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GBP5 (guanylate binding protein 5)

Identity

Other aliasGBP-5
HGNC (Hugo) GBP5
LocusID (NCBI) 115362
Atlas_Id 46108
Location 1p22.2  [Link to chromosome band 1p22]
Location_base_pair Starts at 89258951 and ends at 89272861 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GBP5   19895
Cards
Entrez_Gene (NCBI)GBP5  115362  guanylate binding protein 5
AliasesGBP-5
GeneCards (Weizmann)GBP5
Ensembl hg19 (Hinxton)ENSG00000154451 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000154451 [Gene_View]  ENSG00000154451 [Sequence]  chr1:89258951-89272861 [Contig_View]  GBP5 [Vega]
ICGC DataPortalENSG00000154451
TCGA cBioPortalGBP5
AceView (NCBI)GBP5
Genatlas (Paris)GBP5
WikiGenes115362
SOURCE (Princeton)GBP5
Genetics Home Reference (NIH)GBP5
Genomic and cartography
GoldenPath hg38 (UCSC)GBP5  -     chr1:89258951-89272861 -  1p22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GBP5  -     1p22.2   [Description]    (hg19-Feb_2009)
EnsemblGBP5 - 1p22.2 [CytoView hg19]  GBP5 - 1p22.2 [CytoView hg38]
Mapping of homologs : NCBIGBP5 [Mapview hg19]  GBP5 [Mapview hg38]
OMIM611467   
Gene and transcription
Genbank (Entrez)AF288815 AF328727 AF430642 AF430643 AK090479
RefSeq transcript (Entrez)NM_001134486 NM_052942
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GBP5
Cluster EST : UnigeneHs.513726 [ NCBI ]
CGAP (NCI)Hs.513726
Alternative Splicing GalleryENSG00000154451
Gene ExpressionGBP5 [ NCBI-GEO ]   GBP5 [ EBI - ARRAY_EXPRESS ]   GBP5 [ SEEK ]   GBP5 [ MEM ]
Gene Expression Viewer (FireBrowse)GBP5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)115362
GTEX Portal (Tissue expression)GBP5
Human Protein AtlasENSG00000154451-GBP5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96PP8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96PP8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96PP8
Splice isoforms : SwissVarQ96PP8
PhosPhoSitePlusQ96PP8
Domaine pattern : Prosite (Expaxy)G_GB1_RHD3 (PS51715)   
Domains : Interpro (EBI)G_GB1_RHD3_dom    GBP_C    Guanylate-bd/ATL_C    Guanylate-bd_C_sf    Guanylate-bd_N    P-loop_NTPase   
Domain families : Pfam (Sanger)GBP (PF02263)    GBP_C (PF02841)   
Domain families : Pfam (NCBI)pfam02263    pfam02841   
Conserved Domain (NCBI)GBP5
DMDM Disease mutations115362
Blocks (Seattle)GBP5
SuperfamilyQ96PP8
Human Protein Atlas [tissue]ENSG00000154451-GBP5 [tissue]
Peptide AtlasQ96PP8
HPRD13571
IPIIPI00044587   IPI00645391   
Protein Interaction databases
DIP (DOE-UCLA)Q96PP8
IntAct (EBI)Q96PP8
FunCoupENSG00000154451
BioGRIDGBP5
STRING (EMBL)GBP5
ZODIACGBP5
Ontologies - Pathways
QuickGOQ96PP8
Ontology : AmiGOGolgi membrane  GTPase activity  protein binding  GTP binding  cytoplasm  Golgi apparatus  inflammatory response  membrane  cytoplasmic vesicle  protein localization to Golgi apparatus  identical protein binding  protein homodimerization activity  positive regulation of innate immune response  perinuclear region of cytoplasm  interleukin-1 beta secretion  protein homotetramerization  cellular response to interferon-gamma  interleukin-18 secretion  positive regulation of cytokine production involved in inflammatory response  positive regulation of NLRP3 inflammasome complex assembly  
Ontology : EGO-EBIGolgi membrane  GTPase activity  protein binding  GTP binding  cytoplasm  Golgi apparatus  inflammatory response  membrane  cytoplasmic vesicle  protein localization to Golgi apparatus  identical protein binding  protein homodimerization activity  positive regulation of innate immune response  perinuclear region of cytoplasm  interleukin-1 beta secretion  protein homotetramerization  cellular response to interferon-gamma  interleukin-18 secretion  positive regulation of cytokine production involved in inflammatory response  positive regulation of NLRP3 inflammasome complex assembly  
NDEx NetworkGBP5
Atlas of Cancer Signalling NetworkGBP5
Wikipedia pathwaysGBP5
Orthology - Evolution
OrthoDB115362
GeneTree (enSembl)ENSG00000154451
Phylogenetic Trees/Animal Genes : TreeFamGBP5
HOVERGENQ96PP8
HOGENOMQ96PP8
Homologs : HomoloGeneGBP5
Homology/Alignments : Family Browser (UCSC)GBP5
Gene fusions - Rearrangements
Fusion : QuiverGBP5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGBP5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GBP5
dbVarGBP5
ClinVarGBP5
1000_GenomesGBP5 
Exome Variant ServerGBP5
ExAC (Exome Aggregation Consortium)ENSG00000154451
GNOMAD BrowserENSG00000154451
Varsome BrowserGBP5
Genetic variants : HAPMAP115362
Genomic Variants (DGV)GBP5 [DGVbeta]
DECIPHERGBP5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGBP5 
Mutations
ICGC Data PortalGBP5 
TCGA Data PortalGBP5 
Broad Tumor PortalGBP5
OASIS PortalGBP5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGBP5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGBP5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GBP5
DgiDB (Drug Gene Interaction Database)GBP5
DoCM (Curated mutations)GBP5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GBP5 (select a term)
intoGenGBP5
Cancer3DGBP5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611467   
Orphanet
DisGeNETGBP5
MedgenGBP5
Genetic Testing Registry GBP5
NextProtQ96PP8 [Medical]
TSGene115362
GENETestsGBP5
Target ValidationGBP5
Huge Navigator GBP5 [HugePedia]
snp3D : Map Gene to Disease115362
BioCentury BCIQGBP5
ClinGenGBP5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD115362
Chemical/Pharm GKB GenePA134862968
Clinical trialGBP5
Miscellaneous
canSAR (ICR)GBP5 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGBP5
EVEXGBP5
GoPubMedGBP5
iHOPGBP5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:24:23 CEST 2018

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