GCM1 (glial cells missing transcription factor 1)

2012-05-01  

Identity

HGNC
GCM1
LOCATION
6p12.1
LOCUSID
8521
ALIAS
GCMA,hGCMa

Other Information

Locus ID:

NCBI: 8521
MIM: 603715
HGNC: 4197
Ensembl: ENSG00000137270

Variants:

dbSNP: 8521
ClinVar: 8521
TCGA: ENSG00000137270
COSMIC: GCM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137270ENST00000259803Q9NP62

Expression (GTEx)

0
1
2
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
bone marrow

References

Pubmed IDYearTitleCitations
123970622002GCMa regulates the syncytin-mediated trophoblastic fusion.73
192047262009Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.63
192190682009Glial cell missing-1 transcription factor is required for the differentiation of the human trophoblast.59
234386032013The c-Myc-regulated microRNA-17~92 (miR-17~92) and miR-106a~363 clusters target hCYP19A1 and hGCM1 to inhibit human trophoblast differentiation.51
150816362004Decreased placental GCM1 (glial cells missing) gene expression in pre-eclampsia.37
160049932005Stimulation of GCMa and syncytin via cAMP mediated PKA signaling in human trophoblastic cells under normoxic and hypoxic conditions.31
221095222011Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway.30
236105562013A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta.27
161666242005Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa.24
156405262005FBW2 targets GCMa to the ubiquitin-proteasome degradation system.23

Citation

Dessen P

GCM1 (glial cells missing transcription factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-05-01

Online version: http://atlasgeneticsoncology.org/gene/52694/gcm1