GCM1 (glial cells missing transcription factor 1)

2012-05-01  

Identity

HGNC
LOCATION
6p12.1
LOCUSID
ALIAS
GCMA,hGCMa

Other Information

Locus ID:

NCBI: 8521
MIM: 603715
HGNC: 4197
Ensembl: ENSG00000137270

Variants:

dbSNP: 8521
ClinVar: 8521
TCGA: ENSG00000137270
COSMIC: GCM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137270ENST00000259803Q9NP62

Expression (GTEx)

0
1
2

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
353381522022Functional antagonism between ΔNp63α and GCM1 regulates human trophoblast stemness and differentiation.15
364421322022The multifaceted role of GCM1 during trophoblast differentiation in the human placenta.19
353381522022Functional antagonism between ΔNp63α and GCM1 regulates human trophoblast stemness and differentiation.15
364421322022The multifaceted role of GCM1 during trophoblast differentiation in the human placenta.19
336642222021Aberrant Gcm1 expression mediates Wnt/β-catenin pathway activation in folate deficiency involved in neural tube defects.6
340241232021Induction of the PPARγ (Peroxisome Proliferator-Activated Receptor γ)-GCM1 (Glial Cell Missing 1) Syncytialization Axis Reduces sFLT1 (Soluble fms-Like Tyrosine Kinase 1) in the Preeclamptic Placenta.9
336642222021Aberrant Gcm1 expression mediates Wnt/β-catenin pathway activation in folate deficiency involved in neural tube defects.6
340241232021Induction of the PPARγ (Peroxisome Proliferator-Activated Receptor γ)-GCM1 (Glial Cell Missing 1) Syncytialization Axis Reduces sFLT1 (Soluble fms-Like Tyrosine Kinase 1) in the Preeclamptic Placenta.9
279960932017Dlx3 and GCM-1 functionally coordinate the regulation of placental growth factor in human trophoblast-derived cells.12
283835512017p45 NF-E2 regulates syncytiotrophoblast differentiation by post-translational GCM1 modifications in human intrauterine growth restriction.8
285154472017DLX3 interacts with GCM1 and inhibits its transactivation-stimulating activity in a homeodomain-dependent manner in human trophoblast-derived cells.8
279960932017Dlx3 and GCM-1 functionally coordinate the regulation of placental growth factor in human trophoblast-derived cells.12
283835512017p45 NF-E2 regulates syncytiotrophoblast differentiation by post-translational GCM1 modifications in human intrauterine growth restriction.8
285154472017DLX3 interacts with GCM1 and inhibits its transactivation-stimulating activity in a homeodomain-dependent manner in human trophoblast-derived cells.8
265037852016A Positive Feedback Loop between Glial Cells Missing 1 and Human Chorionic Gonadotropin (hCG) Regulates Placental hCGβ Expression and Cell Differentiation.8

Citation

Dessen P

GCM1 (glial cells missing transcription factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-05-01

Online version: http://atlasgeneticsoncology.org/gene/52694/gcm1