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GCA (grancalcin)

Identity

Alias_namesgrancalcin, EF-hand calcium-binding protein
grancalcin, EF-hand calcium binding protein
Alias_symbol (synonym)GCL
Other alias
HGNC (Hugo) GCA
LocusID (NCBI) 25801
Atlas_Id 56282
Location 2q24.2  [Link to chromosome band 2q24]
Location_base_pair Starts at 162318763 and ends at 162363108 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GCA (2q24.2) / DYNLT1 (6q25.3)GCA (2q24.2) / PSMD14 (2q24.2)GCA (2q24.2) / SH3TC1 (4p16.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GCA   15990
Cards
Entrez_Gene (NCBI)GCA  25801  grancalcin
AliasesGCL
GeneCards (Weizmann)GCA
Ensembl hg19 (Hinxton)ENSG00000115271 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115271 [Gene_View]  chr2:162318763-162363108 [Contig_View]  GCA [Vega]
ICGC DataPortalENSG00000115271
TCGA cBioPortalGCA
AceView (NCBI)GCA
Genatlas (Paris)GCA
WikiGenes25801
SOURCE (Princeton)GCA
Genetics Home Reference (NIH)GCA
Genomic and cartography
GoldenPath hg38 (UCSC)GCA  -     chr2:162318763-162363108 +  2q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GCA  -     2q24.2   [Description]    (hg19-Feb_2009)
EnsemblGCA - 2q24.2 [CytoView hg19]  GCA - 2q24.2 [CytoView hg38]
Mapping of homologs : NCBIGCA [Mapview hg19]  GCA [Mapview hg38]
OMIM607030   
Gene and transcription
Genbank (Entrez)AB209768 AK295413 AK312349 BC005214 BI760070
RefSeq transcript (Entrez)NM_001330265 NM_001330266 NM_001330267 NM_001330268 NM_001330270 NM_001330271 NM_012198
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GCA
Cluster EST : UnigeneHs.377894 [ NCBI ]
CGAP (NCI)Hs.377894
Alternative Splicing GalleryENSG00000115271
Gene ExpressionGCA [ NCBI-GEO ]   GCA [ EBI - ARRAY_EXPRESS ]   GCA [ SEEK ]   GCA [ MEM ]
Gene Expression Viewer (FireBrowse)GCA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)25801
GTEX Portal (Tissue expression)GCA
Protein : pattern, domain, 3D structure
UniProt/SwissProtP28676   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP28676  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP28676
Splice isoforms : SwissVarP28676
PhosPhoSitePlusP28676
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom   
Domain families : Pfam (Sanger)EF-hand_8 (PF13833)   
Domain families : Pfam (NCBI)pfam13833   
Domain families : Smart (EMBL)EFh (SM00054)  
Conserved Domain (NCBI)GCA
DMDM Disease mutations25801
Blocks (Seattle)GCA
PDB (SRS)1F4O    1F4Q    1K94    1K95   
PDB (PDBSum)1F4O    1F4Q    1K94    1K95   
PDB (IMB)1F4O    1F4Q    1K94    1K95   
PDB (RSDB)1F4O    1F4Q    1K94    1K95   
Structural Biology KnowledgeBase1F4O    1F4Q    1K94    1K95   
SCOP (Structural Classification of Proteins)1F4O    1F4Q    1K94    1K95   
CATH (Classification of proteins structures)1F4O    1F4Q    1K94    1K95   
SuperfamilyP28676
Human Protein AtlasENSG00000115271
Peptide AtlasP28676
HPRD06122
IPIIPI00004524   IPI00925681   IPI00926104   IPI01018250   IPI00927040   IPI00926799   
Protein Interaction databases
DIP (DOE-UCLA)P28676
IntAct (EBI)P28676
FunCoupENSG00000115271
BioGRIDGCA
STRING (EMBL)GCA
ZODIACGCA
Ontologies - Pathways
QuickGOP28676
Ontology : AmiGOcalcium-dependent cysteine-type endopeptidase activity  calcium ion binding  protein binding  extracellular region  cytoplasm  cytosol  plasma membrane  proteolysis  azurophil granule lumen  protein homodimerization activity  neutrophil degranulation  protein heterodimerization activity  membrane fusion  extracellular exosome  
Ontology : EGO-EBIcalcium-dependent cysteine-type endopeptidase activity  calcium ion binding  protein binding  extracellular region  cytoplasm  cytosol  plasma membrane  proteolysis  azurophil granule lumen  protein homodimerization activity  neutrophil degranulation  protein heterodimerization activity  membrane fusion  extracellular exosome  
NDEx NetworkGCA
Atlas of Cancer Signalling NetworkGCA
Wikipedia pathwaysGCA
Orthology - Evolution
OrthoDB25801
GeneTree (enSembl)ENSG00000115271
Phylogenetic Trees/Animal Genes : TreeFamGCA
HOVERGENP28676
HOGENOMP28676
Homologs : HomoloGeneGCA
Homology/Alignments : Family Browser (UCSC)GCA
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGCA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GCA
dbVarGCA
ClinVarGCA
1000_GenomesGCA 
Exome Variant ServerGCA
ExAC (Exome Aggregation Consortium)GCA (select the gene name)
Genetic variants : HAPMAP25801
Genomic Variants (DGV)GCA [DGVbeta]
DECIPHERGCA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGCA 
Mutations
ICGC Data PortalGCA 
TCGA Data PortalGCA 
Broad Tumor PortalGCA
OASIS PortalGCA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGCA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGCA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GCA
DgiDB (Drug Gene Interaction Database)GCA
DoCM (Curated mutations)GCA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GCA (select a term)
intoGenGCA
Cancer3DGCA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607030   
Orphanet
MedgenGCA
Genetic Testing Registry GCA
NextProtP28676 [Medical]
TSGene25801
GENETestsGCA
Target ValidationGCA
Huge Navigator GCA [HugePedia]
snp3D : Map Gene to Disease25801
BioCentury BCIQGCA
ClinGenGCA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD25801
Chemical/Pharm GKB GenePA28602
Clinical trialGCA
Miscellaneous
canSAR (ICR)GCA (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGCA
EVEXGCA
GoPubMedGCA
iHOPGCA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:01:51 CEST 2017

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