Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

GDF2 (growth differentiation factor 2)

Identity

Alias (NCBI)BMP-9
BMP9
HHT5
HGNC (Hugo) GDF2
HGNC Alias symbBMP-9
BMP9
LocusID (NCBI) 2658
Atlas_Id 46771
Location 10q11.22  [Link to chromosome band 10q11]
Location_base_pair Starts at 47322454 and ends at 47327588 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)GDF2   4217
Cards
Entrez_Gene (NCBI)GDF2    growth differentiation factor 2
AliasesBMP-9; BMP9; HHT5
GeneCards (Weizmann)GDF2
Ensembl hg19 (Hinxton)ENSG00000263761 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000263761 [Gene_View]  ENSG00000263761 [Sequence]  chr10:47322454-47327588 [Contig_View]  GDF2 [Vega]
ICGC DataPortalENSG00000263761
TCGA cBioPortalGDF2
AceView (NCBI)GDF2
Genatlas (Paris)GDF2
SOURCE (Princeton)GDF2
Genetics Home Reference (NIH)GDF2
Genomic and cartography
GoldenPath hg38 (UCSC)GDF2  -     chr10:47322454-47327588 +  10q11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GDF2  -     10q11.22   [Description]    (hg19-Feb_2009)
GoldenPathGDF2 - 10q11.22 [CytoView hg19]  GDF2 - 10q11.22 [CytoView hg38]
ImmunoBaseENSG00000263761
Genome Data Viewer NCBIGDF2 [Mapview hg19]  
OMIM605120   615506   
Gene and transcription
Genbank (Entrez)AF156891 AF188285 AK314956 BC069643 BC074921
RefSeq transcript (Entrez)NM_016204
Consensus coding sequences : CCDS (NCBI)GDF2
Gene ExpressionGDF2 [ NCBI-GEO ]   GDF2 [ EBI - ARRAY_EXPRESS ]   GDF2 [ SEEK ]   GDF2 [ MEM ]
Gene Expression Viewer (FireBrowse)GDF2 [ Firebrowse - Broad ]
GenevisibleExpression of GDF2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2658
GTEX Portal (Tissue expression)GDF2
Human Protein AtlasENSG00000263761-GDF2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UK05   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UK05  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UK05
PhosPhoSitePlusQ9UK05
Domaine pattern : Prosite (Expaxy)TGF_BETA_1 (PS00250)    TGF_BETA_2 (PS51362)   
Domains : Interpro (EBI)Cystine-knot_cytokine    TGF-b_C    TGF-b_propeptide    TGF-beta-rel    TGFb_CS   
Domain families : Pfam (Sanger)TGF_beta (PF00019)    TGFb_propeptide (PF00688)   
Domain families : Pfam (NCBI)pfam00019    pfam00688   
Domain families : Smart (EMBL)TGFB (SM00204)  
Conserved Domain (NCBI)GDF2
PDB (RSDB)1ZKZ    4FAO    4MPL    4YCG    4YCI    5HZW    5I05   
PDB Europe1ZKZ    4FAO    4MPL    4YCG    4YCI    5HZW    5I05   
PDB (PDBSum)1ZKZ    4FAO    4MPL    4YCG    4YCI    5HZW    5I05   
PDB (IMB)1ZKZ    4FAO    4MPL    4YCG    4YCI    5HZW    5I05   
Structural Biology KnowledgeBase1ZKZ    4FAO    4MPL    4YCG    4YCI    5HZW    5I05   
SCOP (Structural Classification of Proteins)1ZKZ    4FAO    4MPL    4YCG    4YCI    5HZW    5I05   
CATH (Classification of proteins structures)1ZKZ    4FAO    4MPL    4YCG    4YCI    5HZW    5I05   
SuperfamilyQ9UK05
AlphaFold pdb e-kbQ9UK05   
Human Protein Atlas [tissue]ENSG00000263761-GDF2 [tissue]
HPRD05492
Protein Interaction databases
DIP (DOE-UCLA)Q9UK05
IntAct (EBI)Q9UK05
BioGRIDGDF2
STRING (EMBL)GDF2
ZODIACGDF2
Ontologies - Pathways
QuickGOQ9UK05
Ontology : AmiGOossification  angiogenesis  branching involved in blood vessel morphogenesis  vasculogenesis  osteoblast differentiation  negative regulation of endothelial cell proliferation  positive regulation of endothelial cell proliferation  cytokine activity  protein binding  extracellular region  extracellular space  cellular iron ion homeostasis  growth factor activity  negative regulation of DNA replication  negative regulation of endothelial cell migration  positive regulation of pathway-restricted SMAD protein phosphorylation  positive regulation of pathway-restricted SMAD protein phosphorylation  negative regulation of angiogenesis  negative regulation of cell growth  BMP signaling pathway  BMP signaling pathway  positive regulation of BMP signaling pathway  positive regulation of interleukin-8 production  activin receptor signaling pathway  negative regulation of blood vessel endothelial cell migration  positive regulation of endothelial cell differentiation  positive regulation of angiogenesis  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  blood vessel morphogenesis  cartilage development  pathway-restricted SMAD protein phosphorylation  SMAD protein signal transduction  positive regulation of cartilage development  extracellular exosome  cellular response to BMP stimulus  negative regulation of DNA biosynthetic process  
Ontology : EGO-EBIossification  angiogenesis  branching involved in blood vessel morphogenesis  vasculogenesis  osteoblast differentiation  negative regulation of endothelial cell proliferation  positive regulation of endothelial cell proliferation  cytokine activity  protein binding  extracellular region  extracellular space  cellular iron ion homeostasis  growth factor activity  negative regulation of DNA replication  negative regulation of endothelial cell migration  positive regulation of pathway-restricted SMAD protein phosphorylation  positive regulation of pathway-restricted SMAD protein phosphorylation  negative regulation of angiogenesis  negative regulation of cell growth  BMP signaling pathway  BMP signaling pathway  positive regulation of BMP signaling pathway  positive regulation of interleukin-8 production  activin receptor signaling pathway  negative regulation of blood vessel endothelial cell migration  positive regulation of endothelial cell differentiation  positive regulation of angiogenesis  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  blood vessel morphogenesis  cartilage development  pathway-restricted SMAD protein phosphorylation  SMAD protein signal transduction  positive regulation of cartilage development  extracellular exosome  cellular response to BMP stimulus  negative regulation of DNA biosynthetic process  
NDEx NetworkGDF2
Atlas of Cancer Signalling NetworkGDF2
Wikipedia pathwaysGDF2
Orthology - Evolution
OrthoDB2658
GeneTree (enSembl)ENSG00000263761
Phylogenetic Trees/Animal Genes : TreeFamGDF2
Homologs : HomoloGeneGDF2
Homology/Alignments : Family Browser (UCSC)GDF2
Gene fusions - Rearrangements
Fusion : QuiverGDF2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGDF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GDF2
dbVarGDF2
ClinVarGDF2
MonarchGDF2
1000_GenomesGDF2 
Exome Variant ServerGDF2
GNOMAD BrowserENSG00000263761
Varsome BrowserGDF2
ACMGGDF2 variants
VarityQ9UK05
Genomic Variants (DGV)GDF2 [DGVbeta]
DECIPHERGDF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGDF2 
Mutations
ICGC Data PortalGDF2 
TCGA Data PortalGDF2 
Broad Tumor PortalGDF2
OASIS PortalGDF2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDGDF2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaGDF2
DgiDB (Drug Gene Interaction Database)GDF2
DoCM (Curated mutations)GDF2
CIViC (Clinical Interpretations of Variants in Cancer)GDF2
Cancer3DGDF2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605120    615506   
Orphanet236   
DisGeNETGDF2
MedgenGDF2
Genetic Testing Registry GDF2
NextProtQ9UK05 [Medical]
GENETestsGDF2
Target ValidationGDF2
Huge Navigator GDF2 [HugePedia]
ClinGenGDF2 (curated)
Clinical trials, drugs, therapy
MyCancerGenomeGDF2
Protein Interactions : CTDGDF2
Pharm GKB GenePA28632
PharosQ9UK05
Clinical trialGDF2
Miscellaneous
canSAR (ICR)GDF2
HarmonizomeGDF2
DataMed IndexGDF2
Probes
Litterature
PubMed103 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGDF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:10:34 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.