Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

GCGR (glucagon receptor)

Identity

Alias_symbol (synonym)GGR
Other aliasGL-R
HGNC (Hugo) GCGR
LocusID (NCBI) 2642
Atlas_Id 52502
Location 17q25.3  [Link to chromosome band 17q25]
Location_base_pair Starts at 79762008 and ends at 79771889 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
LRRC45 (17q25.3) / GCGR (17q25.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)GCGR   4192
Cards
Entrez_Gene (NCBI)GCGR  2642  glucagon receptor
AliasesGGR; GL-R
GeneCards (Weizmann)GCGR
Ensembl hg19 (Hinxton)ENSG00000215644 [Gene_View]  chr17:79762008-79771889 [Contig_View]  GCGR [Vega]
Ensembl hg38 (Hinxton)ENSG00000215644 [Gene_View]  chr17:79762008-79771889 [Contig_View]  GCGR [Vega]
ICGC DataPortalENSG00000215644
TCGA cBioPortalGCGR
AceView (NCBI)GCGR
Genatlas (Paris)GCGR
WikiGenes2642
SOURCE (Princeton)GCGR
Genetics Home Reference (NIH)GCGR
Genomic and cartography
GoldenPath hg19 (UCSC)GCGR  -     chr17:79762008-79771889 +  17q25.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GCGR  -     17q25.3   [Description]    (hg38-Dec_2013)
EnsemblGCGR - 17q25.3 [CytoView hg19]  GCGR - 17q25.3 [CytoView hg38]
Mapping of homologs : NCBIGCGR [Mapview hg19]  GCGR [Mapview hg38]
OMIM125853   138033   
Gene and transcription
Genbank (Entrez)AK307234 AK314247 BC104854 BC112041 BJ997148
RefSeq transcript (Entrez)NM_000160
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_016409 NT_010663 NW_004929408
Consensus coding sequences : CCDS (NCBI)GCGR
Cluster EST : UnigeneHs.208 [ NCBI ]
CGAP (NCI)Hs.208
Alternative Splicing GalleryENSG00000215644
Gene ExpressionGCGR [ NCBI-GEO ]   GCGR [ EBI - ARRAY_EXPRESS ]   GCGR [ SEEK ]   GCGR [ MEM ]
Gene Expression Viewer (FireBrowse)GCGR [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2642
GTEX Portal (Tissue expression)GCGR
Protein : pattern, domain, 3D structure
UniProt/SwissProtP47871   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP47871  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP47871
Splice isoforms : SwissVarP47871
PhosPhoSitePlusP47871
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F2_1 (PS00649)    G_PROTEIN_RECEP_F2_2 (PS00650)    G_PROTEIN_RECEP_F2_3 (PS50227)    G_PROTEIN_RECEP_F2_4 (PS50261)   
Domains : Interpro (EBI)GPCR_2-like    GPCR_2_extracellular_dom    GPCR_2_GLP1/glucagon_rcpt    GPCR_2_glucagon_rcpt    GPCR_2_secretin-like    GPCR_2_secretin-like_CS   
Domain families : Pfam (Sanger)7tm_2 (PF00002)    HRM (PF02793)   
Domain families : Pfam (NCBI)pfam00002    pfam02793   
Domain families : Smart (EMBL)HormR (SM00008)  
Conserved Domain (NCBI)GCGR
DMDM Disease mutations2642
Blocks (Seattle)GCGR
PDB (SRS)2A83    3CZF    4ERS    4L6R    4LF3   
PDB (PDBSum)2A83    3CZF    4ERS    4L6R    4LF3   
PDB (IMB)2A83    3CZF    4ERS    4L6R    4LF3   
PDB (RSDB)2A83    3CZF    4ERS    4L6R    4LF3   
Structural Biology KnowledgeBase2A83    3CZF    4ERS    4L6R    4LF3   
SCOP (Structural Classification of Proteins)2A83    3CZF    4ERS    4L6R    4LF3   
CATH (Classification of proteins structures)2A83    3CZF    4ERS    4L6R    4LF3   
SuperfamilyP47871
Human Protein AtlasENSG00000215644
Peptide AtlasP47871
HPRD00678
IPIIPI00412345   
Protein Interaction databases
DIP (DOE-UCLA)P47871
IntAct (EBI)P47871
FunCoupENSG00000215644
BioGRIDGCGR
STRING (EMBL)GCGR
ZODIACGCGR
Ontologies - Pathways
QuickGOP47871
Ontology : AmiGOglucagon receptor activity  guanyl-nucleotide exchange factor activity  endosome  plasma membrane  integral component of plasma membrane  generation of precursor metabolites and energy  exocytosis  cell surface receptor signaling pathway  adenylate cyclase-modulating G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  response to nutrient  regulation of blood pressure  hormone-mediated signaling pathway  integral component of membrane  peptide hormone binding  glucose homeostasis  response to starvation  positive regulation of GTPase activity  regulation of glycogen metabolic process  cellular response to glucagon stimulus  cellular response to glucagon stimulus  
Ontology : EGO-EBIglucagon receptor activity  guanyl-nucleotide exchange factor activity  endosome  plasma membrane  integral component of plasma membrane  generation of precursor metabolites and energy  exocytosis  cell surface receptor signaling pathway  adenylate cyclase-modulating G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  response to nutrient  regulation of blood pressure  hormone-mediated signaling pathway  integral component of membrane  peptide hormone binding  glucose homeostasis  response to starvation  positive regulation of GTPase activity  regulation of glycogen metabolic process  cellular response to glucagon stimulus  cellular response to glucagon stimulus  
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkGCGR
Atlas of Cancer Signalling NetworkGCGR
Wikipedia pathwaysGCGR
Orthology - Evolution
OrthoDB2642
GeneTree (enSembl)ENSG00000215644
Phylogenetic Trees/Animal Genes : TreeFamGCGR
HOVERGENP47871
HOGENOMP47871
Homologs : HomoloGeneGCGR
Homology/Alignments : Family Browser (UCSC)GCGR
Gene fusions - Rearrangements
Fusion : MitelmanLRRC45/GCGR [17q25.3/17q25.3]  [t(17;17)(q25;q25)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGCGR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GCGR
dbVarGCGR
ClinVarGCGR
1000_GenomesGCGR 
Exome Variant ServerGCGR
ExAC (Exome Aggregation Consortium)GCGR (select the gene name)
Genetic variants : HAPMAP2642
Genomic Variants (DGV)GCGR [DGVbeta]
DECIPHER (Syndromes)17:79762008-79771889  ENSG00000215644
CONAN: Copy Number AnalysisGCGR 
Mutations
ICGC Data PortalGCGR 
TCGA Data PortalGCGR 
Broad Tumor PortalGCGR
OASIS PortalGCGR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGCGR  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGCGR
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch GCGR
DgiDB (Drug Gene Interaction Database)GCGR
DoCM (Curated mutations)GCGR (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GCGR (select a term)
intoGenGCGR
Cancer3DGCGR(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM125853    138033   
Orphanet23373   
MedgenGCGR
Genetic Testing Registry GCGR
NextProtP47871 [Medical]
TSGene2642
GENETestsGCGR
Huge Navigator GCGR [HugePedia]
snp3D : Map Gene to Disease2642
BioCentury BCIQGCGR
ClinGenGCGR
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2642
Chemical/Pharm GKB GenePA28607
Clinical trialGCGR
Miscellaneous
canSAR (ICR)GCGR (select the gene name)
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGCGR
EVEXGCGR
GoPubMedGCGR
iHOPGCGR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:07:11 CET 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.