Identity
HGNC
LOCATION
8q22.1
LOCUSID
ALIAS
BMP-13,BMP13,CDMP2,KFM,KFS,KFS1,KFSL,SGM1,SYNS4
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 392255
MIM: 601147
HGNC: 4221
Ensembl: ENSG00000156466
Variants:
dbSNP: 392255
ClinVar: 392255
TCGA: ENSG00000156466
COSMIC: GDF6
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000156466 | ENST00000287020 | Q6KF10 |
| ENSG00000156466 | ENST00000287020 | A0A0S2A5D6 |
| ENSG00000156466 | ENST00000620978 | A0PK22 |
| ENSG00000156466 | ENST00000621429 | A0A087X0X2 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| TGF-beta signaling pathway | KEGG | ko04350 |
| TGF-beta signaling pathway | KEGG | hsa04350 |
| Hippo signaling pathway | KEGG | hsa04390 |
| Hippo signaling pathway | KEGG | ko04390 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38087057 | 2023 | A novel DNA methylation signature revealed GDF6 and RCC1 as potential prognostic biomarkers correlated with cell proliferation in clear cell renal cell carcinoma. | 0 |
| 38087057 | 2023 | A novel DNA methylation signature revealed GDF6 and RCC1 as potential prognostic biomarkers correlated with cell proliferation in clear cell renal cell carcinoma. | 0 |
| 35442524 | 2022 | Bone morphogenetic protein 13 in hepatic stellate cells and hepatic fibrosis. | 1 |
| 35442524 | 2022 | Bone morphogenetic protein 13 in hepatic stellate cells and hepatic fibrosis. | 1 |
| 34319658 | 2021 | A Novel Human Long Noncoding RNA SCDAL Promotes Angiogenesis through SNF5-Mediated GDF6 Expression. | 10 |
| 34440463 | 2021 | siRNA Mediate RNA Interference Concordant with Early On-Target Transient Transcriptional Interference. | 1 |
| 34573339 | 2021 | GDF6 Knockdown in a Family with Multiple Synostosis Syndrome and Speech Impairment. | 3 |
| 34319658 | 2021 | A Novel Human Long Noncoding RNA SCDAL Promotes Angiogenesis through SNF5-Mediated GDF6 Expression. | 10 |
| 34440463 | 2021 | siRNA Mediate RNA Interference Concordant with Early On-Target Transient Transcriptional Interference. | 1 |
| 34573339 | 2021 | GDF6 Knockdown in a Family with Multiple Synostosis Syndrome and Speech Impairment. | 3 |
| 32045359 | 2020 | miR-98 is involved in missed abortion by targeting GDF6 and FAPP2. | 7 |
| 32369452 | 2020 | Long-range cis-regulatory elements controlling GDF6 expression are essential for ear development. | 8 |
| 32737436 | 2020 | Rare heterozygous GDF6 variants in patients with renal anomalies. | 4 |
| 32992671 | 2020 | Regenerative Response of Degenerate Human Nucleus Pulposus Cells to GDF6 Stimulation. | 2 |
| 33147457 | 2020 | GDF6-CD99 Signaling Regulates Src and Ewing Sarcoma Growth. | 11 |
Citation
Dessen P
GDF6 (growth differentiation factor 6)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/47057/gdf6
