Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GCKR (glucokinase regulator)

Identity

Alias_namesglucokinase (hexokinase 4) regulatory protein
Other aliasFGQTL5
GKRP
HGNC (Hugo) GCKR
LocusID (NCBI) 2646
Atlas_Id 50240
Location 2p23.3  [Link to chromosome band 2p23]
Location_base_pair Starts at 27496839 and ends at 27523683 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GCKR   4196
Cards
Entrez_Gene (NCBI)GCKR  2646  glucokinase regulator
AliasesFGQTL5; GKRP
GeneCards (Weizmann)GCKR
Ensembl hg19 (Hinxton)ENSG00000084734 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000084734 [Gene_View]  ENSG00000084734 [Sequence]  chr2:27496839-27523683 [Contig_View]  GCKR [Vega]
ICGC DataPortalENSG00000084734
TCGA cBioPortalGCKR
AceView (NCBI)GCKR
Genatlas (Paris)GCKR
WikiGenes2646
SOURCE (Princeton)GCKR
Genetics Home Reference (NIH)GCKR
Genomic and cartography
GoldenPath hg38 (UCSC)GCKR  -     chr2:27496839-27523683 +  2p23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GCKR  -     2p23.3   [Description]    (hg19-Feb_2009)
EnsemblGCKR - 2p23.3 [CytoView hg19]  GCKR - 2p23.3 [CytoView hg38]
Mapping of homologs : NCBIGCKR [Mapview hg19]  GCKR [Mapview hg38]
OMIM600842   613463   
Gene and transcription
Genbank (Entrez)AK291846 AK298448 AK303784 AK309599 BC130481
RefSeq transcript (Entrez)NM_001486
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GCKR
Cluster EST : UnigeneHs.89771 [ NCBI ]
CGAP (NCI)Hs.89771
Alternative Splicing GalleryENSG00000084734
Gene ExpressionGCKR [ NCBI-GEO ]   GCKR [ EBI - ARRAY_EXPRESS ]   GCKR [ SEEK ]   GCKR [ MEM ]
Gene Expression Viewer (FireBrowse)GCKR [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2646
GTEX Portal (Tissue expression)GCKR
Human Protein AtlasENSG00000084734-GCKR [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14397   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14397  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14397
Splice isoforms : SwissVarQ14397
PhosPhoSitePlusQ14397
Domaine pattern : Prosite (Expaxy)GCKR (PS01272)    SIS (PS51464)   
Domains : Interpro (EBI)Glucokinase_regulatory_CS    SIS   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)GCKR
DMDM Disease mutations2646
Blocks (Seattle)GCKR
PDB (SRS)4BB9    4BBA    4LY9    4MQU    4MRO    4MSU    4OHK    4OHM    4OHO    4OHP    4OLH    4OP1    4OP2    4OP3    4PX2    4PX3    4PX5    4PXS   
PDB (PDBSum)4BB9    4BBA    4LY9    4MQU    4MRO    4MSU    4OHK    4OHM    4OHO    4OHP    4OLH    4OP1    4OP2    4OP3    4PX2    4PX3    4PX5    4PXS   
PDB (IMB)4BB9    4BBA    4LY9    4MQU    4MRO    4MSU    4OHK    4OHM    4OHO    4OHP    4OLH    4OP1    4OP2    4OP3    4PX2    4PX3    4PX5    4PXS   
PDB (RSDB)4BB9    4BBA    4LY9    4MQU    4MRO    4MSU    4OHK    4OHM    4OHO    4OHP    4OLH    4OP1    4OP2    4OP3    4PX2    4PX3    4PX5    4PXS   
Structural Biology KnowledgeBase4BB9    4BBA    4LY9    4MQU    4MRO    4MSU    4OHK    4OHM    4OHO    4OHP    4OLH    4OP1    4OP2    4OP3    4PX2    4PX3    4PX5    4PXS   
SCOP (Structural Classification of Proteins)4BB9    4BBA    4LY9    4MQU    4MRO    4MSU    4OHK    4OHM    4OHO    4OHP    4OLH    4OP1    4OP2    4OP3    4PX2    4PX3    4PX5    4PXS   
CATH (Classification of proteins structures)4BB9    4BBA    4LY9    4MQU    4MRO    4MSU    4OHK    4OHM    4OHO    4OHP    4OLH    4OP1    4OP2    4OP3    4PX2    4PX3    4PX5    4PXS   
SuperfamilyQ14397
Human Protein Atlas [tissue]ENSG00000084734-GCKR [tissue]
Peptide AtlasQ14397
HPRD02909
IPIIPI00030293   IPI01012745   IPI00894068   IPI00892943   IPI00892824   
Protein Interaction databases
DIP (DOE-UCLA)Q14397
IntAct (EBI)Q14397
FunCoupENSG00000084734
BioGRIDGCKR
STRING (EMBL)GCKR
ZODIACGCKR
Ontologies - Pathways
QuickGOQ14397
Ontology : AmiGOprotein import into nucleus, translocation  enzyme inhibitor activity  protein binding  nucleus  nucleoplasm  nucleoplasm  nucleoplasm  cytoplasm  mitochondrion  cytosol  cytosol  carbohydrate metabolic process  regulation of glycolytic process  response to fructose  response to fructose  enzyme binding  carbohydrate binding  negative regulation of glucokinase activity  negative regulation of glucokinase activity  urate metabolic process  fructose-6-phosphate binding  fructose-6-phosphate binding  triglyceride homeostasis  carbohydrate derivative metabolic process  
Ontology : EGO-EBIprotein import into nucleus, translocation  enzyme inhibitor activity  protein binding  nucleus  nucleoplasm  nucleoplasm  nucleoplasm  cytoplasm  mitochondrion  cytosol  cytosol  carbohydrate metabolic process  regulation of glycolytic process  response to fructose  response to fructose  enzyme binding  carbohydrate binding  negative regulation of glucokinase activity  negative regulation of glucokinase activity  urate metabolic process  fructose-6-phosphate binding  fructose-6-phosphate binding  triglyceride homeostasis  carbohydrate derivative metabolic process  
NDEx NetworkGCKR
Atlas of Cancer Signalling NetworkGCKR
Wikipedia pathwaysGCKR
Orthology - Evolution
OrthoDB2646
GeneTree (enSembl)ENSG00000084734
Phylogenetic Trees/Animal Genes : TreeFamGCKR
HOVERGENQ14397
HOGENOMQ14397
Homologs : HomoloGeneGCKR
Homology/Alignments : Family Browser (UCSC)GCKR
Gene fusions - Rearrangements
Fusion : QuiverGCKR
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGCKR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GCKR
dbVarGCKR
ClinVarGCKR
1000_GenomesGCKR 
Exome Variant ServerGCKR
ExAC (Exome Aggregation Consortium)ENSG00000084734
GNOMAD BrowserENSG00000084734
Varsome BrowserGCKR
Genetic variants : HAPMAP2646
Genomic Variants (DGV)GCKR [DGVbeta]
DECIPHERGCKR [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGCKR 
Mutations
ICGC Data PortalGCKR 
TCGA Data PortalGCKR 
Broad Tumor PortalGCKR
OASIS PortalGCKR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGCKR  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGCKR
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GCKR
DgiDB (Drug Gene Interaction Database)GCKR
DoCM (Curated mutations)GCKR (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GCKR (select a term)
intoGenGCKR
Cancer3DGCKR(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600842    613463   
Orphanet
DisGeNETGCKR
MedgenGCKR
Genetic Testing Registry GCKR
NextProtQ14397 [Medical]
TSGene2646
GENETestsGCKR
Target ValidationGCKR
Huge Navigator GCKR [HugePedia]
snp3D : Map Gene to Disease2646
BioCentury BCIQGCKR
ClinGenGCKR
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2646
Chemical/Pharm GKB GenePA28611
Clinical trialGCKR
Miscellaneous
canSAR (ICR)GCKR (select the gene name)
Probes
Litterature
PubMed200 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGCKR
EVEXGCKR
GoPubMedGCKR
iHOPGCKR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:08:06 CET 2018

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