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GBF1 (golgi brefeldin A resistant guanine nucleotide exchange factor 1)

Identity

Alias (NCBI)ARF1GEF
HGNC (Hugo) GBF1
HGNC Alias symbKIAA0248
ARF1GEF
HGNC Previous namegolgi-specific brefeldin A resistance factor 1
LocusID (NCBI) 8729
Atlas_Id 63723
Location 10q24.32  [Link to chromosome band 10q24]
Location_base_pair Starts at 102245532 and ends at 102382896 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
APEX1 (14q11.2) / GBF1 (10q24.32)AS3MT (10q24.32) / GBF1 (10q24.32)GBF1 (10q24.32) / ARF3 (12q13.12)
GBF1 (10q24.32) / DENR (12q24.31)GBF1 (10q24.32) / GBF1 (10q24.32)INTS3 (1q21.3) / GBF1 (10q24.32)
NFKB2 (10q24.32) / GBF1 (10q24.32)PIM1 (6p21.2) / GBF1 (10q24.32)SUFU (10q24.32) / GBF1 (10q24.32)
SUFU GBF1NFKB2 GBF1AS3MT GBF1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)GBF1   4181
Cards
Entrez_Gene (NCBI)GBF1    golgi brefeldin A resistant guanine nucleotide exchange factor 1
AliasesARF1GEF
GeneCards (Weizmann)GBF1
Ensembl hg19 (Hinxton)ENSG00000107862 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107862 [Gene_View]  ENSG00000107862 [Sequence]  chr10:102245532-102382896 [Contig_View]  GBF1 [Vega]
ICGC DataPortalENSG00000107862
TCGA cBioPortalGBF1
AceView (NCBI)GBF1
Genatlas (Paris)GBF1
SOURCE (Princeton)GBF1
Genetics Home Reference (NIH)GBF1
Genomic and cartography
GoldenPath hg38 (UCSC)GBF1  -     chr10:102245532-102382896 +  10q24.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GBF1  -     10q24.32   [Description]    (hg19-Feb_2009)
GoldenPathGBF1 - 10q24.32 [CytoView hg19]  GBF1 - 10q24.32 [CytoView hg38]
ImmunoBaseENSG00000107862
Genome Data Viewer NCBIGBF1 [Mapview hg19]  
OMIM603698   
Gene and transcription
Genbank (Entrez)AF068755 AI859700 AK024916 AK025153 AK025330
RefSeq transcript (Entrez)NM_001199378 NM_001199379 NM_001377137 NM_001377138 NM_001377139 NM_001377140 NM_001377141 NM_001391922 NM_001391923 NM_001391924 NM_001391925 NM_001391926 NM_001391927 NM_001391928 NM_001391929 NM_001391930 NM_001391931 NM_004193
Consensus coding sequences : CCDS (NCBI)GBF1
Gene ExpressionGBF1 [ NCBI-GEO ]   GBF1 [ EBI - ARRAY_EXPRESS ]   GBF1 [ SEEK ]   GBF1 [ MEM ]
Gene Expression Viewer (FireBrowse)GBF1 [ Firebrowse - Broad ]
GenevisibleExpression of GBF1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8729
GTEX Portal (Tissue expression)GBF1
Human Protein AtlasENSG00000107862-GBF1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92538   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92538  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92538
PhosPhoSitePlusQ92538
Domaine pattern : Prosite (Expaxy)SEC7 (PS50190)   
Domains : Interpro (EBI)ARM-type_fold    Sec7_C_sf    Sec7_dom    Sec7_dom_sf    Sec7_N   
Domain families : Pfam (Sanger)Sec7 (PF01369)    Sec7_N (PF12783)   
Domain families : Pfam (NCBI)pfam01369    pfam12783   
Domain families : Smart (EMBL)Sec7 (SM00222)  
Conserved Domain (NCBI)GBF1
SuperfamilyQ92538
AlphaFold pdb e-kbQ92538   
Human Protein Atlas [tissue]ENSG00000107862-GBF1 [tissue]
HPRD04740
Protein Interaction databases
DIP (DOE-UCLA)Q92538
IntAct (EBI)Q92538
BioGRIDGBF1
STRING (EMBL)GBF1
ZODIACGBF1
Ontologies - Pathways
QuickGOQ92538
Ontology : AmiGOGolgi membrane  cell activation involved in immune response  guanyl-nucleotide exchange factor activity  protein binding  phosphatidylinositol-3,4,5-trisphosphate binding  mitochondrion  peroxisome  endoplasmic reticulum lumen  endoplasmic reticulum-Golgi intermediate compartment  Golgi apparatus  Golgi stack  cis-Golgi network  trans-Golgi network  lipid droplet  cytosol  endoplasmic reticulum to Golgi vesicle-mediated transport  retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  post-Golgi vesicle-mediated transport  Golgi to endosome transport  Golgi organization  regulation of mitotic cell cycle  protein transport  membrane  neutrophil chemotaxis  cell leading edge  regulation of ARF protein signal transduction  protein localization to Golgi apparatus  retrograde transport, endosome to Golgi  COPI coating of Golgi vesicle  regulation of catalytic activity  cilium assembly  establishment of monopolar cell polarity  protein localization to endoplasmic reticulum exit site  phosphatidylinositol-3,5-bisphosphate binding  Golgi disassembly  endoplasmic reticulum-Golgi intermediate compartment organization  cellular response to virus  reactive oxygen species biosynthetic process  protein localization to endoplasmic reticulum tubular network  regulation of protein localization to cell surface  
Ontology : EGO-EBIGolgi membrane  cell activation involved in immune response  guanyl-nucleotide exchange factor activity  protein binding  phosphatidylinositol-3,4,5-trisphosphate binding  mitochondrion  peroxisome  endoplasmic reticulum lumen  endoplasmic reticulum-Golgi intermediate compartment  Golgi apparatus  Golgi stack  cis-Golgi network  trans-Golgi network  lipid droplet  cytosol  endoplasmic reticulum to Golgi vesicle-mediated transport  retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  post-Golgi vesicle-mediated transport  Golgi to endosome transport  Golgi organization  regulation of mitotic cell cycle  protein transport  membrane  neutrophil chemotaxis  cell leading edge  regulation of ARF protein signal transduction  protein localization to Golgi apparatus  retrograde transport, endosome to Golgi  COPI coating of Golgi vesicle  regulation of catalytic activity  cilium assembly  establishment of monopolar cell polarity  protein localization to endoplasmic reticulum exit site  phosphatidylinositol-3,5-bisphosphate binding  Golgi disassembly  endoplasmic reticulum-Golgi intermediate compartment organization  cellular response to virus  reactive oxygen species biosynthetic process  protein localization to endoplasmic reticulum tubular network  regulation of protein localization to cell surface  
Pathways : BIOCARTAADP-Ribosylation Factor [Genes]   
NDEx NetworkGBF1
Atlas of Cancer Signalling NetworkGBF1
Wikipedia pathwaysGBF1
Orthology - Evolution
OrthoDB8729
GeneTree (enSembl)ENSG00000107862
Phylogenetic Trees/Animal Genes : TreeFamGBF1
Homologs : HomoloGeneGBF1
Homology/Alignments : Family Browser (UCSC)GBF1
Gene fusions - Rearrangements
Fusion : QuiverGBF1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGBF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GBF1
dbVarGBF1
ClinVarGBF1
MonarchGBF1
1000_GenomesGBF1 
Exome Variant ServerGBF1
GNOMAD BrowserENSG00000107862
Varsome BrowserGBF1
ACMGGBF1 variants
VarityQ92538
Genomic Variants (DGV)GBF1 [DGVbeta]
DECIPHERGBF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGBF1 
Mutations
ICGC Data PortalGBF1 
TCGA Data PortalGBF1 
Broad Tumor PortalGBF1
OASIS PortalGBF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGBF1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGBF1
Mutations and Diseases : HGMDGBF1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaGBF1
DgiDB (Drug Gene Interaction Database)GBF1
DoCM (Curated mutations)GBF1
CIViC (Clinical Interpretations of Variants in Cancer)GBF1
Cancer3DGBF1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603698   
Orphanet
DisGeNETGBF1
MedgenGBF1
Genetic Testing Registry GBF1
NextProtQ92538 [Medical]
GENETestsGBF1
Target ValidationGBF1
Huge Navigator GBF1 [HugePedia]
ClinGenGBF1
Clinical trials, drugs, therapy
MyCancerGenomeGBF1
Protein Interactions : CTDGBF1
Pharm GKB GenePA28595
PharosQ92538
Clinical trialGBF1
Miscellaneous
canSAR (ICR)GBF1
HarmonizomeGBF1
DataMed IndexGBF1
Probes
Litterature
PubMed128 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGBF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:51:16 CEST 2021

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