Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

GCDH (glutaryl-CoA dehydrogenase)

Identity

Alias_namesglutaryl-Coenzyme A dehydrogenase
Alias_symbol (synonym)ACAD5
Other aliasGCD
HGNC (Hugo) GCDH
LocusID (NCBI) 2639
Atlas_Id 63733
Location 19p13.13  [Link to chromosome band 19p13]
Location_base_pair Starts at 12891129 and ends at 12899999 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GCDH (19p13.2) / LSP1 (11p15.5)NFIX (19p13.2) / GCDH (19p13.2)SLCO4A1 (20q13.33) / GCDH (19p13.2)
WDR1 (4p16.1) / GCDH (19p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GCDH   4189
Cards
Entrez_Gene (NCBI)GCDH  2639  glutaryl-CoA dehydrogenase
AliasesACAD5; GCD
GeneCards (Weizmann)GCDH
Ensembl hg19 (Hinxton)ENSG00000105607 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105607 [Gene_View]  chr19:12891129-12899999 [Contig_View]  GCDH [Vega]
ICGC DataPortalENSG00000105607
TCGA cBioPortalGCDH
AceView (NCBI)GCDH
Genatlas (Paris)GCDH
WikiGenes2639
SOURCE (Princeton)GCDH
Genetics Home Reference (NIH)GCDH
Genomic and cartography
GoldenPath hg38 (UCSC)GCDH  -     chr19:12891129-12899999 +  19p13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GCDH  -     19p13.13   [Description]    (hg19-Feb_2009)
EnsemblGCDH - 19p13.13 [CytoView hg19]  GCDH - 19p13.13 [CytoView hg38]
Mapping of homologs : NCBIGCDH [Mapview hg19]  GCDH [Mapview hg38]
OMIM231670   608801   
Gene and transcription
Genbank (Entrez)AK098370 AK290407 AK296446 AK298772 AK300841
RefSeq transcript (Entrez)NM_000159 NM_013976
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GCDH
Cluster EST : UnigeneHs.532699 [ NCBI ]
CGAP (NCI)Hs.532699
Alternative Splicing GalleryENSG00000105607
Gene ExpressionGCDH [ NCBI-GEO ]   GCDH [ EBI - ARRAY_EXPRESS ]   GCDH [ SEEK ]   GCDH [ MEM ]
Gene Expression Viewer (FireBrowse)GCDH [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2639
GTEX Portal (Tissue expression)GCDH
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92947   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92947  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92947
Splice isoforms : SwissVarQ92947
Catalytic activity : Enzyme1.3.8.6 [ Enzyme-Expasy ]   1.3.8.61.3.8.6 [ IntEnz-EBI ]   1.3.8.6 [ BRENDA ]   1.3.8.6 [ KEGG ]   
PhosPhoSitePlusQ92947
Domaine pattern : Prosite (Expaxy)ACYL_COA_DH_1 (PS00072)    ACYL_COA_DH_2 (PS00073)   
Domains : Interpro (EBI)Acyl-CoA_DH_CS    Acyl-CoA_Oxase/DH_cen-dom    AcylCo_DH/oxidase_C    AcylCoA_DH/ox_N    AcylCoA_DH/oxidase_NM_dom   
Domain families : Pfam (Sanger)Acyl-CoA_dh_1 (PF00441)    Acyl-CoA_dh_M (PF02770)    Acyl-CoA_dh_N (PF02771)   
Domain families : Pfam (NCBI)pfam00441    pfam02770    pfam02771   
Conserved Domain (NCBI)GCDH
DMDM Disease mutations2639
Blocks (Seattle)GCDH
PDB (SRS)1SIQ    1SIR    2R0M    2R0N   
PDB (PDBSum)1SIQ    1SIR    2R0M    2R0N   
PDB (IMB)1SIQ    1SIR    2R0M    2R0N   
PDB (RSDB)1SIQ    1SIR    2R0M    2R0N   
Structural Biology KnowledgeBase1SIQ    1SIR    2R0M    2R0N   
SCOP (Structural Classification of Proteins)1SIQ    1SIR    2R0M    2R0N   
CATH (Classification of proteins structures)1SIQ    1SIR    2R0M    2R0N   
SuperfamilyQ92947
Human Protein AtlasENSG00000105607
Peptide AtlasQ92947
HPRD01977
IPIIPI00024317   IPI00218112   IPI00908343   IPI00911081   IPI00909645   IPI00815688   
Protein Interaction databases
DIP (DOE-UCLA)Q92947
IntAct (EBI)Q92947
FunCoupENSG00000105607
BioGRIDGCDH
STRING (EMBL)GCDH
ZODIACGCDH
Ontologies - Pathways
QuickGOQ92947
Ontology : AmiGOfatty-acyl-CoA binding  glutaryl-CoA dehydrogenase activity  mitochondrion  mitochondrial matrix  lysine catabolic process  tryptophan metabolic process  fatty acid beta-oxidation using acyl-CoA dehydrogenase  fatty-acyl-CoA biosynthetic process  flavin adenine dinucleotide binding  
Ontology : EGO-EBIfatty-acyl-CoA binding  glutaryl-CoA dehydrogenase activity  mitochondrion  mitochondrial matrix  lysine catabolic process  tryptophan metabolic process  fatty acid beta-oxidation using acyl-CoA dehydrogenase  fatty-acyl-CoA biosynthetic process  flavin adenine dinucleotide binding  
Pathways : KEGGFatty acid degradation    Lysine degradation    Tryptophan metabolism   
NDEx NetworkGCDH
Atlas of Cancer Signalling NetworkGCDH
Wikipedia pathwaysGCDH
Orthology - Evolution
OrthoDB2639
GeneTree (enSembl)ENSG00000105607
Phylogenetic Trees/Animal Genes : TreeFamGCDH
HOVERGENQ92947
HOGENOMQ92947
Homologs : HomoloGeneGCDH
Homology/Alignments : Family Browser (UCSC)GCDH
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGCDH [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GCDH
dbVarGCDH
ClinVarGCDH
1000_GenomesGCDH 
Exome Variant ServerGCDH
ExAC (Exome Aggregation Consortium)GCDH (select the gene name)
Genetic variants : HAPMAP2639
Genomic Variants (DGV)GCDH [DGVbeta]
DECIPHERGCDH [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGCDH 
Mutations
ICGC Data PortalGCDH 
TCGA Data PortalGCDH 
Broad Tumor PortalGCDH
OASIS PortalGCDH [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGCDH  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGCDH
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch GCDH
DgiDB (Drug Gene Interaction Database)GCDH
DoCM (Curated mutations)GCDH (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GCDH (select a term)
intoGenGCDH
Cancer3DGCDH(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM231670    608801   
Orphanet3564   
MedgenGCDH
Genetic Testing Registry GCDH
NextProtQ92947 [Medical]
TSGene2639
GENETestsGCDH
Target ValidationGCDH
Huge Navigator GCDH [HugePedia]
snp3D : Map Gene to Disease2639
BioCentury BCIQGCDH
ClinGenGCDH
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2639
Chemical/Pharm GKB GenePA28604
Clinical trialGCDH
Miscellaneous
canSAR (ICR)GCDH (select the gene name)
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGCDH
EVEXGCDH
GoPubMedGCDH
iHOPGCDH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 13:09:16 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.