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GBP2 (guanylate binding protein 2)

Identity

Alias_namesguanylate binding protein 2
Other alias-
HGNC (Hugo) GBP2
LocusID (NCBI) 2634
Atlas_Id 40692
Location 1p22.2  [Link to chromosome band 1p22]
Location_base_pair Starts at 89106133 and ends at 89126159 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GBP2 (1p22.2) / ARHGAP15 (2q22.2)GBP2 (1p22.2) / ETS2 (21q22.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GBP2   4183
Cards
Entrez_Gene (NCBI)GBP2  2634  guanylate binding protein 2
Aliases
GeneCards (Weizmann)GBP2
Ensembl hg19 (Hinxton)ENSG00000162645 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162645 [Gene_View]  ENSG00000162645 [Sequence]  chr1:89106133-89126159 [Contig_View]  GBP2 [Vega]
ICGC DataPortalENSG00000162645
TCGA cBioPortalGBP2
AceView (NCBI)GBP2
Genatlas (Paris)GBP2
WikiGenes2634
SOURCE (Princeton)GBP2
Genetics Home Reference (NIH)GBP2
Genomic and cartography
GoldenPath hg38 (UCSC)GBP2  -     chr1:89106133-89126159 -  1p22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GBP2  -     1p22.2   [Description]    (hg19-Feb_2009)
EnsemblGBP2 - 1p22.2 [CytoView hg19]  GBP2 - 1p22.2 [CytoView hg38]
Mapping of homologs : NCBIGBP2 [Mapview hg19]  GBP2 [Mapview hg38]
OMIM600412   
Gene and transcription
Genbank (Entrez)AI085798 AI400402 AI445567 AK002150 AK057968
RefSeq transcript (Entrez)NM_004120
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GBP2
Cluster EST : UnigeneHs.734162 [ NCBI ]
CGAP (NCI)Hs.734162
Alternative Splicing GalleryENSG00000162645
Gene ExpressionGBP2 [ NCBI-GEO ]   GBP2 [ EBI - ARRAY_EXPRESS ]   GBP2 [ SEEK ]   GBP2 [ MEM ]
Gene Expression Viewer (FireBrowse)GBP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2634
GTEX Portal (Tissue expression)GBP2
Human Protein AtlasENSG00000162645-GBP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP32456   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP32456  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP32456
Splice isoforms : SwissVarP32456
PhosPhoSitePlusP32456
Domaine pattern : Prosite (Expaxy)G_GB1_RHD3 (PS51715)   
Domains : Interpro (EBI)G_GB1_RHD3_dom    GBP_C    Guanylate-bd/ATL_C    Guanylate-bd_C_sf    Guanylate-bd_N    P-loop_NTPase   
Domain families : Pfam (Sanger)GBP (PF02263)    GBP_C (PF02841)   
Domain families : Pfam (NCBI)pfam02263    pfam02841   
Conserved Domain (NCBI)GBP2
DMDM Disease mutations2634
Blocks (Seattle)GBP2
SuperfamilyP32456
Human Protein Atlas [tissue]ENSG00000162645-GBP2 [tissue]
Peptide AtlasP32456
HPRD02682
IPIIPI00028565   IPI00848358   
Protein Interaction databases
DIP (DOE-UCLA)P32456
IntAct (EBI)P32456
FunCoupENSG00000162645
BioGRIDGBP2
STRING (EMBL)GBP2
ZODIACGBP2
Ontologies - Pathways
QuickGOP32456
Ontology : AmiGOGolgi membrane  GTPase activity  protein binding  GTP binding  nucleus  nucleoplasm  cytoplasm  Golgi apparatus  cytosol  cytosol  immune response  actin cytoskeleton  protein localization to nucleus  protein homodimerization activity  perinuclear region of cytoplasm  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  cellular response to interferon-gamma  cellular response to interleukin-1  cellular response to tumor necrosis factor  
Ontology : EGO-EBIGolgi membrane  GTPase activity  protein binding  GTP binding  nucleus  nucleoplasm  cytoplasm  Golgi apparatus  cytosol  cytosol  immune response  actin cytoskeleton  protein localization to nucleus  protein homodimerization activity  perinuclear region of cytoplasm  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  cellular response to interferon-gamma  cellular response to interleukin-1  cellular response to tumor necrosis factor  
NDEx NetworkGBP2
Atlas of Cancer Signalling NetworkGBP2
Wikipedia pathwaysGBP2
Orthology - Evolution
OrthoDB2634
GeneTree (enSembl)ENSG00000162645
Phylogenetic Trees/Animal Genes : TreeFamGBP2
HOVERGENP32456
HOGENOMP32456
Homologs : HomoloGeneGBP2
Homology/Alignments : Family Browser (UCSC)GBP2
Gene fusions - Rearrangements
Fusion : QuiverGBP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGBP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GBP2
dbVarGBP2
ClinVarGBP2
1000_GenomesGBP2 
Exome Variant ServerGBP2
ExAC (Exome Aggregation Consortium)ENSG00000162645
GNOMAD BrowserENSG00000162645
Varsome BrowserGBP2
Genetic variants : HAPMAP2634
Genomic Variants (DGV)GBP2 [DGVbeta]
DECIPHERGBP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGBP2 
Mutations
ICGC Data PortalGBP2 
TCGA Data PortalGBP2 
Broad Tumor PortalGBP2
OASIS PortalGBP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGBP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGBP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GBP2
DgiDB (Drug Gene Interaction Database)GBP2
DoCM (Curated mutations)GBP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GBP2 (select a term)
intoGenGBP2
Cancer3DGBP2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600412   
Orphanet
DisGeNETGBP2
MedgenGBP2
Genetic Testing Registry GBP2
NextProtP32456 [Medical]
TSGene2634
GENETestsGBP2
Target ValidationGBP2
Huge Navigator GBP2 [HugePedia]
snp3D : Map Gene to Disease2634
BioCentury BCIQGBP2
ClinGenGBP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2634
Chemical/Pharm GKB GenePA28597
Clinical trialGBP2
Miscellaneous
canSAR (ICR)GBP2 (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGBP2
EVEXGBP2
GoPubMedGBP2
iHOPGBP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:24:22 CEST 2018

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