Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GCHFR (GTP cyclohydrolase I feedback regulator)

Identity

Alias_namesGTP cyclohydrolase I feedback regulatory protein
Alias_symbol (synonym)GFRP
HsT16933
Other aliasP35
HGNC (Hugo) GCHFR
LocusID (NCBI) 2644
Atlas_Id 63734
Location 15q15.1  [Link to chromosome band 15q15]
Location_base_pair Starts at 40764087 and ends at 40767713 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GPC6 (13q31.3) / GCHFR (15q15.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GCHFR   4194
Cards
Entrez_Gene (NCBI)GCHFR  2644  GTP cyclohydrolase I feedback regulator
AliasesGFRP; HsT16933; P35
GeneCards (Weizmann)GCHFR
Ensembl hg19 (Hinxton)ENSG00000137880 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137880 [Gene_View]  chr15:40764087-40767713 [Contig_View]  GCHFR [Vega]
ICGC DataPortalENSG00000137880
TCGA cBioPortalGCHFR
AceView (NCBI)GCHFR
Genatlas (Paris)GCHFR
WikiGenes2644
SOURCE (Princeton)GCHFR
Genetics Home Reference (NIH)GCHFR
Genomic and cartography
GoldenPath hg38 (UCSC)GCHFR  -     chr15:40764087-40767713 +  15q15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GCHFR  -     15q15.1   [Description]    (hg19-Feb_2009)
EnsemblGCHFR - 15q15.1 [CytoView hg19]  GCHFR - 15q15.1 [CytoView hg38]
Mapping of homologs : NCBIGCHFR [Mapview hg19]  GCHFR [Mapview hg38]
OMIM602437   
Gene and transcription
Genbank (Entrez)AK223430 AK311872 BC112262 BC112264 BC143904
RefSeq transcript (Entrez)NM_005258
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GCHFR
Cluster EST : UnigeneHs.631717 [ NCBI ]
CGAP (NCI)Hs.631717
Alternative Splicing GalleryENSG00000137880
Gene ExpressionGCHFR [ NCBI-GEO ]   GCHFR [ EBI - ARRAY_EXPRESS ]   GCHFR [ SEEK ]   GCHFR [ MEM ]
Gene Expression Viewer (FireBrowse)GCHFR [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2644
GTEX Portal (Tissue expression)GCHFR
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30047   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30047  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30047
Splice isoforms : SwissVarP30047
PhosPhoSitePlusP30047
Domains : Interpro (EBI)GTP_CycHdrlase_I_reg   
Domain families : Pfam (Sanger)GFRP (PF06399)   
Domain families : Pfam (NCBI)pfam06399   
Domain structure : Prodom (Prabi Lyon)GTP_CycHdrlase_I_reg (PD028559)   
Conserved Domain (NCBI)GCHFR
DMDM Disease mutations2644
Blocks (Seattle)GCHFR
SuperfamilyP30047
Human Protein AtlasENSG00000137880
Peptide AtlasP30047
HPRD03895
IPIIPI00217253   
Protein Interaction databases
DIP (DOE-UCLA)P30047
IntAct (EBI)P30047
FunCoupENSG00000137880
BioGRIDGCHFR
STRING (EMBL)GCHFR
ZODIACGCHFR
Ontologies - Pathways
QuickGOP30047
Ontology : AmiGOenzyme inhibitor activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  nitric oxide biosynthetic process  negative regulation of biosynthetic process  amino acid binding  dendrite  GTP-dependent protein binding  nuclear membrane  neurotransmitter metabolic process  melanosome  negative regulation of GTP cyclohydrolase I activity  protein complex  GTP cyclohydrolase binding  regulation of nitric-oxide synthase activity  protein heterooligomerization  
Ontology : EGO-EBIenzyme inhibitor activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  nitric oxide biosynthetic process  negative regulation of biosynthetic process  amino acid binding  dendrite  GTP-dependent protein binding  nuclear membrane  neurotransmitter metabolic process  melanosome  negative regulation of GTP cyclohydrolase I activity  protein complex  GTP cyclohydrolase binding  regulation of nitric-oxide synthase activity  protein heterooligomerization  
NDEx NetworkGCHFR
Atlas of Cancer Signalling NetworkGCHFR
Wikipedia pathwaysGCHFR
Orthology - Evolution
OrthoDB2644
GeneTree (enSembl)ENSG00000137880
Phylogenetic Trees/Animal Genes : TreeFamGCHFR
HOVERGENP30047
HOGENOMP30047
Homologs : HomoloGeneGCHFR
Homology/Alignments : Family Browser (UCSC)GCHFR
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGCHFR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GCHFR
dbVarGCHFR
ClinVarGCHFR
1000_GenomesGCHFR 
Exome Variant ServerGCHFR
ExAC (Exome Aggregation Consortium)GCHFR (select the gene name)
Genetic variants : HAPMAP2644
Genomic Variants (DGV)GCHFR [DGVbeta]
DECIPHERGCHFR [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGCHFR 
Mutations
ICGC Data PortalGCHFR 
TCGA Data PortalGCHFR 
Broad Tumor PortalGCHFR
OASIS PortalGCHFR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGCHFR  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGCHFR
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GCHFR
DgiDB (Drug Gene Interaction Database)GCHFR
DoCM (Curated mutations)GCHFR (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GCHFR (select a term)
intoGenGCHFR
Cancer3DGCHFR(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602437   
Orphanet
MedgenGCHFR
Genetic Testing Registry GCHFR
NextProtP30047 [Medical]
TSGene2644
GENETestsGCHFR
Target ValidationGCHFR
Huge Navigator GCHFR [HugePedia]
snp3D : Map Gene to Disease2644
BioCentury BCIQGCHFR
ClinGenGCHFR
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2644
Chemical/Pharm GKB GenePA28609
Clinical trialGCHFR
Miscellaneous
canSAR (ICR)GCHFR (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGCHFR
EVEXGCHFR
GoPubMedGCHFR
iHOPGCHFR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 15:50:27 CEST 2017

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