Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GCK (glucokinase (hexokinase 4))

Identity

Other namesFGQTL3
GK
GLK
HHF3
HK4
HKIV
HXKP
LGLK
MODY2
HGNC (Hugo) GCK
LocusID (NCBI) 2645
Location 7p13
Location_base_pair Starts at 44183870 and ends at 44229022 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)GCK   4195
Cards
Entrez_Gene (NCBI)GCK  2645  glucokinase (hexokinase 4)
GeneCards (Weizmann)GCK
Ensembl (Hinxton)ENSG00000106633 [Gene_View]  chr7:44183870-44229022 [Contig_View]  GCK [Vega]
ICGC DataPortalENSG00000106633
cBioPortalGCK
AceView (NCBI)GCK
Genatlas (Paris)GCK
WikiGenes2645
SOURCE (Princeton)NM_000162 NM_033507 NM_033508
Genomic and cartography
GoldenPath (UCSC)GCK  -  7p13   chr7:44183870-44229022 -  7p13   [Description]    (hg19-Feb_2009)
EnsemblGCK - 7p13 [CytoView]
Mapping of homologs : NCBIGCK [Mapview]
OMIM125851   125853   138079   602485   606176   
Gene and transcription
Genbank (Entrez)AK122876 BC001890 BT007062 CD251038 DA640823
RefSeq transcript (Entrez)NM_000162 NM_033507 NM_033508
RefSeq genomic (Entrez)AC_000139 NC_000007 NC_018918 NG_008847 NT_007819 NW_001839004 NW_004929329
Consensus coding sequences : CCDS (NCBI)GCK
Cluster EST : UnigeneHs.1270 [ NCBI ]
CGAP (NCI)Hs.1270
Alternative Splicing : Fast-db (Paris)GSHG0028161
Alternative Splicing GalleryENSG00000106633
Gene ExpressionGCK [ NCBI-GEO ]     GCK [ SEEK ]   GCK [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35557 (Uniprot)
NextProtP35557  [Medical]
With graphics : InterProP35557
Splice isoforms : SwissVarP35557 (Swissvar)
Catalytic activity : Enzyme2.7.1.2 [ Enzyme-Expasy ]   2.7.1.22.7.1.2 [ IntEnz-EBI ]   2.7.1.2 [ BRENDA ]   2.7.1.2 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)HEXOKINASES (PS00378)   
Domains : Interpro (EBI)Hexokinase [organisation]   Hexokinase_C [organisation]   Hexokinase_CS [organisation]   Hexokinase_N [organisation]  
Related proteins : CluSTrP35557
Domain families : Pfam (Sanger)Hexokinase_1 (PF00349)    Hexokinase_2 (PF03727)   
Domain families : Pfam (NCBI)pfam00349    pfam03727   
DMDM Disease mutations2645
Blocks (Seattle)P35557
PDB (SRS)1GLK    1V4S    1V4T    3A0I    3F9M    3FGU    3FR0    3GOI    3H1V    3ID8    3IDH    3IMX    3QIC    3S41    3VEV    3VEY    3VF6    4DCH    4DHY    4ISE    4ISF    4ISG    4IWV    4IXC    4L3Q    4LC9    4MLE    4MLH   
PDB (PDBSum)1GLK    1V4S    1V4T    3A0I    3F9M    3FGU    3FR0    3GOI    3H1V    3ID8    3IDH    3IMX    3QIC    3S41    3VEV    3VEY    3VF6    4DCH    4DHY    4ISE    4ISF    4ISG    4IWV    4IXC    4L3Q    4LC9    4MLE    4MLH   
PDB (IMB)1GLK    1V4S    1V4T    3A0I    3F9M    3FGU    3FR0    3GOI    3H1V    3ID8    3IDH    3IMX    3QIC    3S41    3VEV    3VEY    3VF6    4DCH    4DHY    4ISE    4ISF    4ISG    4IWV    4IXC    4L3Q    4LC9    4MLE    4MLH   
PDB (RSDB)1GLK    1V4S    1V4T    3A0I    3F9M    3FGU    3FR0    3GOI    3H1V    3ID8    3IDH    3IMX    3QIC    3S41    3VEV    3VEY    3VF6    4DCH    4DHY    4ISE    4ISF    4ISG    4IWV    4IXC    4L3Q    4LC9    4MLE    4MLH   
Human Protein AtlasENSG00000106633 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP35557
HPRD00680
IPIIPI00244083   IPI00218767   IPI00218768   IPI00927177   IPI00927398   
Protein Interaction databases
DIP (DOE-UCLA)P35557
IntAct (EBI)P35557
FunCoupENSG00000106633
BioGRIDGCK
InParanoidP35557
Interologous Interaction database P35557
IntegromeDBGCK
STRING (EMBL)GCK
Ontologies - Pathways
Ontology : AmiGOmagnesium ion binding  cellular glucose homeostasis  glucokinase activity  protein binding  ATP binding  glucose binding  nucleoplasm  mitochondrion  cytosol  cell cortex  carbohydrate metabolic process  glycogen biosynthetic process  fructose 2,6-bisphosphate metabolic process  glucose metabolic process  glycolytic process  regulation of glycolytic process  NADP metabolic process  positive regulation of cytosolic calcium ion concentration  hexose transport  fructokinase activity  regulation of glucose transport  glucose transport  mannokinase activity  protein phosphatase binding  second-messenger-mediated signaling  secretory granule  endocrine pancreas development  positive regulation of insulin secretion  negative regulation of epinephrine secretion  cellular response to insulin stimulus  cellular response to glucose starvation  positive regulation of phosphorylation  glucose homeostasis  regulation of potassium ion transport  ADP binding  small molecule metabolic process  cellular response to leptin stimulus  negative regulation of gluconeogenesis  positive regulation of glycogen biosynthetic process  positive regulation of glycolytic process  carbohydrate phosphorylation  regulation of insulin secretion  glucose 6-phosphate metabolic process  detection of glucose  transmembrane transport  calcium ion import  
Ontology : EGO-EBImagnesium ion binding  cellular glucose homeostasis  glucokinase activity  protein binding  ATP binding  glucose binding  nucleoplasm  mitochondrion  cytosol  cell cortex  carbohydrate metabolic process  glycogen biosynthetic process  fructose 2,6-bisphosphate metabolic process  glucose metabolic process  glycolytic process  regulation of glycolytic process  NADP metabolic process  positive regulation of cytosolic calcium ion concentration  hexose transport  fructokinase activity  regulation of glucose transport  glucose transport  mannokinase activity  protein phosphatase binding  second-messenger-mediated signaling  secretory granule  endocrine pancreas development  positive regulation of insulin secretion  negative regulation of epinephrine secretion  cellular response to insulin stimulus  cellular response to glucose starvation  positive regulation of phosphorylation  glucose homeostasis  regulation of potassium ion transport  ADP binding  small molecule metabolic process  cellular response to leptin stimulus  negative regulation of gluconeogenesis  positive regulation of glycogen biosynthetic process  positive regulation of glycolytic process  carbohydrate phosphorylation  regulation of insulin secretion  glucose 6-phosphate metabolic process  detection of glucose  transmembrane transport  calcium ion import  
Pathways : KEGGGlycolysis / Gluconeogenesis    Galactose metabolism    Starch and sucrose metabolism    Amino sugar and nucleotide sugar metabolism    Butirosin and neomycin biosynthesis    Insulin signaling pathway    Insulin secretion    Prolactin signaling pathway    Type II diabetes mellitus    Maturity onset diabetes of the young   
Protein Interaction DatabaseGCK
Wikipedia pathwaysGCK
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)GCK
snp3D : Map Gene to Disease2645
SNP (GeneSNP Utah)GCK
SNP : HGBaseGCK
Genetic variants : HAPMAPGCK
Exome VariantGCK
1000_GenomesGCK 
ICGC programENSG00000106633 
Somatic Mutations in Cancer : COSMICGCK 
CONAN: Copy Number AnalysisGCK 
Mutations and Diseases : HGMDGCK
Mutations and Diseases : intOGenGCK
Genomic VariantsGCK  GCK [DGVbeta]
dbVarGCK
ClinVarGCK
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM125851    125853    138079    602485    606176   
MedgenGCK
GENETestsGCK
Disease Genetic AssociationGCK
Huge Navigator GCK [HugePedia]  GCK [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneGCK
Homology/Alignments : Family Browser (UCSC)GCK
Phylogenetic Trees/Animal Genes : TreeFamGCK
Chemical/Protein Interactions : CTD2645
Chemical/Pharm GKB GenePA28610
Clinical trialGCK
Cancer Resource (Charite)ENSG00000106633
Other databases
Probes
Litterature
PubMed239 Pubmed reference(s) in Entrez
CoreMineGCK
iHOPGCK
OncoSearchGCK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:47:49 CEST 2014

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