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GCDH (glutaryl-CoA dehydrogenase)

Identity

Alias (NCBI)ACAD5
GCD
HGNC (Hugo) GCDH
HGNC Alias symbACAD5
HGNC Previous nameglutaryl-Coenzyme A dehydrogenase
LocusID (NCBI) 2639
Atlas_Id 63733
Location 19p13.13  [Link to chromosome band 19p13]
Location_base_pair Starts at 12891160 and ends at 12899999 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GCDH (19p13.2) / LSP1 (11p15.5)NFIX (19p13.2) / GCDH (19p13.2)SLCO4A1 (20q13.33) / GCDH (19p13.2)
WDR1 (4p16.1) / GCDH (19p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)GCDH   4189
Cards
Entrez_Gene (NCBI)GCDH    glutaryl-CoA dehydrogenase
AliasesACAD5; GCD
GeneCards (Weizmann)GCDH
Ensembl hg19 (Hinxton)ENSG00000105607 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105607 [Gene_View]  ENSG00000105607 [Sequence]  chr19:12891160-12899999 [Contig_View]  GCDH [Vega]
ICGC DataPortalENSG00000105607
TCGA cBioPortalGCDH
AceView (NCBI)GCDH
Genatlas (Paris)GCDH
SOURCE (Princeton)GCDH
Genetics Home Reference (NIH)GCDH
Genomic and cartography
GoldenPath hg38 (UCSC)GCDH  -     chr19:12891160-12899999 +  19p13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GCDH  -     19p13.13   [Description]    (hg19-Feb_2009)
GoldenPathGCDH - 19p13.13 [CytoView hg19]  GCDH - 19p13.13 [CytoView hg38]
ImmunoBaseENSG00000105607
Genome Data Viewer NCBIGCDH [Mapview hg19]  
OMIM231670   608801   
Gene and transcription
Genbank (Entrez)AK098370 AK290407 AK296446 AK298772 AK300841
RefSeq transcript (Entrez)NM_000159 NM_013976
Consensus coding sequences : CCDS (NCBI)GCDH
Gene ExpressionGCDH [ NCBI-GEO ]   GCDH [ EBI - ARRAY_EXPRESS ]   GCDH [ SEEK ]   GCDH [ MEM ]
Gene Expression Viewer (FireBrowse)GCDH [ Firebrowse - Broad ]
GenevisibleExpression of GCDH in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2639
GTEX Portal (Tissue expression)GCDH
Human Protein AtlasENSG00000105607-GCDH [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92947   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92947  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92947
Catalytic activity : Enzyme1.3.8.6 [ Enzyme-Expasy ]   1.3.8.61.3.8.6 [ IntEnz-EBI ]   1.3.8.6 [ BRENDA ]   1.3.8.6 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ92947
Domaine pattern : Prosite (Expaxy)ACYL_COA_DH_1 (PS00072)    ACYL_COA_DH_2 (PS00073)   
Domains : Interpro (EBI)Acyl-CoA_DH_CS    Acyl-CoA_Oxase/DH_cen-dom    AcylCo_DH-like_C    AcylCo_DH/oxidase_C    AcylCoA_DH/ox_N    AcylCoA_DH/ox_N_sf    AcylCoA_DH/oxidase_NM_dom   
Domain families : Pfam (Sanger)Acyl-CoA_dh_1 (PF00441)    Acyl-CoA_dh_M (PF02770)    Acyl-CoA_dh_N (PF02771)   
Domain families : Pfam (NCBI)pfam00441    pfam02770    pfam02771   
Conserved Domain (NCBI)GCDH
PDB (RSDB)1SIQ    1SIR    2R0M    2R0N   
PDB Europe1SIQ    1SIR    2R0M    2R0N   
PDB (PDBSum)1SIQ    1SIR    2R0M    2R0N   
PDB (IMB)1SIQ    1SIR    2R0M    2R0N   
Structural Biology KnowledgeBase1SIQ    1SIR    2R0M    2R0N   
SCOP (Structural Classification of Proteins)1SIQ    1SIR    2R0M    2R0N   
CATH (Classification of proteins structures)1SIQ    1SIR    2R0M    2R0N   
SuperfamilyQ92947
AlphaFold pdb e-kbQ92947   
Human Protein Atlas [tissue]ENSG00000105607-GCDH [tissue]
HPRD01977
Protein Interaction databases
DIP (DOE-UCLA)Q92947
IntAct (EBI)Q92947
BioGRIDGCDH
STRING (EMBL)GCDH
ZODIACGCDH
Ontologies - Pathways
QuickGOQ92947
Ontology : AmiGOfatty-acyl-CoA binding  glutaryl-CoA dehydrogenase activity  glutaryl-CoA dehydrogenase activity  mitochondrion  mitochondrial matrix  lysine catabolic process  tryptophan metabolic process  fatty acid beta-oxidation using acyl-CoA dehydrogenase  fatty acid beta-oxidation using acyl-CoA dehydrogenase  fatty-acyl-CoA biosynthetic process  flavin adenine dinucleotide binding  
Ontology : EGO-EBIfatty-acyl-CoA binding  glutaryl-CoA dehydrogenase activity  glutaryl-CoA dehydrogenase activity  mitochondrion  mitochondrial matrix  lysine catabolic process  tryptophan metabolic process  fatty acid beta-oxidation using acyl-CoA dehydrogenase  fatty acid beta-oxidation using acyl-CoA dehydrogenase  fatty-acyl-CoA biosynthetic process  flavin adenine dinucleotide binding  
Pathways : KEGGLysine degradation    Benzoate degradation via CoA ligation    Tryptophan metabolism    Fatty acid metabolism   
NDEx NetworkGCDH
Atlas of Cancer Signalling NetworkGCDH
Wikipedia pathwaysGCDH
Orthology - Evolution
OrthoDB2639
GeneTree (enSembl)ENSG00000105607
Phylogenetic Trees/Animal Genes : TreeFamGCDH
Homologs : HomoloGeneGCDH
Homology/Alignments : Family Browser (UCSC)GCDH
Gene fusions - Rearrangements
Fusion : QuiverGCDH
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGCDH [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GCDH
dbVarGCDH
ClinVarGCDH
MonarchGCDH
1000_GenomesGCDH 
Exome Variant ServerGCDH
GNOMAD BrowserENSG00000105607
Varsome BrowserGCDH
ACMGGCDH variants
VarityQ92947
Genomic Variants (DGV)GCDH [DGVbeta]
DECIPHERGCDH [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGCDH 
Mutations
ICGC Data PortalGCDH 
TCGA Data PortalGCDH 
Broad Tumor PortalGCDH
OASIS PortalGCDH [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGCDH  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGCDH
Mutations and Diseases : HGMDGCDH
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaGCDH
DgiDB (Drug Gene Interaction Database)GCDH
DoCM (Curated mutations)GCDH
CIViC (Clinical Interpretations of Variants in Cancer)GCDH
Cancer3DGCDH
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM231670    608801   
Orphanet3564   
DisGeNETGCDH
MedgenGCDH
Genetic Testing Registry GCDH
NextProtQ92947 [Medical]
GENETestsGCDH
Target ValidationGCDH
Huge Navigator GCDH [HugePedia]
ClinGenGCDH
Clinical trials, drugs, therapy
MyCancerGenomeGCDH
Protein Interactions : CTDGCDH
Pharm GKB GenePA28604
PharosQ92947
Clinical trialGCDH
Miscellaneous
canSAR (ICR)GCDH
HarmonizomeGCDH
DataMed IndexGCDH
Probes
Litterature
PubMed84 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGCDH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:51:17 CEST 2021

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