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GDF11 (growth differentiation factor 11)

Identity

Alias_symbol (synonym)BMP-11
Other aliasBMP11
HGNC (Hugo) GDF11
LocusID (NCBI) 10220
Atlas_Id 47379
Location 12q13.2  [Link to chromosome band 12q13]
Location_base_pair Starts at 55743280 and ends at 55753370 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GDF11 (12q13.2) / GDF11 (12q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GDF11   4216
Cards
Entrez_Gene (NCBI)GDF11  10220  growth differentiation factor 11
AliasesBMP-11; BMP11
GeneCards (Weizmann)GDF11
Ensembl hg19 (Hinxton)ENSG00000135414 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135414 [Gene_View]  chr12:55743280-55753370 [Contig_View]  GDF11 [Vega]
ICGC DataPortalENSG00000135414
TCGA cBioPortalGDF11
AceView (NCBI)GDF11
Genatlas (Paris)GDF11
WikiGenes10220
SOURCE (Princeton)GDF11
Genetics Home Reference (NIH)GDF11
Genomic and cartography
GoldenPath hg38 (UCSC)GDF11  -     chr12:55743280-55753370 +  12q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GDF11  -     12q13.2   [Description]    (hg19-Feb_2009)
EnsemblGDF11 - 12q13.2 [CytoView hg19]  GDF11 - 12q13.2 [CytoView hg38]
Mapping of homologs : NCBIGDF11 [Mapview hg19]  GDF11 [Mapview hg38]
OMIM603936   
Gene and transcription
Genbank (Entrez)AA053348 AF028333 AF100907 AK091091 BC148591
RefSeq transcript (Entrez)NM_005811
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GDF11
Cluster EST : UnigeneHs.600883 [ NCBI ]
CGAP (NCI)Hs.600883
Alternative Splicing GalleryENSG00000135414
Gene ExpressionGDF11 [ NCBI-GEO ]   GDF11 [ EBI - ARRAY_EXPRESS ]   GDF11 [ SEEK ]   GDF11 [ MEM ]
Gene Expression Viewer (FireBrowse)GDF11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10220
GTEX Portal (Tissue expression)GDF11
Human Protein AtlasENSG00000135414-GDF11 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95390   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95390  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95390
Splice isoforms : SwissVarO95390
PhosPhoSitePlusO95390
Domaine pattern : Prosite (Expaxy)TGF_BETA_1 (PS00250)    TGF_BETA_2 (PS51362)   
Domains : Interpro (EBI)Cystine-knot_cytokine    TGF-b_C    TGF-b_propeptide    TGF-beta-rel    TGFb_CS   
Domain families : Pfam (Sanger)TGF_beta (PF00019)    TGFb_propeptide (PF00688)   
Domain families : Pfam (NCBI)pfam00019    pfam00688   
Domain families : Smart (EMBL)TGFB (SM00204)  
Conserved Domain (NCBI)GDF11
DMDM Disease mutations10220
Blocks (Seattle)GDF11
PDB (SRS)5E4G   
PDB (PDBSum)5E4G   
PDB (IMB)5E4G   
PDB (RSDB)5E4G   
Structural Biology KnowledgeBase5E4G   
SCOP (Structural Classification of Proteins)5E4G   
CATH (Classification of proteins structures)5E4G   
SuperfamilyO95390
Human Protein Atlas [tissue]ENSG00000135414-GDF11 [tissue]
Peptide AtlasO95390
HPRD04895
IPIIPI00030111   IPI01021672   
Protein Interaction databases
DIP (DOE-UCLA)O95390
IntAct (EBI)O95390
FunCoupENSG00000135414
BioGRIDGDF11
STRING (EMBL)GDF11
ZODIACGDF11
Ontologies - Pathways
QuickGOO95390
Ontology : AmiGOskeletal system development  metanephros development  ureteric bud development  cytokine activity  transforming growth factor beta receptor binding  cellular_component  extracellular space  nucleoplasm  nervous system development  mesoderm development  growth factor activity  negative regulation of cell proliferation  positive regulation of pathway-restricted SMAD protein phosphorylation  spinal cord anterior/posterior patterning  pancreas development  regulation of apoptotic process  intracellular membrane-bounded organelle  protein complex  regulation of MAPK cascade  negative regulation of cell differentiation  cell development  cell maturation  camera-type eye morphogenesis  palate development  SMAD protein signal transduction  
Ontology : EGO-EBIskeletal system development  metanephros development  ureteric bud development  cytokine activity  transforming growth factor beta receptor binding  cellular_component  extracellular space  nucleoplasm  nervous system development  mesoderm development  growth factor activity  negative regulation of cell proliferation  positive regulation of pathway-restricted SMAD protein phosphorylation  spinal cord anterior/posterior patterning  pancreas development  regulation of apoptotic process  intracellular membrane-bounded organelle  protein complex  regulation of MAPK cascade  negative regulation of cell differentiation  cell development  cell maturation  camera-type eye morphogenesis  palate development  SMAD protein signal transduction  
NDEx NetworkGDF11
Atlas of Cancer Signalling NetworkGDF11
Wikipedia pathwaysGDF11
Orthology - Evolution
OrthoDB10220
GeneTree (enSembl)ENSG00000135414
Phylogenetic Trees/Animal Genes : TreeFamGDF11
HOVERGENO95390
HOGENOMO95390
Homologs : HomoloGeneGDF11
Homology/Alignments : Family Browser (UCSC)GDF11
Gene fusions - Rearrangements
Fusion: Tumor Portal GDF11
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGDF11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GDF11
dbVarGDF11
ClinVarGDF11
1000_GenomesGDF11 
Exome Variant ServerGDF11
ExAC (Exome Aggregation Consortium)ENSG00000135414
GNOMAD BrowserENSG00000135414
Genetic variants : HAPMAP10220
Genomic Variants (DGV)GDF11 [DGVbeta]
DECIPHERGDF11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGDF11 
Mutations
ICGC Data PortalGDF11 
TCGA Data PortalGDF11 
Broad Tumor PortalGDF11
OASIS PortalGDF11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGDF11  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGDF11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GDF11
DgiDB (Drug Gene Interaction Database)GDF11
DoCM (Curated mutations)GDF11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GDF11 (select a term)
intoGenGDF11
Cancer3DGDF11(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603936   
Orphanet
MedgenGDF11
Genetic Testing Registry GDF11
NextProtO95390 [Medical]
TSGene10220
GENETestsGDF11
Target ValidationGDF11
Huge Navigator GDF11 [HugePedia]
snp3D : Map Gene to Disease10220
BioCentury BCIQGDF11
ClinGenGDF11
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10220
Chemical/Pharm GKB GenePA28631
Clinical trialGDF11
Miscellaneous
canSAR (ICR)GDF11 (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGDF11
EVEXGDF11
GoPubMedGDF11
iHOPGDF11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 12:51:06 CET 2017

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