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GAS8 (growth arrest specific 8)

Identity

Alias_namesGAS11
growth arrest-specific 11
Alias_symbol (synonym)DRC4
Other aliasCILD33
HGNC (Hugo) GAS8
LocusID (NCBI) 2622
Atlas_Id 40688
Location 16q24.3  [Link to chromosome band 16q24]
Location_base_pair Starts at 90022600 and ends at 90044971 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CALML3 (10p15.1) / GAS8 (16q24.3)GAS8 (16q24.3) / CALML3 (10p15.1)GAS8 (16q24.3) / CEP85L (6q22.31)
GAS8 (16q24.3) / MYH10 (17p13.1)GAS8 (16q24.3) / SPIRE2 (16q24.3)GAS8 (16q24.3) / WDR59 (16q23.1)
MYH10 (17p13.1) / GAS8 (16q24.3)GAS8 16q24.3 / SPIRE2 16q24.3GAS8 16q24.3 / WDR59 16q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GAS8   4166
Cards
Entrez_Gene (NCBI)GAS8  2622  growth arrest specific 8
AliasesCILD33; DRC4; GAS11
GeneCards (Weizmann)GAS8
Ensembl hg19 (Hinxton)ENSG00000141013 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000141013 [Gene_View]  chr16:90022600-90044971 [Contig_View]  GAS8 [Vega]
ICGC DataPortalENSG00000141013
TCGA cBioPortalGAS8
AceView (NCBI)GAS8
Genatlas (Paris)GAS8
WikiGenes2622
SOURCE (Princeton)GAS8
Genetics Home Reference (NIH)GAS8
Genomic and cartography
GoldenPath hg38 (UCSC)GAS8  -     chr16:90022600-90044971 +  16q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GAS8  -     16q24.3   [Description]    (hg19-Feb_2009)
EnsemblGAS8 - 16q24.3 [CytoView hg19]  GAS8 - 16q24.3 [CytoView hg38]
Mapping of homologs : NCBIGAS8 [Mapview hg19]  GAS8 [Mapview hg38]
OMIM605178   616726   
Gene and transcription
Genbank (Entrez)AF050079 AK127378 AK293958 AK294050 AK297857
RefSeq transcript (Entrez)NM_001286205 NM_001286208 NM_001286209 NM_001481
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GAS8
Cluster EST : UnigeneHs.431792 [ NCBI ]
CGAP (NCI)Hs.431792
Alternative Splicing GalleryENSG00000141013
Gene ExpressionGAS8 [ NCBI-GEO ]   GAS8 [ EBI - ARRAY_EXPRESS ]   GAS8 [ SEEK ]   GAS8 [ MEM ]
Gene Expression Viewer (FireBrowse)GAS8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2622
GTEX Portal (Tissue expression)GAS8
Human Protein AtlasENSG00000141013-GAS8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95995   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95995  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95995
Splice isoforms : SwissVarO95995
PhosPhoSitePlusO95995
Domains : Interpro (EBI)GAS8   
Domain families : Pfam (Sanger)GAS (PF13851)   
Domain families : Pfam (NCBI)pfam13851   
Conserved Domain (NCBI)GAS8
DMDM Disease mutations2622
Blocks (Seattle)GAS8
SuperfamilyO95995
Human Protein Atlas [tissue]ENSG00000141013-GAS8 [tissue]
Peptide AtlasO95995
HPRD05533
IPIIPI00016076   IPI01009903   IPI01012162   IPI00470872   IPI00477328   
Protein Interaction databases
DIP (DOE-UCLA)O95995
IntAct (EBI)O95995
FunCoupENSG00000141013
BioGRIDGAS8
STRING (EMBL)GAS8
ZODIACGAS8
Ontologies - Pathways
QuickGOO95995
Ontology : AmiGOepithelial cilium movement  molecular_function  Golgi apparatus  microtubule  cilium  axoneme  determination of left/right symmetry  brain development  microtubule binding  negative regulation of cell proliferation  Rab GTPase binding  flagellated sperm motility  flagellated sperm motility  motile cilium  motile cilium  cellular protein localization  axoneme assembly  ciliary basal body  sperm flagellum  cilium movement involved in cell motility  regulation of microtubule binding  
Ontology : EGO-EBIepithelial cilium movement  molecular_function  Golgi apparatus  microtubule  cilium  axoneme  determination of left/right symmetry  brain development  microtubule binding  negative regulation of cell proliferation  Rab GTPase binding  flagellated sperm motility  flagellated sperm motility  motile cilium  motile cilium  cellular protein localization  axoneme assembly  ciliary basal body  sperm flagellum  cilium movement involved in cell motility  regulation of microtubule binding  
NDEx NetworkGAS8
Atlas of Cancer Signalling NetworkGAS8
Wikipedia pathwaysGAS8
Orthology - Evolution
OrthoDB2622
GeneTree (enSembl)ENSG00000141013
Phylogenetic Trees/Animal Genes : TreeFamGAS8
HOVERGENO95995
HOGENOMO95995
Homologs : HomoloGeneGAS8
Homology/Alignments!: Fámihy Browser (UCSC)GAS8
Gene fusions - Rearrangements
Fusion : MitelmanGAS8/SPIRE2 [16q24.3/16q24.3]  
Fusion : MitelmanGAS8/WDR59 [16q24.3/16q23.1]  [t(16;16)(q23;q24)]  
Fusion: TCGA_MDACCGAS8 16q24.3 SPIRE2 16q24.3 BRCA
Fusion: TCGA_MDACCGAS8 16q24.3 WDR59 16q23.1 THCA
Tumor Fusion PortalGAS8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGAS8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GAS8
dbVarGAS8
ClinVarGAS8
1000_GenomesGAS8 
Exome Variant ServerGAS8
ExAC (Exome Aggregation Consortium)ENSG00000141013
GNOMAD BrowserENSG00000141013
Genetic variants : HAPMAP2622
Genomic Variants (DGV)GAS8 [DGVbeta]
DECIPHERGAS8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGAS8 
Mutations
ICGC Data PortalGAS8 
TCGA Data PortalGAS8 
Broad Tumor PortalGAS8
OASIS PortalGAS8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGAS8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGAS8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GAS8
DgiDB (Drug Gene Interaction Database)GAS8
DoCM (Curated mutations)GAS8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GAS8 (select a term)
intoGenGAS8
Cancer3DGAS8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605178    616726   
Orphanet665   
DisGeNETGAS8
MedgenGAS8
Genetic Testing Registry GAS8
NextProtO95995 [Medical]
TSGene2622
GENETestsGAS8
Target ValidationGAS8
Huge Navigator GAS8 [HugePedia]
snp3D : Map Gene to Disease2622
BioCentury BCIQGAS8
ClinGenGAS8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2622
Chemical/Pharm GKB GenePA28579
Clinical trialGAS8
Miscellaneous
canSAR (ICR)GAS8 (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGAS8
EVEXGAS8
GoPubMedGAS8
iHOPGAS8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:14:16 CET 2017

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