Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

GDF3 (growth differentiation factor 3)

Identity

Other namesKFS3
MCOP7
MCOPCB6
HGNC (Hugo) GDF3
LocusID (NCBI) 9573
Atlas_Id 332
Location 12p13.31
Location_base_pair Starts at 7842381 and ends at 7848360 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)GDF3   4218
Cards
Entrez_Gene (NCBI)GDF3  9573  growth differentiation factor 3
GeneCards (Weizmann)GDF3
Ensembl hg19 (Hinxton)ENSG00000184344 [Gene_View]  chr12:7842381-7848360 [Contig_View]  GDF3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000184344 [Gene_View]  chr12:7842381-7848360 [Contig_View]  GDF3 [Vega]
ICGC DataPortalENSG00000184344
TCGA cBioPortalGDF3
AceView (NCBI)GDF3
Genatlas (Paris)GDF3
WikiGenes9573
SOURCE (Princeton)GDF3
Genomic and cartography
GoldenPath hg19 (UCSC)GDF3  -     chr12:7842381-7848360 -  12p13.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GDF3  -     12p13.31   [Description]    (hg38-Dec_2013)
EnsemblGDF3 - 12p13.31 [CytoView hg19]  GDF3 - 12p13.31 [CytoView hg38]
Mapping of homologs : NCBIGDF3 [Mapview hg19]  GDF3 [Mapview hg38]
OMIM606522   613702   613703   613704   
Gene and transcription
Genbank (Entrez)AF110641 AF263538 AY358875 BC030959 DQ892661
RefSeq transcript (Entrez)NM_020634
RefSeq genomic (Entrez)NC_000012 NC_018923 NG_028167 NT_009714 NW_004929383
Consensus coding sequences : CCDS (NCBI)GDF3
Cluster EST : UnigeneHs.86232 [ NCBI ]
CGAP (NCI)Hs.86232
Alternative Splicing : Fast-db (Paris)GSHG0007221
Alternative Splicing GalleryENSG00000184344
Gene ExpressionGDF3 [ NCBI-GEO ]     GDF3 [ SEEK ]   GDF3 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NR23 (Uniprot)
NextProtQ9NR23  [Medical]  [Publications]
With graphics : InterProQ9NR23
Splice isoforms : SwissVarQ9NR23 (Swissvar)
Domaine pattern : Prosite (Expaxy)TGF_BETA_1 (PS00250)    TGF_BETA_2 (PS51362)   
Domains : Interpro (EBI)Cystine-knot_cytokine    Inhibin_asu    TGF-b_C    TGF-b_N    TGF-beta-rel    TGFb_CS   
Related proteins : CluSTrQ9NR23
Domain families : Pfam (Sanger)TGF_beta (PF00019)    TGFb_propeptide (PF00688)   
Domain families : Pfam (NCBI)pfam00019    pfam00688   
Domain families : Smart (EMBL)TGFB (SM00204)  
DMDM Disease mutations9573
Blocks (Seattle)Q9NR23
Human Protein AtlasENSG00000184344
Peptide AtlasQ9NR23
HPRD05938
IPIIPI00299659   
Protein Interaction databases
DIP (DOE-UCLA)Q9NR23
IntAct (EBI)Q9NR23
FunCoupENSG00000184344
BioGRIDGDF3
IntegromeDBGDF3
STRING (EMBL)GDF3
Ontologies - Pathways
QuickGOQ9NR23
Ontology : AmiGOskeletal system development  eye development  in utero embryonic development  response to dietary excess  cytokine activity  transforming growth factor beta receptor binding  extracellular space  cytoplasm  endoderm development  mesoderm development  growth factor activity  regulation of cell fate commitment  positive regulation of pathway-restricted SMAD protein phosphorylation  protein kinase binding  BMP signaling pathway  negative regulation of BMP signaling pathway  notochord development  somite rostral/caudal axis specification  growth  regulation of apoptotic process  regulation of MAPK cascade  negative regulation of epidermal cell differentiation  negative regulation of myoblast differentiation  cell development  formation of anatomical boundary  SMAD protein signal transduction  primitive streak formation  
Ontology : EGO-EBIskeletal system development  eye development  in utero embryonic development  response to dietary excess  cytokine activity  transforming growth factor beta receptor binding  extracellular space  cytoplasm  endoderm development  mesoderm development  growth factor activity  regulation of cell fate commitment  positive regulation of pathway-restricted SMAD protein phosphorylation  protein kinase binding  BMP signaling pathway  negative regulation of BMP signaling pathway  notochord development  somite rostral/caudal axis specification  growth  regulation of apoptotic process  regulation of MAPK cascade  negative regulation of epidermal cell differentiation  negative regulation of myoblast differentiation  cell development  formation of anatomical boundary  SMAD protein signal transduction  primitive streak formation  
Protein Interaction DatabaseGDF3
DoCM (Curated mutations)GDF3
Wikipedia pathwaysGDF3
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerGDF3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GDF3
dbVarGDF3
ClinVarGDF3
1000_GenomesGDF3 
Exome Variant ServerGDF3
SNP (GeneSNP Utah)GDF3
SNP : HGBaseGDF3
Genetic variants : HAPMAPGDF3
Genomic Variants (DGV)GDF3 [DGVbeta]
Mutations
ICGC Data PortalGDF3 
TCGA Data PortalGDF3 
Tumor PortalGDF3
Somatic Mutations in Cancer : COSMICGDF3 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)12:7842381-7848360
CONAN: Copy Number AnalysisGDF3 
Mutations and Diseases : HGMDGDF3
OMIM606522    613702    613703    613704   
MedgenGDF3
NextProtQ9NR23 [Medical]
GENETestsGDF3
Disease Genetic AssociationGDF3
Huge Navigator GDF3 [HugePedia]  GDF3 [HugeCancerGEM]
snp3D : Map Gene to Disease9573
DGIdb (Drug Gene Interaction db)GDF3
BioCentury BCIQGDF3
General knowledge
Homologs : HomoloGeneGDF3
Homology/Alignments : Family Browser (UCSC)GDF3
Phylogenetic Trees/Animal Genes : TreeFamGDF3
Chemical/Protein Interactions : CTD9573
Chemical/Pharm GKB GenePA28633
Clinical trialGDF3
Cancer Resource (Charite)ENSG00000184344
Other databases
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
CoreMineGDF3
GoPubMedGDF3
iHOPGDF3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jun 27 11:36:30 CEST 2015

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.