF
GeneCards (Weizmann)GAS6
Ensembl hg19 (Hinxton)ENSG00000183087 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000183087 [Gene_View]  chr13:113820549-113864103 [Contig_View]  GAS6 [Vega]
ICGC DataPortalENSG00000183087
TCGA cBioPortalGAS6
AceView (NCBI)GAS6
Genatlas (Paris)GAS6
WikiGenes2621
SOURCE (Princeton)GAS6
Genetics Home Reference (NIH)GAS6
Genomic and cartography
GoldenPath hg38 (UCSC)GAS6  -     chr13:113820549-113864103 -  13q34   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GAS6  -     13q34   [Description]    (hg19-Feb_2009)
EnsemblGAS6 - 13q34 [CytoView hg19]  GAS6 - 13q34 [CytoView hg38]
Mapping of homologs : NCBIGAS6 [Mapview hg19]  GAS6 [Mapview hg38]
OMIM600441   
Gene and transcription
Genbank (Entrez)AA045119 AK092028 AK122969 AK126533 AK129751
RefSeq transcript (Entrez)NM_000820 NM_001143945 NM_001143946
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GAS6
Cluster EST : UnigeneHs.646346 [ NCBI ]
CGAP (NCI)Hs.646346
Alternative Splicing GalleryENSG00000183087
Gene ExpressionGAS6 [ NCBI-GEO ]   GAS6 [ EBI - ARRAY_EXPRESS ]   GAS6 [ SEEK ]   GAS6 [ MEM ]
Gene Expression Viewer (FireBrowse)GAS6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2621
GTEX Portal (Tissue expression)GAS6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14393   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14393  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14393
Splice isoforms : SwissVarQ14393
PhosPhoSitePlusQ14393
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    GLA_1 (PS00011)    GLA_2 (PS50998)    LAM_G_DOMAIN (PS50025)   
Domains : Interpro (EBI)cEGF    Coagulation_fac_subgr_Gla_dom    ConA-like_dom    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    GLA_domain    Growth_fac_rcpt_    Laminin_G   
Domain families : Pfam (Sanger)cEGF (PF12662)    EGF_CA (PF07645)    Gla (PF00594)    hEGF (PF12661)    Laminin_G_1 (PF00054)    Laminin_G_2 (PF02210)   
Domain families : Pfam (NCBI)pfam12662    pfam07645    pfam00594    pfam12661    pfam00054    pfam02210   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  GLA (SM00069)  LamG (SM00282)  
Conserved Domain (NCBI)GAS6
DMDM Disease mutations2621
Blocks (Seattle)GAS6
PDB (SRS)1H30    2C5D    4RA0   
PDB (PDBSum)1H30    2C5D    4RA0   
PDB (IMB)1H30    2C5D    4RA0   
PDB (RSDB)1H30    2C5D    4RA0   
Structural Biology KnowledgeBase1H30    2C5D    4RA0   
SCOP (Structural Classification of Proteins)1H30    2C5D    4RA0   
CATH (Classification of proteins structures)1H30    2C5D    4RA0   
SuperfamilyQ14393
Human Protein AtlasENSG00000183087
Peptide AtlasQ14393
HPRD02705
IPIIPI00412410   IPI00032532   IPI00412412   IPI00940478   IPI00921021   
Protein Interaction databases
DIP (DOE-UCLA)Q14393
IntAct (EBI)Q14393
FunCoupENSG00000183087
BioGRIDGAS6
STRING (EMBL)GAS6
ZODIACGAS6
Ontologies - Pathways
QuickGOQ14393
Ontology : AmiGOneuron migration  phosphatidylserine binding  positive regulation of protein phosphorylation  positive regulation of protein phosphorylation  positive regulation of cytokine-mediated signaling pathway  platelet degranulation  positive regulation of glomerular filtration  receptor binding  receptor binding  voltage-gated calcium channel activity  calcium ion binding  protein binding  extracellular region  extracellular space  cytoplasm  endoplasmic reticulum lumen  Golgi lumen  signal peptide processing  protein phosphorylation  ER to Golgi vesicle-mediated transport  phagocytosis  apoptotic process  cell cycle arrest  cell adhesion  signal transduction  signal transduction  enzyme linked receptor protein signaling pathway  cell proliferation  cellular response to starvation  positive regulation of gene expression  negative regulation of tumor necrosis factor-mediated signaling pathway  macrophage cytokine production  cell migration  peptidyl-serine phosphorylation  fusion of virus membrane with host plasma membrane  viral genome replication  platelet activation  protein tyrosine kinase activator activity  receptor tyrosine kinase binding  platelet alpha granule lumen  animal organ regeneration  cell-substrate adhesion  positive regulation of TOR signaling  activation of protein kinase B activity  negative regulation of interferon-gamma production  negative regulation of interleukin-6 production  negative regulation of tumor necrosis factor production  positive regulation of natural killer cell differentiation  positive regulation of peptidyl-serine phosphorylation  negative regulation of protein import into nucleus, translocation  cellular response to interferon-alpha  cellular response to drug  B cell chemotaxis  regulation of growth  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  apoptotic cell clearance  negative regulation of sequence-specific DNA binding transcription factor activity  protein kinase B signaling  positive regulation of protein kinase activity  negative regulation of transcription, DNA-templated  viral entry into host cell  receptor-mediated virion attachment to host cell  positive regulation of protein export from nucleus  receptor agonist activity  positive regulation of fibroblast proliferation  negative regulation of interleukin-1 secretion  positive regulation of phagocytosis  leukocyte migration  positive regulation of protein kinase B signaling  binding, bridging  positive regulation of protein tyrosine kinase activity  extracellular exosome  negative regulation of biomineral tissue development  positive regulation of ERK1 and ERK2 cascade  platelet aggregation  calcium ion transmembrane transport  cellular response to vitamin K  cellular response to glucose stimulus  cellular response to growth factor stimulus  protein targeting to plasma membrane  extracellular matrix assembly  dendritic cell differentiation  hematopoietic stem cell migration to bone marrow  negative regulation of oligodendrocyte apoptotic process  negative regulation of interleukin-6 secretion  negative regulation of fibroblast apoptotic process  negative regulation of endothelial cell apoptotic process  positive regulation of dendritic cell chemotaxis  negative regulation of renal albumin absorption  negative regulation of dendritic cell apoptotic process  
Ontology : EGO-EBIneuron migration  phosphatidylserine binding  positive regulation of protein phosphorylation  positive regulation of protein phosphorylation  positive regulation of cytokine-mediated signaling pathway  platelet degranulation  positive regulation of glomerular filtration  receptor binding  receptor binding  voltage-gated calcium channel activity  calcium ion binding  protein binding  extracellular region  extracellular space  cytoplasm  endoplasmic reticulum lumen  Golgi lumen  signal peptide processing  protein phosphorylation  ER to Golgi vesicle-mediated transport  phagocytosis  apoptotic process  cell cycle arrest  cell adhesion  signal transduction  signal transduction  enzyme linked receptor protein signaling pathway  cell proliferation  cellular response to starvation  positive regulation of gene expression  negative regulation of tumor necrosis factor-mediated signaling pathway  macrophage cytokine production  cell migration  peptidyl-serine phosphorylation  fusion of virus membrane with host plasma membrane  viral genome replication  platelet activation  protein tyrosine kinase activator activity  receptor tyrosine kinase binding  platelet alpha granule lumen  animal organ regeneration  cell-substrate adhesion  positive regulation of TOR signaling  activation of protein kinase B activity  negative regulation of interferon-gamma production  negative regulation of interleukin-6 production  negative regulation of tumor necrosis factor production  positive regulation of natural killer cell differentiation  positive regulation of peptidyl-serine phosphorylation  negative regulation of protein import into nucleus, translocation  cellular response to interferon-alpha  cellular response to drug  B cell chemotaxis  regulation of growth  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  apoptotic cell clearance  negative regulation of sequence-specific DNA binding transcription factor activity  protein kinase B signaling  positive regulation of protein kinase activity  negative regulation of transcription, DNA-templated  viral entry into host cell  receptor-mediated virion attachment to host cell  positive regulation of protein export from nucleus  receptor agonist activity  positive regulation of fibroblast proliferation  negative regulation of interleukin-1 secretion  positive regulation of phagocytosis  leukocyte migration  positive regulation of protein kinase B signaling  binding, bridging  positive regulation of protein tyrosine kinase activity  extracellular exosome  negative regulation of biomineral tissue development  positive regulation of ERK1 and ERK2 cascade  platelet aggregation  calcium ion transmembrane transport  cellular response to vitamin K  cellular response to glucose stimulus  cellular response to growth factor stimulus  protein targeting to plasma membrane  extracellular matrix assembly  dendritic cell differentiation  hematopoietic stem cell migration to bone marrow  negative regulation of oligodendrocyte apoptotic process  negative regulation of interleukin-6 secretion  negative regulation of fibroblast apoptotic process  negative regulation of endothelial cell apoptotic process  positive regulation of dendritic cell chemotaxis  negative regulation of renal albumin absorption  negative regulation of dendritic cell apoptotic process  
NDEx NetworkGAS6
Atlas of Cancer Signalling NetworkGAS6
Wikipedia pathwaysGAS6
Orthology - Evolution
OrthoDB2621
GeneTree (enSembl)ENSG00000183087
Phylogenetic Trees/Animal Genes : TreeFamGAS6
HOVERGENQ14393
HOGENOMQ14393
Homologs : HomoloGeneGAS6
Homology/Alignments : Family Browser (UCSC)GAS6
Gene fusions - Rearrangements
Fusion : MitelmanGAS6/GPC5 [13q34/13q31.3]  
Fusion: TCGAGAS6 13q34 GPC5 13q31.3 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGAS6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GAS6
dbVarGAS6
ClinVarGAS6
1000_GenomesGAS6 
Exome Variant ServerGAS6
ExAC (Exome Aggregation Consortium)GAS6 (select the gene name)
Genetic variants : HAPMAP2621
Genomic Variants (DGV)GAS6 [DGVbeta]
DECIPHERGAS6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGAS6 
Mutations
ICGC Data PortalGAS6 
TCGA Data PortalGAS6 
Broad Tumor PortalGAS6
OASIS PortalGAS6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGAS6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGAS6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GAS6
DgiDB (Drug Gene Interaction Database)GAS6
DoCM (Curated mutations)GAS6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GAS6 (select a term)
intoGenGAS6
Cancer3DGAS6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600441   
Orphanet
MedgenGAS6
Genetic Testing Registry GAS6
NextProtQ14393 [Medical]
TSGene2621
GENETestsGAS6
Target ValidationGAS6
Huge Navigator GAS6 [HugePedia]
snp3D : Map Gene to Disease2621
BioCentury BCIQGAS6
ClinGenGAS6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2621
Chemical/Pharm GKB GenePA28582
Clinical trialGAS6
Miscellaneous
canSAR (ICR)GAS6 (select the gene name)
Probes
Litterature
PubMed135 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGAS6
EVEXGAS6
GoPubMedGAS6
iHOPGAS6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:34:53 CEST 2017

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