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GCG (glucagon)

Identity

Alias_symbol (synonym)GLP1
GLP2
GRPP
Other aliasGLP-1
HGNC (Hugo) GCG
LocusID (NCBI) 2641
Atlas_Id 43798
Location 2q24.2  [Link to chromosome band 2q24]
Location_base_pair Starts at 162142869 and ends at 162152404 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GCG (2q24.2) / CPA1 (7q32.2)GCG (2q24.2) / GCG (2q24.2)PMS1 (2q32.2) / GCG (2q24.2)
PMS1 2q32.2 / GCG 2q24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GCG   4191
Cards
Entrez_Gene (NCBI)GCG  2641  glucagon
AliasesGLP-1; GLP1; GLP2; GRPP
GeneCards (Weizmann)GCG
Ensembl hg19 (Hinxton)ENSG00000115263 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115263 [Gene_View]  chr2:162142869-162152404 [Contig_View]  GCG [Vega]
ICGC DataPortalENSG00000115263
TCGA cBioPortalGCG
AceView (NCBI)GCG
Genatlas (Paris)GCG
WikiGenes2641
SOURCE (Princeton)GCG
Genetics Home Reference (NIH)GCG
Genomic and cartography
GoldenPath hg38 (UCSC)GCG  -     chr2:162142869-162152404 -  2q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GCG  -     2q24.2   [Description]    (hg19-Feb_2009)
EnsemblGCG - 2q24.2 [CytoView hg19]  GCG - 2q24.2 [CytoView hg38]
Mapping of homologs : NCBIGCG [Mapview hg19]  GCG [Mapview hg38]
OMIM138030   
Gene and transcription
Genbank (Entrez)AI818268 BC005278 BG654603 BM272442 BT006813
RefSeq transcript (Entrez)NM_002054
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GCG
Cluster EST : UnigeneHs.741174 [ NCBI ]
CGAP (NCI)Hs.741174
Alternative Splicing GalleryENSG00000115263
Gene ExpressionGCG [ NCBI-GEO ]   GCG [ EBI - ARRAY_EXPRESS ]   GCG [ SEEK ]   GCG [ MEM ]
Gene Expression Viewer (FireBrowse)GCG [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2641
GTEX Portal (Tissue expression)GCG
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01275   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01275  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01275
Splice isoforms : SwissVarP01275
PhosPhoSitePlusP01275
Domaine pattern : Prosite (Expaxy)GLUCAGON (PS00260)   
Domains : Interpro (EBI)Glucagon    Glucagon_GIP_secretin_VIP   
Domain families : Pfam (Sanger)Hormone_2 (PF00123)   
Domain families : Pfam (NCBI)pfam00123   
Domain families : Smart (EMBL)GLUCA (SM00070)  
Conserved Domain (NCBI)GCG
DMDM Disease mutations2641
Blocks (Seattle)GCG
PDB (SRS)1BH0    1D0R    1NAU    2G49    2L63    2L64    2M5P    2M5Q    3IOL    4APD    4ZGM   
PDB (PDBSum)1BH0    1D0R    1NAU    2G49    2L63    2L64    2M5P    2M5Q    3IOL    4APD    4ZGM   
PDB (IMB)1BH0    1D0R    1NAU    2G49    2L63    2L64    2M5P    2M5Q    3IOL    4APD    4ZGM   
PDB (RSDB)1BH0    1D0R    1NAU    2G49    2L63    2L64    2M5P    2M5Q    3IOL    4APD    4ZGM   
Structural Biology KnowledgeBase1BH0    1D0R    1NAU    2G49    2L63    2L64    2M5P    2M5Q    3IOL    4APD    4ZGM   
SCOP (Structural Classification of Proteins)1BH0    1D0R    1NAU    2G49    2L63    2L64    2M5P    2M5Q    3IOL    4APD    4ZGM   
CATH (Classification of proteins structures)1BH0    1D0R    1NAU    2G49    2L63    2L64    2M5P    2M5Q    3IOL    4APD    4ZGM   
SuperfamilyP01275
Human Protein AtlasENSG00000115263
Peptide AtlasP01275
HPRD00676
IPIIPI00744153   
Protein Interaction databases
DIP (DOE-UCLA)P01275
IntAct (EBI)P01275
FunCoupENSG00000115263
BioGRIDGCG
STRING (EMBL)GCG
ZODIACGCG
Ontologies - Pathways
QuickGOP01275
Ontology : AmiGOreceptor binding  hormone activity  protein binding  extracellular region  extracellular space  endoplasmic reticulum lumen  plasma membrane  signal transduction  G-protein coupled receptor signaling pathway  feeding behavior  cell proliferation  protein kinase A signaling  positive regulation of peptidyl-threonine phosphorylation  positive regulation of cAMP biosynthetic process  positive regulation of protein binding  positive regulation of peptidyl-serine phosphorylation  secretory granule lumen  positive regulation of insulin secretion involved in cellular response to glucose stimulus  positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter  identical protein binding  positive regulation of protein kinase activity  regulation of insulin secretion  positive regulation of histone H3-K4 methylation  positive regulation of ERK1 and ERK2 cascade  cellular response to glucagon stimulus  positive regulation of calcium ion import  negative regulation of execution phase of apoptosis  
Ontology : EGO-EBIreceptor binding  hormone activity  protein binding  extracellular region  extracellular space  endoplasmic reticulum lumen  plasma membrane  signal transduction  G-protein coupled receptor signaling pathway  feeding behavior  cell proliferation  protein kinase A signaling  positive regulation of peptidyl-threonine phosphorylation  positive regulation of cAMP biosynthetic process  positive regulation of protein binding  positive regulation of peptidyl-serine phosphorylation  secretory granule lumen  positive regulation of insulin secretion involved in cellular response to glucose stimulus  positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter  identical protein binding  positive regulation of protein kinase activity  regulation of insulin secretion  positive regulation of histone H3-K4 methylation  positive regulation of ERK1 and ERK2 cascade  cellular response to glucagon stimulus  positive regulation of calcium ion import  negative regulation of execution phase of apoptosis  
Pathways : KEGGInsulin secretion   
NDEx NetworkGCG
Atlas of Cancer Signalling NetworkGCG
Wikipedia pathwaysGCG
Orthology - Evolution
OrthoDB2641
GeneTree (enSembl)ENSG00000115263
Phylogenetic Trees/Animal Genes : TreeFamGCG
HOVERGENP01275
HOGENOMP01275
Homologs : HomoloGeneGCG
Homology/Alignments : Family Browser (UCSC)GCG
Gene fusions - Rearrangements
Fusion : MitelmanPMS1/GCG [2q32.2/2q24.2]  [t(2;2)(q24;q32)]  
Fusion: TCGAPMS1 2q32.2 GCG 2q24.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGCG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GCG
dbVarGCG
ClinVarGCG
1000_GenomesGCG 
Exome Variant ServerGCG
ExAC (Exome Aggregation Consortium)GCG (select the gene name)
Genetic variants : HAPMAP2641
Genomic Variants (DGV)GCG [DGVbeta]
DECIPHERGCG [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGCG 
Mutations
ICGC Data PortalGCG 
TCGA Data PortalGCG 
Broad Tumor PortalGCG
OASIS PortalGCG [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGCG  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGCG
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GCG
DgiDB (Drug Gene Interaction Database)GCG
DoCM (Curated mutations)GCG (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GCG (select a term)
intoGenGCG
Cancer3DGCG(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138030   
Orphanet
MedgenGCG
Genetic Testing Registry GCG
NextProtP01275 [Medical]
TSGene2641
GENETestsGCG
Target ValidationGCG
Huge Navigator GCG [HugePedia]
snp3D : Map Gene to Disease2641
BioCentury BCIQGCG
ClinGenGCG
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2641
Chemical/Pharm GKB GenePA28606
Clinical trialGCG
Miscellaneous
canSAR (ICR)GCG (select the gene name)
Probes
Litterature
PubMed252 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGCG
EVEXGCG
GoPubMedGCG
iHOPGCG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:09:33 CEST 2017

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