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GCN1 (GCN1, eIF2 alpha kinase activator homolog)

Identity

Alias_namesGCN1L1
GCN1 (general control of amino-acid synthesis 1, yeast)-like 1
GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
Alias_symbol (synonym)KIAA0219
GCN1L
Other aliasPRIC295
HGNC (Hugo) GCN1
LocusID (NCBI) 10985
Atlas_Id 77727
Location 12q24.23  [Link to chromosome band 12q24]
Location_base_pair Starts at 120127210 and ends at 120194710 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EIF5B (2q11.2) / GCN1 (12q24.23)GCN1 (12q24.23) / 12p13.32 ()GCN1 (12q24.23) / ADGRV1 (5q14.3)
GCN1 (12q24.23) / CCND2 (12p13.32)GCN1 (12q24.23) / GCN1 (12q24.23)GCN1 (12q24.23) / KIAA0825 (5q15)
GCN1 (12q24.23) / LAIR1 (19q13.42)GCN1 (12q24.23) / MSI1 (12q24.31)GCN1 (12q24.23) / PLA2G1B (12q24.31)
GCN1 (12q24.23) / STAB1 (3p21.1)GCN1 (12q24.23) / TXNL4A (18q23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GCN1   4199
Cards
Entrez_Gene (NCBI)GCN1  10985  GCN1, eIF2 alpha kinase activator homolog
AliasesGCN1L; GCN1L1; PRIC295
GeneCards (Weizmann)GCN1
Ensembl hg19 (Hinxton)ENSG00000089154 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000089154 [Gene_View]  chr12:120127210-120194710 [Contig_View]  GCN1 [Vega]
ICGC DataPortalENSG00000089154
TCGA cBioPortalGCN1
AceView (NCBI)GCN1
Genatlas (Paris)GCN1
WikiGenes10985
SOURCE (Princeton)GCN1
Genetics Home Reference (NIH)GCN1
Genomic and cartography
GoldenPath hg38 (UCSC)GCN1  -     chr12:120127210-120194710 -  12q24.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GCN1  -     12q24.23   [Description]    (hg19-Feb_2009)
EnsemblGCN1 - 12q24.23 [CytoView hg19]  GCN1 - 12q24.23 [CytoView hg38]
Mapping of homologs : NCBIGCN1 [Mapview hg19]  GCN1 [Mapview hg38]
OMIM605614   
Gene and transcription
Genbank (Entrez)AK297271 BC021129 BC032335 BC040172 BC046177
RefSeq transcript (Entrez)NM_006836
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GCN1
Cluster EST : UnigeneHs.298716 [ NCBI ]
CGAP (NCI)Hs.298716
Alternative Splicing GalleryENSG00000089154
Gene ExpressionGCN1 [ NCBI-GEO ]   GCN1 [ EBI - ARRAY_EXPRESS ]   GCN1 [ SEEK ]   GCN1 [ MEM ]
Gene Expression Viewer (FireBrowse)GCN1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10985
GTEX Portal (Tissue expression)GCN1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92616   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92616  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92616
Splice isoforms : SwissVarQ92616
PhosPhoSitePlusQ92616
Domaine pattern : Prosite (Expaxy)HEAT_REPEAT (PS50077)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Gcn1    HEAT_type_2    TOG   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)TOG (SM01349)  
Conserved Domain (NCBI)GCN1
DMDM Disease mutations10985
Blocks (Seattle)GCN1
SuperfamilyQ92616
Human Protein AtlasENSG00000089154
Peptide AtlasQ92616
HPRD16127
IPIIPI00001159   
Protein Interaction databases
DIP (DOE-UCLA)Q92616
IntAct (EBI)Q92616
FunCoupENSG00000089154
BioGRIDGCN1
STRING (EMBL)GCN1
ZODIACGCN1
Ontologies - Pathways
QuickGOQ92616
Ontology : AmiGORNA binding  cytoplasm  cytosol  ribosome  polysome  translation  regulation of translation  translation factor activity, RNA binding  membrane  protein kinase regulator activity  protein kinase binding  positive regulation of kinase activity  cellular response to amino acid starvation  positive regulation of transcription from RNA polymerase II promoter in response to stress  ribosome binding  cadherin binding  regulation of protein kinase activity  cellular response to leucine starvation  
Ontology : EGO-EBIRNA binding  cytoplasm  cytosol  ribosome  polysome  translation  regulation of translation  translation factor activity, RNA binding  membrane  protein kinase regulator activity  protein kinase binding  positive regulation of kinase activity  cellular response to amino acid starvation  positive regulation of transcription from RNA polymerase II promoter in response to stress  ribosome binding  cadherin binding  regulation of protein kinase activity  cellular response to leucine starvation  
NDEx NetworkGCN1
Atlas of Cancer Signalling NetworkGCN1
Wikipedia pathwaysGCN1
Orthology - Evolution
OrthoDB10985
GeneTree (enSembl)ENSG00000089154
Phylogenetic Trees/Animal Genes : TreeFamGCN1
HOVERGENQ92616
HOGENOMQ92616
Homologs : HomoloGeneGCN1
Homology/Alignments : Family Browser (UCSC)GCN1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGCN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GCN1
dbVarGCN1
ClinVarGCN1
1000_GenomesGCN1 
Exome Variant ServerGCN1
ExAC (Exome Aggregation Consortium)GCN1 (select the gene name)
Genetic variants : HAPMAP10985
Genomic Variants (DGV)GCN1 [DGVbeta]
DECIPHERGCN1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGCN1 
Mutations
ICGC Data PortalGCN1 
TCGA Data PortalGCN1 
Broad Tumor PortalGCN1
OASIS PortalGCN1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDGCN1
BioMutasearch GCN1
DgiDB (Drug Gene Interaction Database)GCN1
DoCM (Curated mutations)GCN1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GCN1 (select a term)
intoGenGCN1
Cancer3DGCN1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605614   
Orphanet
MedgenGCN1
Genetic Testing Registry GCN1
NextProtQ92616 [Medical]
TSGene10985
GENETestsGCN1
Huge Navigator GCN1 [HugePedia]
snp3D : Map Gene to Disease10985
BioCentury BCIQGCN1
ClinGenGCN1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10985
Chemical/Pharm GKB GenePA28616
Clinical trialGCN1
Miscellaneous
canSAR (ICR)GCN1 (select the gene name)
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGCN1
EVEXGCN1
GoPubMedGCN1
iHOPGCN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 11:13:29 CEST 2017

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