GCC2 (GRIP and coiled-coil domain containing 2)

2012-11-01  

Identity

HGNC
GCC2
LOCATION
2q12.3
LOCUSID
9648
ALIAS
GCC185,RANBP2L4,REN53
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9648
MIM: 612711
HGNC: 23218
Ensembl: ENSG00000135968

Variants:

dbSNP: 9648
ClinVar: 9648
TCGA: ENSG00000135968
COSMIC: GCC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135968ENST00000309863Q8IWJ2
ENSG00000135968ENST00000393321H7BYJ9
ENSG00000135968ENST00000409821B8ZZA5
ENSG00000135968ENST00000409896B8ZZW2
ENSG00000135968ENST00000447558H7C010
ENSG00000135968ENST00000462897U3KPU4
ENSG00000135968ENST00000482325Q8IWJ2
ENSG00000135968ENST00000492785U3KQE0

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Retrograde transport at the Trans-Golgi-NetworkREACTOMER-HSA-6811440

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
182431032008Rab and Arl GTPase family members cooperate in the localization of the golgin GCC185.76
174882912007The trans-Golgi network golgin, GCC185, is required for endosome-to-Golgi transport and maintenance of Golgi structure.56
189460812009Multiple Rab GTPase binding sites in GCC185 suggest a model for vesicle tethering at the trans-Golgi.47
124466652003GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network.46
168854192006A functional role for the GCC185 golgin in mannose 6-phosphate receptor recycling.45
266538562015Protein flexibility is required for vesicle tethering at the Golgi.25
197034032009The localization of the Golgin GCC185 is independent of Rab6A/A' and Arl1.16
218759482011GCC185 plays independent roles in Golgi structure maintenance and AP-1-mediated vesicle tethering.16
221594192011ARL4A acts with GCC185 to modulate Golgi complex organization.14
156547692005The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers.11

Citation

Dessen P

GCC2 (GRIP and coiled-coil domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/53005/gcc2