GCSAM (germinal center associated signaling and motility)

2012-09-01  

Identity

HGNC
LOCATION
3q13.2
LOCUSID
ALIAS
GCAT2,GCET2,HGAL
FUSION GENES

Other Information

Locus ID:

NCBI: 257144
MIM: 607792
HGNC: 20253
Ensembl: ENSG00000174500

Variants:

dbSNP: 257144
ClinVar: 257144
TCGA: ENSG00000174500
COSMIC: GCSAM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174500ENST00000308910Q8N6F7
ENSG00000174500ENST00000460387Q8N6F7
ENSG00000174500ENST00000470085F2Z3F7
ENSG00000174500ENST00000484193Q8N6F7
ENSG00000174500ENST00000487901C9IY73
ENSG00000174500ENST00000488580C9JY41
ENSG00000174500ENST00000495418F2Z3F7

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
125093822003HGAL is a novel interleukin-4-inducible gene that strongly predicts survival in diffuse large B-cell lymphoma.31
125093822003HGAL is a novel interleukin-4-inducible gene that strongly predicts survival in diffuse large B-cell lymphoma.31
178233102007HGAL, a lymphoma prognostic biomarker, interacts with the cytoskeleton and mediates the effects of IL-6 on cell migration.16
232998882013Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation.15
206972482010Immunoarchitectural patterns in follicular lymphoma: efficacy of HGAL and LMO2 in the detection of the interfollicular and diffuse components.9
219888582011Comparison of germinal center markers CD10, BCL6 and human germinal center-associated lymphoma (HGAL) in follicular lymphomas.6
217223132011PRDM1/Blimp1 downregulates expression of germinal center genes LMO2 and HGAL.4
215024242011The efficacy of HGAL and LMO2 in the separation of lymphomas derived from small B cells in nodal and extranodal sites, including the bone marrow.2
252034282015Diagnostic Utility of the Germinal Center-associated Markers GCET1, HGAL, and LMO2 in Hematolymphoid Neoplasms.1
128190182003Two newly characterized germinal center B-cell-associated genes, GCET1 and GCET2, have differential expression in normal and neoplastic B cells.0

Citation

Dessen P

GCSAM (germinal center associated signaling and motility)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52852/gcsam