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GCC2 (GRIP and coiled-coil domain containing 2)

Identity

Alias_namesGRIP and coiled-coil domain-containing 2
Alias_symbol (synonym)GCC185
KIAA0336
Other aliasRANBP2L4
REN53
HGNC (Hugo) GCC2
LocusID (NCBI) 9648
Atlas_Id 53005
Location 2q12.3  [Link to chromosome band 2q12]
Location_base_pair Starts at 108449121 and ends at 108509398 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RANBP2 (2q12.3) / GCC2 (2q12.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GCC2   23218
Cards
Entrez_Gene (NCBI)GCC2  9648  GRIP and coiled-coil domain containing 2
AliasesGCC185; RANBP2L4; REN53
GeneCards (Weizmann)GCC2
Ensembl hg19 (Hinxton)ENSG00000135968 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135968 [Gene_View]  chr2:108449121-108509398 [Contig_View]  GCC2 [Vega]
ICGC DataPortalENSG00000135968
TCGA cBioPortalGCC2
AceView (NCBI)GCC2
Genatlas (Paris)GCC2
WikiGenes9648
SOURCE (Princeton)GCC2
Genetics Home Reference (NIH)GCC2
Genomic and cartography
GoldenPath hg38 (UCSC)GCC2  -     chr2:108449121-108509398 +  2q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GCC2  -     2q12.3   [Description]    (hg19-Feb_2009)
EnsemblGCC2 - 2q12.3 [CytoView hg19]  GCC2 - 2q12.3 [CytoView hg38]
Mapping of homologs : NCBIGCC2 [Mapview hg19]  GCC2 [Mapview hg38]
OMIM612711   
Gene and transcription
Genbank (Entrez)AA171957 AB002334 AF273042 AF432211 AI084646
RefSeq transcript (Entrez)NM_181453
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GCC2
Cluster EST : UnigeneHs.469630 [ NCBI ]
CGAP (NCI)Hs.469630
Alternative Splicing GalleryENSG00000135968
Gene ExpressionGCC2 [ NCBI-GEO ]   GCC2 [ EBI - ARRAY_EXPRESS ]   GCC2 [ SEEK ]   GCC2 [ MEM ]
Gene Expression Viewer (FireBrowse)GCC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9648
GTEX Portal (Tissue expression)GCC2
Human Protein AtlasENSG00000135968-GCC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IWJ2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IWJ2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IWJ2
Splice isoforms : SwissVarQ8IWJ2
PhosPhoSitePlus>/TD>=TL>Q8IWJ2
Domaine pattern : Prosite (Expaxy)GRIP (PS50913)   
Domains : Interpro (EBI)GCC2_Rab_bind    GRIP_dom   
Domain families : Pfam (Sanger)GRIP (PF01465)    Rab_bind (PF16704)   
Domain families : Pfam (NCBI)pfam01465    pfam16704   
Domain families : Smart (EMBL)Grip (SM00755)  
Conserved Domain (NCBI)GCC2
DMDM Disease mutations9648
Blocks (Seattle)GCC2
PDB (SRS)3BBP   
PDB (PDBSum)3BBP   
PDB (IMB)3BBP   
PDB (RSDB)3BBP   
Structural Biology KnowledgeBase3BBP   
SCOP (Structural Classification of Proteins)3BBP   
CATH (Classification of proteins structures)3BBP   
SuperfamilyQ8IWJ2
Human Protein Atlas [tissue]ENSG00000135968-GCC2 [tissue]
Peptide AtlasQ8IWJ2
HPRD11001
IPIIPI00005631   IPI00947067   IPI00917491   IPI00872239   IPI00936924   IPI00916213   IPI00915796   
Protein Interaction databases
DIP (DOE-UCLA)Q8IWJ2
IntAct (EBI)Q8IWJ2
FunCoupENSG00000135968
BioGRIDGCC2
STRING (EMBL)GCC2
ZODIACGCC2
Ontologies - Pathways
QuickGOQ8IWJ2
Ontology : AmiGOprotein targeting to Golgi  protein binding  nucleoplasm  Golgi apparatus  trans-Golgi network  cytosol  protein targeting to lysosome  membrane  microtubule organizing center organization  protein localization to Golgi apparatus  microtubule anchoring  late endosome to Golgi transport  retrograde transport, endosome to Golgi  identical protein binding  Golgi to plasma membrane protein transport  regulation of protein exit from endoplasmic reticulum  recycling endosome to Golgi transport  Golgi ribbon formation  
Ontology : EGO-EBIprotein targeting to Golgi  protein binding  nucleoplasm  Golgi apparatus  trans-Golgi network  cytosol  protein targeting to lysosome  membrane  microtubule organizing center organization  protein localization to Golgi apparatus  microtubule anchoring  late endosome to Golgi transport  retrograde transport, endosome to Golgi  identical protein binding  Golgi to plasma membrane protein transport  regulation of protein exit from endoplasmic reticulum  recycling endosome to Golgi transport  Golgi ribbon formation  
NDEx NetworkGCC2
Atlas of Cancer Signalling NetworkGCC2
Wikipedia pathwaysGCC2
Orthology - Evolution
OrthoDB9648
GeneTree (enSembl)ENSG00000135968
Phylogenetic Trees/Animal Genes : TreeFamGCC2
HOVERGENQ8IWJ2
HOGENOMQ8IWJ2
Homologs : HomoloGeneGCC2
Homology/Alignments : Family Browser (UCSC)GCC2
Gene fusions - Rearrangements
Tumor Fusion PortalGCC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGCC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GCC2
dbVarGCC2
ClinVarGCC2
1000_GenomesGCC2 
Exome Variant ServerGCC2
ExAC (Exome Aggregation Consortium)ENSG00000135968
GNOMAD BrowserENSG00000135968
Genetic variants : HAPMAP9648
Genomic Variants (DGV)GCC2 [DGVbeta]
DECIPHERGCC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGCC2 
Mutations
ICGC Data PortalGCC2 
TCGA Data PortalGCC2 
Broad Tumor PortalGCC2
OASIS PortalGCC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGCC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGCC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GCC2
DgiDB (Drug Gene Interaction Database)GCC2
DoCM (Curated mutations)GCC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GCC2 (select a term)
intoGenGCC2
Cancer3DGCC2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612711   
Orphanet
DisGeNETGCC2
MedgenGCC2
Genetic Testing Registry GCC2
NextProtQ8IWJ2 [Medical]
TSGene9648
GENETestsGCC2
Target ValidationGCC2
Huge Navigator GCC2 [HugePedia]
snp3D : Map Gene to Disease9648
BioCentury BCIQGCC2
ClinGenGCC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9648
Chemical/Pharm GKB GenePA134876902
Clinical trialGCC2
Miscellaneous
canSAR (ICR)GCC2 (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGCC2
EVEXGCC2
GoPubMedGCC2
iHOPGCC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Nov 21 14:14:20 CET 2017

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