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GC (group-specific component (vitamin D binding protein))

Identity

Alias_namesgroup-specific component (vitamin D binding protein)
Alias_symbol (synonym)DBP
VDBP
hDBP
Other aliasDBP/GC
GRD3
Gc-MAF
GcMAF
HEL-S-51
VDBG
HGNC (Hugo) GC
LocusID (NCBI) 2638
Atlas_Id 45713
Location 4q13.3  [Link to chromosome band 4q13]
Location_base_pair Starts at 72607411 and ends at 72650079 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
GC (4q13.3) / GC (4q13.3)HOXC8 (12q13.13) / GC (4q13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GC   4187
Cards
Entrez_Gene (NCBI)GC  2638  group-specific component (vitamin D binding protein)
AliasesDBP; DBP/GC; GRD3; Gc-MAF; 
GcMAF; HEL-S-51; VDBG; VDBP
GeneCards (Weizmann)GC
Ensembl hg19 (Hinxton)ENSG00000145321 [Gene_View]  chr4:72607411-72650079 [Contig_View]  GC [Vega]
Ensembl hg38 (Hinxton)ENSG00000145321 [Gene_View]  chr4:72607411-72650079 [Contig_View]  GC [Vega]
ICGC DataPortalENSG00000145321
TCGA cBioPortalGC
AceView (NCBI)GC
Genatlas (Paris)GC
WikiGenes2638
SOURCE (Princeton)GC
Genetics Home Reference (NIH)GC
Genomic and cartography
GoldenPath hg19 (UCSC)GC  -     chr4:72607411-72650079 -  4q13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GC  -     4q13.3   [Description]    (hg38-Dec_2013)
EnsemblGC - 4q13.3 [CytoView hg19]  GC - 4q13.3 [CytoView hg38]
Mapping of homologs : NCBIGC [Mapview hg19]  GC [Mapview hg38]
OMIM139200   
Gene and transcription
Genbank (Entrez)AA702473 AK223458 AK290827 AK298433 AK309595
RefSeq transcript (Entrez)NM_000583 NM_001204306 NM_001204307
RefSeq genomic (Entrez)NC_000004 NC_018915 NG_012837 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)GC
Cluster EST : UnigeneHs.418497 [ NCBI ]
CGAP (NCI)Hs.418497
Alternative Splicing GalleryENSG00000145321
Gene ExpressionGC [ NCBI-GEO ]   GC [ EBI - ARRAY_EXPRESS ]   GC [ SEEK ]   GC [ MEM ]
Gene Expression Viewer (FireBrowse)GC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2638
GTEX Portal (Tissue expression)GC
Protein : pattern, domain, 3D structure
UniProt/SwissProtP02774   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP02774  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP02774
Splice isoforms : SwissVarP02774
PhosPhoSitePlusP02774
Domaine pattern : Prosite (Expaxy)ALBUMIN_1 (PS00212)    ALBUMIN_2 (PS51438)   
Domains : Interpro (EBI)ALB/AFP/VDB    Serum_albumin-like    Serum_albumin_CS    Serum_albumin_N    VitD-bd    VitD-bind_III   
Domain families : Pfam (Sanger)Serum_albumin (PF00273)    VitD-bind_III (PF09164)   
Domain families : Pfam (NCBI)pfam00273    pfam09164   
Domain families : Smart (EMBL)ALBUMIN (SM00103)  
Conserved Domain (NCBI)GC
DMDM Disease mutations2638
Blocks (Seattle)GC
PDB (SRS)1J78    1J7E    1KW2    1KXP    1LOT    1MA9   
PDB (PDBSum)1J78    1J7E    1KW2    1KXP    1LOT    1MA9   
PDB (IMB)1J78    1J7E    1KW2    1KXP    1LOT    1MA9   
PDB (RSDB)1J78    1J7E    1KW2    1KXP    1LOT    1MA9   
Structural Biology KnowledgeBase1J78    1J7E    1KW2    1KXP    1LOT    1MA9   
SCOP (Structural Classification of Proteins)1J78    1J7E    1KW2    1KXP    1LOT    1MA9   
CATH (Classification of proteins structures)1J78    1J7E    1KW2    1KXP    1LOT    1MA9   
SuperfamilyP02774
Human Protein AtlasENSG00000145321
Peptide AtlasP02774
HPRD00749
IPIIPI00555812   IPI00968182   IPI00965085   IPI00968027   IPI00965382   
Protein Interaction databases
DIP (DOE-UCLA)P02774
IntAct (EBI)P02774
FunCoupENSG00000145321
BioGRIDGC
STRING (EMBL)GC
ZODIACGC
Ontologies - Pathways
QuickGOP02774
Ontology : AmiGOactin binding  vitamin D binding  extracellular region  extracellular region  extracellular space  cytosol  female pregnancy  lactation  axon  response to nutrient levels  response to estradiol  vitamin D metabolic process  lysosomal lumen  perinuclear region of cytoplasm  vitamin transport  vitamin transporter activity  extracellular exosome  blood microparticle  calcidiol binding  
Ontology : EGO-EBIactin binding  vitamin D binding  extracellular region  extracellular region  extracellular space  cytosol  female pregnancy  lactation  axon  response to nutrient levels  response to estradiol  vitamin D metabolic process  lysosomal lumen  perinuclear region of cytoplasm  vitamin transport  vitamin transporter activity  extracellular exosome  blood microparticle  calcidiol binding  
NDEx NetworkGC
Atlas of Cancer Signalling NetworkGC
Wikipedia pathwaysGC
Orthology - Evolution
OrthoDB2638
GeneTree (enSembl)ENSG00000145321
Phylogenetic Trees/Animal Genes : TreeFamGC
HOVERGENP02774
HOGENOMP02774
Homologs : HomoloGeneGC
Homology/Alignments : Family Browser (UCSC)GC
Gene fusions - Rearrangements
Fusion Cancer (Beijing)HOXC8 [12q13.13]  -  GC [4q13.3]  [FUSC002283]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GC
dbVarGC
ClinVarGC
1000_GenomesGC 
Exome Variant ServerGC
ExAC (Exome Aggregation Consortium)GC (select the gene name)
Genetic variants : HAPMAP2638
Genomic Variants (DGV)GC [DGVbeta]
DECIPHER (Syndromes)4:72607411-72650079  ENSG00000145321
CONAN: Copy Number AnalysisGC 
Mutations
ICGC Data PortalGC 
TCGA Data PortalGC 
Broad Tumor PortalGC
OASIS PortalGC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGC  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GC
DgiDB (Drug Gene Interaction Database)GC
DoCM (Curated mutations)GC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GC (select a term)
intoGenGC
Cancer3DGC(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM139200   
Orphanet
MedgenGC
Genetic Testing Registry GC
NextProtP02774 [Medical]
TSGene2638
GENETestsGC
Huge Navigator GC [HugePedia]
snp3D : Map Gene to Disease2638
BioCentury BCIQGC
ClinGenGC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2638
Chemical/Pharm GKB GenePA28601
Clinical trialGC
Miscellaneous
canSAR (ICR)GC (select the gene name)
Probes
Litterature
PubMed216 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGC
EVEXGC
GoPubMedGC
iHOPGC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:07:09 CET 2017

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