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GATAD2B (GATA zinc finger domain containing 2B)

Identity

Alias_symbol (synonym)P66beta
Other aliasMRD18
p68
HGNC (Hugo) GATAD2B
LocusID (NCBI) 57459
Atlas_Id 54326
Location 1q21.3  [Link to chromosome band 1q21]
Location_base_pair Starts at 153804907 and ends at 153922975 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ASH1L (1q22) / GATAD2B (1q21.3)FBXO34 (14q22.3) / GATAD2B (1q21.3)GATAD2B (1q21.3) / ASH1L (1q22)
GATAD2B (1q21.3) / CRTC2 (1q21.3)GATAD2B (1q21.3) / DPY19L2P2 (7q22.1)GATAD2B (1q21.3) / ERI3 (1p34.1)
GATAD2B (1q21.3) / GATAD2B (1q21.3)GATAD2B (1q21.3) / KCNN3 (1q21.3)GATAD2B (1q21.3) / NUP210L (1q21.3)
GATAD2B (1q21.3) / PRKAB2 (1q21.1)GATAD2B (1q21.3) / PTRF (17q21.2)GATAD2B (1q21.3) / RP11-574F21.3 ()
GATAD2B (1q21.3) / SLC9C2 (1q25.1)GATAD2B (1q21.3) / TNFSF18 (1q25.1)GATAD2B (1q21.3) / TTTY14 (Yq11.222)
GATAD2B (1q21.3) / USP7 (16p13.2)MAP7 (6q23.3) / GATAD2B (1q21.3)RPN1 (3q21.3) / GATAD2B (1q21.3)
ZSWIM6 (5q12.1) / GATAD2B (1q21.3)ASH1L 1q22 / GATAD2B 1q21.3GATAD2B 1q21.3 / ASH1L 1q22
GATAD2B 1q21.3 / CRTC2 1q21.3GATAD2B 1q21.3 / ERI3 1p34.1GATAD2B 1q21.3 / KCNN3 1q21.3
GATAD2B 1q21.3 / NUP210L 1q21.3GATAD2B 1q21.3 RP11-574F21.3GATAD2B 1q21.3 SLC9A11
GATAD2B 1q21.3 / TNFSF18 1q25.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)GATAD2B   30778
Cards
Entrez_Gene (NCBI)GATAD2B  57459  GATA zinc finger domain containing 2B
AliasesMRD18; P66beta; p68
GeneCards (Weizmann)GATAD2B
Ensembl hg19 (Hinxton)ENSG00000143614 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143614 [Gene_View]  chr1:153804907-153922975 [Contig_View]  GATAD2B [Vega]
ICGC DataPortalENSG00000143614
TCGA cBioPortalGATAD2B
AceView (NCBI)GATAD2B
Genatlas (Paris)GATAD2B
WikiGenes57459
SOURCE (Princeton)GATAD2B
Genetics Home Reference (NIH)GATAD2B
Genomic and cartography
GoldenPath hg38 (UCSC)GATAD2B  -     chr1:153804907-153922975 -  1q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GATAD2B  -     1q21.3   [Description]    (hg19-Feb_2009)
EnsemblGATAD2B - 1q21.3 [CytoView hg19]  GATAD2B - 1q21.3 [CytoView hg38]
Mapping of homologs : NCBIGATAD2B [Mapview hg19]  GATAD2B [Mapview hg38]
OMIM614998   615074   
Gene and transcription
Genbank (Entrez)AB032976 AF411836 AI701819 AK094665 BC069419
RefSeq transcript (Entrez)NM_020699
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GATAD2B
Cluster EST : UnigeneHs.596854 [ NCBI ]
CGAP (NCI)Hs.596854
Alternative Splicing GalleryENSG00000143614
Gene ExpressionGATAD2B [ NCBI-GEO ]   GATAD2B [ EBI - ARRAY_EXPRESS ]   GATAD2B [ SEEK ]   GATAD2B [ MEM ]
Gene Expression Viewer (FireBrowse)GATAD2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57459
GTEX Portal (Tissue expression)GATAD2B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WXI9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WXI9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WXI9
Splice isoforms : SwissVarQ8WXI9
PhosPhoSitePlusQ8WXI9
Domaine pattern : Prosite (Expaxy)GATA_ZN_FINGER_2 (PS50114)   
Domains : Interpro (EBI)P66_CC    Znf_GATA    Znf_NHR/GATA   
Domain families : Pfam (Sanger)GATA (PF00320)    P66_CC (PF16563)   
Domain families : Pfam (NCBI)pfam00320    pfam16563   
Conserved Domain (NCBI)GATAD2B
DMDM Disease mutations57459
Blocks (Seattle)GATAD2B
SuperfamilyQ8WXI9
Human Protein AtlasENSG00000143614
Peptide AtlasQ8WXI9
HPRD15094
IPIIPI00103554   
Protein Interaction databases
DIP (DOE-UCLA)Q8WXI9
IntAct (EBI)Q8WXI9
FunCoupENSG00000143614
BioGRIDGATAD2B
STRING (EMBL)GATAD2B
ZODIACGATAD2B
Ontologies - Pathways
QuickGOQ8WXI9
Ontology : AmiGOnuclear chromatin  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II distal enhancer sequence-specific DNA binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  zinc ion binding  nuclear speck  nucleosomal DNA binding  ATP-dependent chromatin remodeling  protein complex  
Ontology : EGO-EBInuclear chromatin  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II distal enhancer sequence-specific DNA binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  zinc ion binding  nuclear speck  nucleosomal DNA binding  ATP-dependent chromatin remodeling  protein complex  
NDEx NetworkGATAD2B
Atlas of Cancer Signalling NetworkGATAD2B
Wikipedia pathwaysGATAD2B
Orthology - Evolution
OrthoDB57459
GeneTree (enSembl)ENSG00000143614
Phylogenetic Trees/Animal Genes : TreeFamGATAD2B
HOVERGENQ8WXI9
HOGENOMQ8WXI9
Homologs : HomoloGeneGATAD2B
Homology/Alignments : Family Browser (UCSC)GATAD2B
Gene fusions - Rearrangements
Fusion : MitelmanASH1L/GATAD2B [1q22/1q21.3]  [t(1;1)(q21;q22)]  
Fusion : MitelmanGATAD2B/ASH1L [1q21.3/1q22]  [t(1;1)(q21;q22)]  
Fusion : MitelmanGATAD2B/CRTC2 [1q21.3/1q21.3]  [t(1;1)(q21;q21)]  
Fusion : MitelmanGATAD2B/ERI3 [1q21.3/1p34.1]  [t(1;1)(p34;q21)]  
Fusion : MitelmanGATAD2B/KCNN3 [1q21.3/1q21.3]  [t(1;1)(q21;q21)]  
Fusion : MitelmanGATAD2B/NUP210L [1q21.3/1q21.3]  [t(1;1)(q21;q21)]  
Fusion : MitelmanGATAD2B/PRKAB2 [1q21.3/1q21.1]  [t(1;1)(q21;q21)]  
Fusion : MitelmanGATAD2B/SLC9C2 [1q21.3/1q25.1]  [t(1;1)(q21;q25)]  
Fusion : MitelmanGATAD2B/TNFSF18 [1q21.3/1q25.1]  [t(1;1)(q21;q25)]  
Fusion: TCGAASH1L 1q22 GATAD2B 1q21.3 BRCA
Fusion: TCGAGATAD2B 1q21.3 ASH1L 1q22 LUAD
Fusion: TCGAGATAD2B 1q21.3 CRTC2 1q21.3 OV
Fusion: TCGAGATAD2B 1q21.3 ERI3 1p34.1 BLCA
Fusion: TCGAGATAD2B 1q21.3 KCNN3 1q21.3 PRAD
Fusion: TCGAGATAD2B 1q21.3 NUP210L 1q21.3 BRCA LUAD OV
Fusion: TCGAGATAD2B 1q21.3 RP11-574F21.3 LUAD
Fusion: TCGAGATAD2B 1q21.3 SLC9A11 BRCA
Fusion: TCGAGATAD2B 1q21.3 TNFSF18 1q25.1 GBM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGATAD2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GATAD2B
dbVarGATAD2B
ClinVarGATAD2B
1000_GenomesGATAD2B 
Exome Variant ServerGATAD2B
ExAC (Exome Aggregation Consortium)GATAD2B (select the gene name)
Genetic variants : HAPMAP57459
Genomic Variants (DGV)GATAD2B [DGVbeta]
DECIPHERGATAD2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGATAD2B 
Mutations
ICGC Data PortalGATAD2B 
TCGA Data PortalGATAD2B 
Broad Tumor PortalGATAD2B
OASIS PortalGATAD2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGATAD2B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGATAD2B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GATAD2B
DgiDB (Drug Gene Interaction Database)GATAD2B
DoCM (Curated mutations)GATAD2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GATAD2B (select a term)
intoGenGATAD2B
Cancer3DGATAD2B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614998    615074   
Orphanet22339   
MedgenGATAD2B
Genetic Testing Registry GATAD2B
NextProtQ8WXI9 [Medical]
TSGene57459
GENETestsGATAD2B
Huge Navigator GATAD2B [HugePedia]
snp3D : Map Gene to Disease57459
BioCentury BCIQGATAD2B
ClinGenGATAD2B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57459
Chemical/Pharm GKB GenePA142671747
Clinical trialGATAD2B
Miscellaneous
canSAR (ICR)GATAD2B (select the gene name)
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGATAD2B
EVEXGATAD2B
GoPubMedGATAD2B
iHOPGATAD2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:16:56 CEST 2017

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