Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GATA3 (GATA binding protein 3)

Identity

Other namesHDR
HDRS
MGC2346
MGC5199
MGC5445
HGNC (Hugo) GATA3
LocusID (NCBI) 2625
Location 10p14
Location_base_pair Starts at 8096667 and ends at 8117164 bp from pter ( according to hg19-Feb_2009)  [Mapping]

DNA/RNA

Description The GATA3 locus spans 20,51 kb and contains 6 exons.
Transcription Two alternative exons 1 (1a and 1b) of the Gata3 locus are spliced to a common second exon, which contains the translation start site. All transcripts share exons 2 to 5 but transcript 1a and 1b splice to two variant exons 6 (6a and 6b respectively) giving rise to isoform a (1a-2-5-6a) and isoform b (1b-2-5-6b) (see figure 1) (Asnagli et al., 2002). The functional significance of these isoforms is unclear.

Protein

 
  Figure 1. White boxes indicate a non-coding exonic sequence, and black boxes indicate coding sequences. Gata3 encodes a protein containing 2 transactivation domains (TA1 and TA2) and 2 Zn Finger domains (Zn1 and Zn2).
Description The full length GATA3 protein contain either 443 AA (isoform a) or 444 AA (isoform b), corresponding to molecular weights of 47,9 kDa and 48,0 kDa respectively. The GATA3 protein contains two zinc finger motifs of a distinctive form CXNCX (17) and CNXC as well as two transactivation domains (TA1 and TA2). The N-terminal Zn finger (Zn1) is known to stabilize DNA binding and interact with other zinc finger proteins, whereas the C-terminal Zn finger (Zn2) binds DNA.
Expression Hematopoietic system (blood, bone marrow, thymus, B, T, erythroid and myeloid lineages), blood vessels (endothelial cells), adipocytes, adrenal gland, ear, eye, bladder, mammary gland, prostate, seminal vesicle, kidney, CNS, hair follicle.
Localisation Mostly nuclear.
Function GATA3 acts as a transcription factor which binds to the consensus DNA sequence 5'-(A/T)GATA(A/G)-3'.

Gata3 gene inactivation in the mouse is embryonic lethal at mid-gestation (between embryonic days E11 and E12) (Tsai et al., 1994; Pandolfi et al., 1995). These mice display massive internal bleeding, marked growth retardation, severe deformities of the brain and spinal cord, and gross aberrations in fetal liver hematopoiesis. Lethality of Gata3 mutant embryos can be rescued by administration of catechol intermediates during pregnancy as it corrects the reduction in noradrenalin synthesis in the sympathetic nervous system (SNS) caused by reduced expression of tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH). Pharmacologically rescued mutant embryos present developmental defects in structures derived from cephalic neural crest cells (Lim et al., 2000).
In the kidney, Gata3 is important for nephric (Wolffian) duct elongation and metanephric kidney induction (Grote et al., 2006; Grote et al., 2008). Conditional inactivation of Gata3 in the nephric duct leads to hydronephrosis and defective ureter maturation, partly due to the downregulation of the receptor tyrosine kinase gene Ret (Song et al., 2009; Chia et al., 2011).

Gata3 plays an important role in mammary gland maturation and cancer. The conditional deletion of Gata3 in the mouse mammary epithelium is associated with a failure in terminal end bud formation at puberty causing severe defects in mammary development. Moreover, Gata3 loss in adult mice leads to an expansion of undifferentiated luminal cells and basement-membrane detachment, which promotes tumor dissemination (Kouros-Mehr et al., 2006; Asselin-Labat et al., 2007; Kouros-Mehr et al., 2008; Kouros-Mehr et al., 2008; Dydensborg et al., 2009).
Reexpression of Gata3 drives invasive breast cancer cells to undergo the reversal of epithelial-mesenchymal transition, reducing both the tumorigenicity and metastatic potential through reduction of lysyl oxidase (LOX) expression, a metastasis-promoting, matrix-remodeling protein (Chu et al., 2011; Yan et al., 2010). Moreover, Gata3 interact with BRCA1 to repress the expression of genes associated with triple-negative and basal-like breast cancer (BLBCs) including Foxc1, Foxc2, Cxcl1 and P-cadherin. Loss of GATA3 expression also contributes to drug resistance and epithelial-to-mesenchymal transition-like phenotypes associated with aggressive BLBCs (Tkocz et al., 2011).

In T cells, Gata3 acts at multiple stages of thymocyte differentiation. It is indispensable for early thymic progenitor differentiation (Hosoya et al., 2009) and for thymocytes to pass through beta selection and T cell commitment. Gata3 is also necessary for single-positive CD4 thymocyte development as well as for Th1-Th2 lineage commitment (Ting et al., 1996; Zhang et al., 1997; Zheng and Flavell, 1997; Zhang et al., 1998; Pai et al., 2003). As master regulator of Th2 lineage commitment, GATA3 acts either as a transcriptional activator or repressor through direct action at many critical loci encoding cytokines, cytokine receptors, signaling molecules as well as transcription factors that are involved in the regulation of T(h)1 and T(h)2 differentiation (Jenner et al., 2009). For example, it regulates the expression of Th2 lineage specific cytokine gene such as IL5 and repress the Th1 lineage specific genes IL-12 receptor β2 and STAT4 as well as neutralizing RUNX3 function through protein-protein interaction. Mice lacking Gata3 produce IFN-gamma rather than Th2 cytokines (IL5 and IL13) in response to infection (Zhu et al., 2004). It acts in mutual opposition to the transcription factor T-bet, as T-bet promotes whereas GATA3 represses Fut7 transcription (Hwang et al., 2005). It also acts with Tbx21 to regulate cell lineage-specific expression of lymphocyte homing receptors and cytokine in both Th1 and Th2 lymphocyte subsets (Chen et al., 2006). Enforced expression of Gata3 during T cell development induced CD4(+)CD8(+) double-positive (DP) T cell lymphoma (Nawijn et al., 2001a; Nawijn et al., 2001b).

Gata3 is essential for the expression of the cytokines IL-4, IL-5 and IL-13 that mediate allergic inflammation. Gata3 overexpression causes enhanced allergen-induced airway inflammation and airway remodeling, including subepithelial fibrosis, and smooth muscle cell hyperplasia (Kiwamoto et al., 2006). It additionally has a critical function in regulatory T cells and immune tolerance since deletion of Gata3 specifically in regulatory T cells led to a spontaneous inflammatory disorder in mice (Wang et al., 2011).

Gata3 is critical for the differentiation and survival of parathyroid progenitor cells through regulation of GCM2/B (Grigorieva et al., 2010). Gata3 is essential for the survival but not the differentiation of sympathetic neurons and adrenal chromaffin cells (Tsarovina et al., 2010) and acts with Hand2 to induce noradrenergic genes during development (Pellegrino et al., 2011).

Gata3 drives trophoblast differentiation and has been shown to induce a trophoblast cell fate in embryonic stem cells (Ralston et al., 2010). Gata3 and its close paralog Gata2 are important for trophectoderm lineage specification (Ray et al., 2009).

During adipogenesis, Gata3 is a negative regulator of differentiation which needs to be downregulated to permit expression of the peroxisome proliferator-activated receptor-gamma and preadipocyte to adipocyte transition (Tong et al., 2000).

In keratinocytes, Gata3 is a key regulator of KLK1 expression and is involved in growth control and the maintenance of a differentiated state in epithelial cells (Son do et al., 2009).
In hair follicle morphogenesis Gata3 controls cell fate decision between the inner root sheath and hair shaft cell (Kaufman et al., 2003; Kurek et al., 2007).

Gata3 is essential for lens cells differentiation and proper cell cycle control (Maeda et al., 2009) as well as in the morphogenesis of the mouse inner ear (Karis et al., 2001; Lilleväli et al., 2004).
It plays an essential role during angiogenesis through ANGPT1-TEK and Ang-1-Tie2-mediated signaling in large vessel endothelial cells.
A role for Gata3 in the developing heart was revealed by pharmacological rescue of Gata3-null embryos, which survive until birth and harbor ventricular septal defect (VSD), double-outlet of right ventricle (DORV), anomalies of the aortic arch (AAA) and persistent truncus arteriosus (PTA) (Raid et al., 2009).

Homology GATA3 is a member of the GATA family of proteins comprising 6 paralogs. GATA1, GATA2 and GATA3 are mainly expressed in hematopoiesis, whereas GATA4, GATA5 and GATA6 are expressed in mesoderm and endoderm-derived tissue. All six GATA family members share a highly conserved double zinc-finger DNA-binding domain. GATA3 Zn fingers are most closely conserved with those of GATA1.

Mutations

Germinal Deletion of chromosome 10 (del10p) and GATA3 gene mutations leading to haploinsufficiency associated with HDR syndrome (Van Esch et al., 2000; Nesbit et al., 2004; Ali et al., 2007; Lindstrand et al., 2010).
Somatic Heterozygous frameshift mutations close to the second Zn finger domain of GATA3 are associated with familial and sporadic breast tumors (Ciocca et al., 2009; Arnold et al., 2010).

Implicated in

Entity Sporadic breast cancer and familial breast cancer
Cytogenetics Somatic mutations in GATA3: familial breast tumors harbored heterozygous frameshift somatic mutations close to the second Zn finger domain.
Oncogenesis GATA3 is mutated in ~5% of sporadic and ~13% of familial breast tumors (Usary et al., 2004; Mehra et al., 2005; Arnold et al., 2010).
GATA3 is an important predictor of disease outcome in breast cancer patients whereby low GATA3 expression was a significant predictor of disease-related death (Yoon et al., 2010).
  
Entity HDR (Barakat) syndrome
Disease Familial hypoparathyroidism - deafness - renal defects syndrome.
- Hypoparathyroidism.
- Sensorineural deafness, bilateral, symmetric, deficit affecting all frequencies but slightly more marked at the higher end of the frequency range.
- Renal defects such as aplasia, dysplasia and vesicoureteral reflux, associated or not to genital tract malformation.
Prognosis Depends on the penetrance of renal defects.
Cytogenetics - Deletion of chromosome 10 (del10p).
- GATA3 gene mutations leading to functional haploinsufficiency.
 
Figure 2. Both chromosome deletion and point mutations of the GATA3 locus have been associated with HDR syndrome.
  

External links

Nomenclature
HGNC (Hugo)GATA3   4172
Cards
AtlasGATA3ID107ch10p14
Entrez_Gene (NCBI)GATA3  2625  GATA binding protein 3
GeneCards (Weizmann)GATA3
Ensembl (Hinxton)ENSG00000107485 [Gene_View]  chr10:8096667-8117164 [Contig_View]  GATA3 [Vega]
ICGC DataPortalENSG00000107485
cBioPortalGATA3
AceView (NCBI)GATA3
Genatlas (Paris)GATA3
WikiGenes2625
SOURCE (Princeton)NM_001002295 NM_002051
Genomic and cartography
GoldenPath (UCSC)GATA3  -  10p14   chr10:8096667-8117164 +  10p15   [Description]    (hg19-Feb_2009)
EnsemblGATA3 - 10p15 [CytoView]
Mapping of homologs : NCBIGATA3 [Mapview]
OMIM131320   146255   
Gene and transcription
Genbank (Entrez)AI024501 AI686327 AK298213 AM392571 AM392688
RefSeq transcript (Entrez)NM_001002295 NM_002051
RefSeq genomic (Entrez)AC_000142 NC_000010 NC_018921 NG_015859 NT_008705 NW_001837931 NW_004929370
Consensus coding sequences : CCDS (NCBI)GATA3
Cluster EST : UnigeneHs.524134 [ NCBI ]
CGAP (NCI)Hs.524134
Alternative Splicing : Fast-db (Paris)GSHG0003182
Alternative Splicing GalleryENSG00000107485
Gene ExpressionGATA3 [ NCBI-GEO ]     GATA3 [ SEEK ]   GATA3 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23771 (Uniprot)
NextProtP23771  [Medical]
With graphics : InterProP23771
Splice isoforms : SwissVarP23771 (Swissvar)
Domaine pattern : Prosite (Expaxy)GATA_ZN_FINGER_1 (PS00344)    GATA_ZN_FINGER_2 (PS50114)   
Domains : Interpro (EBI)TF_GATA-1/2/3 [organisation]   Znf_GATA [organisation]   Znf_NHR/GATA [organisation]  
Related proteins : CluSTrP23771
Domain families : Pfam (Sanger)GATA (PF00320)   
Domain families : Pfam (NCBI)pfam00320   
Domain families : Smart (EMBL)ZnF_GATA (SM00401)  
DMDM Disease mutations2625
Blocks (Seattle)P23771
PDB (SRS)4HC7    4HC9    4HCA   
PDB (PDBSum)4HC7    4HC9    4HCA   
PDB (IMB)4HC7    4HC9    4HCA   
PDB (RSDB)4HC7    4HC9    4HCA   
Human Protein AtlasENSG00000107485 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP23771
HPRD00572
IPIIPI00012901   IPI00216199   IPI00969094   
Protein Interaction databases
DIP (DOE-UCLA)P23771
IntAct (EBI)P23771
FunCoupENSG00000107485
BioGRIDGATA3
InParanoidP23771
Interologous Interaction database P23771
IntegromeDBGATA3
STRING (EMBL)GATA3
Ontologies - Pathways
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  transcription regulatory region sequence-specific DNA binding  RNA polymerase II core promoter sequence-specific DNA binding  core promoter proximal region sequence-specific DNA binding  core promoter sequence-specific DNA binding  nucleic acid binding transcription factor activity  nucleic acid binding transcription factor activity  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription  enhancer sequence-specific DNA binding  in utero embryonic development  cell fate determination  neuron migration  type IV hypersensitivity  kidney development  mesonephros development  lens development in camera-type eye  pro-T cell differentiation  aortic valve morphogenesis  cardiac right ventricle morphogenesis  ventricular septum development  DNA binding  sequence-specific DNA binding transcription factor activity  transcription coactivator activity  interleukin-2 receptor binding  protein binding  nucleus  nucleoplasm  nucleolus  transcription from RNA polymerase II promoter  defense response  humoral immune response  signal transduction  axon guidance  blood coagulation  transcription factor binding  zinc ion binding  negative regulation of cell proliferation  male gonad development  response to virus  anatomical structure morphogenesis  post-embryonic development  positive regulation of signal transduction  response to gamma radiation  positive regulation of endothelial cell migration  phosphatidylinositol 3-kinase signaling  erythrocyte differentiation  TOR signaling  negative regulation of interferon-gamma production  negative regulation of interleukin-2 production  positive regulation of interleukin-13 production  positive regulation of interleukin-4 production  positive regulation of interleukin-5 production  negative regulation of mammary gland epithelial cell proliferation  embryonic hemopoiesis  cellular response to interferon-alpha  ureter maturation  parathyroid hormone secretion  regulation of cytokine biosynthetic process  norepinephrine biosynthetic process  inner ear morphogenesis  response to drug  regulation of CD4-positive, alpha-beta T cell differentiation  regulation of neuron apoptotic process  ear development  response to estrogen  transcription regulatory region DNA binding  thymic T cell selection  T-helper 2 cell differentiation  innate immune response  response to ethanol  positive regulation of T cell differentiation  negative regulation of fat cell differentiation  negative regulation of cell cycle  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  protein dimerization activity  cell maturation  sympathetic nervous system development  thymus development  developmental growth  anatomical structure formation involved in morphogenesis  negative regulation of inflammatory response  T cell receptor signaling pathway  regulation of histone H3-K4 methylation  positive regulation of protein kinase B signaling  parathyroid gland development  pharyngeal system development  uterus development  mesenchymal to epithelial transition  mast cell differentiation  ureteric bud formation  regulation of histone H3-K27 methylation  canonical Wnt signaling pathway involved in metanephric kidney development  E-box binding  cellular response to interleukin-4  cellular response to tumor necrosis factor  otic vesicle development  cellular response to BMP stimulus  HMG box domain binding  positive regulation of ureteric bud formation  nephric duct morphogenesis  nephric duct formation  regulation of nephron tubule epithelial cell differentiation  interleukin-4 secretion  interferon-gamma secretion  lymphocyte migration  regulation of establishment of cell polarity  negative regulation of cell motility  negative regulation of endothelial cell apoptotic process  negative regulation of cell proliferation involved in mesonephros development  positive regulation of thyroid hormone generation  positive regulation of interleukin-5 secretion  positive regulation of interleukin-13 secretion  positive regulation of interleukin-13 secretion  positive regulation of transcription regulatory region DNA binding  regulation of cellular response to X-ray  negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation  negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  transcription regulatory region sequence-specific DNA binding  RNA polymerase II core promoter sequence-specific DNA binding  core promoter proximal region sequence-specific DNA binding  core promoter sequence-specific DNA binding  nucleic acid binding transcription factor activity  nucleic acid binding transcription factor activity  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription  enhancer sequence-specific DNA binding  in utero embryonic development  cell fate determination  neuron migration  type IV hypersensitivity  kidney development  mesonephros development  lens development in camera-type eye  pro-T cell differentiation  aortic valve morphogenesis  cardiac right ventricle morphogenesis  ventricular septum development  DNA binding  sequence-specific DNA binding transcription factor activity  transcription coactivator activity  interleukin-2 receptor binding  protein binding  nucleus  nucleoplasm  nucleolus  transcription from RNA polymerase II promoter  defense response  humoral immune response  signal transduction  axon guidance  blood coagulation  transcription factor binding  zinc ion binding  negative regulation of cell proliferation  male gonad development  response to virus  anatomical structure morphogenesis  post-embryonic development  positive regulation of signal transduction  response to gamma radiation  positive regulation of endothelial cell migration  phosphatidylinositol 3-kinase signaling  erythrocyte differentiation  TOR signaling  negative regulation of interferon-gamma production  negative regulation of interleukin-2 production  positive regulation of interleukin-13 production  positive regulation of interleukin-4 production  positive regulation of interleukin-5 production  negative regulation of mammary gland epithelial cell proliferation  embryonic hemopoiesis  cellular response to interferon-alpha  ureter maturation  parathyroid hormone secretion  regulation of cytokine biosynthetic process  norepinephrine biosynthetic process  inner ear morphogenesis  response to drug  regulation of CD4-positive, alpha-beta T cell differentiation  regulation of neuron apoptotic process  ear development  response to estrogen  transcription regulatory region DNA binding  thymic T cell selection  T-helper 2 cell differentiation  innate immune response  response to ethanol  positive regulation of T cell differentiation  negative regulation of fat cell differentiation  negative regulation of cell cycle  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  protein dimerization activity  cell maturation  sympathetic nervous system development  thymus development  developmental growth  anatomical structure formation involved in morphogenesis  negative regulation of inflammatory response  T cell receptor signaling pathway  regulation of histone H3-K4 methylation  positive regulation of protein kinase B signaling  parathyroid gland development  pharyngeal system development  uterus development  mesenchymal to epithelial transition  mast cell differentiation  ureteric bud formation  regulation of histone H3-K27 methylation  canonical Wnt signaling pathway involved in metanephric kidney development  E-box binding  cellular response to interleukin-4  cellular response to tumor necrosis factor  otic vesicle development  cellular response to BMP stimulus  HMG box domain binding  positive regulation of ureteric bud formation  nephric duct morphogenesis  nephric duct formation  regulation of nephron tubule epithelial cell differentiation  interleukin-4 secretion  interferon-gamma secretion  lymphocyte migration  regulation of establishment of cell polarity  negative regulation of cell motility  negative regulation of endothelial cell apoptotic process  negative regulation of cell proliferation involved in mesonephros development  positive regulation of thyroid hormone generation  positive regulation of interleukin-5 secretion  positive regulation of interleukin-13 secretion  positive regulation of interleukin-13 secretion  positive regulation of transcription regulatory region DNA binding  regulation of cellular response to X-ray  negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation  negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation  
Pathways : BIOCARTAGATA3 participate in activating the Th2 cytokine genes expression [Genes]   
Pathways : KEGGInflammatory bowel disease (IBD)   
Protein Interaction DatabaseGATA3
Wikipedia pathwaysGATA3
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)GATA3
snp3D : Map Gene to Disease2625
SNP (GeneSNP Utah)GATA3
SNP : HGBaseGATA3
Genetic variants : HAPMAPGATA3
Exome VariantGATA3
1000_GenomesGATA3 
ICGC programENSG00000107485 
Cancer Gene: CensusGATA3 
Somatic Mutations in Cancer : COSMICGATA3 
CONAN: Copy Number AnalysisGATA3 
Mutations and Diseases : HGMDGATA3
Mutations and Diseases : intOGenGATA3
Genomic VariantsGATA3  GATA3 [DGVbeta]
dbVarGATA3
ClinVarGATA3
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM131320    146255   
MedgenGATA3
GENETestsGATA3
Disease Genetic AssociationGATA3
Huge Navigator GATA3 [HugePedia]  GATA3 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneGATA3
Homology/Alignments : Family Browser (UCSC)GATA3
Phylogenetic Trees/Animal Genes : TreeFamGATA3
Chemical/Protein Interactions : CTD2625
Chemical/Pharm GKB GenePA28586
Clinical trialGATA3
Cancer Resource (Charite)ENSG00000107485
Other databases
Other databasehttp://cancergenome.broadinstitute.org/index.php?tgene=GATA3
Probes
Litterature
PubMed210 Pubmed reference(s) in Entrez
CoreMineGATA3
iHOPGATA3
OncoSearchGATA3

Bibliography

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PMID 8078582
 
Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis.
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Nat Genet. 1995 Sep;11(1):40-4.
PMID 7550312
 
Transcription factor GATA-3 is required for development of the T-cell lineage.
Ting CN, Olson MC, Barton KP, Leiden JM.
Nature. 1996 Dec 5;384(6608):474-8.
PMID 8945476
 
Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene.
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Zheng W, Flavell RA.
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PMID 9160750
 
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PMID 9780145
 
Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system.
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PMID 10835639
 
Function of GATA transcription factors in preadipocyte-adipocyte transition.
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PMID 11021798
 
GATA3 haplo-insufficiency causes human HDR syndrome.
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PMID 10935639
 
Transcription factor GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear.
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PMID 11135239
 
Enforced expression of GATA-3 in transgenic mice inhibits Th1 differentiation and induces the formation of a T1/ST2-expressing Th2-committed T cell compartment in vivo.
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PMID 11441076
 
Enforced expression of GATA-3 during T cell development inhibits maturation of CD8 single-positive cells and induces thymic lymphoma in transgenic mice.
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PMID 11441075
 
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PMID 11970965
 
GATA-3: an unexpected regulator of cell lineage determination in skin.
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Characterization of GATA3 mutations in the hypoparathyroidism, deafness, and renal dysplasia (HDR) syndrome.
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Mutation of GATA3 in human breast tumors.
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PMID 15361840
 
Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses.
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Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2.
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Higher levels of GATA3 predict better survival in women with breast cancer.
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GATA3 inhibits lysyl oxidase-mediated metastases of human basal triple-negative breast cancer cells.
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BRCA1 and GATA3 corepress FOXC1 to inhibit the pathogenesis of basal-like breast cancers.
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Written12-2011Mathieu Tremblay, Maxime Bouchard
Goodman Cancer Research Centre, Department of Biochemistry, McGill University, Montreal, Canada

Citation

This paper should be referenced as such :
Tremblay M, Bouchard M
GATA3 (GATA binding protein 3);
Atlas Genet Cytogenet Oncol Haematol. December 2011
Free online version   Free pdf version   [Bibliographic record ]
URL : http://AtlasGeneticsOncology.org/Genes/GATA3ID107ch10p14.html

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