GCG (glucagon)

2007-02-01  

Identity

HGNC
LOCATION
2q24.2
LOCUSID
ALIAS
GLP-1,GLP1,GLP2,GRPP
FUSION GENES

Other Information

Locus ID:

NCBI: 2641
MIM: 138030
HGNC: 4191
Ensembl: ENSG00000115263

Variants:

dbSNP: 2641
ClinVar: 2641
TCGA: ENSG00000115263
COSMIC: GCG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115263ENST00000375497P01275
ENSG00000115263ENST00000418842P01275

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Insulin secretionKEGGhsa04911
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Synthesis, secretion, and deacylation of GhrelinREACTOMER-HSA-422085
Incretin synthesis, secretion, and inactivationREACTOMER-HSA-400508
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)REACTOMER-HSA-381771
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Glucagon-type ligand receptorsREACTOMER-HSA-420092
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Regulation of insulin secretionREACTOMER-HSA-422356
Glucagon-like Peptide-1 (GLP1) regulates insulin secretionREACTOMER-HSA-381676
Glucagon signaling in metabolic regulationREACTOMER-HSA-163359

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447216SchizophreniaDiseaseClinicalAnnotationassociated24624910
PA449061clozapineChemicalClinicalAnnotationassociated24624910
PA450688olanzapineChemicalClinicalAnnotationassociated24624910

References

Pubmed IDYearTitleCitations
177243302007Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.278
220376452011Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.212
156160222005Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury.147
129600952003Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets.134
208719752011Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down?108
206826872010Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.88
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
230640142012A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin.77
125198562003Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects.65
161329642005Alpha cell function in health and disease: influence of glucagon-like peptide-1.65

Citation

Dessen P

GCG (glucagon)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43798/gcg