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GCC2 (GRIP and coiled-coil domain containing 2)

Identity

Alias (NCBI)GCC185
RANBP2L4
REN53
HGNC (Hugo) GCC2
HGNC Alias symbGCC185
KIAA0336
HGNC Previous nameGRIP and coiled-coil domain-containing 2
LocusID (NCBI) 9648
Atlas_Id 53005
Location 2q12.3  [Link to chromosome band 2q12]
Location_base_pair Starts at 108449206 and ends at 108509415 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RANBP2 (2q12.3) / GCC2 (2q12.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)GCC2   23218
Cards
Entrez_Gene (NCBI)GCC2    GRIP and coiled-coil domain containing 2
AliasesGCC185; RANBP2L4; REN53
GeneCards (Weizmann)GCC2
Ensembl hg19 (Hinxton)ENSG00000135968 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135968 [Gene_View]  ENSG00000135968 [Sequence]  chr2:108449206-108509415 [Contig_View]  GCC2 [Vega]
ICGC DataPortalENSG00000135968
TCGA cBioPortalGCC2
AceView (NCBI)GCC2
Genatlas (Paris)GCC2
SOURCE (Princeton)GCC2
Genetics Home Reference (NIH)GCC2
Genomic and cartography
GoldenPath hg38 (UCSC)GCC2  -     chr2:108449206-108509415 +  2q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GCC2  -     2q12.3   [Description]    (hg19-Feb_2009)
GoldenPathGCC2 - 2q12.3 [CytoView hg19]  GCC2 - 2q12.3 [CytoView hg38]
ImmunoBaseENSG00000135968
Genome Data Viewer NCBIGCC2 [Mapview hg19]  
OMIM612711   
Gene and transcription
Genbank (Entrez)AA171957 AB002334 AF273042 AF432211 AI084646
RefSeq transcript (Entrez)NM_181453
Consensus coding sequences : CCDS (NCBI)GCC2
Gene ExpressionGCC2 [ NCBI-GEO ]   GCC2 [ EBI - ARRAY_EXPRESS ]   GCC2 [ SEEK ]   GCC2 [ MEM ]
Gene Expression Viewer (FireBrowse)GCC2 [ Firebrowse - Broad ]
GenevisibleExpression of GCC2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9648
GTEX Portal (Tissue expression)GCC2
Human Protein AtlasENSG00000135968-GCC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IWJ2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IWJ2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IWJ2
PhosPhoSitePlusQ8IWJ2
Domaine pattern : Prosite (Expaxy)GRIP (PS50913)   
Domains : Interpro (EBI)GCC2_Rab_bind    GRIP_dom   
Domain families : Pfam (Sanger)GRIP (PF01465)    Rab_bind (PF16704)   
Domain families : Pfam (NCBI)pfam01465    pfam16704   
Domain families : Smart (EMBL)Grip (SM00755)  
Conserved Domain (NCBI)GCC2
PDB (RSDB)3BBP   
PDB Europe3BBP   
PDB (PDBSum)3BBP   
PDB (IMB)3BBP   
Structural Biology KnowledgeBase3BBP   
SCOP (Structural Classification of Proteins)3BBP   
CATH (Classification of proteins structures)3BBP   
SuperfamilyQ8IWJ2
AlphaFold pdb e-kbQ8IWJ2   
Human Protein Atlas [tissue]ENSG00000135968-GCC2 [tissue]
HPRD11001
Protein Interaction databases
DIP (DOE-UCLA)Q8IWJ2
IntAct (EBI)Q8IWJ2
BioGRIDGCC2
STRING (EMBL)GCC2
ZODIACGCC2
Ontologies - Pathways
QuickGOQ8IWJ2
Ontology : AmiGOprotein binding  nucleoplasm  Golgi apparatus  Golgi apparatus  trans-Golgi network  cytosol  protein targeting to lysosome  membrane  microtubule organizing center organization  small GTPase binding  protein localization to Golgi apparatus  microtubule anchoring  late endosome to Golgi transport  late endosome to Golgi transport  retrograde transport, endosome to Golgi  identical protein binding  Golgi to plasma membrane protein transport  regulation of protein exit from endoplasmic reticulum  recycling endosome to Golgi transport  Golgi ribbon formation  
Ontology : EGO-EBIprotein binding  nucleoplasm  Golgi apparatus  Golgi apparatus  trans-Golgi network  cytosol  protein targeting to lysosome  membrane  microtubule organizing center organization  small GTPase binding  protein localization to Golgi apparatus  microtubule anchoring  late endosome to Golgi transport  late endosome to Golgi transport  retrograde transport, endosome to Golgi  identical protein binding  Golgi to plasma membrane protein transport  regulation of protein exit from endoplasmic reticulum  recycling endosome to Golgi transport  Golgi ribbon formation  
NDEx NetworkGCC2
Atlas of Cancer Signalling NetworkGCC2
Wikipedia pathwaysGCC2
Orthology - Evolution
OrthoDB9648
GeneTree (enSembl)ENSG00000135968
Phylogenetic Trees/Animal Genes : TreeFamGCC2
Homologs : HomoloGeneGCC2
Homology/Alignments : Family Browser (UCSC)GCC2
Gene fusions - Rearrangements
Fusion : QuiverGCC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGCC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GCC2
dbVarGCC2
ClinVarGCC2
MonarchGCC2
1000_GenomesGCC2 
Exome Variant ServerGCC2
GNOMAD BrowserENSG00000135968
Varsome BrowserGCC2
ACMGGCC2 variants
VarityQ8IWJ2
Genomic Variants (DGV)GCC2 [DGVbeta]
DECIPHERGCC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGCC2 
Mutations
ICGC Data PortalGCC2 
TCGA Data PortalGCC2 
Broad Tumor PortalGCC2
OASIS PortalGCC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGCC2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGCC2
Mutations and Diseases : HGMDGCC2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaGCC2
DgiDB (Drug Gene Interaction Database)GCC2
DoCM (Curated mutations)GCC2
CIViC (Clinical Interpretations of Variants in Cancer)GCC2
Cancer3DGCC2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612711   
Orphanet
DisGeNETGCC2
MedgenGCC2
Genetic Testing Registry GCC2
NextProtQ8IWJ2 [Medical]
GENETestsGCC2
Target ValidationGCC2
Huge Navigator GCC2 [HugePedia]
ClinGenGCC2
Clinical trials, drugs, therapy
MyCancerGenomeGCC2
Protein Interactions : CTDGCC2
Pharm GKB GenePA134876902
PharosQ8IWJ2
Clinical trialGCC2
Miscellaneous
canSAR (ICR)GCC2
HarmonizomeGCC2
DataMed IndexGCC2
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGCC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:10:30 CEST 2021

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