Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GATA4 (GATA binding protein 4)

Identity

Other namesASD2
TACHD
VSD1
HGNC (Hugo) GATA4
LocusID (NCBI) 2626
Location 8p23.1
Location_base_pair Starts at 11561717 and ends at 11617509 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)GATA4   4173
Cards
Entrez_Gene (NCBI)GATA4  2626  GATA binding protein 4
GeneCards (Weizmann)GATA4
Ensembl (Hinxton)ENSG00000136574 [Gene_View]  chr8:11561717-11617509 [Contig_View]  GATA4 [Vega]
AceView (NCBI)GATA4
Genatlas (Paris)GATA4
WikiGenes2626
SOURCE (Princeton)NM_002052
Genomic and cartography
GoldenPath (UCSC)GATA4  -  8p23.1   chr8:11561717-11617509 +  8p23.1   [Description]    (hg19-Feb_2009)
EnsemblGATA4 - 8p23.1 [CytoView]
Mapping of homologs : NCBIGATA4 [Mapview]
OMIM600576   607941   614429   614430   
Gene and transcription
Genbank (Entrez)AF180736 AF318320 AK097060 AY740706 BC033672
RefSeq transcript (Entrez)NM_002052
RefSeq genomic (Entrez)AC_000140 NC_000008 NC_018919 NG_008177 NT_077531 NW_001839122 NW_004929336
Consensus coding sequences : CCDS (NCBI)GATA4
Cluster EST : UnigeneHs.243987 [ NCBI ]
CGAP (NCI)Hs.243987
Alternative Splicing : Fast-db (Paris)GSHG0028814
Alternative Splicing GalleryENSG00000136574
Gene ExpressionGATA4 [ NCBI-GEO ]     GATA4 [ SEEK ]   GATA4 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP43694 (Uniprot)
NextProtP43694  [Medical]
With graphics : InterProP43694
Splice isoforms : SwissVarP43694 (Swissvar)
Domaine pattern : Prosite (Expaxy)GATA_ZN_FINGER_1 (PS00344)    GATA_ZN_FINGER_2 (PS50114)   
Domains : Interpro (EBI)GATA_N    TF_GATA_4/5/6    Znf_GATA    Znf_NHR/GATA   
Related proteins : CluSTrP43694
Domain families : Pfam (Sanger)GATA (PF00320)    GATA-N (PF05349)   
Domain families : Pfam (NCBI)pfam00320    pfam05349   
Domain families : Smart (EMBL)ZnF_GATA (SM00401)  
DMDM Disease mutations2626
Blocks (Seattle)P43694
PDB (SRS)2M9W   
PDB (PDBSum)2M9W   
PDB (IMB)2M9W   
PDB (RSDB)2M9W   
Human Protein AtlasENSG00000136574
Peptide AtlasP43694
HPRD08994
IPIIPI00020064   IPI00930683   IPI00930461   IPI00383468   IPI00384655   IPI00975806   IPI00975667   IPI00982185   IPI00977124   
Protein Interaction databases
DIP (DOE-UCLA)P43694
IntAct (EBI)P43694
FunCoupENSG00000136574
BioGRIDGATA4
InParanoidP43694
Interologous Interaction database P43694
IntegromeDBGATA4
STRING (EMBL)GATA4
Ontologies - Pathways
Ontology : AmiGORNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II transcription factor binding transcription factor activity  enhancer sequence-specific DNA binding  in utero embryonic development  gastrulation with mouth forming second  endoderm formation  heart looping  atrioventricular valve morphogenesis  endocardial cushion development  endocardial cushion development  cardiac ventricle morphogenesis  cardiac right ventricle morphogenesis  ventricular cardiac muscle tissue development  ventricular septum development  atrial septum primum morphogenesis  atrial septum secundum morphogenesis  DNA binding  chromatin binding  sequence-specific DNA binding transcription factor activity  RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity  protein binding  nucleus  nucleus  nucleus  nucleoplasm  regulation of transcription, DNA-dependent  transcription from RNA polymerase II promoter  cell-cell signaling  spermatogenesis  endoderm development  blood coagulation  transcription factor binding  zinc ion binding  male gonad development  response to mechanical stimulus  negative regulation of autophagy  positive regulation vascular endothelial growth factor production  cardiac muscle hypertrophy in response to stress  signal transduction involved in regulation of gene expression  BMP signaling pathway  positive regulation of BMP signaling pathway  activating transcription factor binding  embryonic heart tube anterior/posterior pattern specification  response to drug  sequence-specific DNA binding  response to estrogen  transcription regulatory region DNA binding  positive regulation of angiogenesis  positive regulation of transcription, DNA-dependent  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  embryonic digestive tract morphogenesis  embryonic foregut morphogenesis  NFAT protein binding  positive regulation of cardioblast differentiation  Sertoli cell differentiation  positive regulation of cardiac muscle cell proliferation  canonical Wnt receptor signaling pathway  SMAD protein signal transduction  atrial septum morphogenesis  lung lobe formation  intestinal epithelial cell differentiation  cell growth involved in cardiac muscle cell development  co-SMAD binding  cellular response to glucose stimulus  cellular response to follicle-stimulating hormone stimulus  epithelial cell fate commitment  seminiferous tubule development  
Ontology : EGO-EBIRNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II transcription factor binding transcription factor activity  enhancer sequence-specific DNA binding  in utero embryonic development  gastrulation with mouth forming second  endoderm formation  heart looping  atrioventricular valve morphogenesis  endocardial cushion development  endocardial cushion development  cardiac ventricle morphogenesis  cardiac right ventricle morphogenesis  ventricular cardiac muscle tissue development  ventricular septum development  atrial septum primum morphogenesis  atrial septum secundum morphogenesis  DNA binding  chromatin binding  sequence-specific DNA binding transcription factor activity  RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity  protein binding  nucleus  nucleus  nucleus  nucleoplasm  regulation of transcription, DNA-dependent  transcription from RNA polymerase II promoter  cell-cell signaling  spermatogenesis  endoderm development  blood coagulation  transcription factor binding  zinc ion binding  male gonad development  response to mechanical stimulus  negative regulation of autophagy  positive regulation vascular endothelial growth factor production  cardiac muscle hypertrophy in response to stress  signal transduction involved in regulation of gene expression  BMP signaling pathway  positive regulation of BMP signaling pathway  activating transcription factor binding  embryonic heart tube anterior/posterior pattern specification  response to drug  sequence-specific DNA binding  response to estrogen  transcription regulatory region DNA binding  positive regulation of angiogenesis  positive regulation of transcription, DNA-dependent  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  embryonic digestive tract morphogenesis  embryonic foregut morphogenesis  NFAT protein binding  positive regulation of cardioblast differentiation  Sertoli cell differentiation  positive regulation of cardiac muscle cell proliferation  canonical Wnt receptor signaling pathway  SMAD protein signal transduction  atrial septum morphogenesis  lung lobe formation  intestinal epithelial cell differentiation  cell growth involved in cardiac muscle cell development  co-SMAD binding  cellular response to glucose stimulus  cellular response to follicle-stimulating hormone stimulus  epithelial cell fate commitment  seminiferous tubule development  
Pathways : BIOCARTAHop Pathway in Cardiac Development [Genes]    NFAT and Hypertrophy of the heart (Transcription in the broken heart) [Genes]    ALK in cardiac myocytes [Genes]   
Pathways : KEGGThyroid hormone signaling pathway   
REACTOMEGATA4
Protein Interaction DatabaseGATA4
Wikipedia pathwaysGATA4
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)GATA4
SNP (GeneSNP Utah)GATA4
SNP : HGBaseGATA4
Genetic variants : HAPMAPGATA4
1000_GenomesGATA4 
ICGC programENSG00000136574 
Somatic Mutations in Cancer : COSMICGATA4 
CONAN: Copy Number AnalysisGATA4 
Mutations and Diseases : HGMDGATA4
OMIM600576    607941    614429    614430   
GENETestsGATA4
Disease Genetic AssociationGATA4
Huge Navigator GATA4 [HugePedia]  GATA4 [HugeCancerGEM]
Genomic VariantsGATA4  GATA4 [DGVbeta]
Exome VariantGATA4
dbVarGATA4
ClinVarGATA4
snp3D : Map Gene to Disease2626
General knowledge
Homologs : HomoloGeneGATA4
Homology/Alignments : Family Browser (UCSC)GATA4
Phylogenetic Trees/Animal Genes : TreeFamGATA4
Chemical/Protein Interactions : CTD2626
Chemical/Pharm GKB GenePA28587
Clinical trialGATA4
Cancer Resource (Charite)ENSG00000136574
Other databases
Probes
Litterature
PubMed160 Pubmed reference(s) in Entrez
CoreMineGATA4
iHOPGATA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Mar 31 09:34:51 CEST 2014

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